Allan W. Wolkoff

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First Name

Allan

Last Name

Wolkoff

NPI

1700961703

Faculty ID

3303

CMO Specialties

Clinical Terms

Employment Status

Full Time

Patient Type

Adult

Department

Gender

Male

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<p><span>Dr. Allan Wolkoff's interest in research was sparked when he worked in a biochemistry lab to help pay college bills. He began his medical studies at Dartmouth Medical College and transferred to the Albert Einstein College of Medicine where he obtained his M.D. degree. With the exception of a two year period when he was Clinical Associate in Gastroenterology-Hepatology in the Digestive Disease Branch, National Institute of Arthritis, Metabolism and Digestive Disease, he has remained at Albert Einstein. His early mentor, Irwin M. Arias, M.D. of the National Institutes of Health said of Wolkoff&rsquo;s work, &ldquo;He built an exemplary global reputation in hepatology research, education, training and scholarship. A major participant in the creation of the Marion Bessin Liver Research Center at Albert Einstein, Dr. Wolkoff has taken advantage of the strong, interactive basic science departments and is a leader in bridging understanding of hepatocyte biology with the pathogenesis of acquired and inheritable liver diseases.&rdquo; </span></p>
<p><span>Dr. Wolkoff is a pioneer in the combining of disciplines that inform basic understanding of hepatocyte function and relation to disease and is recognized worldwide for providing new windows into physiology and pathophysiology.&nbsp;</span><span>He has had articles published in over 100 peer-reviewed publications, given many invited lectures and has had continuous NIH-supported research. In addition, he has served on advisory committees of several NIH-supported liver research centers. In 2006, he was presented the AASLD Distinguished Service Award. In 2012, he received the&nbsp;<span>highly prestigious 2012 Distinguished Scientific Achievement Award from the American Liver Foundation.</span></span></p>

Research Areas

Research Profile

Clinical Profile

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Clinical Focus

Diseases of the liver and biliary tract including chronic liver disease, fatty liver disease, hepatitis, inheritable disorders of the liver, drug toxicity, and unexplained jaundice.<quillbot-extension-portal></quillbot-extension-portal>

Research Focus

Research interests include the mechanism by which the liver removes drugs and other compounds from the circulation and how its dysfunction may lead to drug toxicity.<quillbot-extension-portal></quillbot-extension-portal>

Elsevier Profile

EMR ID

3553

Biography

<p>Allan W. Wolkoff, MD, is Chief, Hepatology, Herman Lopata Chair in Liver Disease Research and Professor, Medicine and Developmental &amp; Molecular Biology at Montefiore Einstein. His clinical focus centers on diseases of the liver and biliary tract, including chronic liver disease, fatty liver disease, hepatitis, inheritable disorders of the liver, drug toxicity and unexplained jaundice.</p><p>Dr. Wolkoff began his medical studies at Dartmouth Medical College and transferred to Einstein, where he earned his Doctor of Medicine in 1972. He completed an internship at Bronx Municipal Hospital Center in 1973 before becoming an Assistant Resident in Medicine until 1974. Following this, Dr. Wolkoff became a Clinical Associate in Gastroenterology-Hepatology at the National Institutes of Health (NIH) until 1976.</p><p>A pioneer in combining disciplines that inform basic understanding of hepatocyte function and relation to disease, Dr. Wolkoff is recognized worldwide for providing new windows into physiology and pathophysiology. His research interests include the mechanism by which the liver removes drugs and other compounds from circulation and how its dysfunction may lead to drug toxicity. He has had articles published in over 100 peer-reviewed publications, given many invited lectures and has had continuous NIH-supported research.</p><p>Dr. Wolkoff has served on advisory committees of several NIH-supported liver research centers. In 2006, he was presented with the American Association for the Study of Liver Diseases (AASLD) Distinguished Service Award. In 2012, he received the highly prestigious Distinguished Scientific Achievement Award from the American Liver Foundation. He was named Physician of the Year by the Greater New York Division of the American Liver Foundation in 2015 and won the National Leadership Award from the American Liver Foundation in 2022.</p>

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Clara Y. Tow

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First Name

Clara

Last Name

Tow

NPI

1174822845

Faculty ID

15844

CMO Specialties

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Employment Status

Full Time

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Adult

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Female

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Professional Interests

<p>Dr. Tow is a transplant hepatologist and Assistant Professor of Medicine at Montefiore Medical Center and Albert Einstein College of Medicine. She serves as the Clinical Site Director of Hepatology at the Weiler Division of MMC, Associate Program Director of the Gastroenterology &amp; Liver Diseases Fellowship Program, and the Co-Director of the AECOM Gastroenterology &amp; Hepatology Systems Course.</p>
<p>Dr. Tow holds a B.A. in Biological Sciences from Cornell University College of Arts and Sciences and graduated Phi Beta Kappa and Magna Cum Laude for her work in developmental research. While attending Weill Cornell Medical College, she developed her passion for transplant medicine and was awarded Alpha Omega Alpha and Honors in Research for her characterization of mitochondrial injury during ischemia-reperfusion injury. Dr. Tow completed her internship and residency in Internal Medicine at New York Presbyterian Hospital - Weill Cornell Medical Center, where she served as an education resident, and fellowship in Gastroenterology and Liver Diseases at Montefiore Medical Center. Subsequently she pursued her advanced fellowship training in Transplant Hepatology at New York Presbyterian Hospital &ndash; Columbia University Medical Center.</p>
<p>Dr. Tow has been at Montefiore/Einstein since 2018, where she specializes on the complications of advanced liver diseases, liver cancer, and liver transplant. She believes every patient is an integral part of the Montefiore family and that patient knowledge is power. Her goal is to provide patients and their families the best medical care that is embedded in kindness, dignity, and respect.&nbsp;</p>

