David Weithorn
Dr. Weithorn focuses on using minimally invasive techniques, including robotic surgery, to treat a wide range of surgical diseases, including gallstones (gallbladder removal), hiatal hernia repair, anti-reflux surgery, diverticulitis, colon cancer, ventral and inguinal hernias including complex hernias, recurrent ventral and inguinal hernias, and neurectomy procedures for chronic inguinal pain after inguinal hernia repair.
Dr. Weithorn is interested in outcomes-based research using minimally invasive surgical techniques to reduce morbidity and speed recovery for a wide range of general surgical conditions, especially acute and/or emergent surgical conditions. H
<p>David Weithorn, MD, is a general surgeon and Assistant Professor, Surgery at Montefiore Einstein. A fellowship-trained minimally invasive general surgeon, Dr. Weithorn focuses on using minimally invasive techniques, including robotic surgery, to treat a wide range of surgical diseases, including gallstones (gallbladder removal), hiatal hernia repair, anti-reflux surgery, diverticulitis, colon cancer, ventral and inguinal hernias including complex hernias, recurrent ventral and inguinal hernias, and neurectomy procedures for chronic inguinal pain after inguinal hernia repair.</p><p>After receiving his Bachelor of Science from University of Florida in 2011, Dr. Weithorn attended the Herbert Wertheim College of Medicine, earning his Doctor of Medicine in 2015. He completed his residency in general surgery at Montefiore Medical Center in 2020, then pursued fellowship in robotic/minimally invasive surgery at Hackensack University Medical Center, training with pioneers in robotic surgery.</p><p>Dr. Weithorn is interested in outcomes-based research using minimally invasive surgical techniques to reduce morbidity and speed recovery for a wide range of general surgical conditions, especially acute and/or emergent surgical conditions. He has shared his work through peer-reviewed journal articles and national presentations.</p><p>Dr. Weithorn is board certified by the American Board of Surgery and is a member of the American College of Surgeons and the Society of American Gastrointestinal and Endoscopic Surgeons.</p>
Jacqueline Weingarten-Arams
Nutrition
Pulmonary hypertension
Sepsis
<p>Jacqueline Weingarten-Arams, MD, is an attending physician and Professor, Pediatrics at Montefiore Einstein. Dr. Weingarten-Arams’ pediatric critical care expertise focuses on cardiac critical care, acute hypoxemic respiratory failure, nutrition in critical illness and energy expenditure, cardiopulmonary resuscitation (quality CPR) and extracorporeal life support (ECMO).</p><p>After obtaining her Bachelor of Science in nutritional biochemistry at Cornell University in 1982, Dr. Weingarten-Arams earned her Doctor of Medicine at the same institution in 1986. She then completed her pediatric residency at Columbia University in 1990, where she was Chief Resident in her final year. Following this, Dr. Weingarten-Arams completed a fellowship in pediatric critical care medicine at New York Hospital Cornell University Medical College in 1996.</p><p>Dr. Weingarten-Arams research focus includes the use of deliberate simulated practice in improving outcomes in pediatric critical illness, pediatric resuscitation and pediatric airway management. Her other projects involve chronic critical illness, bioethics in pediatric critical care and oxidative injury in respiratory failure. She has been principal investigator and co-investigator on several research projects, and her work has been shared through numerous peer-reviewed publications and invited presentations.</p><p>Dr. Weingarten-Arams is a Diplomate of the National Board of Medical Examiners and the American Board of Pediatrics. She is a Fellow of the American Academy of Pediatrics and the American College of Chest Physicians. She is also a member of several professional organizations, including the American Medical Association, the Pediatric Cardiac Intensive Care Society and the Society of Critical Care Medicine. Dr. Weingarten-Arams has been named in Castle Connolly’s “Top Doctors: New York Metro Area” for multiple years. In 2006, she was inducted into the Leo M. Davidoff Society and in 2019, Dr. Weingarten-Arams won the William Obrinsky Award for Excellence in Medical Student Education.</p>
Marc Vimolratana
Dr. Vimolratana is a general thoracic surgeon with a clinical focus on thoracic surgical oncology, including minimally invasive surgery for lung and esophageal cancer. His other clinical interests include mediastinal and chest wall tumors, tracheal disorders, thoracic outlet syndrome, and benign esophageal diseases. <quillbot-extension-portal></quillbot-extension-portal>
Dr. Vimolratana’s research focuses on improving patient outcomes after complex lung and esophageal surgery. He has shared his findings through publications in peer-reviewed journals and abstracts at national meetings. <quillbot-extension-portal></quillbot-extension-portal>
