Allan W. Wolkoff

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Full Name
Allan W. Wolkoff
Profile Image URL
https://assets.montefioreeinstein.org/profiles/images/physphoto/Wolkoff_Allan_W_MD_2574.jpg
Type
Provider
Faculty
First Name
Allan
Last Name
Wolkoff
NPI
1700961703
Faculty ID
3303
Employment Status
Full Time
Patient Type
Adult
Department
einstein-dept-medicine
einstein-dept-developmental-molecular-biology
Gender
Male
Email
allan.wolkoff@einsteinmed.edu
Phone
718-430-3798
Titles
Type
Academic
Department
Department of Medicine
Department Link
Rank
Professor
Division
Hepatology
Type
Academic
Department
Department of Developmental & Molecular Biology
Department Link
Rank
Professor
Type
Administrative
Title
Associate Chair for Research, Department of Medicine
Type
Administrative
Title
Herman Lopata Chair in Liver Disease Research
Type
Administrative
Title
Chief, Division of Hepatology, Department of Medicine
Type
Administrative
Title
Director, Marion Bessin Liver Research Center
Locations
Is Primary
Off
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.84592 40.84546)
Address Line 1
1516 Jarrettt Place
City
Bronx
State
NY
Zip
10461-2607
Location Title
Montefiore Jarrett Place Practice
Is Primary
On
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.8444 40.85103)
Address Line 1
1300 Morris Park Avenue
City
Bronx
State
NY
Zip
10461-1900
Location Title
Montefiore at AECOM
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Off
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.84154 40.84612)
Address Line 1
1250 Waters place
City
Bronx
State
NY
Zip
10461-2720
Location Title
Montefiore at 1250 Waters Place
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Off
Type
Academic
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.8459022 40.8504961)
Building
Ullmann Building
Room
517
Address Line 1
Albert Einstein College of Medicine
Address Line 2
Jack and Pearl Resnick Campus
Address Line 3
1300 Morris Park Avenue
City
Bronx
State
NY
Zip
10461
Location Title
Albert Einstein College of Medicine
Education and Trainings
Education Type Label
Medical Education
Education Institution
Albert Einstein College of Medicine
Education Type Label
Medical Education
Education Institution
Dartmouth Medical School
Education Type Label
Fellowship
Education Institution
National Institutes of Health
Education Type Label
Residency
Education Institution
Jacobi Medical Center
Professional Interests

<p><span>Dr. Allan Wolkoff's interest in research was sparked when he worked in a biochemistry lab to help pay college bills. He began his medical studies at Dartmouth Medical College and transferred to the Albert Einstein College of Medicine where he obtained his M.D. degree. With the exception of a two year period when he was Clinical Associate in Gastroenterology-Hepatology in the Digestive Disease Branch, National Institute of Arthritis, Metabolism and Digestive Disease, he has remained at Albert Einstein. His early mentor, Irwin M. Arias, M.D. of the National Institutes of Health said of Wolkoff&rsquo;s work, &ldquo;He built an exemplary global reputation in hepatology research, education, training and scholarship. A major participant in the creation of the Marion Bessin Liver Research Center at Albert Einstein, Dr. Wolkoff has taken advantage of the strong, interactive basic science departments and is a leader in bridging understanding of hepatocyte biology with the pathogenesis of acquired and inheritable liver diseases.&rdquo; </span></p>
<p><span>Dr. Wolkoff is a pioneer in the combining of disciplines that inform basic understanding of hepatocyte function and relation to disease and is recognized worldwide for providing new windows into physiology and pathophysiology.&nbsp;</span><span>He has had articles published in over 100 peer-reviewed publications, given many invited lectures and has had continuous NIH-supported research. In addition, he has served on advisory committees of several NIH-supported liver research centers. In 2006, he was presented the AASLD Distinguished Service Award. In 2012, he received the&nbsp;<span>highly prestigious 2012 Distinguished Scientific Achievement Award from the American Liver Foundation.</span></span></p>

