Michele H. Mokrzycki
<p>Dr. Mokrzycki is a graduate of Boston College (B.S., 1983), and the University of Vermont College of Medicine (M.D., 1987) and received a Masters of Science in Clinical Research from the Albert Einstein College of Medicine (M.S. 2000). She completed both an Internal Medicine Residency and Clinical Nephrology Fellowship at the University of Connecticut Health Science Center in Farmington, CT. Dr Mokrzycki has been on faculty at the Albert Einstein College of Medicine since 1992, where she is a Professor of Medicine in the Division of Nephrology. She is a full time clinical nephrologist at the Montefiore Medical Center, Moses Campus.</p>
<p>Dr Mokrzycki's research interests have focused primarily on hemodialysis vascular access related complications, specifically, complications associated with tunneled catheter use such as infection/bacteremia/inflammation and dysfunction/thrombosis. </p>
<p>She is the recipient of a grant from the AETNA Foundation to study the effect of a multidisciplinary team approach to improve outcomes associated with catheter bacteremia in hemodialysis patients. </p>
<p>Dr Mokrzycki served on the Program Committee Member for the National Kidney Foundation (NKF) for 2 years, and on Faculty for the Therapeutic Apheresis Academy (TAA) for 5 years, which is held annually at the University of Virginia College of Medicine. She has been an invited speaker and/or chaired sessions at the American Society of Nephrology (ASN), National Kidney Foundation (NKF), the Vascular Access Society (VAS), Hemodialysis University (HDU), Annual Dialysis Conference (ADC), the American Society of Diagnostic and Interventional Nephrology (ASDIN), and the VEITH symposium.</p>
<p>Dr Mokrzycki served on the Catheter Endpoints Workgroup of the Kidney Health Initiative (KHI), formed by the American Society of Nephrology,the FDA and other stakeholders in End Stage Kidney Disease Innovation. Dr Mokrzycki currently serves as the Chair of the Vascular Accesss Outcomes Workgroup, a subgroup of the Nephrologists Transforming Dialysis Safety Initiative (NTDS), which is a collaboration between the American Society of Nephrology and the Centers for Disease Control. </p>
<p> </p>
<p>Dr. Mokrzycki is board certified in Nephrology and is a Fellow of the American Society of Nephrology. Clinical interests include Glomerular Diseases, Acute and Chronic Kidney Diseases, Hypertension, Kidney Stones, Renal Cystic Diseases, Dialysis, and Vascular Access for Hemodialysis.</p>
<p>Dr. Mokrzycki completed a Masters Program in Clinical Research at the Albert Einstein College of Medicine. The author of over 50 peer-reviewed publications, Dr. Mokrzycki’s research focuses on reducing hemodialysis vascular access infectious and thrombotic complications.</p>
<ol>
<li><strong>Mokrzycki MH</strong>, Yamase H, Kohn OF. Renal malacoplakia with papillary necrosis and renal failure. Am J Kidney Dis 19:587-91, 1992.</li>
<li><strong>Mokrzycki MH</strong>, Kaplan AA. Therapeutic Plasma Exchange: Complications and management. Am J Kidney Dis 23:817-27, 1994.</li>
<li><strong>Mokrzycki MH</strong>, Rickles F, Kaplan AA, Kohn OF. Thrombotic thrombocytopenic purpura in pregnancy: Successful treatment with plasma exchange. Blood Purif 13:271-82, 1995.</li>
<li>Posner L, <strong>Mokrzycki MH</strong>. Transient central diabetes insipidus in the setting of underlying chronic nephrogenic diabetes insipidus associated with lithium use. Am J Nephrol 16:339-43,1996.</li>
<li>Kerr A, Spector J, <strong>Mokrzycki MH</strong>, Blau S, Simon R. V asodilator provocation of occult urinar y tract hemorrhage. J Trauma 40:152-4, 1996.</li>
<li><strong>Mokrzycki MH</strong><span style="text-decoration: underline;">,</span> Kaplan AA. Protein losses in continuous renal replacement therapies. J Am Soc Nephrol 7:1-5, 1996.</li>
<li><strong>Mokrzycki MH</strong><span style="text-decoration: underline;">,</span> Harris C, May H, Laut J, Palmisano J. Lactic acidosis associated with stavudine (d4T): Report of 5 cases. Clin Inf Dis 30:198-200, 2000.</li>
<li><strong>Mokrzycki MH</strong>, Schroppel B, von Gersdorff G, Rush H, Zdunek M, Feingold R. Tunneled cuffed catheter associated infections in hemodialysis patients seropositive for the human immunodeficiency virus. J Am Soc Nephrol 11:2122-2127, 2000.</li>
<li>Barisoni L, <strong>Mokrzycki MH</strong>, Sablay L, Nagata M, Yamase H, Mundel P. Podocyte cell cycle regulation and proliferation in collapsing glomerulopathies. Kidney Int 58:137-143, 2000.</li>
<li>Zdunek MP, Mitra A, <strong>Mokrzycki MH</strong>. Plasma exchange for the removal of digoxin-specific antibody fragments in renal failure: Timing is important for maximizing clearance. Am J Kidney Dis 36:177-183, 2000.</li>
<li>Solomon N, <strong>Mokrzycki MH</strong>. Levofloxacin-associated allergic interstitial nephritis. Clin Nephrol 54:356, 2000.</li>
