Glycobiology & Intracellular Trafficking

The secretory pathway produces glycoproteins that reside in the ER, Golgi, lysosomes and endosomes, or travel to the plasma membrane, or are secreted from the cell. The Stanley lab identifies roles for glycans on key glycoproteins like Notch receptors and receptor tyrosine kinases in cells and mutant mice. The Steidl lab uses recognition of glycans on proteoglycans to isolate potentially novel subsets of hematopoietic and leukemic cells. The Kielian lab investigates mechanisms of entry and exit of enveloped RNA viruses that fuse with the plasma membrane, including Dengue and Chikungunya. The Meier lab studies transport of RNA-protein complexes across the nuclear envelope and within the nucleus. Trafficking mechanisms within the cell are a broad focus.