Research Areas
Hepatocyte cell biology: mechanisms of microtubule-based subcellular trafficking of transporters and receptors including the roles of molecular motors and accessory proteins
CHAM Provider
Off
Professional Title
M.D.
Clinical Focus

Diseases of the liver and biliary tract including chronic liver disease, fatty liver disease, hepatitis, inheritable disorders of the liver, drug toxicity, and unexplained jaundice.<quillbot-extension-portal></quillbot-extension-portal>

Research Focus

Research interests include the mechanism by which the liver removes drugs and other compounds from the circulation and how its dysfunction may lead to drug toxicity.<quillbot-extension-portal></quillbot-extension-portal>

EMR ID
3553
Biography

<p>Allan W. Wolkoff, MD, is Chief, Hepatology, Herman Lopata Chair in Liver Disease Research and Professor, Medicine and Developmental &amp; Molecular Biology at Montefiore Einstein. His clinical focus centers on diseases of the liver and biliary tract, including chronic liver disease, fatty liver disease, hepatitis, inheritable disorders of the liver, drug toxicity and unexplained jaundice.</p><p>Dr. Wolkoff began his medical studies at Dartmouth Medical College and transferred to Einstein, where he earned his Doctor of Medicine in 1972. He completed an internship at Bronx Municipal Hospital Center in 1973 before becoming an Assistant Resident in Medicine until 1974. Following this, Dr. Wolkoff became a Clinical Associate in Gastroenterology-Hepatology at the National Institutes of Health (NIH) until 1976.</p><p>A pioneer in combining disciplines that inform basic understanding of hepatocyte function and relation to disease, Dr. Wolkoff is recognized worldwide for providing new windows into physiology and pathophysiology. His research interests include the mechanism by which the liver removes drugs and other compounds from circulation and how its dysfunction may lead to drug toxicity. He has had articles published in over 100 peer-reviewed publications, given many invited lectures and has had continuous NIH-supported research.</p><p>Dr. Wolkoff has served on advisory committees of several NIH-supported liver research centers. In 2006, he was presented with the American Association for the Study of Liver Diseases (AASLD) Distinguished Service Award. In 2012, he received the highly prestigious Distinguished Scientific Achievement Award from the American Liver Foundation. He was named Physician of the Year by the Greater New York Division of the American Liver Foundation in 2015 and won the National Leadership Award from the American Liver Foundation in 2022.</p>

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Jayanta Roy-Chowdhury

Submitted by Anonymous (not verified) on
Full Name
Jayanta Roy-Chowdhury
Profile Image URL
https://assets.montefioreeinstein.org/profiles/images/3063-jayanta-roy-chowdhury.jpg
Type
Provider
Faculty
First Name
Jayanta
Last Name
Roy-Chowdhury
NPI
1669561908
Faculty ID
3063
CMO Specialties
Clinical Terms
Employment Status
Full Time
Patient Type
Adult
Department
einstein-dept-medicine
einstein-dept-genetics
Gender
Male
Email
jayanta.roy-chowdhury@einsteinmed.edu
Phone
718-430-2265
Titles
Type
Academic
Department
Department of Medicine
Department Link
Rank
Professor
Division
Hepatology
Type
Academic
Department
Department of Genetics
Department Link
Rank
Professor
Type
Administrative
Title
Scientific Director, Gene Therapy Facility
Locations
Is Primary
On
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.84563 40.84596)
Address Line 1
1575 Blondell Avenue
City
Bronx
State
NY
Zip
10461-2601
Location Title
Montefiore Medical Park at 1575 Blondell
Is Primary
Off
Type
Academic
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.8459022 40.8504961)
Building
Ullmann Building
Room
523
Address Line 1
Albert Einstein College of Medicine
Address Line 2
Jack and Pearl Resnick Campus
Address Line 3
1300 Morris Park Avenue
City
Bronx
State
NY
Zip
10461
Location Title
Albert Einstein College of Medicine
Education and Trainings
Education Type Label
Medical Education
Education Institution
Calcutta University
Education Type Label
Medical Education
Education Institution
Calcutta University
Education Type Label
Fellowship
Education Institution
Stony Brook University Hospital
Education Type Label
Residency
Education Institution
Medical College Hospital
Education Type Label
Residency
Education Institution
Royal College of Physicians, Edinburgh, Scotland
Education Type Label
Residency
Education Institution
Nassau University Medical Center
Professional Interests