<li><strong>Mokrzycki MH</strong>, Jean-Jerome K, Rush H, Zdunek MP, Rosenberg SO. A randomized trial of minidose warfarin for the prevention of late malfunction in tunneled, cuffed hemodialysis catheters. Kidney Int 59:1935-1942, 2001.</li>
<li>Swiatecka-Urban A, <strong>Mokrzycki MH</strong>, Kaskel F, Da Silva F, Denamur E. Novel WT1 mutation (C388Y) in a female child with Denys-Drash syndrome. Pediatr Nephrol 16:627-630, 2001.</li>
<li><strong>Mokrzycki MH,</strong> Singhal A. Cost-Effectiveness of Three Strategies of Managing Tunneled-Cuffed Hemodialysis Catheters (TCC) in Clinically Mild or Asymptomatic Bacteremias. Nephrol Dial Transpl 17(12): 2196-203, 2002.</li>
<li>Negulescu O, Coco M, Croll J, <strong>Mokrzycki MH</strong>. Large atrial thrombus formation associated with tunneled cuffed hemodialysis catheters. Clin Nephrol 59(1):40-6, 2003.</li>
<li>Golestaneh L, Laut J, Rosenberg S, Zhang M, <strong>Mokrzycki MH</strong>. Favourable outcomes in episodes of Pseudomonas bacteremia when associated with tunneled cuffed catheters (TCC) in chronic hemodialysis patients. Nephrol Dial Transplant. May;21(5):1328-33,2006.</li>
<li><strong>Mokrzycki MH</strong>, Zhang M, Cohen H, Golestaneh L, Laut JM, Rosenberg SO. Tunneled Hemodialysis Catheter Bacteremia: Risk factors for bacteremia recurrence, infectious complications and mortality. Nephrol Dial Transplant. 21(4):1024-31,2006.</li>
<li><strong>Mokrzycki MH</strong>, Zhang M, Golestaneh L, Laut J, Rosenberg SO.A randomized controlled trial comparing two management models for the treatment of tunneled cuffed catheter (TCC) bacteremia: A collaborative team model versus usual physician-managed care. Am J Kidney Dis 48(4):587-95, 2006.</li>
<li>McKenzie LM, Hendrickson, SL, Briggs WA, Dart RA, Korbet SM, <strong>Mokrzycki MH</strong>, Kimmel PL, Ahuja TS, Berns JS, Simon EE, Smith MC, Trachtman H, Michel DM, Schelling JR, Cho M, Zhou YC, Binns-Roemer E, Kirk GD, Kopp JB, Winkler CA. NPHS2 variation in sporadic focal segmental glomerulosclerosis. J Am Soc Nephrol 18(11): 2987-95, 2007</li>
<li><strong>Mokrzycki MH.</strong> Use of prophylactic topical or intraluminal antibiotics for hemodialysis catheters. Nat Clin Pract Nephrol 4(9):478-9, 2008.</li>
<li>Kopp JB, Smith MW, Nelson GW, Johnson RC, Freedman BI, Bowden DW, Oleksyk T, McKenzie LM, Kajiyama H, Ahuja TS, Berns JS, Briggs W, Cho ME, Dart RA, Kimmel PL, Korbet SM, Michel DM, <strong>Mokrzycki MH</strong>, Schelling JR, Simon E, Trachtman H, Vlahov D, Winkler CA. MYH9 is a major-effect risk gene for focal segmental glomerulosclerosis. Nat Genet. 40 (10):1175-84, 2008.</li>
<li>Sachdeva M, Bitzer M, <strong>Mokrzycki MH</strong>. Vascular access type and changes in inflammatory markers in incident dialysis patients: a pilot study. J Vascular Access 10(3):174-179, 2009.</li>
<li>Golestaneh L, Gofran A, <strong>Mokrzycki MH</strong>, Chen JL. Removal of vancomycin in sustained low-efficiency dialysis (SLED): a need for better surveillance and dosing. Clin Neph 72 (4):286-291.</li>
<li>Okafor C, Ward DM, <strong>Mokrzycki MH,</strong> Weinstein R, Clark P, Balogun RA. Introduciton and overview of therapeutic apheresis. J Clin Apheresis, 2010.</li>
<li>Lok CE, <strong>Mokrzycki MH</strong>. Advances in Hemodialysis Catheter-related Infection. U.S. Nephrol, 2010.</li>
<li><strong>Mokrzycki MH</strong>, Lok CE. Traditional and nontraditional strategies to optimize catheter function: <em>Go with more flow.</em> Kidney Int, 2010.</li>
<li>Lok CE, <strong>Mokrzycki MH</strong>. Update 2010: Catheter-related Infection in Hemodialysis Patients. Kidney Int. 2010.</li>
<li>Lok CE, <strong>Mokrzycki MH</strong>. Prevention and management of catheter-related infection in hemodialysis patients. Kidney Int. 2010;79(6):587-98.</li>
<li><strong>Mokrzycki MH</strong>, Balogun RA. Therapeutic Apheresis: a review of complications and recommendations for prevention and management. J Clin Apher 2011:26(5):243-8.</li>
<li>Lee T, <strong>Mokrzycki MH</strong>, Moist L, Maya I, Vazquez M, Lok CE; North American Vascular Access Consortium. Standardized definitions for hemodialysis vascular access. Semin Dial 2011;24(5):515-24.</li>
<li>Kopp JB, Nelson GW, Sampath K, Johnson RC, Genovese G, An P, Friedman D, Briggs W, Dart R, Korbet S, <strong>Mokrzycki MH</strong>, Kimmel PL, Limous S, Ahuja TS, Berns JS, Fryc J, Simon EE, Smith MC, Trachtman H, Michel DM, Schelling JR, Vlahov D, Pollack M, Winkler CA. APOL1 genetic variants in focal segmental glomerulosclerosis and HIV-Associated nephropathy. J Am Soc Nephrol 2011;22(11):2129-37.</li>
<li>Sachdeva M, Hung A, Kovalchuk O, Bitzer M, <strong>Mokrzycki MH</strong>. The initial vascular access type contributes to inflammation in incident hemodialysis patients. Int J Nephrol Volume 2012; (2012) Article ID: 917465.</li>
