David M. Loeb
<p>Dr. Loeb has an active translational research laboratory focused on understanding bone tumor metastasis. His laboratory developed a clinically relevant mouse model of sarcoma metastasis, and has used this model to perform preclinical testing of novel agents that can interfere with this process. More basic scientific studies in the lab involve exploring the role of the Wnt signaling pathway in Ewing sarcoma migration, invasion, and metastasis. Dr. Loeb is also studying the role of an enzyme called RNA helicase DDX3 in Ewing sarcoma biology, especially how this enzyme affects the repair of damaged DNA. More recently, the laboratory has developed an interest in targeting the metabolic reprogramming associated with metastasis as a way to prevent the outgrowth of distant metastases from disseminated tumor cells.</p>
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<p>Dr. Loeb is also actively involved in clinical research, including the development of radiopharmaceutical agents for the treatment of bone metastases and the development of a small molecule inhibitor of DDX3. He serves as the local PI for a clinical trial of reduced intensity haploidentical bone marrow transplantation for children with high risk solid tumors. Finally, as an offshoot of his laboratory work, Dr. Loeb is involved in the development of biomarkers of metastatic risk and of minimal residual disease in children, adolescents, and young adults with sarcomas.</p>
<p>Dr. Loeb is a leading pediatric oncologist and NIH-funded researcher. He has extensive expertise in sarcoma research and clinical care and is a bone marrow transplantation specialist. Dr. Loeb’s research spans the spectrum from basic and translational studies to clinical trials using novel therapies.</p>
<p>Dr. Loeb's PubMed bibliography can be found here: </p>
<p><a href="https://www.ncbi.nlm.nih.gov/sites/myncbi/1fiIspwqfwUE46/bibliography/5…;
<p>David Loeb, MD, PhD, is Chief, Pediatric Hematology, Oncology and Cellular Therapy at Children’s Hospital at Montefiore and Professor, Pediatrics and Professor, Developmental and Molecular Biology at Montefiore Einstein. His clinical work focuses on tumors of connective tissue, such as bone and muscle. He also has expertise in the care of children with other solid tumors. As a member of the bone marrow transplantation team, Dr. Loeb also cares for patients with acute leukemias and has expertise in the application of immunotherapy to childhood cancer.</p><p>Dr. Loeb earned his Bachelor of Arts in biology in 1987 at Johns Hopkins University. In 1993, he received his Doctor of Philosophy in Pathology and, in 1994, his Doctor of Medicine at Columbia University. In 1994, he also began an internship in Pediatrics at the Johns Hopkins University School of Medicine, followed by a residency in 1995 and a fellowship in Pediatric Hematology Oncology at the same institution.</p><p>Dr. Loeb has an active translational research laboratory focused on understanding bone tumor metastasis. His laboratory developed a clinically relevant mouse model of sarcoma metastasis and has used this model to perform preclinical testing of novel agents that can interfere with this process. One area of focus is the metabolic differences between cancer cells and normal cells, and between metastases and the primary tumor, with the intention of targeting these differences therapeutically. More basic scientific studies in the lab involve exploring the role of the Wnt signaling pathway in Ewing sarcoma and osteosarcoma migration, invasion and metastasis. Dr. Loeb also studies the role of an enzyme called RNA helicase DDX3 in Ewing sarcoma biology, especially how this enzyme affects the repair of damaged DNA.</p><p>Dr. Loeb is also actively involved in clinical research, including the development of radiopharmaceutical agents for the treatment of bone metastases and the development of a small molecule inhibitor of DDX3. He has also directed a clinical trial of reduced intensity haploidentical bone marrow transplantation for children with high risk solid tumors. Stemming from his laboratory work, Dr. Loeb is involved in the development of biomarkers of metastatic risk and of minimal residual disease in children, adolescents and young adults with sarcomas. Dr. Loeb’s original research, based on his clinical and laboratory studies, has been published in multiple journals and books.</p><p>Dr. Loeb has been a recipient of many awards, including the Director’s Teaching Award in Clinical Science from Sidney Kimmel Comprehensive Cancer Center in 2006, 2010 and 2015, and The Justin Straus Chordoma Research Award in 2009.</p>
Mauricio Drummond, Jr.