<p class="MsoNormal"><strong><em>Key Words: &nbsp;Liver, Inherited liver diseases; Cell and Gene Therapy</em></strong></p>
<p class="MsoNormal" style="margin-bottom: 6.0pt; line-height: normal;">&nbsp;</p>
<p style="margin: 0px 0px 8px; text-indent: 0.5in;"><span style="margin: 0px; font-family: 'Arial',sans-serif; font-size: 9pt;">Our current focus is on developing cell and gene-based therapies for monogenic liver diseases, such as inherited hyperbilirubinemia (Crigler-Najjar syndrome, CN-1), </span><span style="margin: 0px; font-family: Symbol; font-size: 9pt;">a</span><sub><span style="margin: 0px; font-family: 'Arial',sans-serif; font-size: 9pt;">1</span></sub><span style="margin: 0px; font-family: 'Arial',sans-serif; font-size: 9pt;"> antitrypsin (AAT) deficiency, dyslipidemias and hemophilias A and B.</span></p>
<p style="margin: 0px; text-indent: 0.5in;"><strong><span style="margin: 0px; font-family: 'Arial',sans-serif; font-size: 9pt;">&nbsp;Subproject 1.</span></strong><span style="margin: 0px; font-family: 'Arial',sans-serif; font-size: 9pt;">&nbsp; <strong>Hepatocyte-based therapies for genetic liver diseases.</strong>&nbsp; To develop a minimally invasive alternative to liver transplantation, we are developing strategies to repopulate the liver by transplanted hepatocytes. To overcome the hurdles of inefficient hepatocyte engraftment and failure of transplanted hepatocytes to proliferate, we are evaluating targeted hepatic irradiation and mitotic stimulation of the transplanted hepatocytes. Regiospecific conformal hepatic irradiation (HIR) is being used to transiently disrupt the sinusoidal endothelial barrier, thereby enhancing initial engraftment. HIR makes the host hepatocytes in the irradiated region less mitotically competent. We are exploring different types of mitotic agents to stimulate the proliferation of the engrafted hepatocytes, which can competitively repopulate the host liver. We are also evaluating whether co-transplantation of liver sinusoidal endothelial cells can augment liver repopulation by hepatocytes. Our work was translated into the first successful hepatocyte transplantation in a CN-1 patient, and more recently in two patients with urea cycle disorders and one with phenyl ketonuria.&nbsp; </span></p>
<p style="margin: 0px; text-indent: 0.5in;"><span style="margin: 0px; font-family: 'Arial',sans-serif; font-size: 9pt;">AAT deficiency (ATD) is one of the most common potentially lethal monogenic liver disorders in the West. In classic ATD, a mutant misfolded AAT (ATZ) tis secreted inefficiently and is retained within hepatocytes. Circulatory AAT deficiency leads to unrestrained neutrophil elastase activity in the lung, causing pulmonary emphysema, whereas ATZ accumulation within hepatocytes results liver disease. We showed that wildtype hepatocytes transplanted into transgenic mice expressing human ATZ competitively replace the host hepatocytes. Our current focus is to disrupt ATZ expression in a fraction of the hepatocyte mass by DNA break-enhanced homologous recombination in vivo, so that the gene-edited hepatocytes can repopulate the liver, thereby providing normal AAT and correcting the liver disease.</span></p>
<p style="margin: 0px; text-indent: 0.5in;"><strong><span style="margin: 0px; font-family: 'Arial',sans-serif; font-size: 9pt;">Subproject 2.</span></strong><span style="margin: 0px; font-family: 'Arial',sans-serif; font-size: 9pt;">&nbsp; <strong style="mso-bidi-font-weight: normal;">Transplantation of endothelial cells to repopulate mutant liver endothelial cells (LSEC): </strong>LSECs are highly specialized endothelial cells that are important in maintaining liver architecture, as well as hepatocyte regeneration and function. In addition, these cells express coagulation factor VIII (the deficiency of which causes hemophilia A) and Von Willebrand factor. In ongoing work, we have found that intravenous infusion of LSECs <span style="margin: 0px;">&nbsp;</span>following regional HIR results in engraftment of LSECs in the liver. Subsequent pharmacological stimulation of the LSECs results in regional liver repopulation by the transplanted cells. This procedure has cured the bleeding disorder in Factor VIII-deficient hemophilic mice. </span></p>
<p style="margin: 0px 0px 8px; text-indent: 0.5in;"><span style="margin: 0px; font-family: 'Arial',sans-serif; font-size: 9pt;">In ongoing studies we are correcting the genetic lesions in mutant hepatocytes and LSECs, using CRISPR-cas or zinc finger nuclease-enhanced homologous recombination to generate phenotypically corrected for transplantation into animal models of inherited human liver diseases. </span></p>
<p class="MsoNormal" style="margin-bottom: 6.0pt; line-height: normal;">&nbsp;</p>