<p>Marc Vimolratana, MD, MS, is Assistant Professor, Cardiothoracic and Vascular Surgery at Montefiore Einstein. Dr. Vimolratana is a general thoracic surgeon with a clinical focus on thoracic surgical oncology, including minimally invasive surgery for lung and esophageal cancer. His other clinical interests include mediastinal and chest wall tumors, tracheal disorders, thoracic outlet syndrome, and benign esophageal diseases. Dr. Vimolratana takes a patient-centered approach to patient care and is committed to using minimally invasive techniques, including VATS and robotic surgery, whenever possible to minimize surgical trauma and pain for patients.</p><p>Dr. Vimolratana studied chemistry at Yale, earning a Bachelor of Science and Master of Science in 2006. He attended medical school at the University of California, San Francisco, earning a Doctor of Medicine in 2014. After many years in California, he moved to New York for postdoctoral training at NewYork-Presbyterian Hospital/Weill Cornell Medical Center, where he completed a residency in general surgery in 2019, serving as chief resident in his final year. Dr. Vimolratana continued at NewYork-Presbyterian Hospital for fellowship training in cardiothoracic surgery prior to joining the faculty at Montefiore Einstein in 2021.</p><p>Dr. Vimolratana’s research focuses on improving patient outcomes after complex lung and esophageal surgery. He has shared his findings through publications in peer-reviewed journals and abstracts at national meetings.</p><p>Dr. Vimolratana is certified by the American Board of Thoracic Surgery and the American Board of Surgery. He is a member of several professional organizations, including the American College of Surgeons, the Society of Thoracic Surgeons and the European Society of Thoracic Surgeons. He has been honored with numerous awards for academic excellence and clinical care.</p>
Joseph T. Vazzana
<p><em> </em></p>
Mark I. Travin
Dr. Travin's <span style="color:#4d4d4d;font-family:Arial, Helvetica, source-code-pro, Menlo, Monaco, Consolas, 'Courier New', monospace;font-size:16px;background-color:#ffffff;">clinical focus is on cardiac stress testing, radionuclide myocardial (perfusion and metabolic) imaging, and quantitative blood flow.</span><quillbot-extension-portal></quillbot-extension-portal>
<span style="color:#4d4d4d;font-family:Arial, Helvetica, source-code-pro, Menlo, Monaco, Consolas, 'Courier New', monospace;font-size:16px;background-color:#ffffff;">Dr. Travin's research focus is on cardiac innervation radionuclide imaging with I-123 mIBG and analogous PET tracers, and quantitative blood flow assessment with myocardial perfusion PET.</span><quillbot-extension-portal></quillbot-extension-portal>
<p>Mark I. Travin, MD, FACC, MASNC, is Director of Cardiovascular Nuclear Medicine at Montefiore. He is also a Professor of Radiology and Medicine at our Albert Einstein College of Medicine. His clinical focus is on cardiac stress testing, radionuclide myocardial (perfusion and metabolic) imaging, and quantitative blood flow.</p><p>Dr. Travin earned his Bachelor of Science and Master of Science degrees in 1979 at Yale College, followed by his Doctor of Medicine degree in 1983 from the University of Pennsylvania School of Medicine. After graduating, he went on to complete both an internship and a residency in medicine at Lenox Hill Hospital. In 1986, Dr. Travin began a fellowship in cardiology at the Brown University Integrated Fellowship Program. After that, he went on to complete a clinical and research fellowship in medicine and cardiology, with emphasis in nuclear cardiology at Massachusetts General Hospital and Spaulding Rehabilitation Hospital. </p><p>Dr. Travin?s research focus is on cardiac innervation radionuclide imaging with I-123 mIBG and analogous PET tracers, and quantitative blood flow assessment with myocardial perfusion PET. He has a significant body of published research on cardiac imaging, and has received numerous awards and honors, including the Cardiology Program Director?s Training Award, and the American Society of Nuclear Cardiology 2015 Zaret-Beller Distinguished Journal of Nuclear Cardiology Service Award. </p>
Vlad A. Tomuta
Aaron Zev Tokayer
<p>Dr. Tokayer received his B.A. in from Yeshiva College and his M.D. from Albert Einstein College of Medicine of Yeshiva University. He completed an internship and residency at the Bronx Municipal Hospital Center and GI and Hepatology fellowship at Johns Hopkins Medical Center. He received an MHS degree in Clinical Epidemiology from Johns Hopkins School of Public Health. Dr. Tokayer then joined the Montefiore GI Faculty in 1992. He has been involved in the spectrum of clinical patient care, endoscopic interventions and teaching in the GI fellowship program. His areas of interest include clinical practice, patient care and education, endoscopic procedures and interventions, functional GI and motility disorders. He is Director of the GI Motility Lab where studies such as Esophageal Manometry, Esophageal Acid Monitoring and Impedance Testing, Ano-rectal Manometry and Defecatory Testing, Hydrogen Breath Testing for Bacterial overgrowth and Carbohydrate Maldigestion , and studies of gastric and intestinal transit. He works closely with colleagues of the Department of Radiology and Nuclear Medicine as well as the Department of Surgery in diagnosing and treating GI motility disorders.</p>
Alecia M. Thompson
Dr. Thompson-Branch's research has focused on the role of cytokines in bronchopulmonary dysplasia and use of ultrasound to diagnose necrotizing enterocolitis.
