Adilia Hormigo

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First Name

Adilia

Last Name

Hormigo

NPI

1427029461

Faculty ID

17230

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Full Time

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Adult

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Female

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Research Profile

Clinical Profile

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Clinical Focus

Dr. Hormigo's clinical expertise is the treatment of malignancies of the central nervous system and neurologic complications of cancer.

Research Focus

Dr. Hormigo’s translational research focuses on new strategies in cancer immunology, including personalized treatment for patients with malignant brain tumors, understanding and overcoming the tumor microenvironment resistance to treatment and defining biomarkers of treatment response. She has been a primary investigator on innovative clinical trials. Her work has been published in numerous peer-reviewed journals.

Elsevier Profile

EMR ID

94869

Biography

<p>Adilia Hormigo, MD, PhD, is Leader, Neuro-Oncology Program, Co-Leader, Neuro-Oncology Multidisciplinary Disease Team and Professor, Hematology-Oncology, Neurosurgery, and Microbiology &amp; Immunology at Montefiore Einstein. She is also a member of the Cancer Therapeutics Program. Her clinical expertise is the treatment of malignancies of the central nervous system and neurologic complications of cancer.</p><p>Dr. Hormigo earned her Doctor of Medicine with honors from the University of Lisbon and her Doctor of Philosophy from New York University. She pursued a residency in neurology at New York Presbyterian-Weill Cornell University/Memorial Sloan-Kettering Cancer Center. She also completed research and clinical neuro-oncology fellowships at Memorial Sloan-Kettering Cancer Center. In addition, she held faculty positions at Memorial Sloan-Kettering Cancer jointly with Cornell University and at the Icahn School of Medicine at Mount Sinai, where she served as Director of Neuro-Oncology and founded the Neuro-Oncology Fellowship Program.</p><p>Dr. Hormigo&rsquo;s translational research focuses on new strategies in cancer immunology, including personalized treatment for patients with malignant brain tumors, understanding and overcoming the tumor microenvironment resistance to treatment and defining biomarkers of treatment response. She has been a primary investigator on innovative clinical trials. Her work has been published in numerous peer-reviewed journals.</p><p>Dr. Hormigo is board certified in neurology and certified in neuro-oncology. She is a fellow of the American Neurological Association and a member of many professional societies, including the Society for Neuro-Oncology, the American Society of Clinical Oncology, the American Association for Cancer Research and the Society for the Immunotherapy of Cancer. In addition, she has received numerous awards and honors, including Excellence in Teaching the Neurology Clerkship at Cornell University and the Memorial Sloan-Kettering Cancer Center Society and Memorial Sloan-Kettering Brain Tumor Center awards. She also received recognition as a CRI -V Foundation Clinic and Laboratory Integration Program (CLIP) Investigator.</p>

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Katharine A. McNeill

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First Name

Katharine

Last Name

McNeill

NPI

1598995730

Faculty ID

15494

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Full Time

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Adult

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Female

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Elsevier Profile

EMR ID

1542

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Patrick A. LaSala

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First Name

Patrick

Last Name

LaSala

NPI

1700980125

Faculty ID

6319

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part-time

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Adult

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Male

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Expert Summary

<p>Dr. LaSala developed a program of computer–based localization techniques to refine surgical approaches to intracranial targets such as tumors and eplipetic zones to facilitate their removal. The methods are frequently minimally invasive and help safeguard surrounding vital brain structures. Dr. LaSala is the Department’s Chair of the Quality Improvement Committee and also sits on the Medical Centers Quality Improvement Peer review board. Dr. LaSala is a co-investigator on several multi-institution clinical research trials for the treatment of benign and malignant brain tumors.</p>

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Elsevier Profile

EMR ID

3365

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Eugene S. Flamm

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First Name

Eugene

Last Name

Flamm

NPI

1265536684

Faculty ID

5565

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Full Time

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Adult

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Male

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<p>Dr. Flamm specializes in intracranial Neurosurgery for vascular disease such as aneurysms, vascular malformations and benign brain tumors.&nbsp;His goal is to combat neurological disease through ever-more effective diagnosis, treatment, rehabilitation and research. He has been active in academic neurosurgery throughout his career and has directed a number of national clinical trials.&nbsp;Dr. Flamm has been Chairman of Neurosurgery at Montefiore Medical Center for the past 15 years</p>