Research Areas
The focus of our laboratory is inherited liver-based disorders, including their mechanisms, personalized disease modeling based on pluripotent stem cell-derived hepatocytes, and novel treatments based on cell transplantation and gene therapy.
CHAM Provider
Off
Professional Title
M.B.,B.S.
Selected Publications

<p><strong><span style="text-decoration: underline;">Recent Publications</span>:</strong></p>
<p style="background: #FEFEFE; margin: 0in 0in 3.0pt 0in;"><span style="font-size: 9.0pt; font-family: 'Arial',sans-serif; color: black;">Ding J, Yannam GR, Roy-Chowdhury N, Hidvegi T, Basma H, Rennard SI, Wong RJ, Avsar Y, Guha C,Perlmutter DH, Fox IJ,<strong><span style="font-family: 'Arial',sans-serif;">&nbsp;Roy-Chowdhury J.&nbsp;</span></strong>Spontaneous hepatic repopulation in transgenic mice expressingmutant human alpha 1-anti-trypsin by wildtype donor hepatocytes. J. Clin. Invest. 121:1930-4, 2011.</span></p>
<p style="background: #FEFEFE; margin: 0in 0in 3.0pt 0in;"><span style="font-size: 9.0pt; font-family: 'Arial',sans-serif; color: #373a3c;">Chen Y, Li Y, Wang X,&nbsp;&nbsp;Zhang W, Sauer V, Chang CJ, Han B, Tchaikovskaya T, Avsar Y, Tafaleng E, Madhusudana Girija S, Tar K, Stephen S, Bouhassira E, Guha C, Fox IJ,<strong><span style="font-family: 'Arial',sans-serif;">&nbsp;Roy-Chowdhury J</span></strong>&nbsp;and&nbsp;<strong><span style="font-family: 'Arial',sans-serif;">Roy-Chowdhury N</span></strong>. Amelioration of hyperbilirubinemia in Gunn rats after transplantation of hepatocytes derived from human induced pluripotent stem cells. Stem Cell Reports 5:1-9, 2015.</span></p>
<p style="background: #FEFEFE; margin: 0in 0in 3.0pt 0in;"><span style="font-size: 9.0pt; font-family: 'Arial',sans-serif; color: #373a3c;">Sauer V,</span><span style="font-family: 'Arial',sans-serif; color: #373a3c;">&nbsp;</span><span style="font-size: 9.0pt; font-family: 'Arial',sans-serif; color: #373a3c;">Tchaikovskaya T, Wang X, Li Y, Zhang W Tar K, Polgar Z, Ding J, Guha C, Fox IJ,<strong><span style="font-family: 'Arial',sans-serif;">&nbsp;Roy-Chowdhury N, Roy-Chowdhury J.</span></strong>&nbsp;Human urinary epithelial cells as a source of engraftable hepatocyte-like cells using stem cell technology. Cell transplant, 2016, 25:2221-2243.</span></p>
