Proteomics (LMAP) The Proteomics Facility, supported by the Laboratory for Macromolecular Analysis and Proteomics (LMAP), provides Einstein researchers with a comprehensive mass spectrometry resource for analysis of proteins, peptides and other selected families of biomolecules. Expert staff scientists are available to help plan and execute a successful proteomics based analysis. They also assist in data analysis, including statistics and data visualization. Services Protein-related studies: Identification and quantification of purified proteins and/or complex proteomes (label-free, SILAC, isobaric tagging) Determination of protein-protein interactions and protein-nucleic acid interactions Computational determination of regulated protein pathways, complexes and other networks Identification and quantification of protein post-translational modifications Mapping of protein and proteome localization in the cell, in particular chromatin complexes High throughput analysis (100s samples per day) of histone post-translational modifications Determination of protein synthesis rate (turnover) as complementary quantitative dimension of protein abundance Preliminary data analysis, including time-series statistics and assistance in biomarker selection Other biomolecules: Spatial localization of molecules by imaging (in situ) mass spectrometry Confirmation of synthetic and recombinant molecules High-resolution analysis of metabolites, drugs, peptides and other small molecules Targeted assays and pharmacokinetics Related Shared Facilities Analytical Imaging Macromolecular Therapeutics Development Structural NMR Center Affiliations Montefiore Einstein Comprehensive Cancer Center Selected Publications ACS Chemical Biology. 2012 Apr 20;7(4):744-52 Journal of American Chemical Society. 2012 Jan 25;134(3):1468-70 Proteomics, Clinical Applications. 2012 Oct;6(9-10):502-6 The Journal of Biological Chemistry. 2012 Feb 24;287(9):6503-17 Location and Contacts Proteomics (LMAP) Ullmann 403 Simone Sidoli, Ph.D.Scientific Director718-430-3475simone.sidoli@einsteinmed.eduLouis M. Weiss, M.D., M.P.H.Associate Scientific Director718-430-2142louis.weiss@einsteinmed.eduJennifer Aguilan, Ph.D. Operations Director718-430-3479jennifer.aguilan@einsteinmed.edu