<li>Lee T, Lok C, Vazquez M, Moist L, Maya I, <strong>Mokrzycki M</strong>. Minimizing hemodialysis catheter dysfunction: An ounce of prevention. Int J Nephrol; Volume 2012 (2012), Article ID: 170857.</li>
<li>Golestaneh L, <strong>Mokrzycki MH</strong>. Vascular Access in Therapeutic Apheresis: Update 2013. J Clin Apheresis. 2013: 28(1):64-72.</li>
<li>Nica A, Lok CE, Harris J, Lee TC, <strong>Mokrzycki MH</strong>, Maya ID, Vazquez MA, Xi W, Moist LM; From the North American Vascular Access Consortium (NAVAC). Understanding Surgical Preference and Practice in Hemodialysis Vascular Access creation. Semin Dial. 2013:26(4):520-526.</li>
<li>Bhatt DL, Kandzari DE, O’Neill WW, D’Agostino R, Flack JM, Katzen BT, Leon MB, Liu M, Mauri L, Negoita M, Cohen SA, Oparil S, Rocha-Singh K, Townsend RR, Bakris GL. A controlled trial of renal denervation for resistant hypertension. N. Engl. J. Med. 2014;370 (15):1393-1401.</li>
<li><strong>Mokrzycki MH</strong>, Lok CE. Optimizing central venous catheter primary prevention trials in hemodialysis patients. Am. J.Kidney Dis. 2015;66(6):939-941.</li>
<li>Gipson DS, Troost JP, Lafayette RA, Hladunewich MA, Trachtman H, Gadegbeku CA, Sedor JR, Holzman LB, Moxey-Mims MM, Perumal K, Kaskel FJ, Nelson P, Tuttle KR, Bagnasco SM, Hogan MC, Dell KM, Appel GB, Lieske JC, Ilori TO, Sethna CB, Fervenza FC, Hogan SL, Nachman PH, Rosenberg AZ, Greenbaum LA, Meyers KE, Hewitt SM, Choi MJ, Kopp JB, Zhdanova , Hodgin JB, Johnstone DB, Adler SG, Avila-Casado C, Neu AM, Hingorani SR, Lemley KV, Nast CC, Brady TM, Barisoni-Thomas L, Fornoni A, Jennette JC, Cattran DC, Palmer MB, Gibson KL, Reich HN, <strong>Mokrzycki MH</strong>, Sambandam KK, Zilleruelo GE, Licht C, Sampson MG, Song P, Mariani LH, Kretzler M. Complete remission in the nephrotic syndrome study network. Clin J Am Soc Nephrol. 2016;11 (1):81-89.</li>
<li>Johns, TS, <strong>Mokrzycki MH</strong>. Optimal approach for the diagnosis of hemodialysis catheter-related bacteremia. Clin J Am Soc Nephrol 2016; 11.</li>
<li>Liang E, Rodriguez M, Mueller M, Abramowitz MK, <strong>Mokrzycki MH</strong>. Outcomes Associated with a Heparin-Free Hemodialysis Protocol and Review of the Literature. J. Clin. Nephrol. Renal Care. 2016, 2(1): 10-16.</li>
<li>Allon M, Brouwer-Maier DJ, Abreo K, Baskin KM, Bregel K, Chand D, Easom A, Mermel L, <strong>Mokrzycki MH</strong>, Patel PR, Roy-Chaudhury P, Shenoy S, Valentini RP, Wasse H. Moving Points in Nephrology: Recommended Clinical Trial Endpoints for Hemodialysis Catheters. Clin J Am Soc Nephrol. 2017</li>
<li> Golestaneh L, <strong>Mokrzycki MH</strong>. Prevention of Hemodialysis Catheters Infections: Ointments, Dressings, Locks and Catheter Hub Devices. Hemodial Int. Nov 2018</li>
<li>Der E, Suryawanshi H, Morozov P, Kustagi M, Goilav B, Ranabathou S, Izmirly P, Clancy R, Belmont HM, Koenigsberg M, <strong>Mokrzycki M</strong>, Rominieki H, Graham JA, Rocca JP, Bornkamp N, Jordan N, Schulte E, Wu M, Pullman J, Slowikowski K, Raychaudhuri S, Guthridge J, James J, Buyon J, Tuschl T, Putterman C; Accelerating Medicines Partnership Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA/SLE) Consortium. Tubular cell and keratinocyte single-cell transcriptomics applied to lupus nephritis reveal type I IFN and fibrosis relevant pathways. Nat Immunol. 2019 Jul;20(7):915-927</li>
<li>Fisher M, Golestaneh L, Allon M, <span style="font-family: 'Times New Roman', serif; font-size: 12pt;"> </span><span style="font-family: 'Times New Roman', serif; font-size: 12pt;">Abreo K, </span><strong style="font-family: 'Times New Roman', serif; font-size: 12pt;">Mokrzycki MH. </strong>Preventing Central Vein Catheter Associated Bloodstream Infections in Hemodialysis: Review of Current Evidence-Based Strategies and Novel Therapies. <span style="font-size: 12pt; font-family: 'Times New Roman', serif;">Clin J Am Soc Nephrol 2020;15:132-151</span></li>
<li><span style="font-size: 12.0pt; font-family: 'Times New Roman','serif'; mso-fareast-font-family: 'Times New Roman'; mso-ansi-language: EN-US; mso-fareast-language: EN-US; mso-bidi-language: AR-SA;">Vachharajani T , Wong L, Niyyar VD, Abreo KD, <strong>Mokrzycki MH</strong>, for the Vascular Access Workgroup of the Nephrologists Transforming Dialysis Safety Initiative of the American Society of Nephrology. Buttonhole cannulation of arteriovenous fistulas in the United States. Kidney360. 2020 </span></li>
<li><strong style="text-indent: -0.25in; font-family: 'Times New Roman', serif; font-size: 12pt;"><span style="font-size: 12pt;">Mokrzycki MH</span></strong><span style="text-indent: -0.25in; font-size: 12pt; font-family: 'Times New Roman', serif;"> and Coco M. Management of hemodialysis patients with suspected or confirmed COVID-19 infection: perspective of two nephrologists in the United States. Kidney360. 2020:1(4);273-278.</span></li>