<p style="background: #FEFEFE; margin: 0in 0in 3.0pt 0in;"><span style="font-size: 9.0pt; font-family: 'Arial',sans-serif; color: #373a3c;">Soltys KA, Setoyama K, Tafaleng EN, et al.&nbsp;</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/28027971"><span style="font-size: 9.0pt; font-family: 'Arial',sans-serif;">Host conditioning and rejection monitoring in hepatocyte transplantation in humans.</span></a><span style="font-size: 9.0pt; font-family: 'Arial',sans-serif; color: #373a3c;">&nbsp;J Hepatol. 66:987-1000, 2017. doi: 10.1016/j.jhep.2016.12.017.&nbsp;&nbsp;PMID: 28027971.</span></p>
<p style="background: #FEFEFE; margin: 0in 0in 3.0pt 0in;"><span style="font-size: 9.0pt; font-family: 'Arial',sans-serif; color: #373a3c;">Peterson EA, Polgar Z, Devakanmalai GS, Li Y, Jaber FL, Zhang W, Wang X, Iqbal NJ, Murray JW, Roy-Chowdhury N, Quispe Tintaya W, Maslov AY, Tchaikovskaya TL, Sharma Y, Rogler LE, Gupta S, Zhu L<strong><span style="font-family: 'Arial',sans-serif;">, Roy-Chowdhury J</span></strong>, Shafritz DA. Genes and pathways promoting long-term liver repopulation by ex vivo hYAP-ERT2 transduced hepatcytes and treatment of jaundice Gunn rats. Hepatology Communications 2019; 3:129-146</span></p>
<p style="text-align: justify; background: white; margin: 0in 0in 3.0pt 0in;"><span style="font-size: 9.0pt; font-family: 'Arial',sans-serif; color: #373a3c; background: white;">Barahman M, Zhang W, Harris HY, Aiyer A, Kabarriti R, Kinkhabwala M, Roy-Chowdhury N, Beck AP, Scanlan TS,&nbsp;<strong><span style="font-family: 'Arial',sans-serif;">Roy-Chowdhury J</span></strong>, Asp P,&nbsp;&nbsp;Guha C.&nbsp;</span><a href="https://www.sciencedirect.com/science/article/pii/S0168827819300224&quot; target="_blank" rel="noopener"><span style="font-size: 9.0pt; font-family: 'Arial',sans-serif; background: white;">Radiation-primed hepatocyte transplantation in murine monogeneic dyslipidemia normalizes cholesterol and prevents atherosclerosis.</span><span style="font-family: 'Arial',sans-serif;">&nbsp;</span><span style="font-size: 9.0pt; font-family: 'Arial',sans-serif;">J Hepatol. 2019 70:1170-1179.</span></a></p>
<p style="text-align: justify; background: white; margin: 0in 0in 3.0pt 0in;"><span style="font-size: 9.0pt; font-family: 'Arial',sans-serif; color: #373a3c;">Li Y, Guha C, Asp P, Wang X, Tchaikovskya TL, Kim K, Mendel M, Cost GJ, Perlmutter DH, Roy-Chowdhury N, Fox IJ, Conway A, <strong>Roy-Chowdhury J</strong>. Resolution of hepatic fibrosis after ZFN-mediated gene editing in the PiZ mouse model of human &alpha;1-antitrypsin deficiency. Hepatol Commun. 2023 Feb 27;7(3):e0070. PMCID: PMC9974076.</span></p>

EMR ID
3232
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Jonathan L. Panitch