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Elsevier Profile

EMR ID

4297

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Emad N. Eskandar

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First Name

Emad

Last Name

Eskandar

NPI

1972576239

Faculty ID

15647

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Full Time

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Adult

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Male

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Professional Interests

<p><strong>Clinical Interests: Epilepsy, Trigeminal neuralgia, Parkinson Disease, and Brain tumors</strong>.<br /> Dr. Eskandar specializes in the surgical diagnosis and treatment of epilepsy in both children and adults.&nbsp;&nbsp; He is a world-leader in this field, and has over 15 years of experience in utilizing the most current techniques. &nbsp;These techniques include keyhole surgery (minimal incision), stereotactic electro-encephalography (SEEG), minimally invasive foramen-ovale electrodes, vagal nerve stimulation, responsive neuro-stimulation (RNS or Neuropace), and laser ablation of epileptic areas. &nbsp;&nbsp;</p>
<p>In addition, Dr. Eskandar is an expert in the treatment of trigeminal neuralgia, an extremely painful condition affecting the face.&nbsp;&nbsp; He has vast experience in all the major therapeutic treatment modalities including micro-vascular decompression, percutaneous rhizotomy, and radiosurgery.&nbsp; He can provide comprehensive medical and surgical care for this debilitating condition.</p>
<p>Dr. Eskandar has vast experience in using deep brain stimulation (DBS) for the treatment of Parkinson Disease, Dystonia, Essential Tremor, and severe Obsessive-Compulsive Disorder.&nbsp;&nbsp; He employs different methods for surgery including awake-surgery with micro-electrode recordings, frameless surgery, and surgery under anesthesia using real-time imaging.</p>
<p>Finally, Dr. Eskandar treats all types of brain tumors including meningiomas, gliomas, low grade tumors, and metastatic brain tumors.&nbsp; He specializes in the use of advanced brain-imaging and brain-mapping techniques to minimize the risk of injury and to maximize tumor resection.&nbsp; Dr. Eskandar is a pioneer in brain mapping and has published many seminal papers on this topic.</p>
<p><strong>Research Interests</strong>: <br /> Dr. Eskandar also heads an active basic research laboratory investigating the Basal Ganglia, a group of centrally located nuclei in the brain.&nbsp;&nbsp; The Basal Ganglia play a central role in theories of learning, motivation, depression and drug addiction.&nbsp; His group uses microelectrode and electrochemical recordings to evaluate the role of the basal ganglia in both primates and humans performing complex behavioral tasks.&nbsp; The group also uses electrical stimulation to directly modulate neuronal activity during complex behaviors. This is a unique approach in that ideas from the laboratory can quickly be tested in the clinical arena and vice-versa.&nbsp; In addition, his group is actively working to develop the next generation of brain stimulators that will be MRI safe, use more intelligent technological interfaces and employ the latest innovations in miniaturization and battery technology.&nbsp;</p>
<p>The Eskandar lab has made numerous important scientific contributions.&nbsp; For example, one recent study, published in <em>Nature</em>, found that a part of the brain called the Cingulate Cortex plays an important role in adapting to varying degrees of cognitive difficulty.&nbsp; Another recent paper in <em>Nature Neuroscience,</em> found that delivering micro-stimulation in one part of the basal ganglia, the caudate nucleus, significantly increases the rate of learning beyond baseline rates.&nbsp; These findings suggest that the caudate plays a critical role in learning, and that learning can be enhanced to promote recovery after traumatic brain injury or stroke.&nbsp;</p>
<p><strong>Background:<br /> </strong>Dr. Eskandar received a Bachelor of Arts degree in chemistry from the University of Nebraska. He earned a medical degree at the University of Southern California, Los Angeles, and a master of business administration degree at the Sloan School of Management at the Massachusetts Institute of Technology. He was a neurological surgery resident at Massachusetts General Hospital in Boston, MA, and a neurophysiology fellow at Harvard Medical School.&nbsp;He previously, held the Charles Anthony Pappas endowed chair of Neurosurgery at Harvard Medical School where he also served as Professor of Neurosciences.&nbsp;</p>
<p>Dr. Eskandar is board-certified by the American Board of Neurological Surgery. He is a member of the American Association of Neurological Surgeons and the American Academy of Neurological Surgeons. He is the current President of the American Society for Stereotactic and Functional Neurosurgery.</p>