<p>With an emphasis on general pediatrics and neonatology, Dr. Thompson completed her residency at NYU Medical Center in 2007 and fellowship at Yale-New Haven Hospital in 2010. During her fellowship, Dr. Thompson also audited the Robert Wood Johnson Clinical Scholars Program, with an interest in performing clinical research. Her research has focused on the role of cytokines in bronchopulmonary dysplasia and use of ultrasound to diagnose necrotizing enterocolitis. She plans to conduct research on the use of near-infrared spectroscopy to delineate central nervous system pathology in preterm infants and predict short-term neurologic outcomes.</p>
Brendon M. Stiles
<p class="MsoNoSpacing">Brendon Stiles, MD, is Professor and Chief, Thoracic Surgery and Surgical Oncology, Department of Cardiothoracic & Vascular Surgery at Montefiore-Einstein. Dr. Stiles is also the Associate Director for Surgical Services in the Montefiore-Einstein Cancer Center. Dr. Stiles’ clinical focus is on the treatment of lung and esophageal cancer and on neoadjuvant immunotherapy. Taking a patient-first philosophy, Dr. Stiles provides world-class personalized care, using minimally invasive, organ-sparing techniques and targeting surgical therapy to the specific needs of the patient and his or her individual tumor.</p>
<p class="MsoNoSpacing">Dr. Stiles is also heavily involved with translational and basic research. Translationally, Dr. Stiles is interested in neoadjuvant immunotherapy and in predicting and augmenting response to immunotherapy. In the laboratory, he has been funded by the AATS, TSF, the Lung Cancer Research Foundation, the DOD CDMRP Lung Cancer Research Program, and the Mark Foundation. </p>
<p class="MsoNoSpacing">Dr. Stiles' laboratory currently investigates the protein ART1, an extracellular mono-ADP-ribosyltransferase. Recently, Dr. Stiles and his team discovered that ART1 may play an important role in one mechanism of resistance in lung cancers. ART1 mono-ADP-ribosylates the P2X7 receptor (P2X7R) on immune cells, which ultimately causes NAD-induced cell death (NICD) in T cells, macrophages, and dendritic cells. They found ART1 to be highly expressed in multiple human non-small cell lung cancer cell lines and in the majority of human lung adenocarcinomas they sampled.<span style="mso-spacerun: yes;"> </span>ART1 expression allows cancers to blunt the immune response against them. Indeed, they found that inhibiting ART1 with a therapeutic monoclonal antibody in mouse models of lung cancer caused a dramatic reduction of tumor burden and an enrichment of immune cells in the tumor.</p>
<p class="MsoNoSpacing"><span style="font-size: 12pt;">Current efforts are underway to better understand regulation of ART1 expression, to identify more targets of extracellular mono-ADP-ribosylation, and to refine pre-clincal models to test their therapeutic antibody targeting ART1.</span></p>
<p class="MsoNoSpacing"> </p>
<p class="MsoNoSpacing"> </p>
Tumor microenvironment,
Mono-ADP-ribosylation,
ART1
Predictors of response to immunotherapy.