Dr. Drummond’s clinical focus is in pediatric sports medicine with a special focus on knee pathology.
Dr. Drummond’s research interests include discoid meniscus, trochlear dysplasia, patellofemoral instability and ACL tears
<p>Mauricio Drummond Jr., MD, is an attending surgeon and Assistant Professor, Pediatrics and Orthopedic Surgery at Children’s Hospital at Montefiore. Dr. Drummond’s clinical focus is in pediatric sports medicine with a special focus on knee pathology. His interests include pediatric orthopedic surgery, complex pediatric and adolescent sports medicine, ACL, PCL and multiligament knee injuries, discoid meniscus, meniscus transplantation, patellofemoral instability, trochlear dysplasia, cartilage preservation and pediatric trauma and limb deformities.</p><p>In 1996, Dr. Drummond earned his Doctor of Medicine from Universidade Federal do Rio de Janeiro (Federal University of Rio de Janeiro) in Rio de Janeiro, Brazil. He completed his residency training at the same institution, and practiced as a knee specialist for more than 13 years in Brazil. In 2018, he came to the United States, completing an orthopedic surgery research fellowship at Cleveland Clinic Foundation in 2019 and an orthopedic sports medicine fellowship at the University of Pittsburgh Medical Center in 2020. He continued his postdoctoral training, completing his pediatric orthopedics and limb deformity fellowship at Montefiore Medical Center in 2021 and his pediatric orthopedics fellowship at Connecticut Children’s Medical Center in 2022.</p><p>Dr. Drummond’s research interests include discoid meniscus, trochlear dysplasia, patellofemoral instability and ACL tears. He has shared his work nationally and internationally through peer-reviewed journals and podium and poster presentations. He is also a reviewer for the <em>American Journal of Sports Medicine</em>.</p><p>Dr. Drummond is a member of several professional organizations including the International Society of Arthroscopy and Knee Orthopaedic Sports Medicine (ISAKOS), the American Orthopaedic Society for Sports Medicine (AOSSM), the Pediatric Orthopaedic Society of North America (POSNA) and the Pediatric Research in Sports Medicine Society (PRiSM).</p>
Shiu M. Young
Rui Yang
<p>Dr. Yang earned his medical degree at Beijing Medical University in China followed by an orthopaedic residency at Peking University People’s Hospital in Beijing, China. Following his training in China, he came to the United States where he earned a Master’s degree in Biological Sciences from Hunter College at the City University of New York. Dr. Yang completed a second orthopaedic surgery residency at the University of Texas, in Houston and then he did a fellowship in Orthopaedic Oncology at Memorial Sloan-Kettering Cancer Center.</p>
<p>Dr. Yang specializes in the diagnosis and treatment of benign and malignant tumors in the musculoskeletal system. A multidisciplinary approach is emphasized in his practice. He performs surgery to remove the tumor fom the limb and pelvis, and rebuild them using techniques tailored for each individual patient. Dr. Yang is also interested in treating metastatic bony lesions originating from other parts of the body.</p>
<p>Dr. Yang has a strong interest in the research of musculoskeletal tumors. He has been studying the tumorigenesis of osteosarcoma and the genetic profile of the tumors as comparison to its normal counterpart tissues. He has also studied the mechanism of chemotherapy resistance in osteosarcoma and related signaling pathways, as well as novel strategies to overcome it in collaboration with the pediatric sarcoma teams.</p>