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Clinical Profile

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<p>Emad N. Eskandar, MD, specializes in the surgical diagnosis and treatment of epilepsy in both children and adults. He is a world leader in this field, with more than 15 years of experience in utilizing the most current techniques. These techniques include keyhole surgery (minimal incision), stereotactic electro-encephalography (SEEG), minimally invasive foramen-ovale electrodes, vagal nerve stimulation, responsive neuro-stimulation (RNS or NeuroPace) and laser ablation of epileptic areas.</p><p>In addition, Dr. Eskandar is an expert in the treatment of trigeminal neuralgia, an extremely painful condition affecting the face. He has vast experience in all the major therapeutic treatment modalities, including micro-vascular decompression, percutaneous rhizotomy and radiosurgery. He can provide comprehensive medical and surgical care for this debilitating condition.</p><p>Dr. Eskandar also has long-standing expertise in using deep brain stimulation (DBS) for the treatment of Parkinson disease, dystonia, essential tremor and severe obsessive-compulsive disorder. Dr. Eskandar employs all current available techniques, including awake-surgery with micro-electrode recordings, frameless surgery and surgery under anesthesia using real-time imaging.</p><p>Finally, Dr. Eskandar treats all types of brain tumors, including meningiomas, gliomas, low-grade tumors and metastatic brain tumors. He specializes in the use of advanced brain-imaging and brain-mapping techniques to minimize the risk of injury and to maximize tumor resection. Dr. Eskandar is an expert in brain mapping and has published many seminal papers on this technique.</p>

Research Focus

<p>Dr. Eskandar heads an active basic research laboratory investigating the Basal Ganglia, a group of centrally located nuclei in the brain. The Basal Ganglia play a central role in theories of learning, motivation, depression and drug addiction. His group uses microelectrode and electrochemical recordings to evaluate the role of the basal ganglia in both primates and humans performing complex behavioral tasks. The group also uses electrical stimulation to directly modulate neuronal activity during complex behaviors. This is a unique approach in that ideas from the laboratory can quickly be tested in the clinical arena and vice-versa. In addition, his group is actively working to develop the next generation of brain stimulators that will be MRI safe, use more intelligent technological interfaces and employ the latest innovations in miniaturization and battery technology.</p>