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Clinical Profile

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Professional Title

Clinical Focus

Dr. Tow specializes in the treatment of complications of advanced liver diseases, liver cancer, and liver transplant. She believes every patient is an integral part of the Montefiore Einstein family and that patient knowledge is power. Her goal is to provide patients and their families with the best medical care embedded in kindness, dignity, and respect.<quillbot-extension-portal></quillbot-extension-portal>

Research Focus

Dr. Tow&rsquo;s research focuses on social determinants of health and outcomes related to liver transplantation and the care of advanced liver disease. She has spoken at invited lectures nationally and internationally, and her work has been published in many peer-reviewed journals, books, chapters, review articles, and abstracts.<quillbot-extension-portal></quillbot-extension-portal>

Elsevier Profile

EMR ID

29458

Biography

<p>Clara Y. Tow, MD, is Clinical Site Director, Hepatology, Associate Program Director, Gastroenterology &amp; Liver Diseases Fellowship Program, Co-Course Director, Gastroenterology &amp; Hepatology Systems Course and Assistant Professor, Medicine at Montefiore Einstein. Dr. Tow specializes in the treatment of complications of advanced liver diseases, liver cancer and liver transplant. She believes every patient is an integral part of the Montefiore Einstein family and that patient knowledge is power. Her goal is to provide patients and their families with the best medical care embedded in kindness, dignity and respect.</p><p>After obtaining her Bachelor of Arts in biological sciences from Cornell University College of Arts and Sciences, Dr. Tow earned her Doctor of Medicine from Weill Cornell Medical College. She then completed her internship and residency in internal medicine at NewYork-Presbyterian Hospital, Weill Cornell Medical Center. Following this, she completed a gastroenterology and liver diseases fellowship at Montefiore Medical Center before pursuing her advanced fellowship training in transplant hepatology at NewYork-Presbyterian Hospital.</p><p>Dr. Tow&rsquo;s research focuses on social determinants of health and outcomes related to liver transplantation and the care of advanced liver disease. She has spoken at invited lectures nationally and internationally, and her work has been published in many peer-reviewed journals, books, chapters, review articles and abstracts.</p><p>Dr. Tow is board certified by the American Board of Internal Medicine in transplant hepatology, gastroenterology and internal medicine. She is a member of the American Association for the Study of Liver Diseases (AASLD), the American Society of Transplantation (AST) and the European Association for the Study of the Liver (EASL). She is also a member of the Empire Liver Foundation and a Medical Advisor for the American Liver Foundation. In 2014, Dr. Tow won the Erica C. Jones &amp; Naina Sinha-Gregory Prize in Medicine.</p>

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Aaron Zev Tokayer

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First Name

Aaron

Last Name

Tokayer

NPI

1336220755

Faculty ID

704

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Per Diem

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Adult

Department

Gender

Male

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Professional Interests

<p>Dr. Tokayer received his B.A. in from Yeshiva College and his M.D. from Albert Einstein College of Medicine of Yeshiva University. &nbsp;He completed an internship and residency at the Bronx Municipal Hospital Center and GI and Hepatology fellowship at Johns Hopkins Medical Center. He received an MHS degree in Clinical Epidemiology from Johns Hopkins School of Public Health. Dr. Tokayer then joined the Montefiore GI Faculty in 1992. He has been involved in the spectrum of clinical patient care, endoscopic interventions and teaching in the GI fellowship program. His areas of interest include clinical practice, patient care and education, endoscopic procedures and interventions, functional GI and motility disorders. He is Director of the GI Motility Lab where studies such as Esophageal Manometry,&nbsp; Esophageal Acid Monitoring and Impedance Testing, Ano-rectal Manometry and Defecatory Testing, Hydrogen Breath Testing for Bacterial overgrowth and Carbohydrate Maldigestion , and studies of gastric and intestinal transit. He works closely with colleagues of the Department of Radiology and Nuclear Medicine as well as the Department of Surgery in diagnosing and treating GI motility disorders.</p>

Research Profile

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Elsevier Profile

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Jonathan M. Schwartz

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First Name

Jonathan

Last Name

Schwartz

NPI

1215945738

Faculty ID

648

CMO Specialties

Clinical Terms

Employment Status

Full Time

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Adult

Department

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Male

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Professional Interests

<p>Jonathan M. Schwartz is a board Certified Transplant Hepatologist. &nbsp;He is a graduate of Tel Aviv University, Sackler School of Medicine. He was an Internal Medicine Resident at Albert Einstein College of Medicine and a Fellow in Gastroenterology/Transplant Hepatology at the University of Washington in Seattle. &nbsp;He returned to New York in 2011 from Portland, Oregon where he served as an Associate Professor of Medicine at Oregon Health and Sciences University.</p>
<p>Dr. &nbsp;Schwartz has an interest in treating patients with acute and chronic liver diseases including those patients with advanced liver diseases who require liver transplantation.</p>
<p>He has a special interest in the multidisciplinary care of patients with liver tumors.</p>