<li><span style="font-variant-numeric: normal; font-variant-east-asian: normal; font-stretch: normal; font-size: 7pt; line-height: normal; font-family: 'Times New Roman';"> </span><span style="text-indent: -0.25in; font-size: 12pt; font-family: 'Times New Roman', serif;">Fisher M, Yunes M, <strong>Mokrzycki MH</strong>, Golestaneh L, Alahiri E, Coco M. “Chronic Hemodialysis Patients Hospitalized with COVID-19 – Short-term Outcomes in Bronx, New York”. Kidney360 June 2020</span>1.<span style="font-variant-numeric: normal; font-variant-east-asian: normal; font-stretch: normal; font-size: 7pt; line-height: normal; font-family: 'Times New Roman';"> </span></li>
<li><strong style="text-indent: -0.25in;"><span style="font-size: 12.0pt; font-family: 'Times New Roman',serif;">Mokrzycki MH</span></strong><span style="text-indent: -0.25in; font-size: 12pt; font-family: 'Times New Roman', serif;">, Leigh KA, Kliger AS, Niyyar VD, Bren Asp V, Golestaneh L, Taylor Q, Novosad SA. Implementation of an Electronic Catheter Checklist in Outpatient Hemodialysis Facilities: Results of a Pilot Quality Improvement Project. Kidney360 April 2021, 2(4) 684-694</span>
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<p><em><strong><span style="text-indent: -0.25in; font-size: 12pt; font-family: 'Times New Roman', serif;">Book Chapter</span></strong></em></p>
<p class="MsoListParagraph" style="text-indent: -.25in; mso-list: l0 level1 lfo1; tab-stops: list .5in;"><!-- [if !supportLists]--><span style="font-size: 12.0pt; mso-bidi-font-size: 10.0pt; font-family: 'Times New Roman',serif;"><span style="mso-list: Ignore;">1.<span style="font: 7.0pt 'Times New Roman';"> </span></span></span><span style="font-size: 12.0pt; mso-bidi-font-size: 10.0pt; font-family: 'Times New Roman',serif;">Fisher M, <strong style="mso-bidi-font-weight: normal;">Mokrzycki MH.</strong> Infectious complications in vascular access. Handbook of Dialysis. Nissenson: Handbook of Dialysis Therapy, 6e.</span> <span style="font-size: 12.0pt; mso-bidi-font-size: 10.0pt; font-family: 'Times New Roman',serif;">Elsevir (In press, 2021)</span></p>
<p>Michele H. Mokrzycki, MD, MS, is an attending nephrologist and Professor, Medicine at Montefiore Einstein. Dr. Mokrzycki’s clinical interests include glomerular diseases, acute and chronic kidney diseases, hypertension, kidney stones, renal cystic diseases, dialysis and vascular access for hemodialysis.</p><p>After earning her Bachelor of Science from Boston College in 1983, Dr. Morkrzycki pursued her Doctor of Medicine at University of Vermont College of Medicine, earning the degree in 1987. She performed her postdoctoral training at University of Connecticut Health Center, completing her residency in internal medicine in 1990 and her fellowship in clinical nephrology in 1992. Dr. Mokrzycki later pursued additional education, completing her Master of Science in clinical research at Einstein in 2000.</p><p>Author of over 50 peer-reviewed publications, Dr. Mokrzycki’s research focuses on reducing hemodialysis vascular access infectious and thrombotic complications. She is on the editorial board for <em>Kidney360</em>, and is an invited reviewer for several publications including the <em>Journal of the American Society of Nephrology, Hemodialysis International</em> and the <em>Journal of Vascular Access.</em></p><p>Dr. Mokrzycki is board certified in Nephrology. She is a Fellow of the American Society of Nephrology and a member of several professional societies including the National Kidney Foundation, New York Society of Nephrology and the North American Vascular Access Consortium. In 2020, she was recognized as Reviewer of the Year by <em>Kidney360</em>.</p>
Manasa Kanneganti
<p>Manasa Kanneganti, MD, is a vascular surgeon at Montefiore Medical Center and Assistant Professor of Surgery at Albert Einstein College of Medicine. Dr. Kanneganti’s clinical focus centers on peripheral arterial disease and diabetic foot ulcers with a focus on limb salvage, venous insufficiency, hemodialysis access, aortic disease, thoracic outlet syndrome, mesenteric insufficiencies and sclerotherapy.</p><p>After receiving her Bachelor of Arts in medical sciences and psychology from Boston University College of Arts and Sciences in 2012, Dr. Kanneganti earned her Doctor of Medicine at Boston University School of Medicine in 2015. She continued her medical training at Montefiore Medical Center, completing a general surgery internship in 2016 and her general surgery residency in 2020. She then completed a vascular surgery fellowship at the University of Virginia in 2022.</p><p>Dr. Kanneganti’s research interests include hemodialysis access, thoracic outlet syndrome and limb salvage. Her work has been shared through numerous peer-reviewed publications, book chapters, abstract presentations, invited lectures and expert panels. She is also a reviewer for the Journal of Vascular Surgery.</p><p>Dr. Kanneganti is board certified by the American Board of Surgery in General Surgery and Vascular Surgery. She is a member of several professional organizations, including the Society for Vascular Surgery, the Society for Clinical Vascular Surgery and the Vascular and Endovascular Surgery Society, among others.</p>