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Diagnosis and treatment of benign and malignant tumors in the musculoskeletal system, including metastatic bony lesions as well as primary tumors.<quillbot-extension-portal></quillbot-extension-portal>
Dr. Yang has a strong interest in the research of musculoskeletal tumors. He has been studying the tumor genesis of osteosarcoma and the genetic profile of the tumors as compared to normal counterpart tissues. He has also studied the mechanism of chemotherapy resistance in osteosarcoma and related signaling pathways, in addition to novel strategies to overcome it in collaboration with pediatric sarcoma teams.<quillbot-extension-portal></quillbot-extension-portal>
<p>1. Peer-reviewed Papers</p>
<p>1) <strong>Yang, R.</strong>, Piperdi, S., Zhang, Y., Neophytou, N., Zhu, W., Hoang, B.H., Mason, G., Geller, D., Dorfman, H,, Healey, J.H., Phinney, D.G., and Gorlick, R. Transcriptional Profiling Identifies the Signaling Axes of the Insulin Growth Factor and the Transforming Growth Factor-beta as involved in the Pathogenesis of Osteosarcoma. Clin Orthop Relat Res. 2015. PMID: 26463566</p>
<p>2) Nathan, S.S., Huvos, A.G., Casas-Ganem, J.E., <strong>Yang, R.,</strong> Linkov, I., Sowers, R., DiResta, G.R., Gorlick, R., Healey, J.H. Tumour interstitial fluid pressure may regulate angiogenic factors in osteosarcoma <a href="http://www.ncbi.nlm.nih.gov/pubmed/20052438">.</a> Ann Acad Med Singapore. 2009; 38(12):1041-7. PMID: 20052438</p>
<p>3) Li, N., <strong>Yang, R.</strong>, Zhang, W., Dorfman, H., Rao, P., and Gorlick, R. Genetically Transforming Human Mesenchymal Stem Cells to Sarcomas: changes in cellular phenotype and multilineage differentiation potential. Cancer. 2009; 115(20): 4795-806. PMID: 19593798</p>
<p>4) <strong>Yang, R</strong>., Piperdi, S., and Gorlick, R. Activation of the RAF/MEK/ERK pathway mediates apoptosis induced by chelerythrine in osteosarcoma. Clin Cancer Res. 2008;14(20): 6396-404. PMID: 18927278</p>
<p>5) <strong>Yang, R.</strong>, Qin, J., Hoang, B.H., Healey, J.H., and Gorlick, R. Polymorphisms and methylation of the reduced folate carrier in osteosarcoma. Clin Orthop Relat Res 2008;466:2046-51. PMID: 18528741</p>
<p>6) Nathan, S.S., Huvos, A.G., Casas-Ganem, J.E., <strong>Yang, R.</strong>, Linkov, I., Sowers, R., Diresta, G.R., Gorlick, R., and Healey, J.H. Tumor interstitial fluid pressure may regulate angiogenic factors in osteosarcoma. J Orthop Res 2008;26:1-6. PMID: 18473395</p>
<p>7) <strong>Yang, R.</strong>, Li, W.W., Hoang, B.H., Kim, H., Banerjee, D., Kheradpour, A., Healey, J.H., Meyers, P.A., Bertino, J.R., and Gorlick, R. Quantitative correlation between promoter methylation and messenger RNA levels of the reduced folate carrier. BMC Cancer 2008;8:124. PMID: 18452618</p>
<p>8) <strong>Yang, R.</strong>, Kolb, E.A., Qin, J., Chou, A., Sowers, R., Hoang, B., Healey, J.H., Huvos, A.G., Meyers, P.A. and Gorlick, R. The folate receptor alpha is frequently overexpressed in osteosarcoma samples and plays a role in the uptake of the physiologic substrate 5-methyltetrahydrofolate. Clin Cancer Res 2007;13:2557-67. PMID: 17473184</p>
<p>9) <strong>Yang, R.</strong>, Hoang, B.H., Kubo, T., Kawano, H., Chou, A., Sowers, R., Huvos, A.G., Meyers, P.A., Healey, J.H. and Gorlick, R. Over-expression of parathyroid hormone Type 1 receptor confers an aggressive phenotype in osteosarcoma. Int J Cancer 2007;121:943-54. PMID: 17410535</p>
<p>10) Laverdiere, C., Hoang, B.H., <strong>Yang, R.</strong>, Sowers, R., Qin, J., Meyers, P.A., Huvos, A.G., Healey, J.H. and Gorlick, R. Messenger RNA expression levels of CXCR4 correlate with metastatic behavior and outcome in patients with osteosarcoma. Clin Cancer Res 2005;11:2561-7. PMID: 15814634</p>