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Elsevier Profile

Selected Publications

<p><strong><br /></strong></p>
<ul>
<li>Estes JD, Stolpman D, Olyaei A, Ham JM, <strong>Schwartz JM</strong>, Orloff SL.&nbsp; High Prevalence of Potentially Hepatotoxic Herbal Supplement Use in Fulminant Hepatic Failure Patients. Arch Surg. 2003;138(8):852-8.</li>
<li><strong>Schwartz JM</strong>, Beymer C, Althaus SJ, Larson AM, Zaman A, Glickerman D, Kowdley KV.&nbsp; Cardiopulmonary Consequences of Transjugular Intrahepatic Portosystemic Shunts: Role of Increased Pulmonary Artery Pressure. J Clin Gastroenterol 2004;38(7):590-594.</li>
<li>Lim LL, Scarborough J, Thorne J, Graham E, Kempen J, Mackensen F, Nguyen Q D, Prabriputaloong T, Read R, Suhler EB, <strong>Schwartz JM</strong>, &nbsp;Smith JR. Uveitis in Patients with Autoimmune Hepatitis. Am J Ophthalmol. 2009;147(2):332-338.</li>
<li>O&rsquo;Glasser AY, Scott DA, Corless CL, Zaman A, Sasaki A, Gopal DV, Rayhill SC, Orloff SL, Ham JM, Rabkin JM, Flora K, Davies CH, Broberg CS, and <strong>Schwartz JM.</strong>Hepatic and Cardiac Iron Overload Among Patients with End-Stage Liver Disease Referred for Liver Transplantation. Clinical Transplantation. Clin Transplant. 2010 Sep-Oct;24(5):643-51.</li>
<li>Kanwal F, Befeler A, Chari R, Marrero J, Kahn J, Afdhal N, Morgan T, Roberts L, Mohanty SR, <strong>Schwartz J</strong>, Van Thiel D, Hassanein TI, Li J, Zeringue A, DiBisceglie A. Rate of Potentially Curative Treatment in Patients with Hepatocellular Carcinoma.&nbsp; Aliment Pharmacol Ther. 2012 Aug;36(3):257-65.</li>
<li>Bichoupan K1,&nbsp;<strong>Schwartz JM,</strong>&nbsp;Martel-Laferriere V,&nbsp;Giannattasio ER,&nbsp;Marfo K,&nbsp;Odin JA,&nbsp;Liu LU,&nbsp;Schiano TD,&nbsp;Perumalswami P,&nbsp;Bansal M,&nbsp;Gaglio PJ,&nbsp;Kalia H,Dieterich DT,&nbsp;Branch AD,&nbsp;Reinus JF. Effect of Fibrosis on Adverse Events in Patients with Hepatitis C Treated with Telaprevir. Aliment Pharmacol Ther.&nbsp;2014;39(2):209-16.</li>
<li><strong>Schwartz J</strong> and Carithers RL.&nbsp; Epidemiology and Etiologic Associations of Primary Hepatocellular Carcinoma.&nbsp; In Rose BD, editor. Up to date in Gastroenterology and Hepatology.&nbsp; Up to date, Inc. Wellesley, MA, Updated 2014.</li>
<li><strong>Schwartz JM </strong>and Carithers RL, Jr.&nbsp; Clinical features, diagnosis, and screening for primary hepatocellular carcinoma.&nbsp; Up to date in Gastroenterology and Hepatology.&nbsp; Up to date, Inc. Wellesley, MA, Updated 2014.</li>
<li>Curley SA, Stewart KE, <strong>Schwartz JM</strong>, Carthers RL, Jr.&nbsp; Nonsurgical therapies for localized hepatocellular carcinoma.&nbsp; Up to date, Inc. Wellesley, MA, Updated 2014.<strong>&nbsp;</strong></li>
<li><strong>Schwartz JM</strong>.&nbsp; Approach to the patient with a focal liver lesion.&nbsp; Up to date Inc Gastroenterology and Hepatology.&nbsp; Up to date, Inc. Wellesley, MA, Updated 2014.</li>
<li>Hartwell L and <strong>Schwartz JM.&nbsp; </strong>AsymptomaticLiver Chemistry Abnormalities. Journal of Clinical Outcomes Management. 2009; 16 (11): 525-34.</li>
<li>Urquhart J<strong>, Schwartz, JM.</strong> Hepatocellular Carcinoma Surveillance in a Western Population with Hepatitis B. Current Hepatitis Reports, 2011.</li>
<li><strong>Schwartz, JM </strong>and Reinus JF.&nbsp; Prevalence and Natural History of Alcoholic Liver Disease.&nbsp; Clinics in Liver Disease. 2012; 16 (4): 659-66.</li>
</ul>
<p>&nbsp;</p>

EMR ID

3842

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Renee M. Moadel

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First Name

Renee

Last Name

Moadel

NPI

1396849717

Faculty ID

8617

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Full Time

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Adult

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Female

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Off

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<span style="color:#4d4d4d;font-family:Arial, Helvetica, source-code-pro, Menlo, Monaco, Consolas, 'Courier New', monospace;font-size:16px;background-color:#ffffff;">Dr. Moadel has been with Montefiore since 2002, with a clinical focus on therapeutic radiopharmaceuticals in oncology and pediatric nuclear medicine, and a particular interest in the therapy of thyroid, liver, and prostate cancers.</span><quillbot-extension-portal></quillbot-extension-portal>