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Full Name
Jonathan L. Panitch
Profile Image URL
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Type
Provider
Faculty
First Name
Jonathan
Last Name
Panitch
NPI
1821452475
Faculty ID
17568
CMO Specialties
Clinical Terms
Employment Status
Full Time
Patient Type
Adult
Department
einstein-dept-medicine
Gender
Male
Email
jpanitch@montefiore.org
Phone
718-904-2400
Titles
Type
Academic
Department
Department of Medicine
Department Link
Rank
Assistant Professor
Division
Hepatology
Locations
Is Primary
On
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.845 40.85026)
Address Line 1
1825 Eastchester Road
City
Bronx
State
NY
Zip
10467-2404
Location Title
Montefiore Weiler Hospital
Is Primary
Off
Type
Academic
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.8460414 40.8489787)
Address Line 1
Jack D. Weiler Hospital
Address Line 3
1825 Eastchester Road
City
Bronx
State
NY
Zip
10461
Location Title
Jack D. Weiler Hospital
Education and Trainings
Education Type Label
Medical Education
Education Institution
Ben-Gurion University
Education Type Label
Fellowship
Education Institution
Montefiore Medical Center
Education Type Label
Residency
Education Institution
Maimonides Medical Center
CHAM Provider
Off
Professional Title
M.D.
EMR ID
111834
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Sanjeev Gupta

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Full Name
Sanjeev Gupta
Profile Image URL
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Type
Provider
Faculty
Expert
First Name
Sanjeev
Last Name
Gupta
NPI
1831274315
Faculty ID
8041
Employment Status
Full Time
Patient Type
Adult
Department
einstein-dept-medicine
einstein-dept-pathology
Gender
Male
Email
sanjeev.gupta@einsteinmed.edu
Phone
718-430-3309
Titles
Type
Academic
Department
Department of Medicine
Department Link
Rank
Professor
Division
Hepatology
Type
Academic
Department
Department of Pathology
Department Link
Rank
Professor
Type
Administrative
Title
The Eleazar & Feige Reicher Chair in Translational Medicine, Department of Medicine
Tags
me-patientcare-cancer-research-stem-cell-cancer-biology
Locations
Is Primary
On
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.84154 40.84612)
Address Line 1
1250 Waters place
City
Bronx
State
NY
Zip
10461-2720
Location Title
Montefiore at 1250 Waters Place
Is Primary
Off
Type
Academic
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.8459022 40.8504961)
Building
Ullmann Building
Room
625
Address Line 1
Albert Einstein College of Medicine
Address Line 2
Jack and Pearl Resnick Campus
Address Line 3
1300 Morris Park Avenue
City
Bronx
State
NY
Zip
10461
Location Title
Albert Einstein College of Medicine
Education and Trainings
Education Type Label
Medical Education
Education Institution
University of Rajasthan, Sardar Patel Med Coll
Education Type Label
Fellowship
Education Institution
Hammersmith Hospital
Education Type Label
Fellowship
Education Institution
Los Angeles County and Univ of Southern CA
Education Type Label
Fellowship
Education Institution
Jacobi Medical Center
Education Type Label
Residency
Education Institution
Jacobi Medical Center
Education Type Label
Residency
Education Institution
Postgraduate Institute of Medical Educ. & Research
Education Type Label
Residency
Education Institution
Hammersmith Hospital
Professional Interests

<p>Liver regeneration is critical for health. We focus on physiology of liver regeneration during development, early childhood and adulthood to inform mechanistic disruptions in diseases. The latter ranges from acute liver failure, effects of drugs, toxins, alcohol, virus hepatitis, obesity-related metabolic (or nonalcoholic) liver disease, chronic hepatitis, e.g., Wilson disease with copper toxicosis, and allograft rejection. The mechanisms concerning DNA damage response directed by ATM gene and downstream partners are of considerable interest to us.&nbsp; &nbsp; &nbsp;</p>
<p>These aspects are joined with study of cell type-specific contributions as well as aspects of stem cell biology for liver regeneration. We apply cell transplantation approaches to better understand the biology and regenerative potential of various cell types. Expression of therapeutic constructs and transplantation of those cells is another area of investigative interest. We address the role of endogenous stem/progenitor cells in therapeutic development. Tissue engineering to generate auxiliary liver has potential in these areas and is also advancing liver regenerartion in experimental models.</p>
<p>We use a variety of methods, including microarrays or deep sequencing for gene expression, cell and molecular biology methods, and multiple small and large animal models. The findings are integrated with analyses of human tissue and blood samples.</p>
<p>Unique aspects of our work include use of established drugs for mechanistic interrogations and therapeutic applications, and an uncommon depth and breadth of multidisciplinary tools. We collaborate with leading investigators at Einstein or elsewhere as appropriate.</p>

