Audrey M. Uong

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First Name

Audrey

Last Name

Uong

NPI

1518387323

Faculty ID

15425

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Full Time

Patient Type

Pediatric

Department

Gender

Female

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Clinical Focus

Dr. Uong's clinical focus has been in pediatrics.

Research Focus

The care of hospitalized pediatric patients with asthma has been a main focus of research for Dr. Uong. She is also interested in researching the improvement of transitions of care in hospitalized pediatric patients.

Elsevier Profile

EMR ID

53070

Biography

<p>Audrey M. Uong, MD, is an Attending Physician, Division of Hospital Medicine at Children&rsquo;s Hospital at Montefiore (CHAM) and an Assistant Professor of Pediatrics at our Albert Einstein College of Medicine. Since joining the Montefiore team in 2019, her clinical focus has been in pediatrics.</p><p>In 2008, Dr. Uong received her Bachelor of Arts in Asian Languages and Civilizations from Amherst College. Her studies continued at New York Medical College, where she received her Doctor of Medicine in 2014. Following this, Dr. Uong continued her studies at Albert Einstein Medical College and received her Master of Science in Clinical Research Methods in 2019. She began her postgraduate training in 2014 with a 3-year internship and residency at Cohen Children&rsquo;s Medical Center. She then completed a fellowship in Pediatric Hospital Medicine at CHAM in 2019.</p><p>The care of hospitalized pediatric patients with asthma has been a main focus of research for Dr. Uong. She is also interested in researching the improvement of transitions of care in hospitalized pediatric patients. Her work has been published in numerous peer-reviewed journals and review articles, and has been presented nationally.</p><p>In 2019, Dr. Uong received the CHAM Research Day Oral Presentation Award, given to her from faculty judges for receiving top scores. Dr. Uong is board certified by the American Board of Pediatrics and is a member of numerous professional societies, including the American Academy of Pediatrics and the Academic Pediatric Association.</p>