Research Focus

<span style="color:#4d4d4d;font-family:Arial, Helvetica, source-code-pro, Menlo, Monaco, Consolas, 'Courier New', monospace;font-size:16px;background-color:#ffffff;">In addition to sarcoma, pulmonary embolism, and infection imaging, Dr. Moadel&rsquo;s research focuses on engineering-driven medicine and the use of Y-90 microsphere therapy (a minimally evasive procedure combining embolization and radiation) for treating liver cancers. Her research examines many topics, ranging from nuclear therapy of breast cancer to methods of body scanning.</span><quillbot-extension-portal></quillbot-extension-portal>

Elsevier Profile

EMR ID

4056

Biography

<p>Renee M. Moadel, MD, MSc, is an Attending Physician in the Department of Radiology and an Assistant Professor of Nuclear Medicine and Medicine at our Albert Einstein College of Medicine. Dr. Moadel has been with Montefiore since 2002, with a clinical focus on therapeutic radiopharmaceuticals in oncology and pediatric nuclear medicine, and a particular interest in the therapy of thyroid, liver, and prostate cancers.</p><p>Dr. Moadel received her Doctor of Medicine in 1996 and Master of Clinical Research in 2007 at our Albert Einstein College of Medicine. From 1996 to 2001, Dr. Moadel completed her postgraduate training with a residency in medicine and nuclear medicine, a chief residency in nuclear medicine, and a fellowship in nuclear medicine at our Albert Einstein College of Medicine.</p><p>In addition to sarcoma, pulmonary embolism, and infection imaging, Dr. Moadel&rsquo;s research focuses on engineering-driven medicine and the use of Y-90 microsphere therapy (a minimally evasive procedure combining embolization and radiation) for treating liver cancers. Her research examines many topics, ranging from nuclear therapy of breast cancer to methods of body scanning. Dr. Moadel&rsquo;s work has been published in a number of reviewed journals, books, and review articles.</p><p>In 1998, Dr. Moadel was the recipient of the Leo M. Davidoff Society Award for Teaching in Internal Medicine by Montefiore, which honors teachers who have made significant contributions to the education of students of our Albert Einstein College of Medicine.</p><p>She is board certified by the American College of Nuclear Medicine, sitting on the Board of Regents.</p>

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Sanjeev Gupta

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First Name

Sanjeev

Last Name

Gupta

NPI

1831274315

Faculty ID

8041

CMO Specialties

Clinical Terms

Employment Status

Full Time

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Adult

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Male

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<p>Liver regeneration is critical for health. We focus on physiology of liver regeneration during development, early childhood and adulthood to inform mechanistic disruptions in diseases. The latter ranges from acute liver failure, effects of drugs, toxins, alcohol, virus hepatitis, obesity-related metabolic (or nonalcoholic) liver disease, chronic hepatitis, e.g., Wilson disease with copper toxicosis, and allograft rejection. The mechanisms concerning DNA damage response directed by ATM gene and downstream partners are of considerable interest to us.&nbsp; &nbsp; &nbsp;</p>
<p>These aspects are joined with study of cell type-specific contributions as well as aspects of stem cell biology for liver regeneration. We apply cell transplantation approaches to better understand the biology and regenerative potential of various cell types. Expression of therapeutic constructs and transplantation of those cells is another area of investigative interest. We address the role of endogenous stem/progenitor cells in therapeutic development. Tissue engineering to generate auxiliary liver has potential in these areas and is also advancing liver regenerartion in experimental models.</p>
<p>We use a variety of methods, including microarrays or deep sequencing for gene expression, cell and molecular biology methods, and multiple small and large animal models. The findings are integrated with analyses of human tissue and blood samples.</p>
<p>Unique aspects of our work include use of established drugs for mechanistic interrogations and therapeutic applications, and an uncommon depth and breadth of multidisciplinary tools. We collaborate with leading investigators at Einstein or elsewhere as appropriate.</p>

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Expert Tags

Areas of Expertise

Expert Summary

<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt;">Dr. Gupta is a pioneer in the development of cell therapy &ndash; treating disease by introducing healthy cells into the body.&nbsp; He has discovered various mechanisms for coaxing transplanted cells to attach to host tissue and multiply, paving the way for treating health problems such as&nbsp; high cholesterol, hemophilia, liver failure, and hepatitis.&nbsp;</span></p>
<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt;">Dr. Gupta has successfully manipulated human stem cells to generate liver cells and defined some of the fundamental ways by which gene expression is regulated in stem cells. Dr. Gupta serves as an expert for the National Institutes of Health, U.S. Department of Veterans Affairs, U.S. Department of Defense, Wellcome Trust, and national scientific bodies in over ten countries.</span></p>
<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt;">In the 1990s, Dr. Gupta contributed to the first ever clinical trial of a cell/gene therapy for familial hypercholesterolemia (high cholesterol), which results from a gene defect. He also showed that Wilson&rsquo;s disease (a genetic condition characterized by excessive accumulation of copper in the liver and brain) could potentially be cured by use of cell therapy.&nbsp;</span></p>