Research Areas
Liver regeneration in health and disease
Biology and differentiation of hepatic stem cells
DNA damage response involving ATM and downstream pathways
Translational studies using liver cell and animal models
Therapeutics including cell and gene therapy
Areas of Expertise
Stem cell research
Expert Summary

<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt;">Dr. Gupta is a pioneer in the development of cell therapy &ndash; treating disease by introducing healthy cells into the body.&nbsp; He has discovered various mechanisms for coaxing transplanted cells to attach to host tissue and multiply, paving the way for treating health problems such as&nbsp; high cholesterol, hemophilia, liver failure, and hepatitis.&nbsp;</span></p>
<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt;">Dr. Gupta has successfully manipulated human stem cells to generate liver cells and defined some of the fundamental ways by which gene expression is regulated in stem cells. Dr. Gupta serves as an expert for the National Institutes of Health, U.S. Department of Veterans Affairs, U.S. Department of Defense, Wellcome Trust, and national scientific bodies in over ten countries.</span></p>
<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt;">In the 1990s, Dr. Gupta contributed to the first ever clinical trial of a cell/gene therapy for familial hypercholesterolemia (high cholesterol), which results from a gene defect. He also showed that Wilson&rsquo;s disease (a genetic condition characterized by excessive accumulation of copper in the liver and brain) could potentially be cured by use of cell therapy.&nbsp;</span></p>

