Mitochondria, Metabolism, and Cell Death Control

Mitochondria are hubs for metabolism, cell death, calcium and redox homeostasis, and biosynthesis that impact multiple aspects of normal physiology and disease. The Augenlicht lab investigates connections between intestinal stem cell mitochondrial structure and function and cancer risk and aging. The Ito lab studies contributions of mitochondrial metabolism to hematopoietic stem cell fate and hematological disorders. The Kitsis lab investigates mitochondrial cell death programs and metabolism/energetics and roles in disease. The Maryanovich lab studies roles of mitochondrial metabolism in mesenchymal stem cell aging. The Will lab investigates connections between iron and cysteine-homeostasis and hematopoietic and leukemic stem cell gene regulation. Other labs at Einstein study roles of mitochondria in thermogenesis and diabetes.