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Elsevier Profile

Selected Publications

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<li>Thirunavukkarasu C, Sharma Y, Tchaikovskaya T, Maslov AY, Gupta S. Transcriptional profiling reveals ataxia telangiectasia mutated pathways regulate joint copper and arsenic toxicity for hepatic metalloplasia and anti-cancer therapies. Life Sci. 2022 Jul 6;120787. doi: 10.1016/j.lfs.2022.120787.&nbsp;</li>
<li>Chang CJ, Ge EJ Bush AI, Casini A, Cobine PA, Cross JR, DeNicola GM, Dou Q, Franz KJ, Gohil VM, Gupta S, Kaler SG, Lutsenko S, Mittal V, Petris MJ, Polishchuk R, Ralle M, Schilsky ML, Tonks NK, Vahdat LK, Van Aelst L, Xi D, Yuan P, Brady DC. Connecting copper and cancer from transition metal signaling to metalloplasia in the clinic. Nat Rev Cancer 2022 Feb;22(2):102-113. doi: 10.1038/s41568-021-00417-2. Epub 2021 Nov 11. PMID: 34764459</li>
<li>Viswanathan P, Gupta P, Sharma Y, Maisuradze L, Bandi S, Gupta S. Caffeine disrupts ataxia telangiectasia mutated gene-related pathways and exacerbates acetaminophen toxicity in human fetal immortalized hepatocytes. Toxicology. 2021 May 7;457:152811. doi: 10.1016/j.tox.2021.152811. PMID: 33971260</li>
<li>Viswanathan P, Sharma Y, Jaber FL, Tchaikovskaya T, Gupta S. Transplanted hepatocytes rescue mice in acetaminophen-induced acute liver failure through paracrine signals for hepatic ATM and STAT3 pathways. FASEB J 2021 Apr;35(4):e21471. doi: 10.1096/fj.202002421R. PMID: 33683737</li>
<li>Jaber FL, Sharma Y, Mui BG, Kapoor S, Gupta S. Tumor necrosis factor directs allograft-related innate responses and its neutralization improves hepatocyte engraftment in rats. Am J Pathol 2021; 191(1):79-89. doi: 10.1016/j.ajpath.2020.09.014. Epub 2020 Oct 27. PMID: 33127336</li>
<li>Viswanathan P, Sharma Y, Gupta S. Ataxia telangiectasia mutated pathway disruption affects hepatic DNA and tissue damage in nonalcoholic fatty liver disease. Exp Mol Pathol. 2020 Apr; 113:104369. doi: 10.1016/j.yexmp.2020.104369. Epub 2020 Jan 7. PMID: 31917286</li>
<li>Gupta P, Sharma Y, Viswanathan P, Gupta S. Cellular receptor signaling and ATM pathway intersections regulate hepatic DNA repair. Cytokine 2020 Mar; 127:154946. doi: 10.1016/j.cyto.2019.154946. Epub 2019 Dec 11. PMID: 31837586</li>
<li>Bandi S, Tchaikovskaya T, Gupta S. Hepatic differentiation in human pluripotent stem cells by developmental stage-specific metabolomics products. Differentiation 2019; 105:54-70. Jan 28;105:54-70. doi: 10.1016/j.diff.2019.01.005. PMID: 30776728.</li>
<li>Kakabadze Z, Karalashvili L, Chakhunashvili D, Havlioglu N, Janelidze M, Kakabadze A, Sharma Y, Gupta S. Decellularized bovine placentome for portacavally-interposed heterotopic liver transplantation in rats. Mater Sci Eng C Mater Biol Appl. 2019 Apr; 97:293-301. doi: 10.1016/j.msec.2018.12.025. Epub 2018 Dec 10. PMID: 30678914.</li>
<li>Yadav N, Jaber FL, Sharma Y, Viswanathan P, Gupta S. Efficient reconstitution of hepatic microvasculature by endothelin receptor antagonism in liver sinusoidal endothelial cells. Hum Gene Ther 2018; Sep 28. doi: 10.1089/hum.2018.166. PMID: 30266073,&nbsp;</li>
<li>Sharma Y, Liu J, Kristian KE, Follenzi A, Gupta S. In Atp7b-/- mice modeling Wilson's disease liver repopulation with bone marrow-derived myofibroblasts or inflammatory cells and not hepatocytes is delterious.&nbsp;<span title="Gene expression">Gene Expr</span>. 2018 Jul 20. doi: 10.3727/105221618X15320123457380. PMID: 30029699</li>
<li>Bandi S, Gupta S, Tchaikovskaya T, Gupta S. Differentiation in stem/progenitor cells along fetal or adult hepatic stages requires transcriptional regulators independently of oscillations in microRNA expression.&nbsp;<span title="Experimental cell research">Exp Cell Res</span>. 2018 Sep 1;370(1):1-12. doi: 10.1016/j.yexcr.2018.06.004. Epub 2018 Jun 6.</li>
<li>Benten D, Kluwe J, Wirth JW, Thiele ND, Follenzi A, Bhargava KK, Palestro CJ, Koepke M, Tjandra R, Volz T, Lutgehetmann M, Gupta S. A humanized mouse model with liver fibrosis following expansion of transplanted hepatic stellate cells in injury and inflammation. Lab Invest 2018 Apr;98(4):525-536. doi: 10.1038/s41374-017-0010-7. Epub 2018 Jan 19.PMID: 29352225.</li>
<li>Viswanathan P, Sharma Y, Gupta P, Gupta S. Replicative stress and alterations in cell cycle checkpoint controls following acetaminophen hepatotoxicity restrict hepatic regeneration. Cell Prolif 2018; Jun;51(3):e12445. doi: 10.1111/cpr.12445. Epub 2018 Mar 5. PMID: 29504225.</li>
<li>Kakabadze Z, Kakabadze A, Chakhunashvili D, Karalashvili L, Berishvili E, Sharma Y, Gupta S. Decellularized human placenta supports hepatic tissue and allows rescue in acute liver failure. Hepatology 2018 May;67(5):1956-1969.&nbsp;PMID: 29211918.&nbsp;</li>
</ul>