<p>11) Nathan, S.S., DiResta, G.R., Casas-Ganem, J.E., Hoang, B.H., Sowers, R., <strong>Yang, R.</strong>, Huvos, A.G., Gorlick, R. Elevated physiologic tumor pressure promotes proliferation and chemosensitivity in human osteosarcoma. Clin Cancer Res 2005;11:2389-97. PMID: 15788690</p>
<p>12) Flintoff, W.F., Sadlish, H., Gorlick, R., <strong>Yang, R.</strong>, Williams, F.M. Functional analysis of altered reduced folate carrier sequence changes identified in osteosarcomas. Biochim Biophys Acta 2004;1690:110-7. PMID: 15469899</p>
<p>13) Hoang, B.H., Kubo, T., Healey, J.H., <strong>Yang, R.</strong>, Nathan, S.S., Kolb, E.A., Mazza, B., Meyers, P.A. and Gorlick, R. Dickkopf 3 inhibits invasion and motility of Saos-2 osteosarcoma cells by modulating the Wnt-beta-catenin pathway. Cancer Res 2004;64:2734-9. PMID: 15087387</p>
<p>14) Hoang, B.H., Kubo, T., Healey, J.H., Sowers, R., Mazza, B., <strong>Yang, R.</strong>, Huvos, A.G., Meyers, P.A. and Gorlick, R. Expression of LDL receptor-related protein 5 (LRP5) as a novel marker for disease progression in high-grade osteosarcoma. Int J Cancer 2004;109:106-11. PMID: 14735475</p>
<p>15) <strong>Yang, R.</strong>, Sowers, R., Mazza, B., Healey, J.H., Huvos, A., Grier, H., Bernstein, M., Beardsley, G.P., Krailo, M.D., Devidas, M., Bertino, J.R., Meyers, P.A. and Gorlick, R. Sequence alterations in the reduced folate carrier are observed in osteosarcoma tumor samples. Clin Cancer Res 2003;9:837-44. PMID: 12576457</p>
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<p>2. Book Chapters</p>
<p align="left">1) Orthopedic Oncology. Editor: Xun, W.P., Feng, C.H. People’s Military Medical Publisher.</p>
<p>(ISBN: 7-80157-159-2), 2001.</p>
<p>2) Review of Surgery: A Guiding Book for Medical Students. Section of Orthopedics. Editor: Jiang, B.G. Beijing Medical University Publisher. (ISBN: 7-81034-946-5), 1999.</p>
<p>Dr. Yang is a fellowship-trained orthopedic surgeon recognized for his multidisciplinary approach to the diagnosis and treatment of benign and malignant tumors in the musculoskeletal system, including metastatic bony lesions as well as primary tumors. He also serves as an Assistant Professor at our Albert Einstein College of Medicine.</p><p>Dr. Yang earned his medical degree at Beijing Medical University in China followed by an orthopedic residency at Peking University People?s Hospital in Beijing, China. Following his training in China, he came to the United States where he earned a master?s degree in biological sciences from Hunter College at the City University of New York. Dr. Yang completed a second orthopedic surgery residency at the University of Texas, in Houston, followed by a fellowship in orthopedic oncology at Memorial Sloan-Kettering Cancer Center.</p><p>Dr. Yang has a strong interest in the research of musculoskeletal tumors. He has been studying the tumor genesis of osteosarcoma and the genetic profile of the tumors as compared to normal counterpart tissues. He has also studied the mechanism of chemotherapy resistance in osteosarcoma and related signaling pathways, in addition to novel strategies to overcome it in collaboration with pediatric sarcoma teams.</p>
Eric G. Walter
<p>Reconstructive foot surgery.</p>
<p>Podiatric sports medicine.</p>
Reconstructive foot surgery and podiatric sports medicine
Foot surgery and outcomes analysis
<p>Eric G. Walter, DPM, FACFAS, is a board-certified podiatrist specializing in reconstructive foot surgery and podiatric sports medicine. He is an Assistant Professor at our Albert Einstein College of Medicine and an Adjunct Assistant Professor at New York College of Podiatric Medicine. He received his medical degree from New York College of Podiatric Medicine (NYCPM).</p><p>He completed his residency at NYCPM and affiliated hospitals. Dr. Walter conducts research focused on foot surgery and outcomes analysis.</p>