Elsevier Profile

Selected Publications

<p><strong>Selected Publications from over 200</strong></p>
<ul>
<li>Martinez-Rubio C, Paulk AC, McDonald EJ, Widge AS, <strong>Eskandar EN</strong>. Multimodal Encoding of Novelty, Reward, and Learning in the Primate Nucleus Basalis of Meynert. <strong>J Neurosci.</strong> 2018 Feb 21;38(8):1942-1958<strong>. </strong></li>
<li>Herrington TM, Briscoe J, <strong>Eskandar E</strong>. Structural and Functional Network Dysfunction in Parkinson Disease. <strong>Radiology</strong>. 2017 Dec;285(3):725-727.</li>
<li>Asaad WF, Lauro PM, Perge JA, <strong>Eskandar EN</strong>. Prefrontal Neurons Encode a Solution to the Credit-Assignment Problem. <strong>J Neurosci</strong>. 2017 Jul 19;37(29):6995-7007.</li>
<li>Herrington TM, Cheng JJ, <strong>Eskandar EN</strong>. Mechanisms of deep brain stimulation. <strong>J </strong><strong>Neurophysiol</strong>. 2016 Jan 1;115(1):19-38.</li>
<li>Katnani HA, Patel SR, Kwon CS, Abdel-Aziz S, Gale JT, <strong>Eskandar EN</strong>. Temporally Coordinated Deep Brain Stimulation in the Dorsal and Ventral Striatum Synergistically Enhances Associative Learning. <strong>Sci Rep</strong>. 2016 Jan 4;6:18806.</li>
<li>Ishizawa Y, Ahmed OJ, Patel SR, Gale JT, Sierra-Mercado D, <strong>Brown EN</strong>, <strong>Eskandar&nbsp; EN</strong>. Dynamics of Propofol-Induced Loss of Consciousness Across Primate Neocortex.&nbsp; <strong>J Neurosci</strong>. 2016 Jul 20;36(29):7718-26.</li>
<li>Patel SR, Sheth SA, Martinez-Rubio C, Mian MK, Asaad WF, Gerrard JL, Kwon CS,&nbsp; Dougherty DD, Flaherty AW, Greenberg BD, Gale JT, Williams ZM, <strong>Eskandar EN</strong>. Studying task-related activity of individual neurons in the human brain. <strong>Nature Protocols</strong>. 2013 Apr 18;8(5):949-957.</li>
<li>Sheth S, Mian M, Patel S, Asaad W, Williams Z, Dougherty D, Bush G, <strong>Eskandar E</strong>.&nbsp; Human Dorsal Anterior Cingulate Neurons Mediate Behavioral Adaptation.&nbsp; <strong>Nature. </strong>2012 Aug 9;488(7410):218-21<strong>.</strong></li>
<li>Patel S, Sheth S, Mian M, Gale J, Dougherty D, Greenberg B, <strong>Eskandar E</strong>.&nbsp; Single neuronal responses during a financial decision-making task in the human nucleus accumbens.&nbsp; <strong>J Neuroscience</strong>, 2012 May 23;32(21):7311-5. PubMed PMID:22623676.</li>
<li>Mian MK, Sheth SA, Patel SR, Spiliopoulos K, <strong>Eskandar EN</strong>, Williams ZM. Encoding of Rules by Neurons in the Human Dorsolateral Prefrontal Cortex. <strong>Cereb Cortex.</strong> 2012 Nov 21. [Epub ahead of print] PubMed PMID: 23172774.</li>
<li>Sheth SA, Abuelem T, Gale JT, <strong>Eskandar EN</strong>. Basal ganglia neurons dynamically facilitate exploration during associative learning. <strong>J Neurosci</strong>. 2011. Mar 30;31(13):4878-85.</li>
<li>Asaad W<strong>, Eskandar, E. </strong>&nbsp;Encoding of both Positive and Negative Reward Prediction Errors by Neurons of the Primate Lateral Prefrontal Cortex and Caudate Nucleus.&nbsp; <strong>&nbsp;J. Neurosci. </strong>2011 Dec 7;31(49):17772-87<strong>. </strong></li>
<li>Truccolo W, Donoghue JA, Hochberg LR, <strong>Eskandar EN,</strong> Madsen JR, Anderson WS, <strong>Brown EN,</strong> Halgren E, Cash SS. Single-neuron dynamics in human focal epilepsy. <strong>Nat Neurosci</strong>. 2011 May;14(5):635-41.</li>
<li>Kramer MA, Eden UT, Kolaczyk ED, Zepeda R, <strong>Eskandar EN</strong>, <strong>Cash SS</strong>. Coalescence and fragmentation of cortical networks during focal seizures. <strong>J Neurosci</strong>. 2010 Jul 28;30(30):10076-85.</li>
<li>Williams ZM<strong>, Eskandar EN</strong>. Selective enhancement of associative learning by microstimulation of the anterior caudate.&nbsp; <strong>Nature Neurosci</strong>. 2006. 9(4):562-8.</li>
</ul>

EMR ID

11669

Biography

<p>Dr. Eskandar is a world-renowned neurosurgeon and a prominent neurosurgical leader. He is an expert in the management of Deep Brain Stimulation (DBS), brain tumors, epilepsy, trigeminal neuralgia and Parkinson Disease.</p><p>Dr. Eskandar received a Bachelor of Arts degree in chemistry from the University of Nebraska. He earned a medical degree at the University of Southern California, Los Angeles, and a master of business administration degree at the Sloan School of Management at the Massachusetts Institute of Technology. He was a neurological surgery resident at Massachusetts General Hospital in Boston, MA, and a neurophysiology fellow at Harvard Medical School.</p><p>Previously, he was the Charles Anthony Pappas endowed chair of Neurosurgery at Harvard Medical School where he also served as Professor of Neurosciences. He was a Neurosurgeon at Massachusetts General Hospital, where he also held several positions including Director of Functional Neurosurgery, Director of Neurosurgery Residency, Director of Movement Disorders Surgery Service and Director of Epilepsy Surgery Service.</p><p>Dr. Eskandar is board-certified by the American Board of Neurological Surgery. He is a member of the American Association of Neurological Surgeons and the American Academy of Neurological Surgeons. He is the current President of the American Society for Stereotactic and Functional Neurosurgery.</p>

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Celina Crisman

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First Name

Celina

Last Name

Crisman

NPI

1255699963

Faculty ID

17951

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Full Time

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Adult

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Female

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Clinical Focus

Neurosurgical oncology and focuses on the diagnosis and surgical treatment of cranial lesions in adult patients