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Sarah Sungurlu

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First Name

Sarah

Last Name

Sungurlu

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1174819478

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17214

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Female

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Kate R. Steinberg

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First Name

Kate

Last Name

Steinberg

NPI

1528488459

Faculty ID

16973

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Full Time

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Adult

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Female

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Elsevier Profile

EMR ID

141643

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Simon D. Spivack

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First Name

Simon

Last Name

Spivack

NPI

1366438475

Faculty ID

11003

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Full Time

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Adult

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Male

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Professional Interests

<p>Focusing diagnostics and therapeutics on those most likely to benefit is a key to successful intervention&nbsp;at both the public health and clinical levels. The translational goal of the Spivack laboratory is to identify individuals at particularly high risk for lung malignancy, and selected non-malignant lung diseases, upon whom to focus smoking/toxin exposure cessation (primary prevention), chemoprevention (secondary prevention), and early disease detection efforts (disease screening, tertiary prevention).</p>
<p>The laboratory is currently exploring individual Gene x Environment signatures as susceptibility markers by exploring quantitative gene (mRNA) expression phenotypes, and the DNA sequence, methylation, microRNA, and other epigenetic features potentially underlying these expression phenotypes, <em>in vitro</em> and in human populations. This is performed in the setting of defined tobacco, diet, and other exposures. There are both mechanistic and translational components to the studies.&nbsp;</p>
<p><br /><strong>Mechanistically</strong>, the role of epigenetic variation in promoter regions in the 5' and 3' regulatory regions of carcinogenesis and oxidant pathway genes is being explored <em>in vitro</em>, using human genomic DNA reporter constructs, and native gene regulation models. High resolution technologies include the realtime quantitation of native mRNA and microRNA by the laboratory's RNA-specific strategy (<em>patented</em>); the&nbsp;tagged-bisulfite genomic sequencing strategy to determine single base resolution CpG methylation status (tBGS, <em>patented</em>);&nbsp;&nbsp;an experimental strategy for assaying microRNA binding to mRNA, for determining the role of miRNA in candidate gene regulation&nbsp;(<em>patented</em>); and evaluation of functional consequences of DNA&nbsp;methylation detail, using a novel patch reporter construct (<em>patented</em>).&nbsp; A new method to engineer methyl-cytosines into the epigenome has recently been developed.</p>
<p>Whole (epi)genome approaches to identify molecular events unique to lung cancer&nbsp;are being completed, which will represent one of the initial cross-platform 'omics level discovery examinations of&nbsp;lung&nbsp;tissues.&nbsp; The execution of each individual discovery platform involves&nbsp;expert local collaborators and cores&nbsp;in (epi)genetics and genomics, and the "integromics" is critically reliant on Einstein strengths in informatics and biostatistical analyses.</p>
<p>&nbsp;</p>
<p><strong>Translationally</strong>, human lung carcinogenesis biomarkers are being established by pairing laser capture microdissected lung with several unique, non-invasively collected surrogate specimens developed in the laboratory. These include mRNA expression signatures from brush-exfoliated buccal mucosa cells, microRNAs detected in exhaled breath condensate representing first reports for a new exhaled airway biomarker class, and exhaled metabolomic signatures. These airway-derived specimens continue to accrue from a sampling (currently n&gt;1000) of a population assembled in a lung cancer case-control context.&nbsp; The specimens are being studied with a view toward developing non-invasive assays in populations.</p>
<p>&nbsp;</p>
<p>The overall aim is to develop informative non-invasive risk profiling, preventive, and early disease detection strategies for the lung in human populations.</p>
<p>&nbsp;</p>
<p>&nbsp;<em>Work is funded by ongoing NIH,</em><em> DoD,&nbsp;and&nbsp;Foundation support.</em></p>
<p>&nbsp;</p>
<p><strong>Clinical Specialties</strong></p>
<ul style="font-size: 1em; color: #333333; padding: 0px; margin: 20px 0px 25px 38px;">
<li style="padding: 0px; margin: 12px 0px 5px 0px;">lung nodule evaluation</li>
<li style="padding: 0px; margin: 12px 0px 5px 0px;">lung cancer diagnostics and screening</li>
<li style="padding: 0px; margin: 12px 0px 5px 0px;">interstitial lung disease</li>
<li style="padding: 0px; margin: 12px 0px 5px 0px;">environmental lung disease</li>
<li style="padding: 0px; margin: 12px 0px 5px 0px;">refractory asthma</li>
<li style="padding: 0px; margin: 12px 0px 5px 0px;">general pulmonary medicine</li>
</ul>

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Areas of Expertise

Expert Summary

<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt;">A researcher and clinician, Dr. Spivack is developing tests for detecting lung cancer at the earliest possible stage&mdash;before it becomes fatal by spreading to other parts of the body. In one of several NIH-funded studies, his laboratory is working on a noninvasive, early-diagnosis test for lung cancer that detects particular genetic elements and chemicals in exhaled breath.</span></p>
<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt;">In addition to general pulmonary medicine, Dr. Spivack&rsquo;s clinical practice focuses on lung nodule and lung cancer diagnosis, diffuse interstitial lung diseases, and environmental lung diseases.</span></p>

Research Profile

Clinical Profile

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Clinical Focus

Dr. Spivack specializes in consultative pulmonary medicine, with an emphasis on the evaluation of lung nodules, lung cancer screening, asthma, and environmental and interstitial lung disease.<span style="color:#4d4d4d;font-family:Arial, Helvetica, source-code-pro, Menlo, Monaco, Consolas, 'Courier New', monospace;font-size:16px;background-color:#ffffff;"><strong></strong></span>

Research Focus

Dr. Spivack&rsquo;s research focuses on the development of non-invasive early detection airway biomarkers of lung cancer risk, as well as epigenetics, gene regulation, gene-environment interaction and non-invasive measurement of deep lung phenomena in humans.