EMR ID

3601

Is Open Scheduling

Off

Joseph D. Frager

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First Name

Joseph

Last Name

Frager

NPI

1992705974

Faculty ID

6662

CMO Specialties

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Employment Status

Full Time

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Adult

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Male

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<p>Dr. Frager specializes in disorders of the Colon and Upper GI Tract including: Colon Polyps, Diverticulitis, Peptic Ulcer Disease, Gastroesophageal Reflux and Gallstones.</p>

Research Focus

<p>Immunology of the GI Tract</p>

Elsevier Profile

EMR ID

3272

Biography

<p>Joseph Frager, MD, is an Attending Physician in Gastroenterology and Assistant Professor of Medicine at Montefiore Einstein. Dr. Frager specializes in the diagnosis and treatment of disorders of the colon and upper gastrointestinal tract including colon polyps, diverticulitis, peptic ulcer disease, gastroesophageal reflux and gallstones.</p><p>After earning his Doctor of Medicine from University of Pennsylvania School of Medicine in 1980, Dr. Frager came to Montefiore for his postgraduate training. He completed his internal medicine internship and residency in 1983, followed by his fellowship in gastroenterology in 1985.</p><p>Dr. Frager&rsquo;s research focus is on the immunology of the gastrointestinal tract. He has shared his work through peer-reviewed journals and abstracts.</p><p>Dr. Frager is board certified in Internal Medicine by the American Board of Internal Medicine. He is a member of the American College of Gastroenterology, the American Gastroenterology Association and the New York Society for Gastrointestinal Endoscopy.</p>

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Brett E. Fortune

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First Name

Brett

Last Name

Fortune

NPI

1720121585

Faculty ID

17475

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Full Time

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Male

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<p>Brett E. Fortune, MD, MSc, is Medical Director, Liver Transplant Program, and Associate Professor, Medicine at Montefiore Einstein. His clinical focus centers on providing care for patients with advanced liver disease and those who need or have received liver transplantation.</p>
<p>After obtaining his Bachelor of Science in biological sciences in 1999 from North Carolina State University, Dr. Fortune earned his Doctor of Medicine from Wake Forest University School of Medicine in 2004. He then completed an internship and residency in internal medicine at The Ohio State University Medical Center in 2007. After this, he participated in a gastroenterology fellowship at the University of Colorado Denver, where he also earned his Master of Science in clinical sciences, completing both in 2011. Dr. Fortune remained there for another year to participate in a transplant hepatology fellowship, which he completed in 2012.</p>
<p>Dr. Fortune&rsquo;s research focuses on clinical outcomes related to cirrhosis and portal hypertension complications as well as quality improvement in the care of patients with cirrhosis or those who have received a liver transplant. His work has been published in numerous peer-reviewed journals or books. He is currently Associate Editor for Liver Transplantation and Liver Section Editor for Digestive Disease Interventions, and has sat on the editorial board for Hepatology.</p>
<p>Dr. Fortune is board certified in Internal Medicine, Gastroenterology and Transplant Hepatology by the American Board of Internal Medicine. He is a member of many professional organizations, such as the American Association for the Study of Liver Diseases (AASLD), the American Gastroenterology Association (AGA) and the American Liver Foundation. Dr. Fortune won the Kushlan Junior Faculty Award, Section of Digestive Diseases in 2015 and the Howard M. Spiro Digestive Disease Fellowship Teaching Award in 2016 from Yale School of Medicine.</p>

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Elsevier Profile

EMR ID

P1004568

Biography

<p>Brett E. Fortune, MD, MSc, is Medical Director, Liver Transplant Program, and Associate Professor, Medicine at Montefiore Einstein. His clinical focus centers on providing care for patients with advanced liver disease and those who need or have received liver transplantation.</p><p>After obtaining his Bachelor of Science in biological sciences in 1999 from North Carolina State University, Dr. Fortune earned his Doctor of Medicine from Wake Forest University School of Medicine in 2004. He then completed an internship and residency in internal medicine at The Ohio State University Medical Center in 2007. After this, he participated in a gastroenterology fellowship at the University of Colorado Denver, where he also earned his Master of Science in clinical sciences, completing both in 2011. Dr. Fortune remained there for another year to participate in a transplant hepatology fellowship, which he completed in 2012.</p><p>Dr. Fortune&rsquo;s research focuses on clinical outcomes related to cirrhosis and portal hypertension complications as well as quality improvement in the care of patients with cirrhosis or those who have received a liver transplant. His work has been published in numerous peer-reviewed journals or books. He is currently Associate Editor for <em>Liver Transplantation</em> and Liver Section Editor for <em>Digestive Disease Interventions</em>, and has sat on the editorial board for <em>Hepatology</em>.</p><p>Dr. Fortune is board certified in Internal Medicine, Gastroenterology and Transplant Hepatology by the American Board of Internal Medicine. He is a member of many professional organizations, such as the American Association for the Study of Liver Diseases (AASLD), the American Gastroenterology Association (AGA) and the American Liver Foundation. Dr. Fortune won the Kushlan Junior Faculty Award, Section of Digestive Diseases in 2015 and the Howard M. Spiro Digestive Disease Fellowship Teaching Award in 2016 from Yale School of Medicine.</p>

