Allison Taylor

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Allison

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Taylor

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1588720429

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1479

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Pediatric

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Female

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Primary Care

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Pediatric Medicine<quillbot-extension-portal></quillbot-extension-portal>

EMR ID

3801

Biography

<p>Allison Taylor, MD, is an Attending Physician at the Children&rsquo;s Hospital at Montefiore and Assistant Professor of Pediatrics at the Albert Einstein College of Medicine. Her clinical interests focus on General Pediatrics.</p><p>Dr. Taylor received her Bachelor of Arts degree from Brown University and her Doctor of Medicine from the Albert Einstein College of Medicine. She completed her Pediatric residency at Columbia Presbyterian Medical Center and has been working and teaching at the Family Care Center at Montefiore for over 25 years.</p><p>Dr. Taylor is co-director of breastfeeding education for pediatric residents at Montefiore and provides breastfeeding education to expectant mothers through the FCC Child Birth Class series.&nbsp; She is also a strong advocate of early childhood literacy.</p><p>She has been on the Castle Connolly Top Doctors list since 2016. &nbsp;Dr. Taylor is board certified in pediatrics and a fellow of the American Academy of Pediatrics.</p>

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Sarah Sungurlu

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First Name

Sarah

Last Name

Sungurlu

NPI

1174819478

Faculty ID

17214

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Full Time

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Adult

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Female

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Elsevier Profile

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165589

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Christina K. Sullivan

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First Name

Christina

Last Name

Sullivan

NPI

1740365196

Faculty ID

84

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part-time

Patient Type

Pediatric

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Female

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Primary Care

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Dr. Sullivan's clinical focus is on general pediatrics and the education of medical students and residents.<quillbot-extension-portal></quillbot-extension-portal>

Research Focus

Dr. Sullivan&rsquo;s research is varied, investigating areas of general pediatrics, resident education, smoking cessation and narrative medicine.

EMR ID

4201

Biography

<p>Christina K. Sullivan, MD, is Medical Director, Comprehensive Family Care Center, Pediatric Practice at Montefiore and Assistant Clinical Professor, Pediatrics at our Albert Einstein College of Medicine. Her clinical focus is on general pediatrics and the education of medical students and residents.</p><p>After earning her Bachelor of Arts in Biochemistry at Brown University in 1984, Dr. Sullivan attended the University of Connecticut School of Medicine, earning her Doctor of Medicine in 1990. She pursued her postdoctoral training at Mount Sinai Medical Center, completing an internship and residency in Pediatrics in 1993.</p><p>Dr. Sullivan&rsquo;s research is varied, investigating areas of general pediatrics, resident education, smoking cessation and narrative medicine.</p><p>In 1998, Dr. Sullivan was awarded the William Obrinsky Award from the Albert Einstein College of Medicine for excellence in student teaching. In 2003, she was inducted into the Leo Davidoff Society for excellence in medical student education. She is board certified and is a member of the American Academy of Pediatrics.</p>