Elsevier Profile

Selected Publications

<ol>
<li>Zhenqiu Huang, Alex Maslov, Xiao Dong, Shixiang Sun, Moonsook Lee, Chirag Shah, Ali Sadoughi, Aditi Desai, Dhruv Patel, Taha Siddiqui, Jaiminkumar Patel, Miao Shi, Spencer Waldman, Ava Marsh, Yakov Peter, <strong>*Simon D Spivack,</strong> *Jan Vijg. Somatic Mutations At Single Base Resolution in Single Bronchial Progenitor Cells Collected From Human Lung. <em>(Nature Genetics, April 2022, </em><a href="https://www.nature.com/articles/s41588-022-01035-w&quot; target="_blank">https://www.nature.com/articles/s41588-022-01035-w</a&gt;). (*co-senior authors).</li>
<li>Shi M, Han W, Loudig O, Shah CD, Dobkin JB, Keller S, Sadoughi A, Zhu C, Siegel RE, Fernandez MK, DeLaRosa L, Patel D, Desai A, Siddiqui T, Gombar S, Suh Y, Wang T, Hosgood HD, Pradhan K, Ye K, <strong>Spivack SD.</strong> Initial development and testing of an exhaled microRNA detection strategy for lung cancer case-control discrimination. Sci Rep. 2023 Apr 24;13(1):6620. doi: 10.1038/s41598-023-33698-8. PMID: 37095155; PMCID: PMC10126132.</li>
<li>Yoo EJ, Kim JS, Stransky S, <strong>Spivack S,</strong> Sidoli S. Advances in proteomics methods for the analysis of exhaled breath condensate. Mass Spectrom Rev. 2024 Jul-Aug;43(4):713-722. doi: 10.1002/mas.21871. Epub 2023 Dec 27. PMID: 38149478.</li>
<li>Zefi O, Waldman S, Marsh A, Shi MK, Sonbolian Y, Khulan B, Siddiqui T, Desai A, Patel D, Okorozo A, Khader S, Dobkin J, Sadoughi A, Shah C, <strong>*Spivack S,</strong> *Peter Y. Distinctive field effects of smoking and lung cancer case-control status on bronchial basal cell growth and signaling. Respir Res. 2024 Aug 19;25(1):317. doi: 10.1186/s12931-024-02924-w. PMID: 39160511; PMCID: PMC11334309. *(co-senior authors)</li>
<li>Mitchell MI, Ben-Dov IZ, Ye K, Liu C, Shi M, Sadoughi A, Shah C, Siddiqui T, Okorozo A, Gutierrez M, Unawane R, Biamonte L, Parikh K, <strong>Spivack S,</strong> Loudig O. Exhaled breath condensate contains extracellular vesicles (EVs) that carry miRNA cargos of lung tissue origin that can be selectively purified and analyzed. J Extracell Vesicles. 2024 Apr;13(4):e12440. doi: 10.1002/jev2.12440. Erratum in: J Extracell Vesicles. 2024 May;13(5):e12453. doi: 10.1002/jev2.12453. PMID: 38659349; PMCID: PMC11043690.</li>
<li>Khulan B, Ye K, Shi MK, Waldman S, Marsh A, Siddiqui T, Okorozo A, Desai A, Patel D, Dobkin J, Sadoughi A, Shah C, Gera S, Peter Y, Liao W, *Vijg J, *<strong>Spivack SD</strong>. Normal bronchial field basal cells show persistent methylome-wide impact of tobacco smoking, including in known cancer genes. Epigenetics. 2025 Dec;20(1):2466382. doi: 10.1080/15592294.2025.2466382. Epub 2025 Feb 20. PMID: 39980243; PMCID: PMC11849931. *(co-senior authors)</li>
</ol>