Anna Y. Zolotnitskaya
<p>Anna Zolotnitskaya, MD, is Medical Director, Pediatric Dialysis at the Children’s Hospital at Montefiore Einstein and Assistant Professor, Pediatrics at our Albert Einstein College of Medicine. Dr. Zolotnitskaya’s clinical focus is on pediatric dialysis and pediatric renal transplantation. She leads a multidisciplinary dialysis team that provides patient-centered, evidence-based care for children and young adults with end-stage kidney disease. </p><p>After obtaining her Doctor of Medicine at St. Petersburg Pediatric Academy in St. Petersburg, Russia, in 1983, Dr. Zolotnitskaya completed her pediatrics internship at the same institution in 1984. She remained there to complete her pediatrics residency in 1989, before completing an additional pediatrics residency at Soroka Medical Center in Beer-Sheva, Israel, in 1994. Following this, Dr. Zolotnitskaya completed a pediatric nephrology fellowship at Montefiore Einstein in 1998, followed by an additional pediatrics residency at Columbia University College of Physicians and Surgeons, St. Luke’s-Roosevelt Hospital in 2001. </p><p>Dr. Zolotnitskaya has been principal investigator and co-investigator in clinical trials that investigate medications employed for the care of children with advanced chronic kidney disease. Her work has been published in numerous peer-reviewed journals and abstracts, and she has given several invited presentations. She is also a reviewer for the <em>Journal of Pediatrics: Clinical Practice</em>. </p><p>Dr. Zolotnitskaya is board certified by the American Board of Pediatric Nephrology, the American Board of Pediatrics and the Israeli Board of Pediatrics. She is a member of the American Academy of Pediatrics, the American Society of Nephrology and the American Society of Pediatric Nephrology.
</p>
Diana S. Wolfe
<p>Diana S Wolfe, MD MPH is an Associate Professor in the Department of Obstetrics & Gynecology and Women’s Health, Division of Maternal Fetal Medicine. She is Associate Program Director of the Maternal Fetal Medicine Fellowship Program. </p>
<p>She established the MFM Cardiology Joint Program in 2015 in response to the rising contribution of cardiovascular conditions to pregnancy related morbidity and mortality. The aim was to establish a multidisciplinary program to optimize the care of high-risk pregnant patients with known or suspected cardiac disease, as there is a real potential for communication gaps when patients are seen separately in contrast with parallel visits by different specialists. Patients are at all stages of their reproductive lives including preconception, pregnancy and postpartum. She works closely with the department of Cardiology both in the outpatient and inpatient setting to establish delivery plans and continued care postpartum. </p>
<p> </p>
<p>In addition, Dr. Wolfe has worked in global health, her most recent work in Africa was in Butare (Huye), Rwanda, serving as MFM subspecialist in the Human Resources for Health (HRH) program, directed by the Clinton Health Access Initiative (CHAI) and the Ministry of Health (MOH) of Rwanda. Dr. Wolfe was the first MFM subspecialist from Einstein to commence HRH at CHUB, Butare, Rwanda. Her interest began locally when she volunteered as a bilingual pregnancy counselor in Escondido, California. She then started working in Africa in 1998 where she served as a Peace Corps Volunteer in Mali, West Africa. She was part of the national Maternal and Child Health Program. She worked as health educator in a remote village, Karangasso, located in the Sikasso region, with a birth assistant to develop health education for 7 local villages on subjects such as infant nutrition, prenatal care, family planning, and developing community health committees for each village. She also initiated a birth assistant training program with the head nurse of the nearest local health center that included training subjects such as management of postpartum hemorrhage, contraception, and first steps in obstetric emergencies. During medical school, Dr. Wolfe worked on “the Assessment of the Knowledge of Women’s Health,” a project that initiated with the Bedoin community of Israel. She implemented the same pre and post-training test to the 7 Malian villages where she served in the Peace Corps as well as to several villages in the Peruvian Amazon. </p>
<p> </p>
<p> </p>
Dr. Wolfe’s clinical focus is on maternal and fetal medicine (MFM).