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Kate R. Steinberg

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First Name

Kate

Last Name

Steinberg

NPI

1528488459

Faculty ID

16973

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Full Time

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Adult

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Female

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141643

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Luke R. Sponholz

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Luke

Last Name

Sponholz

NPI

1679837579

Faculty ID

18058

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Full Time

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Adult

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Male

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55833

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Simon D. Spivack

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Simon

Last Name

Spivack

NPI

1366438475

Faculty ID

11003

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Clinical Terms

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Full Time

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Adult

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Male

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Professional Interests

<p>Focusing diagnostics and therapeutics on those most likely to benefit is a key to successful intervention&nbsp;at both the public health and clinical levels. The translational goal of the Spivack laboratory is to identify individuals at particularly high risk for lung malignancy, and selected non-malignant lung diseases, upon whom to focus smoking/toxin exposure cessation (primary prevention), chemoprevention (secondary prevention), and early disease detection efforts (disease screening, tertiary prevention).</p>
<p>The laboratory is currently exploring individual Gene x Environment signatures as susceptibility markers by exploring quantitative gene (mRNA) expression phenotypes, and the DNA sequence, methylation, microRNA, and other epigenetic features potentially underlying these expression phenotypes, <em>in vitro</em> and in human populations. This is performed in the setting of defined tobacco, diet, and other exposures. There are both mechanistic and translational components to the studies.&nbsp;</p>
<p><br /><strong>Mechanistically</strong>, the role of epigenetic variation in promoter regions in the 5' and 3' regulatory regions of carcinogenesis and oxidant pathway genes is being explored <em>in vitro</em>, using human genomic DNA reporter constructs, and native gene regulation models. High resolution technologies include the realtime quantitation of native mRNA and microRNA by the laboratory's RNA-specific strategy (<em>patented</em>); the&nbsp;tagged-bisulfite genomic sequencing strategy to determine single base resolution CpG methylation status (tBGS, <em>patented</em>);&nbsp;&nbsp;an experimental strategy for assaying microRNA binding to mRNA, for determining the role of miRNA in candidate gene regulation&nbsp;(<em>patented</em>); and evaluation of functional consequences of DNA&nbsp;methylation detail, using a novel patch reporter construct (<em>patented</em>).&nbsp; A new method to engineer methyl-cytosines into the epigenome has recently been developed.</p>
<p>Whole (epi)genome approaches to identify molecular events unique to lung cancer&nbsp;are being completed, which will represent one of the initial cross-platform 'omics level discovery examinations of&nbsp;lung&nbsp;tissues.&nbsp; The execution of each individual discovery platform involves&nbsp;expert local collaborators and cores&nbsp;in (epi)genetics and genomics, and the "integromics" is critically reliant on Einstein strengths in informatics and biostatistical analyses.</p>
<p>&nbsp;</p>
<p><strong>Translationally</strong>, human lung carcinogenesis biomarkers are being established by pairing laser capture microdissected lung with several unique, non-invasively collected surrogate specimens developed in the laboratory. These include mRNA expression signatures from brush-exfoliated buccal mucosa cells, microRNAs detected in exhaled breath condensate representing first reports for a new exhaled airway biomarker class, and exhaled metabolomic signatures. These airway-derived specimens continue to accrue from a sampling (currently n&gt;1000) of a population assembled in a lung cancer case-control context.&nbsp; The specimens are being studied with a view toward developing non-invasive assays in populations.</p>
<p>&nbsp;</p>
<p>The overall aim is to develop informative non-invasive risk profiling, preventive, and early disease detection strategies for the lung in human populations.</p>
<p>&nbsp;</p>
<p>&nbsp;<em>Work is funded by ongoing NIH,</em><em> DoD,&nbsp;and&nbsp;Foundation support.</em></p>
<p>&nbsp;</p>
<p><strong>Clinical Specialties</strong></p>
<ul style="font-size: 1em; color: #333333; padding: 0px; margin: 20px 0px 25px 38px;">
<li style="padding: 0px; margin: 12px 0px 5px 0px;">lung nodule evaluation</li>
<li style="padding: 0px; margin: 12px 0px 5px 0px;">lung cancer diagnostics and screening</li>
<li style="padding: 0px; margin: 12px 0px 5px 0px;">interstitial lung disease</li>
<li style="padding: 0px; margin: 12px 0px 5px 0px;">environmental lung disease</li>
<li style="padding: 0px; margin: 12px 0px 5px 0px;">refractory asthma</li>
<li style="padding: 0px; margin: 12px 0px 5px 0px;">general pulmonary medicine</li>
</ul>

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Expert Summary

<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt;">A researcher and clinician, Dr. Spivack is developing tests for detecting lung cancer at the earliest possible stage&mdash;before it becomes fatal by spreading to other parts of the body. In one of several NIH-funded studies, his laboratory is working on a noninvasive, early-diagnosis test for lung cancer that detects particular genetic elements and chemicals in exhaled breath.</span></p>
<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt;">In addition to general pulmonary medicine, Dr. Spivack&rsquo;s clinical practice focuses on lung nodule and lung cancer diagnosis, diffuse interstitial lung diseases, and environmental lung diseases.</span></p>

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Clinical Focus

Dr. Spivack specializes in consultative pulmonary medicine, with an emphasis on the evaluation of lung nodules, lung cancer screening, asthma, and environmental and interstitial lung disease.<span style="color:#4d4d4d;font-family:Arial, Helvetica, source-code-pro, Menlo, Monaco, Consolas, 'Courier New', monospace;font-size:16px;background-color:#ffffff;"><strong></strong></span>

Research Focus

Dr. Spivack&rsquo;s research focuses on the development of non-invasive early detection airway biomarkers of lung cancer risk, as well as epigenetics, gene regulation, gene-environment interaction and non-invasive measurement of deep lung phenomena in humans.