Elsevier Profile

EMR ID

163350

Biography

<p>Celina Crisman , MD, MPH, is an attending physician and Assistant Professor, Neurological Surgery at Montefiore Einstein. Dr. Crisman specializes in neurosurgical oncology and focuses on the diagnosis and surgical treatment of cranial lesions in adult patients. Through a dedicated fellowship, she received specialized training in surgical approaches to benign and malignant cranial tumors and enjoys applying the most advanced techniques and surgical adjuncts to each case. Dr. Crisman performs awake tumor resection when indicated and works closely with a multidisciplinary team to maximize resection of tumors in eloquent regions. She also cares for patients with general neurosurgical needs ranging from hydrocephalus, chiari malformation and herniated discs, as well as traumatic bleeds.</p><p>Dr. Crisman obtained her Bachelor of Science in biology and biology and society from Cornell University, and earned her Doctor of Medicine from Columbia University Valegos College of Physicians and Surgeons. She completed her residency in neurological surgery at Rutgers University and was a neurosurgical oncology fellow at Memorial Sloan Kettering. Dr. Crisman also earned a Masters in Public Health from the Harvard Chan School of Public Health.</p>

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Vijay Agarwal

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First Name

Vijay

Last Name

Agarwal

NPI

1902123128

Faculty ID

15932

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Full Time

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Adult

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Male

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Clinical Focus

<p>Dr. Agarwal is a fellowship trained neurosurgeon who offers comprehensive treatments for adult patients with benign and malignant brain tumors. He specializes in the treatment of patients with primary brain tumors such as gliomas, meningiomas and pituitary tumors, as well as skull base and metastatic brain tumors. In addition, Dr. Agarwal treats cerebrovascular disease, including intracranial aneurysms and arteriovenous malformations.</p>

Research Focus

<p>Dr. Agarwal's research focuses on the genetics and proteomics of brain tumors. Specifically, he studies the genetic modifications and overexpression of certain markers that have been implicated in brain tumor growth and development. He also has a keen interest in neuroinnovation and medical devices.</p>

Elsevier Profile

EMR ID

14261

Biography

<p>Vijay Agarwal, MD, is Associate Professor, Neurosurgery and Associate Professor, <a href="https://www.einsteinmed.edu/departments/otorhinolaryngology-head-neck-s…; target="_blank">Otorhinolaryngology - Head &amp; Neck Surgery</a> at Montefiore Einstein. His clinical focus is on comprehensive treatments for adult patients with benign and malignant brain tumors. Dr. Agarwal specializes in the treatment of patients with primary brain tumors such as gliomas, meningiomas and pituitary tumors, as well as skull base and metastatic brain tumors. In addition, he treats cerebrovascular disease, including intracranial aneurysms and arteriovenous malformations.</p><p>Dr. Agarwal received his Bachelor of Science in Electrical and Biomedical Engineering in 2002 from the University of California, Los Angeles. In 2010, he received his Doctor of Medicine from Chicago Medical School, where he graduated with honors. Dr. Agarwal completed his residency in Neurosurgery at Duke University Medical Center in 2016 and a fellowship in Minimally Invasive and Endoscopic Skull Base Neurosurgery at the Center for MIS Neurosurgery in Sydney, Australia. In 2017, Dr. Agarwal completed a fellowship in Open Skull Base Neurosurgery at the Mayo Clinic, and in 2018 completed an Open Cerebrovascular fellowship at Emory University Hospital in Atlanta, Georgia.</p><p>Building on his clinical focus, Dr. Agarwal's research focuses on the genetics and proteomics of brain tumors. Specifically, he studies the genetic modifications and overexpression of certain markers that have been implicated in brain tumor growth and development. He also has a keen interest in neuro-innovation and medical devices.</p><p>Dr. Agarwal routinely presents nationally and abroad on innovative skull base surgical techniques and his research efforts. For his work in Africa, he was awarded an honorary membership to the South African Otorhinolaryngology/Skull Base Society. He has also published two textbooks, with another in process, on complex and combined skull base approaches with Cambridge University Press and Elsevior Publishing Company.</p><p>Dr. Agarwal is a member of the Alpha Omega Alpha Honor Medical Society, the North American Skull Base Society, the Congress of Neurological Surgeons and the American Association of Neurological Surgeons.</p>

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