<ol>
<li>Wolfe DS, Hameed AB, Taub CC, Zaidi AN, Bortnick AE. <a href="https://www.ncbi.nlm.nih.gov/pubmed/30278179">Addressing maternal mortality: the pregnant cardiac patient.</a> Am J Obstet Gynecol. 2019 Feb;220(2):167.e1-167.e8. doi: 10.1016/j.ajog.2018.09.035. Epub 2018 Sep 29.</li>
<li>Sahasrabudhe N, Teigen N, Wolfe DS, Taub C. <a href="https://www.ncbi.nlm.nih.gov/pubmed/29581907">Pregnancy after Prosthetic Aortic Valve Replacement: How Do We Monitor Prosthetic Valvular Function during Pregnancy?</a>Case Rep Obstet Gynecol. 2018 Jan 17;2018:4935957. doi: 10.1155/2018/4935957. eCollection 2018.</li>
<li>Kim SY, Wolfe DS, Taub CC. <a href="https://www.ncbi.nlm.nih.gov/pubmed/29063738">Cardiovascular outcomes of pregnancy in Marfan's syndrome patients: A literature review.</a> Congenit Heart Dis. 2018 Mar;13(2):203-209. doi: 10.1111/chd.12546. Epub 2017 Oct 23. Review.</li>
<li>Wolfe DS, Williams SF, Ross MG, Beall MH, Apuzzio JJ. <a href="https://www.ncbi.nlm.nih.gov/pubmed/23943702">Does preeclampsia predict the risk of late postpartum eclampsia?</a> AJP Rep. 2013 May;3(1):13-6. doi: 10.1055/s-0032-1329127. Epub 2013 Jan 25.</li>
<li><a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Wolfe%20D%5BAuthor%5D&cau… D</a>1, <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Gong%20M%5BAuthor%5D&caut… M</a>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Han%20G%5BAuthor%5D&cauth… G</a>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Magee%20TR%5BAuthor%5D&ca… TR</a>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Ross%20MG%5BAuthor%5D&cau… MG</a>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Desai%20M%5BAuthor%5D&cau… M</a>.Nutrient sensor mediated programmed nonalcoholic fatty liver disease in low birthweight offspring. <a title="American journal of obstetrics and gynecology." href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Nutrient+sensor-mediated+prog… J Obstet Gynecol.</a> 2012 Oct;207(4):308.e1-6. doi: 10.1016/j.ajog.2012.07.033. Epub 2012 Jul 31.</li>
</ol>
<p>Diana S. Wolfe, MD, MPH, FACOG is Attending Physician at Montefiore and Associate Professor of Obstetrics and Gynecology and Women’s Health at our Albert Einstein College of Medicine. Dr. Wolfe’s clinical focus is on maternal and fetal medicine (MFM). In 2015, she established the MFM-Cardiology Joint Program at Montefiore—a multidisciplinary program to reduce morbidity and prevent mortality in expecting mothers with cardiovascular disease by optimizing the care of high-risk pregnant patients.</p><p>From 1988 to 1993, Dr. Wolfe pursued her Bachelor of Science in biology through the University of California San Diego, participating in the Education Abroad Program with Universita di Bologna, Italy from 1990 through 1991. In 1996 she began studies at University of California, Berkeley focusing on maternal child health, earning her Master of Public Health in 1998. After two years serving in the health extension of the Child Health Survival Program with the Peace Corps in Mali, Dr. Wolfe pursued her Doctor of Medicine at Ben Gurion University, Israel, receiving her degree in 2004.</p><p>Building on her clinical focus, Dr. Wolfe’s research investigates cardio-obstetrics, preconception health, maternal morbidity and contraception in high risk women. She has published her research in several reviewed journals, book chapters and review articles.</p><p>Dr. Wolfe is board certified and is a member of the American College of Obstetrics and Gynecology and the Society for Maternal Fetal Medicine. She is active in global health, most recently working in Butare (Huye), Rwanda, serving as MFM subspecialist in the Human Resources for Health program, directed by the Clinton Health Access Initiative and the Ministry of Health of Rwanda.</p>
Samson Wiseman
Daniel A. Weiser
<p><span style="text-decoration: underline;"><strong>Childhood cancer research laboratory</strong></span></p>
<p>Our laboratory is focused on childhood cancer research with a goal of elucidating the underlying biology of the most aggressive malignancies. In such patients with typically incurable cancer, we are striving to identify new approaches to and types of treatment. We have multiple ongoing projects:</p>
<p><strong>+ Identification of biologic drivers of ultra-high-risk neuroblastoma</strong>. Neuroblastoma is one of the most common and deadly childhood cancers. Despite intensive research, there are limited therapeutic strategies for patients with <em>de novo </em>chemotherapy resistance that leads to particularly poor outcomes. We have been studying neuroblastoma since 2009 and are identifying additional biologic drivers of highly lethal tumors.</p>
<p>We compare tumor features from patients with early death from tumor progression compared to those with a maintained complete response. We assess unique histo-morphologic and proteomic features and computationally integrate these data with genomic and transcriptomic datasets to develop a combined predictor of primary refractory disease. Patients with this entity require non-standard and/or intensified treatment. Oncogenic drivers are being characterized in the lab which will facilitate strategies for novel pharmacologic intervention.</p>