Elsevier Profile

Selected Publications

<ol>
<li>Zhenqiu Huang, Alex Maslov, Xiao Dong, Shixiang Sun, Moonsook Lee, Chirag Shah, Ali Sadoughi, Aditi Desai, Dhruv Patel, Taha Siddiqui, Jaiminkumar Patel, Miao Shi, Spencer Waldman, Ava Marsh, Yakov Peter, <strong>*Simon D Spivack,</strong> *Jan Vijg. Somatic Mutations At Single Base Resolution in Single Bronchial Progenitor Cells Collected From Human Lung. <em>(Nature Genetics, April 2022, </em><a href="https://www.nature.com/articles/s41588-022-01035-w&quot; target="_blank">https://www.nature.com/articles/s41588-022-01035-w</a&gt;). (*co-senior authors).</li>
<li>Shi M, Han W, Loudig O, Shah CD, Dobkin JB, Keller S, Sadoughi A, Zhu C, Siegel RE, Fernandez MK, DeLaRosa L, Patel D, Desai A, Siddiqui T, Gombar S, Suh Y, Wang T, Hosgood HD, Pradhan K, Ye K, <strong>Spivack SD.</strong> Initial development and testing of an exhaled microRNA detection strategy for lung cancer case-control discrimination. Sci Rep. 2023 Apr 24;13(1):6620. doi: 10.1038/s41598-023-33698-8. PMID: 37095155; PMCID: PMC10126132.</li>
<li>Yoo EJ, Kim JS, Stransky S, <strong>Spivack S,</strong> Sidoli S. Advances in proteomics methods for the analysis of exhaled breath condensate. Mass Spectrom Rev. 2024 Jul-Aug;43(4):713-722. doi: 10.1002/mas.21871. Epub 2023 Dec 27. PMID: 38149478.</li>
<li>Zefi O, Waldman S, Marsh A, Shi MK, Sonbolian Y, Khulan B, Siddiqui T, Desai A, Patel D, Okorozo A, Khader S, Dobkin J, Sadoughi A, Shah C, <strong>*Spivack S,</strong> *Peter Y. Distinctive field effects of smoking and lung cancer case-control status on bronchial basal cell growth and signaling. Respir Res. 2024 Aug 19;25(1):317. doi: 10.1186/s12931-024-02924-w. PMID: 39160511; PMCID: PMC11334309. *(co-senior authors)</li>
<li>Mitchell MI, Ben-Dov IZ, Ye K, Liu C, Shi M, Sadoughi A, Shah C, Siddiqui T, Okorozo A, Gutierrez M, Unawane R, Biamonte L, Parikh K, <strong>Spivack S,</strong> Loudig O. Exhaled breath condensate contains extracellular vesicles (EVs) that carry miRNA cargos of lung tissue origin that can be selectively purified and analyzed. J Extracell Vesicles. 2024 Apr;13(4):e12440. doi: 10.1002/jev2.12440. Erratum in: J Extracell Vesicles. 2024 May;13(5):e12453. doi: 10.1002/jev2.12453. PMID: 38659349; PMCID: PMC11043690.</li>
<li>Khulan B, Ye K, Shi MK, Waldman S, Marsh A, Siddiqui T, Okorozo A, Desai A, Patel D, Dobkin J, Sadoughi A, Shah C, Gera S, Peter Y, Liao W, *Vijg J, *<strong>Spivack SD</strong>. Normal bronchial field basal cells show persistent methylome-wide impact of tobacco smoking, including in known cancer genes. Epigenetics. 2025 Dec;20(1):2466382. doi: 10.1080/15592294.2025.2466382. Epub 2025 Feb 20. PMID: 39980243; PMCID: PMC11849931. *(co-senior authors)</li>
</ol>