Clinical:
Lung cancer,
Lung cancer screening,
Neoadjuvant therapy,
<p>Dr. Stiles’ clinical focus is on the treatment of lung and esophageal cancer and on neoadjuvant immunotherapy. Taking a patient-first philosophy, Dr. Stiles provides world-class personalized care, using minimally invasive, organ-sparing techniques and targeting surgical therapy to the specific needs of the patient and his or her individual tumor.
</p>
Dr. Stiles’ clinical focus is on the treatment of lung and esophageal cancer and unusual thoracic cancers including metastatic tumors and those invading the heart. He also has a clinical interest in treating benign chest and upper gastrointestinal diseases. <quillbot-extension-portal></quillbot-extension-portal>
Dr. Stiles is actively involved in both clinical and translational research, particularly focusing on lung cancer. His clinical research concentrates on the management of early stage or screen detected lung cancer and on novel multidisciplinary treatment strategies for patients with lung cancer. In the laboratory, he investigates a protein called ART1 and its role in protecting cancer cells from the immune system. He has developed a novel drug targeting ART1 with a goal of advancing it to clinical use. He has co-authored numerous manuscripts on the management of early stage or screen-detected lung cancer, guidelines for the management of early stage lung cancer, papers regarding neoadjuvant immunotherapy for lung cancer patients and a comprehensive review on the tumor microenvironment in lung cancer.<quillbot-extension-portal></quillbot-extension-portal>
<p style="margin-right: 0in; margin-left: 0in; font-size: 12pt; font-family: 'Times New Roman', serif;"><span style="font-family: Arial, sans-serif;">Wennerberg, Erik et al, Expression of the mono-ADP-ribosyltransferase ART1 by tumor cells mediates immune resistance in non-small cell lung cancer. <em>Science Translational Medicine. </em>2022 Mar 16;14(636):eabe8195. </span><u style="font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 14px;"><span style="font-size: 11.0pt; font-family: 'Calibri',sans-serif; mso-fareast-font-family: Calibri; mso-fareast-theme-font: minor-latin; color: #0563c1; mso-ansi-language: EN-US; mso-fareast-language: EN-US; mso-bidi-language: AR-SA;"><a href="https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.s…;
<p style="margin-right: 0in; margin-left: 0in; font-size: 12pt; font-family: 'Times New Roman', serif;"><span style="font-family: Arial, sans-serif; color: #222222;">Altorki, Nasser K., et al. "The lung microenvironment: an important regulator of tumour growth and metastasis." </span><em style="font-size: 12pt;"><span style="font-family: Arial, sans-serif;">Nature Reviews Cancer</span></em><span style="font-size: 12pt;"> 19.1 (2019): 9-31.</span></p>
<p style="margin-right: 0in; margin-left: 0in; font-size: 12pt; font-family: 'Times New Roman', serif;"><span style="font-family: Arial, sans-serif; color: #222222;">Yao, Zhan, et al. "TGF-β IL-6 axis mediates selective and adaptive mechanisms of resistance to molecular targeted therapy in lung cancer." </span><em><span style="font-family: Arial, sans-serif;">Proceedings of the National Academy of Sciences</span></em> 107.35 (2010): 15535-15540.</p>
<p style="margin-right: 0in; margin-left: 0in; font-size: 12pt; font-family: 'Times New Roman', serif;"><span style="font-family: Arial, sans-serif; color: #222222;">Gao, Dingcheng, et al. "Myeloid progenitor cells in the premetastatic lung promote metastases by inducing mesenchymal to epithelial transition." </span><em><span style="font-family: Arial, sans-serif;">Cancer research</span></em> 72.6 (2012): 1384-1394.</p>
<p style="margin-right: 0in; margin-left: 0in; font-size: 12pt; font-family: 'Times New Roman', serif;"><span style="font-family: Arial, sans-serif; color: #222222;">Altorki, Nasser K., et al. "Neoadjuvant durvalumab with or without stereotactic body radiotherapy in patients with early-stage non-small-cell lung cancer: A single-centre, randomised phase 2 trial." </span><em><span style="font-family: Arial, sans-serif;">The Lancet Oncology</span></em> 22.6 (2021): 824-835.</p>
<p style="margin-right: 0in; margin-left: 0in; font-size: 12pt; font-family: 'Times New Roman', serif;"><span style="font-family: Arial, sans-serif; color: #222222;">Wennerberg, Erik, et al. "Expression of ART1, an extracellular mono ADP-ribosylase, promotes lung cancer growth and dissemination by limiting tumor infiltration of P2X7R+ CD8+ T cells and CD103+ dendritic cells." </span><em><span style="font-family: Arial, sans-serif;">JOURNAL FOR IMMUNOTHERAPY OF CANCER</span></em>. Vol. 7. CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND: BMC, 2019.</p>