<p><strong>+ Characterization of neuroblastoma development from neural crest cells</strong>. We are studying pathways and interactions that results in uncontrolled cell proliferation early in neuroblastoma development with an ultimate goal of identifying new targets and approaches for pharmacologic intervention.</p>
<p><strong>+ Evaluation of novel combinatorial targeted therapeutic approaches in neuroblastoma</strong>. With expected outcomes lagging behind those of more common childhood cancers, children with neuroblastoma require new approaches to treatment. Our lab works with multiple international clinical and research consortium groups to perform preclinical studies that substantiate human clinical trials. </p>
<p><strong>+ Detection of circulating tumor DNA in osteosarcoma</strong>. With no reliable non-invasive approach for disease monitoring during and after treatment, we are applying cutting edge next-generation sequencing approaches to identify solid tumors with a blood-based “liquid” biopsies. This will allow clinicians to assess tumor responsiveness to chemotherapy and predict likelihood of recurrence.</p>
<p><strong>+ Assessment of accelerated aging using miRNA-seq in survivors of childhood cancer</strong>. Chemotherapy has many untoward effects on healthy cells and leads to many signs of accelerated aging in children treated for cancer. Using a known microRNA “aging” signature discovered at Albert Einstein College of Medicine, we are studying what causes this phenotype in childhood cancer, with a goal of offering improved intervention to minimize long-term toxicity of treatment.</p>
<p><strong><span style="text-decoration: underline;">Physician Summary</span></strong></p>
<p>Daniel A. Weiser, MD, is board-certified in pediatric hematology/oncology with clinical expertise in neuroblastoma and other tumors of the adrenal glands, kidneys, liver, and gonads. He is the medical director of the intra-abdominal solid tumor program at the Children’s Hospital at Montefiore and brings together a highly specialized multi-disciplinary care team to provide comprehensive treatment for diverse pediatric malignancies. In addition, Dr. Weiser directs a childhood cancer research laboratory that focuses on the identification of new targeted agents for cancer therapy, especially in the treatment of rare and aggressive malignancies such as neuroblastoma. His research goals are to understand the role of certain genes in the risk, development, and treatment of cancer. The approaches taken and agents studied hold promise for improving management of all patients with solid tumors.</p>
<p>Dr. Weiser participates in the efforts of a number of professional organizations including the Children’s Oncology Group (COG), American Association for Cancer Research (AACR), American Society of Clinical Oncology (ASCO), Advances in Neuroblastoma Research Association (ANRA), National Pediatric Cancer Foundation (NPCF), and the American Academy of Pediatrics (AAP). He has received numerous awards including the Brigid Leventhal Special Merit Award from ASCO and the Conquer Cancer Foundation, and a prestigious K12 from the National Cancer Institute for the training of the next generation of physician-scientists in pediatric cancer. Dr. Weiser is actively involved in teaching and mentorship of trainees, and takes great pride in providing advanced and compassionate care to his patients and their families.</p>
<p><strong>Clinical Expertise</strong></p>
<ul>
<li>Neuroblastoma (adrenal tumors)</li>
<li>Wilms tumor (renal tumors)</li>
<li>Hepatoblastoma (liver tumors)</li>
<li>Germ cell tumors (including testicular and ovarian tumors)</li>
<li>Thyroid and other rare tumors</li>
<li>Experimental therapeutics</li>
<li>Cancer genetics and biomarkers</li>
</ul>
<p><strong>Board Certifications</strong></p>
<ul>
<li>Pediatrics</li>
<li>Pediatric Hematology/Oncology</li>
</ul>
<p><strong>Professional Education</strong></p>
<ul>
<li>M.D. – Stony Brook University, NY</li>
<li>Residency – Children’s Hospital of NY-Presbyterian, Columbia University, NY</li>
<li>Chief Residency – Children’s Hospital of NY-Presbyterian, Columbia University, NY</li>
<li>Fellowship – The Children’s Hospital of Philadelphia, PA</li>
</ul>
DR. Weiser's clinical focuses are neuroblastoma and adrenal tumors, Wilms tumor and other kidney (renal) tumors, hepatoblastoma, and other liver tumors, germ cell tumors (including testicular and ovarian tumors), Thyroid and other rare tumors, experimental therapeutics, and cancer genetics and biomarkers.
Dr. Weiser’s research goals are to understand the role of certain genes in the risk, development, and treatment of cancer. The approaches taken and agents studied hold promise in the treatment of all solid tumors. Dr. Weiser’s laboratory focuses on childhood cancer research with a goal of elucidating the underlying biology of the most aggressive malignancies. He has multiple ongoing projects, such as identification of biologic drivers of neuroblastoma at ultra-high risk for treatment failure, characterization of neuroblastoma development from neural crest cells, and evaluation of novel combinatorial targeted therapeutic approaches in neuroblastoma, among others.