EMR ID

4969

Biography

<p>Simon D. Spivack, MD, MPH, is Professor, Medicine, Epidemiology and Genetics at Montefiore Einstein. He is also former Emeritus Chief, Pulmonary Medicine. Clinically, Dr. Spivack specializes in consultative pulmonary medicine, with an emphasis on the evaluation of lung nodules, lung cancer screening, asthma, and environmental and interstitial lung disease. </p><p>After obtaining his Bachelor of Science in Psychobiology from McGill University in Montreal, Canada in 1980, Dr. Spivack earned his Doctor of Medicine from the State University of New York Upstate Medical University in 1985. He then completed an internship and residency in internal medicine at the University of Massachusetts Medical Center in 1988. Dr. Spivack then earned his Master of Public Health at Harvard University, School of Public Health in 1989. He completed a clinical pulmonary and critical care medicine and lung research fellowship at the University of Vermont in 1992. </p><p>Dr. Spivack&rsquo;s research focuses on the development of non-invasive early detection airway biomarkers of lung cancer risk, as well as epigenetics, gene regulation, gene-environment interaction and non-invasive measurement of deep lung phenomena in humans. His work has been published in numerous peer-reviewed journals, articles, chapters and books, and he has given many national/international presentations, organized symposia and visiting professorships. Dr. Spivack is on the Editorial Board for Scientific Reports and is a reviewer for journals such as <em>PLoS Genetics</em>, <em>Genetics in Medicine</em>, <em>Nature Protocols</em>, <em>American Journal of Respiratory &amp; Critical Care Medicine</em>, <em>Carcinogenesis</em>, <em>Cancer Research</em> and others. He holds multiple United States patents. He has been continually funded by the National Institutes of Health (NIH) for research for over 25 years.
</p><p>Dr. Spivack is board certified in internal medicine, pulmonary medicine and critical care medicine. He is a member of the American Thoracic Society (ATS), the American Association for Cancer Research (AACR) and the American Lung Association (ALA). He is a frequent peer-reviewer on various NIH study sections. In the past, Dr. Spivack won the Excellence in Research Award from ALA and the NIH/National Institute of Environmental Health Sciences (NIEHS) Clinical Scientist Development Award.

</p>

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Staceyann Smith

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First Name

Staceyann

Last Name

Smith

NPI

1386024370

Faculty ID

15910

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Clinical Terms

Employment Status

Full Time

Patient Type

Pediatric

Department

Gender

Female

Provider Type

Primary Care

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On

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Clinical Focus

Pediatric Medicine<quillbot-extension-portal></quillbot-extension-portal>

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EMR ID

14251

Biography

<p>Staceyann Smith, MD, MPH, is an attending physician and Assistant Professor, Pediatrics at Montefiore Einstein. Her clinical focus centers on childhood obesity and health and wellness.</p><p>After completing her Bachelor of Science in human science from Georgetown University in 2009, Dr. Smith earned her Doctor of Medicine and her Master of Public Health at the University of Connecticut in 2015. She completed her general pediatrics residency at St. Christopher's Hospital for Children in 2018.</p><p>Building on her clinical focus, Dr. Smith&rsquo;s research focuses on quality improvement regarding childhood obesity management in general pediatric clinic settings. She has been primary co-investigator and physician site lead on research projects.</p><p>Dr. Smith is a Diplomate of the American Board of Pediatrics and is a member of the American Academy of Pediatrics and the Academic Pediatric Association.</p>

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Olena Slinchenkova

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Olena

Last Name

Slinchenkova

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1013205632

Faculty ID

14967

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Adult

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55793

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Sumeet Singh-Tan

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First Name

Sumeet

Last Name

Singh-Tan

NPI

1215318001

Faculty ID

16569

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Adult

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Female

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14316

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Chirag D. Shah

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Chirag

Last Name

Shah

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1164629770

Faculty ID

15234

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Adult

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