Stanley F. Wainapel
<p>My primary areas of clinical and research interest are: Complementary/Alternative Medicine (CAM); physical disability among physicians and medical students; medical problems in musicians; ethical aspects of rehabilitation research; and disability in the novels of Charles Dickens. My long-term research goal is to write a book on Dickens and Medicine. </p>
<span class="TextRun SCXW33707701 BCX8" data-contrast="none" lang="EN-US" style="white-space:pre-wrap;margin:0px;padding:0px;user-select:text;-webkit-user-drag:none;-webkit-tap-highlight-color:transparent;font-size:11pt;line-height:16px;font-family:Arial, Arial_EmbeddedFont, Arial_MSFontService, sans-serif;font-variant-ligatures:none !important;" xml:lang="EN-US">Dr. Wainapel has a wide range of clinical interests including geriatric rehabilitation, complementary/alternative therapies for pain management, vision rehabilitation, and performing arts medicine</span><span class="EOP SCXW33707701 BCX8" data-ccp-props="{"201341983":0,"335559739":0,"335559740":240}" style="white-space:pre-wrap;margin:0px;padding:0px;user-select:text;-webkit-user-drag:none;-webkit-tap-highlight-color:transparent;font-size:11pt;line-height:16px;font-family:Arial, Arial_EmbeddedFont, Arial_MSFontService, sans-serif;"> </span>
<span class="TextRun SCXW12926019 BCX8" data-contrast="none" lang="EN-US" style="margin:0px;padding:0px;user-select:text;-webkit-user-drag:none;-webkit-tap-highlight-color:transparent;white-space:pre-wrap;background-color:#ffffff;font-size:11pt;line-height:16px;font-family:Arial, Arial_EmbeddedFont, Arial_MSFontService, sans-serif;font-variant-ligatures:none !important;" xml:lang="EN-US"><span class="NormalTextRun SCXW12926019 BCX8" style="margin:0px;padding:0px;user-select:text;-webkit-user-drag:none;-webkit-tap-highlight-color:transparent;"></span></span>Vision rehabilitation, the history of Physical Medicine and Rehabilitation, physical disabilities among physicians, and bioethics are the main focuses of Dr. Wainapel’s research.<span 201341983":0,"335559739":0,"335559740":240}"="" class="EOP SCXW12926019 BCX8" data-ccp-props="{" style="margin:0px;padding:0px;user-select:text;-webkit-user-drag:none;-webkit-tap-highlight-color:transparent;white-space:pre-wrap;background-color:#ffffff;font-size:11pt;line-height:16px;font-family:Arial, Arial_EmbeddedFont, Arial_MSFontService, sans-serif;"></span><quillbot-extension-portal></quillbot-extension-portal>
<p>Stanley F. Wainapel, MD, MPH, is Clinical Director, Physical Medicine and Rehabilitation at Montefiore, and Professor of Clinical Physical Medicine and Rehabilitation at our Albert Einstein College of Medicine. Since joining the Montefiore team, his clinical focus has been general rehabilitation, vision rehabilitation, chronic pain, and acupuncture.</p><p>In 1970, Dr. Wainapel received his Bachelor of Arts after completing a 6-year medical program at Boston University. During this time, he also attended Boston University School of Medicine, where he received his Doctor of Medicine in 1970. He began his postgraduate training in 1970 with a year-long internship in medicine at Genessee Hospital, followed by a residency at Albert Einstein College of Medicine, which he completed in 1974. In 1982, Dr. Wainapel his Master of Public Health in 1989 from Boston University.</p><p>Vision rehabilitation, the history of Physical Medicine and Rehabilitation, physical disabilities among physicians, and bioethics are the main focuses of Dr. Wainapel’s research. His work has been presented nationally at many guest lectures and published in numerous books and textbooks.</p><p>From 1982 to 1985, Dr. Wainapel was President of the American Society of Handicapped Physicians. He also spent a year as President of the New York Society of Physical Medicine and Rehabilitation in 1991. Dr. Wainapel is a diplomat of the National Board of Medical Examiners and the American Board of Physical Medicine and Rehabilitation.</p>