<p>Daniel A. Weiser, MD, is a Medical Director of the Intra-abdominal Solid Tumor Program in the Pediatrics Hematology/Oncology department at Children’s Hospital at Montefiore. He is also Associate Professor in the Pediatrics and Genetics departments at the Albert Einstein College of Medicine. His clinical focuses are neuroblastoma and adrenal tumors, Wilms tumor and other kidney (renal) tumors, hepatoblastoma and other liver tumors, germ cell tumors (including testicular and ovarian tumors), Thyroid and other rare tumors, experimental therapeutics, and cancer genetics and biomarkers. Dr. Weiser is actively involved in teaching and mentorship of trainees and takes great pride in his active participation in patient care.</p><p>Dr. Weiser received his Bachelor of Science in Neurobiology in 1995 at Haverford College, PA. In 2004, he received his Doctor of Medicine at Stony Brook University School of Medicine, NY. He is currently earning his Master of Science in Translational Research at the University of Pennsylvania. He began a residency in Pediatrics at the New York-Presbyterian, Columbia University in 2007. Dr. Weiser then completed a three-year fellowship in Pediatric Hematology/Oncology at The Children’s Hospital of Philadelphia. </p><p>Dr. Weiser’s research goals are to understand the role of certain genes in the risk, development, and treatment of cancer. The approaches taken and agents studied hold promise in the treatment of all solid tumors. Dr. Weiser’s laboratory focuses on childhood cancer research with a goal of elucidating the underlying biology of the most aggressive malignancies. He has multiple ongoing projects, such as identification of biologic drivers of neuroblastoma at ultra-high risk for treatment failure, characterization of neuroblastoma development from neural crest cells, and evaluation of novel combinatorial targeted therapeutic approaches in neuroblastoma, among others. His research has been published in many reviewed journals. </p><p>Dr. Weiser participates in the efforts of a number of professional organizations including the Children’s Oncology Group (COG), American Association for Cancer Research (AACR), American Society of Clinical Oncology (ASCO), and the American Academy of Pediatrics (AAP). He has received many awards including the Brigid Leventhal Special Merit Award through ASCO, and he has been awarded a prestigious K12 from the NCI for the training of the next generation of physician-scientists in pediatric cancer.</p><p>He is board certified in Pediatric Hematology/Oncology and General Pediatrics.</p>
Jacqueline Weingarten-Arams
Nutrition
Pulmonary hypertension
Sepsis
<p>Jacqueline Weingarten-Arams, MD, is an attending physician and Professor, Pediatrics at Montefiore Einstein. Dr. Weingarten-Arams’ pediatric critical care expertise focuses on cardiac critical care, acute hypoxemic respiratory failure, nutrition in critical illness and energy expenditure, cardiopulmonary resuscitation (quality CPR) and extracorporeal life support (ECMO).</p><p>After obtaining her Bachelor of Science in nutritional biochemistry at Cornell University in 1982, Dr. Weingarten-Arams earned her Doctor of Medicine at the same institution in 1986. She then completed her pediatric residency at Columbia University in 1990, where she was Chief Resident in her final year. Following this, Dr. Weingarten-Arams completed a fellowship in pediatric critical care medicine at New York Hospital Cornell University Medical College in 1996.</p><p>Dr. Weingarten-Arams research focus includes the use of deliberate simulated practice in improving outcomes in pediatric critical illness, pediatric resuscitation and pediatric airway management. Her other projects involve chronic critical illness, bioethics in pediatric critical care and oxidative injury in respiratory failure. She has been principal investigator and co-investigator on several research projects, and her work has been shared through numerous peer-reviewed publications and invited presentations.</p><p>Dr. Weingarten-Arams is a Diplomate of the National Board of Medical Examiners and the American Board of Pediatrics. She is a Fellow of the American Academy of Pediatrics and the American College of Chest Physicians. She is also a member of several professional organizations, including the American Medical Association, the Pediatric Cardiac Intensive Care Society and the Society of Critical Care Medicine. Dr. Weingarten-Arams has been named in Castle Connolly’s “Top Doctors: New York Metro Area” for multiple years. In 2006, she was inducted into the Leo M. Davidoff Society and in 2019, Dr. Weingarten-Arams won the William Obrinsky Award for Excellence in Medical Student Education.</p>
Alecia M. Thompson
Dr. Thompson-Branch's research has focused on the role of cytokines in bronchopulmonary dysplasia and use of ultrasound to diagnose necrotizing enterocolitis.
<p>With an emphasis on general pediatrics and neonatology, Dr. Thompson completed her residency at NYU Medical Center in 2007 and fellowship at Yale-New Haven Hospital in 2010. During her fellowship, Dr. Thompson also audited the Robert Wood Johnson Clinical Scholars Program, with an interest in performing clinical research. Her research has focused on the role of cytokines in bronchopulmonary dysplasia and use of ultrasound to diagnose necrotizing enterocolitis. She plans to conduct research on the use of near-infrared spectroscopy to delineate central nervous system pathology in preterm infants and predict short-term neurologic outcomes.</p>
Sonia S. Talathi
<span style="color:#313335;font-family:'Leitura News', Georgia, Cambria, 'Times New Roman', Times, serif;font-size:medium;background-color:#ffffff;">Dr. Talathi specializes in endovascular and surgical treatments for the management of vascular diseases. </span><quillbot-extension-portal></quillbot-extension-portal>
<span style="color:#313335;font-family:'Leitura News', Georgia, Cambria, 'Times New Roman', Times, serif;font-size:medium;background-color:#ffffff;">Her research interests include peripheral vascular disease, dialysis access and quality improvement.</span><quillbot-extension-portal></quillbot-extension-portal>
<p style="box-sizing:border-box;border:0px solid rgb(226, 232, 240);margin-bottom:0px;color:#313335;font-family:'Leitura News', Georgia, Cambria, 'Times New Roman', Times, serif;font-size:medium;background-color:#ffffff;"><span style="box-sizing:border-box;border:0px solid rgb(226, 232, 240);">Sonia S. Talathi, MD, is a Vascular Surgeon at Montefiore and Assistant Professor of Cardiothoracic and Vascular Surgery at Albert Einstein College of Medicine. Dr. Talathi received her medical degree from the University of Alabama at Birmingham School of Medicine and later completed her residency in general surgery at Montefiore-Einstein, where she served as Administrative Chief Resident. She went on to complete her fellowship in vascular surgery at Northwell Health in Long Island, New York, and was subsequently named Fellow Teacher of the Year. </span></p><p style="box-sizing:border-box;border:0px solid rgb(226, 232, 240);margin-top:2rem;margin-bottom:0px;color:#313335;font-family:'Leitura News', Georgia, Cambria, 'Times New Roman', Times, serif;font-size:medium;background-color:#ffffff;"><span style="box-sizing:border-box;border:0px solid rgb(226, 232, 240);">Dr. Talathi specializes in endovascular and surgical treatments for the management of vascular diseases. Her research interests include peripheral vascular disease, dialysis access and quality improvement. She has published multiple scientific papers and presented at numerous national meetings. </span></p>