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Kristina R. Chacko

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First Name

Kristina

Last Name

Chacko

NPI

1528246097

Faculty ID

13632

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Full Time

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Female

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<p>Kristina R. Chacko, MD, is an Associate Professor of Medicine at the Albert Einstein College of Medicine in Bronx, NY. &nbsp;She joined the Einstein-Montefiore Liver Center in 2013 after completing a fellowship in Transplant Hepatology at Mount Sinai School of Medicine in New York, NY. &nbsp;She received her bachelor of arts in philosophy at Boston College and attended medical school at Baylor College of Medicine in Houston, TX. &nbsp;She completed her internal medicine residency at Emory University in Atlanta, GA, and gastroenterology fellowship at New York University.&nbsp;&nbsp;Her clinical and research interests include the diagnosis and management of alcoholic hepatitis, non-alcoholic fatty liver disease, autoimmune liver diseases, and liver transplantation.&nbsp; As the program director of the ACGME-accredited transplant hepatology fellowship at Montefiore Medical Center, she is directly involved in the development and execution of the hepatology curriculum for gastroenterology and hepatology fellows.&nbsp;</p>

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Clinical Focus

<p><span style="color:#616161;font-family:'SF Pro Text', 'Segoe UI', 'Segoe WP', Tahoma, Arial, sans-serif, Roboto;font-size:14px;letter-spacing:-0.24px;background-color:#f5f5f5;">Transplant Hepatology, Autoimmune Hepatitis, Fatty Liver Disease (Alcohol/Non-alcohol), Acute alcoholic hepatitis, Living Donor Transplant</span></p>

Research Focus

<span style="color:#616161;font-family:'SF Pro Text', 'Segoe UI', 'Segoe WP', Tahoma, Arial, sans-serif, Roboto;font-size:14px;letter-spacing:-0.24px;background-color:#f5f5f5;">Research interest includes alcohol-related liver disease, liver transplantation, viral hepatitis and autoimmune liver disease.</span>