Natalia Vasquez-Canizares
<p>Natalia Vasquez Canizares, MD, MS, is an Attending Physician of Pediatric Rheumatology at the Children’s Hospital at Montefiore (CHAM) and an Assistant Professor of Pediatrics at our Albert Einstein College of Medicine.</p>Dr. Vasquez Canizares received her Doctor of Medicine at Universidad de La Sabana in Chia, Colombia, then completed medical internships at Hospital Universitario de La Samaritana in Bogota, Colombia, and Hospital Universitario Austral in Pilar, Argentina. She completed a residency in Pediatrics at Cooper University Hospital and did her Pediatric Rheumatology Fellowship at CHAM. She also completed a Master of Science in Clinical Research at Albert Einstein College of Medicine.<br /><br />Dr. Vasquez Canizares’s clinical focus is on pediatric rheumatic diseases, with a particular interest in children with juvenile scleroderma. She is an active member of the scleroderma work group within the Childhood Arthritis and Rheumatology Research Alliance (CARRA), a collaborator with the Pediatric Rheumatology European Society (PReS) in scleroderma-related research and a recipient of two grants from CARRA and the Arthritis Foundation to study treatment therapies and outcome measures in juvenile scleroderma. She is board certified and a member of the American College of Rheumatology, the American Medical Association and the Childhood Arthritis and Rheumatology Research Alliance.<p> </p>
Victoria Vapnyar
Audrey M. Uong
Dr. Uong's clinical focus has been in pediatrics.
The care of hospitalized pediatric patients with asthma has been a main focus of research for Dr. Uong. She is also interested in researching the improvement of transitions of care in hospitalized pediatric patients.
<p>Audrey M. Uong, MD, is an Attending Physician, Division of Hospital Medicine at Children’s Hospital at Montefiore (CHAM) and an Assistant Professor of Pediatrics at our Albert Einstein College of Medicine. Since joining the Montefiore team in 2019, her clinical focus has been in pediatrics.</p><p>In 2008, Dr. Uong received her Bachelor of Arts in Asian Languages and Civilizations from Amherst College. Her studies continued at New York Medical College, where she received her Doctor of Medicine in 2014. Following this, Dr. Uong continued her studies at Albert Einstein Medical College and received her Master of Science in Clinical Research Methods in 2019. She began her postgraduate training in 2014 with a 3-year internship and residency at Cohen Children’s Medical Center. She then completed a fellowship in Pediatric Hospital Medicine at CHAM in 2019.</p><p>The care of hospitalized pediatric patients with asthma has been a main focus of research for Dr. Uong. She is also interested in researching the improvement of transitions of care in hospitalized pediatric patients. Her work has been published in numerous peer-reviewed journals and review articles, and has been presented nationally.</p><p>In 2019, Dr. Uong received the CHAM Research Day Oral Presentation Award, given to her from faculty judges for receiving top scores. Dr. Uong is board certified by the American Board of Pediatrics and is a member of numerous professional societies, including the American Academy of Pediatrics and the Academic Pediatric Association.</p>