EMR ID

4969

Biography

<p>Simon D. Spivack, MD, MPH, is Professor, Medicine, Epidemiology and Genetics at Montefiore Einstein. He is also former Emeritus Chief, Pulmonary Medicine. Clinically, Dr. Spivack specializes in consultative pulmonary medicine, with an emphasis on the evaluation of lung nodules, lung cancer screening, asthma, and environmental and interstitial lung disease. </p><p>After obtaining his Bachelor of Science in Psychobiology from McGill University in Montreal, Canada in 1980, Dr. Spivack earned his Doctor of Medicine from the State University of New York Upstate Medical University in 1985. He then completed an internship and residency in internal medicine at the University of Massachusetts Medical Center in 1988. Dr. Spivack then earned his Master of Public Health at Harvard University, School of Public Health in 1989. He completed a clinical pulmonary and critical care medicine and lung research fellowship at the University of Vermont in 1992. </p><p>Dr. Spivack&rsquo;s research focuses on the development of non-invasive early detection airway biomarkers of lung cancer risk, as well as epigenetics, gene regulation, gene-environment interaction and non-invasive measurement of deep lung phenomena in humans. His work has been published in numerous peer-reviewed journals, articles, chapters and books, and he has given many national/international presentations, organized symposia and visiting professorships. Dr. Spivack is on the Editorial Board for Scientific Reports and is a reviewer for journals such as <em>PLoS Genetics</em>, <em>Genetics in Medicine</em>, <em>Nature Protocols</em>, <em>American Journal of Respiratory &amp; Critical Care Medicine</em>, <em>Carcinogenesis</em>, <em>Cancer Research</em> and others. He holds multiple United States patents. He has been continually funded by the National Institutes of Health (NIH) for research for over 25 years.
</p><p>Dr. Spivack is board certified in internal medicine, pulmonary medicine and critical care medicine. He is a member of the American Thoracic Society (ATS), the American Association for Cancer Research (AACR) and the American Lung Association (ALA). He is a frequent peer-reviewer on various NIH study sections. In the past, Dr. Spivack won the Excellence in Research Award from ALA and the NIH/National Institute of Environmental Health Sciences (NIEHS) Clinical Scientist Development Award.

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Victoria Lynn Shulman

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First Name

Victoria

Last Name

Shulman

NPI

1487730339

Faculty ID

5542

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part-time

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Pediatric

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Female

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3853

Biography

Victoria Shulman, MD, is an attending physician at the Children&rsquo;s Hospital at Montefiore Einstein and Assistant Professor, Pediatrics at our Albert Einstein College of Medicine. Dr. Shulman&rsquo;s clinical focus is in pediatric emergency medicine, with a particular area of interest in resident and medical student education. <br /><br />After obtaining her Bachelor of Arts from the City University of New York, Queens College in 1986, Dr. Shulman earned her Doctor of Medicine at Albert Einstein College of Medicine in 1990. She completed her pediatrics internship and residency at Montefiore Einstein in 1994, where she was Chief Resident in her final year. <br /><br />Dr. Shulman&rsquo;s research aligns with her clinical expertise. Her work has been published in the Journal of Adolescent Health and the Journal of Neurology, as well as chapters in scientific books. <br /><br />Dr. Shulman is board certified by the American Board of Pediatrics. In 1994, she received the Leo M. Davidoff Society Certificate of Distinction for the teaching of medical students. In 2023, Dr. Shulman was inducted as a member of the Leo M. Davidoff Society.<br />