Elsevier Profile

Selected Publications

<p style="text-align: left;"><span style="color: #222222; font-family: Arial, sans-serif; font-size: 13px;"><span style="color: #212121; font-family: BlinkMacSystemFont, -apple-system, 'Segoe UI', Roboto, Oxygen, Ubuntu, Cantarell, 'Fira Sans', 'Droid Sans', 'Helvetica Neue', sans-serif; font-size: 16px;">Nahas J, Tow CY, <strong>Chacko KR</strong>, Haider T, Massoumi H. Granulocyte colony-stimulating factor does not improve mortality in severe alcoholic hepatitis: a single-center experience from the United States. Gastroenterol Hepatol Bed Bench. 2023;16(1):524-526. PMID: 37070107</span></span></p>
<p style="text-align: left;"><span style="color: #222222; font-family: Arial, sans-serif; font-size: 13px;"><span style="color: #212121; font-family: BlinkMacSystemFont, -apple-system, 'Segoe UI', Roboto, Oxygen, Ubuntu, Cantarell, 'Fira Sans', 'Droid Sans', 'Helvetica Neue', sans-serif; font-size: 16px;">D&iacute;az LA, Fuentes-L&oacute;pez E, Ayares G, Idalsoaga F, Arnold J, Valverde MA, Perez D, G&oacute;mez J, Escarate R, Villal&oacute;n A, Ram&iacute;rez CA, Hernandez-Tejero M, Zhang W, Qian S, Simonetto DA, Ahn JC, Buryska S, Dunn W, Mehta H, Agrawal R, Cabezas J, Garc&iacute;a-Carrera I, Cuy&agrave;s B, Poca M, Soriano G, Sarin SK, Maiwall R, Jalal PK, Abdulsada S, Higuera-de-la-Tijera F, Kulkarni AV, Rao PN, Salazar PG, Skladan&yacute; L, Bystrianska N, Clemente-Sanchez A, Villaseca-G&oacute;mez C, Haider T, <strong>Chacko KR</strong>, Romero GA, Pollarsky FD, Restrepo JC, Castro-Sanchez S, Toro LG, Yaquich P, Mendizabal M, Garrido ML, Marciano S, Dirchwolf M, Vargas V, Jim&eacute;nez C, Louvet A, Garc&iacute;a-Tsao G, Roblero JP, Abraldes JG, Shah VH, Kamath PS, Arrese M, Singal AK, Bataller R, Arab JP. MELD 3.0 adequately predicts mortality and renal replacement therapy requirements in patients with alcohol-associated hepatitis. JHEP Rep. 2023 Mar 15;5(8):100727. PMID: 37456675;&nbsp;</span></span></p>
<p style="text-align: left;"><span style="color: #222222; font-family: Arial, sans-serif; font-size: 13px;"><span style="color: #212121; font-family: BlinkMacSystemFont, -apple-system, 'Segoe UI', Roboto, Oxygen, Ubuntu, Cantarell, 'Fira Sans', 'Droid Sans', 'Helvetica Neue', sans-serif; font-size: 16px;">Arab JP, D&iacute;az LA, Baeza N, Idalsoaga F, Fuentes-L&oacute;pez E, Arnold J, Ram&iacute;rez CA, Morales-Arraez D, Ventura-Cots M, Alvarado-Tapias E, Zhang W, Clark V, Simonetto D, Ahn JC, Buryska S, Mehta TI, Stefanescu H, Horhat A, Bumbu A, Dunn W, Attar B, Agrawal R, Haque ZS, Majeed M, Cabezas J, Garc&iacute;a-Carrera I, Parker R, Cuy&agrave;s B, Poca M, Soriano G, Sarin SK, Maiwall R, Jalal PK, Abdulsada S, Higuera-de la Tijera MF, Kulkarni AV, Rao PN, Guerra Salazar P, Skladan&yacute; L, Bystrianska N, Prado V, Clemente-Sanchez A, Rinc&oacute;n D, Haider T, <strong>Chacko KR</strong>, Cairo F, de Sousa Coelho M, Romero GA, Pollarsky FD, Restrepo JC, Castro-Sanchez S, Toro LG, Yaquich P, Mendizabal M, Garrido ML, Narvaez A, Bessone F, Marcelo JS, Piombino D, Dirchwolf M, Arancibia JP, Altamirano J, Kim W, Araujo RC, Duarte-Rojo A, Vargas V, Rautou PE, Issoufaly T, Zamarripa F, Torre A, Lucey MR, Mathurin P, Louvet A, Garc&iacute;a-Tsao G, Gonz&aacute;lez JA, Verna E, Brown RS, Roblero JP, Abraldes JG, Arrese M, Shah VH, Kamath PS, Singal AK, Bataller R. Identification of optimal therapeutic window for steroid use in severe alcohol-associated hepatitis: A worldwide study. J Hepatol. 2021 Nov;75(5):1026-1033. doi: 10.1016/j.jhep.2021.06.019. Epub 2021 Jun 21. PMID: 34166722.</span></span></p>
<p style="text-align: left;"><span style="color: #222222; font-family: Arial, sans-serif; font-size: 13px;"><span style="color: #212121; font-family: BlinkMacSystemFont, -apple-system, 'Segoe UI', Roboto, Oxygen, Ubuntu, Cantarell, 'Fira Sans', 'Droid Sans', 'Helvetica Neue', sans-serif; font-size: 16px;">Andacoglu O, &Ouml;zbek U, Liu J, Figueredo C, <strong>Chacko KR</strong>, Tow C, Reinus JF, Kinkhabwala M. Comparison of 1-Year Morbidity Following Liver Transplant for Acute Alcoholic Hepatitis Versus Alcoholic Cirrhosis. Exp Clin Transplant. 2021 May;19(5):439-444. Epub 2021 Jan 11. PMID: 33455569.</span></span></p>
<p style="text-align: left;"><span style="color: #212121; font-family: BlinkMacSystemFont, -apple-system, 'Segoe UI', Roboto, Oxygen, Ubuntu, Cantarell, 'Fira Sans', 'Droid Sans', 'Helvetica Neue', sans-serif; font-size: 16px;">Fontana RJ, Brown RS Jr, Moreno-Zamora A, Prieto M, Joshi S, Londo&ntilde;o MC, Herzer K, Chacko KR, Stauber RE, Knop V, Jafri SM, Castells L, Ferenci P, Torti C, Durand CM, Loiacono L, Lionetti R, Bahirwani R, Weiland O, Mubarak A, ElSharkawy AM, Stadler B, Montalbano M, Berg C, Pellicelli AM, Stenmark S, Vekeman F, Ionescu-Ittu R, Emond B, Reddy KR. Daclatasvir combined with sofosbuvir or simeprevir in liver transplant recipients with severe recurrent hepatitis C infection. Liver Transpl. 2016 Apr;22(4):446-58. PMID: 26890629.</span></p>
<p style="text-align: left;"><span style="color: #212121; font-family: BlinkMacSystemFont, -apple-system, 'Segoe UI', Roboto, Oxygen, Ubuntu, Cantarell, 'Fira Sans', 'Droid Sans', 'Helvetica Neue', sans-serif; font-size: 16px;"><strong>Chacko KR</strong>, Wolkoff AW. Intrahepatic Cholestasis of Pregnancy: New Diagnostic Insights. Ann Hepatol. 2017 March-April;16(2):176-178.&nbsp; PMID: 28233755.</span></p>
<p style="text-align: left;"><span style="color: #212121; font-family: BlinkMacSystemFont, -apple-system, 'Segoe UI', Roboto, Oxygen, Ubuntu, Cantarell, 'Fira Sans', 'Droid Sans', 'Helvetica Neue', sans-serif; font-size: 16px;"><strong>Chacko KR</strong>, Reinus J. Spectrum of Alcoholic Liver Disease. Clin Liver Dis. 2016 Aug;20(3):419-27. doi: 10.1016/j.cld.2016.02.002. Epub 2016 May 31. PMID: 27373606.</span></p>
<p style="text-align: left;"><span style="color: #212121; font-family: BlinkMacSystemFont, -apple-system, 'Segoe UI', Roboto, Oxygen, Ubuntu, Cantarell, 'Fira Sans', 'Droid Sans', 'Helvetica Neue', sans-serif; font-size: 16px;"><strong>Chacko KR</strong>, Reinus J. Extrahepatic Complications of Nonalcoholic Fatty Liver Disease. Clin Liver Dis. 2016 May;20(2):387-401. doi: 10.1016/j.cld.2015.10.004. Epub 2016 Feb 18. PMID: 27063276.</span></p>

EMR ID

5713

Is Open Scheduling

On