<p style="margin-right: 0in; margin-left: 0in; font-size: 12pt; font-family: 'Times New Roman', serif;"><span style="font-family: Arial, sans-serif; color: #222222;">Chen, Chuang, et al. "ART1, an extracellular ADP-ribosyltransferase, is over-expressed in non-small cell lung cancer and facilitates cancer cell survival by immune-mediated mechanisms." </span><em><span style="font-family: Arial, sans-serif;">Journal of Thoracic Oncology</span></em> 11.2 (2016): S44.</p>
<p style="margin-right: 0in; margin-left: 0in; font-size: 12pt; font-family: 'Times New Roman', serif;"><span style="font-family: Arial, sans-serif; color: #222222;">https://scholar.google.com/citations?user=fR4OkgkAAAAJ&hl=en&oi…;
<p>Brendon Stiles, MD, is Professor and Chief, Thoracic Surgery and Surgical Oncology, Department of Cardiothoracic & Vascular Surgery at Montefiore Einstein, and the Associate Director for Surgical Services in the Montefiore Einstein Cancer Center. Dr. Stiles’ clinical focus is on the treatment of lung and esophageal cancer and unusual thoracic cancers including metastatic tumors and those invading the heart. He also has a clinical interest in treating benign chest and upper gastrointestinal diseases. Taking a patient-first philosophy, Dr. Stiles provides world-class personalized care, using minimally invasive, organ-sparing techniques and targeting surgical therapy to the specific needs of the patient and his or her individual tumor.</p><p>“The recruitment of Dr. Stiles elevates the treatment of lung cancer to a historic level,” said Robert E. Michler, MD, Surgeon-in-Chief and Chairman and Professor, Department of Surgery and Department of Cardiothoracic & Vascular Surgery at Montefiore-Einstein. “Every thoracic surgical therapy available anywhere in the world will now be offered by Dr. Stiles at Montefiore-Einstein.”</p><p>After earning his Bachelor of Arts in 1994 at the University of Virginia, Dr. Stiles continued at UVA, earning his Doctor of Medicine in 1999. He conducted his training in general surgery at the University of Virginia Health System. From 2001 to 2003, Dr. Stiles served as a surgical research fellow at Memorial Sloan-Kettering Cancer Center before returning to the University of Virginia Health System to complete his surgical residency. Dr. Stiles completed a cardiothoracic surgery residency at NewYork-Presbyterian Hospital-Weill Cornell and Memorial Sloan-Kettering Cancer Center in 2008. Dr. Stiles joined the faculty at NewYork-Presbyterian Hospital-Weill Cornell before being recruited by Dr. Michler to Montefiore-Einstein in 2021.</p><p>Dr. Stiles is actively involved in both clinical and translational research, particularly focusing on lung cancer. His clinical research concentrates on the management of early stage or screen detected lung cancer and on novel multidisciplinary treatment strategies for patients with lung cancer. In the laboratory, he investigates a protein called ART1 and its role in protecting cancer cells from the immune system. He has developed a novel drug targeting ART1 with a goal of advancing it to clinical use. He has co-authored numerous manuscripts on the management of early stage or screen-detected lung cancer, guidelines for the management of early stage lung cancer, papers regarding neoadjuvant immunotherapy for lung cancer patients and a comprehensive review on the tumor microenvironment in lung cancer. In addition to publications in peer-reviewed journals, he has also given several invited national and international talks on his research and on the clinical management of lung and esophageal cancer.</p><p>Dr. Stiles is highly active in the lung cancer care community, having lost his own father to lung cancer in 2005. He is committed to raising money for lung cancer research, serving as chair of the Lung Cancer Research Foundation since 2017. He is also an invited member of the National Lung Cancer Roundtable and on the Lung-RADS Steering Committee for lung cancer screening with the American College of Radiology. Dr. Stiles is a member of several professional organizations including the American Association for Thoracic Surgery, the Society of Thoracic Surgeons, the American Society of Clinical Oncology, the European Society of Thoracic Surgeons and the International Association for the Study of Lung Cancer.</p>