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Yang Shi

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Yang

Last Name

Shi

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1962714261

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14864

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Elsevier Profile

Selected Publications

<ol>
<li>Jui Choudhuri, <strong><span style="text-decoration: underline;">Yang Shi</span></strong> (2019). Skin Nodules in a 40-year-old Caribbean Man: What Can We Learn about Adult T-cell Leukemia/Lymphoma in the United States? <strong>American Society for Clinical Pathology Case Reports. </strong>April 2019.</li>
<li>Etan Marks, <strong><span style="text-decoration: underline;">Yang Shi</span></strong>(2018). Duodenal-type Follicular Lymphoma: A Clinicopathologic Review. <strong>Archives of Pathology &amp; Laboratory Medicine </strong>142 (4): 542-547.</li>
<li><strong><span style="text-decoration: underline;">Yang Shi</span></strong>, Evan Kulbacki, Endi Wang (2018). Delayed diagnosis of Type B Niemann-Pick Disease in a 31-year-old Caucasian woman. <strong>Hematopathology.</strong>1-4</li>
<li>Evan Himchak, Etan Marks, <strong><span style="text-decoration: underline;">Yang Shi</span></strong>, Yanhua Wang (2018). Did I miss it? Discovering Hidden Co-existing Hematological Neoplasms: A Single Institutional Review of 100 Collision Tumors. <strong>International Journal of Surgical Pathology.</strong> 26(4):296-305</li>
<li><strong><span style="text-decoration: underline;">Yang Shi</span></strong> (2018). Chronic myeloid leukemia blast phase with erythroid differentiation in a twenty-year-old male patient presented with hematemesis. <strong>American Society for Clinical Pathology Case Reports. </strong>April 2018.</li>
<li>Etan Marks, Yanhua Wang, <strong><span style="text-decoration: underline;">Yang Shi</span></strong>, Joseph Susa, Mark Jacobson, D. Yitzchak Goldstein (2018). Specific TCR Gene Rearrangements in Mycosis Fungoides: Does Advanced Clinical Stage Show A Preference? <strong>Journal of Clinical Pathology.</strong> 2018;71:1072-1077</li>
<li>Urvi Shah, Sengotuvel Viswanathan, Beamon Agarwal, Aditi Shastri, Ioannis Mantzaris, Murali Janakiram, Noah Kornblum, Ira Braunschweig, Amit K. Verma, <strong><span style="text-decoration: underline;">Yang Shi</span></strong>, John F. Reinus, Olga Derman (2018). Sinusoidal-Obstruction Syndrome (SOS) in Multiple Myeloma with Renal Failure. <strong>Case Reports in Oncological Medicine, </strong>Published online&nbsp;Dec 3, 2018&nbsp;</li>
<li>Etan Marks, <strong><span style="text-decoration: underline;">Yang Shi</span></strong>, Yanhua Wang (2017). CD117 (KIT) is a Useful Marker in The Diagnosis of Plasmablastic Plasma Cell Myeloma. <strong>Histopathology.</strong> 71(1):81-88.</li>
<li>Zhonghua Li, <strong><span style="text-decoration: underline;">Yang Shi</span></strong>, John&nbsp;G.&nbsp;Pizzolo, and Yanhua Wang (2017). Utilization of Cytospin Slides in Flow Cytometry Laboratory: A Tool for Correlation of Morphology and Immunophenotype. <strong>Journal of Hematopathology.</strong> 10(2): 55-63.</li>
<li><strong><span style="text-decoration: underline;">Yang Shi</span></strong>, Xiaoxian Zhao, Lisa Durkin, Heesun Joyce Rogers, Eric D Hsi (2016). Aberrant activation-induced cytidine deaminase expression in Philadelphia chromosome-positive B-cell acute lymphoblastic leukemia. <strong>Human Pathology.</strong> 52:173-8</li>
<li><strong><span style="text-decoration: underline;">Yang Shi</span></strong>, Andrew J Rand, Jennifer H Crow, Joseph O Moore, Anand S Lagoo (2015). Blast phase in chronic myelogenous leukemia (CML) is skewed towards unusual blast types in patients treated with tyrosine kinase inhibitors (TKIs): a comparative study of 67 cases.&nbsp; <strong>American Journal of Clinical Pathology. </strong>143(1):105-19.&nbsp;</li>
<li><strong><span style="text-decoration: underline;">Yang Shi</span></strong>, Endi Wang (2014). Blastic plasmacytoid dendritic cell neoplasm: a clinicopathologic review.&nbsp; <strong>Archives of Pathology &amp; Laboratory Medicine</strong>. 138(4):564-9.</li>
<li><span style="text-decoration: underline;"><strong>Yang Shi</strong></span>, Endi Wang (2015). Hepatosplenic T-Cell Lymphoma: A Clinicopathologic Review with an Emphasis on Diagnostic Differentiation from Other T-Cell/Natural Killer-Cell Neoplasms.&nbsp; Archives of Pathology &amp; Laboratory Medicine.&nbsp; 139(9):1173-80.&nbsp;</li>
<li>Miglena Komforti, <strong><span style="text-decoration: underline;">Yang Shi</span></strong>, Maggie Stocker, Endi Wang (2014). Suspicious mammographic masses in the breast of a 65-year-old female: Splenosis in an unusual body site due to a remote ballistic trauma. <strong>British Journal of Haematology</strong>. 167(2):148</li>
<li><strong><span style="text-decoration: underline;">Yang Shi</span></strong>, Evan Kulbacki, David H.K. Chui, Endi Wang (2013). Gigantic splenomegaly in a 27-year-old male of South-East Asian descent with concurrent diagnosis of myeloproliferative neoplasm and hemoglobin H disease. <strong>European Journal of Haematology.</strong> 91(3):284-5.</li>
</ol>

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77786

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Chirag D. Shah

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Amrita K. Seehra

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Amrita

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Seehra

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1538548060

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Scott J. Schafler

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Scott

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Schafler

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Shawn K. Samuel

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