CHAM Provider
Off
Professional Title
M.B.,B.S.
M.D.
Selected Publications

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<ul type="disc">
<li>Thirunavukkarasu C, Sharma Y, Tchaikovskaya T, Maslov AY, Gupta S. Transcriptional profiling reveals ataxia telangiectasia mutated pathways regulate joint copper and arsenic toxicity for hepatic metalloplasia and anti-cancer therapies. Life Sci. 2022 Jul 6;120787. doi: 10.1016/j.lfs.2022.120787.&nbsp;</li>
<li>Chang CJ, Ge EJ Bush AI, Casini A, Cobine PA, Cross JR, DeNicola GM, Dou Q, Franz KJ, Gohil VM, Gupta S, Kaler SG, Lutsenko S, Mittal V, Petris MJ, Polishchuk R, Ralle M, Schilsky ML, Tonks NK, Vahdat LK, Van Aelst L, Xi D, Yuan P, Brady DC. Connecting copper and cancer from transition metal signaling to metalloplasia in the clinic. Nat Rev Cancer 2022 Feb;22(2):102-113. doi: 10.1038/s41568-021-00417-2. Epub 2021 Nov 11. PMID: 34764459</li>
<li>Viswanathan P, Gupta P, Sharma Y, Maisuradze L, Bandi S, Gupta S. Caffeine disrupts ataxia telangiectasia mutated gene-related pathways and exacerbates acetaminophen toxicity in human fetal immortalized hepatocytes. Toxicology. 2021 May 7;457:152811. doi: 10.1016/j.tox.2021.152811. PMID: 33971260</li>
<li>Viswanathan P, Sharma Y, Jaber FL, Tchaikovskaya T, Gupta S. Transplanted hepatocytes rescue mice in acetaminophen-induced acute liver failure through paracrine signals for hepatic ATM and STAT3 pathways. FASEB J 2021 Apr;35(4):e21471. doi: 10.1096/fj.202002421R. PMID: 33683737</li>
<li>Jaber FL, Sharma Y, Mui BG, Kapoor S, Gupta S. Tumor necrosis factor directs allograft-related innate responses and its neutralization improves hepatocyte engraftment in rats. Am J Pathol 2021; 191(1):79-89. doi: 10.1016/j.ajpath.2020.09.014. Epub 2020 Oct 27. PMID: 33127336</li>
<li>Viswanathan P, Sharma Y, Gupta S. Ataxia telangiectasia mutated pathway disruption affects hepatic DNA and tissue damage in nonalcoholic fatty liver disease. Exp Mol Pathol. 2020 Apr; 113:104369. doi: 10.1016/j.yexmp.2020.104369. Epub 2020 Jan 7. PMID: 31917286</li>
<li>Gupta P, Sharma Y, Viswanathan P, Gupta S. Cellular receptor signaling and ATM pathway intersections regulate hepatic DNA repair. Cytokine 2020 Mar; 127:154946. doi: 10.1016/j.cyto.2019.154946. Epub 2019 Dec 11. PMID: 31837586</li>
<li>Bandi S, Tchaikovskaya T, Gupta S. Hepatic differentiation in human pluripotent stem cells by developmental stage-specific metabolomics products. Differentiation 2019; 105:54-70. Jan 28;105:54-70. doi: 10.1016/j.diff.2019.01.005. PMID: 30776728.</li>
<li>Kakabadze Z, Karalashvili L, Chakhunashvili D, Havlioglu N, Janelidze M, Kakabadze A, Sharma Y, Gupta S. Decellularized bovine placentome for portacavally-interposed heterotopic liver transplantation in rats. Mater Sci Eng C Mater Biol Appl. 2019 Apr; 97:293-301. doi: 10.1016/j.msec.2018.12.025. Epub 2018 Dec 10. PMID: 30678914.</li>
<li>Yadav N, Jaber FL, Sharma Y, Viswanathan P, Gupta S. Efficient reconstitution of hepatic microvasculature by endothelin receptor antagonism in liver sinusoidal endothelial cells. Hum Gene Ther 2018; Sep 28. doi: 10.1089/hum.2018.166. PMID: 30266073,&nbsp;</li>
<li>Sharma Y, Liu J, Kristian KE, Follenzi A, Gupta S. In Atp7b-/- mice modeling Wilson's disease liver repopulation with bone marrow-derived myofibroblasts or inflammatory cells and not hepatocytes is delterious.&nbsp;<span title="Gene expression">Gene Expr</span>. 2018 Jul 20. doi: 10.3727/105221618X15320123457380. PMID: 30029699</li>
<li>Bandi S, Gupta S, Tchaikovskaya T, Gupta S. Differentiation in stem/progenitor cells along fetal or adult hepatic stages requires transcriptional regulators independently of oscillations in microRNA expression.&nbsp;<span title="Experimental cell research">Exp Cell Res</span>. 2018 Sep 1;370(1):1-12. doi: 10.1016/j.yexcr.2018.06.004. Epub 2018 Jun 6.</li>
<li>Benten D, Kluwe J, Wirth JW, Thiele ND, Follenzi A, Bhargava KK, Palestro CJ, Koepke M, Tjandra R, Volz T, Lutgehetmann M, Gupta S. A humanized mouse model with liver fibrosis following expansion of transplanted hepatic stellate cells in injury and inflammation. Lab Invest 2018 Apr;98(4):525-536. doi: 10.1038/s41374-017-0010-7. Epub 2018 Jan 19.PMID: 29352225.</li>
<li>Viswanathan P, Sharma Y, Gupta P, Gupta S. Replicative stress and alterations in cell cycle checkpoint controls following acetaminophen hepatotoxicity restrict hepatic regeneration. Cell Prolif 2018; Jun;51(3):e12445. doi: 10.1111/cpr.12445. Epub 2018 Mar 5. PMID: 29504225.</li>
<li>Kakabadze Z, Kakabadze A, Chakhunashvili D, Karalashvili L, Berishvili E, Sharma Y, Gupta S. Decellularized human placenta supports hepatic tissue and allows rescue in acute liver failure. Hepatology 2018 May;67(5):1956-1969.&nbsp;PMID: 29211918.&nbsp;</li>
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