Shiu M. Young

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First Name

Shiu

Last Name

Young

NPI

1467742726

Faculty ID

14110

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Employment Status

Full Time

Patient Type

Adult

Department

Gender

Female

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Clinical Profile

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Elsevier Profile

EMR ID

5826

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Daniel A. Weiser

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First Name

Daniel

Last Name

Weiser

NPI

1225239700

Faculty ID

13846

CMO Specialties

Clinical Terms

Employment Status

Full Time

Patient Type

Pediatric

Department

Gender

Male

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Phone

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Professional Interests

<p><span style="text-decoration: underline;"><strong>Childhood cancer research laboratory</strong></span></p>
<p>Our laboratory is focused on childhood cancer research with a goal of elucidating the underlying biology of the most aggressive malignancies. In such patients with typically incurable cancer, we are striving to identify new approaches to and types of treatment. We have multiple ongoing projects:</p>
<p><strong>+ Identification of biologic drivers of ultra-high-risk neuroblastoma</strong>. Neuroblastoma is one of the most common and deadly childhood cancers. Despite intensive research, there are limited therapeutic strategies for patients with <em>de novo </em>chemotherapy resistance that leads to particularly poor outcomes. We have been studying neuroblastoma since 2009 and are identifying additional biologic drivers of highly lethal tumors.</p>
<p>We compare tumor features from patients with early death from tumor progression compared to those with a maintained complete response. We assess unique histo-morphologic and proteomic features and computationally integrate these data with genomic and transcriptomic datasets to develop a combined predictor of primary refractory disease. Patients with this entity require non-standard and/or intensified treatment. Oncogenic drivers are being characterized in the lab which will facilitate strategies for novel pharmacologic intervention.</p>
<p><strong>+ Characterization of neuroblastoma development from neural crest cells</strong>.&nbsp; We are studying pathways and interactions that results in uncontrolled cell proliferation early in neuroblastoma development with an ultimate goal of identifying new targets and approaches for pharmacologic intervention.</p>
<p><strong>+ Evaluation of novel combinatorial targeted therapeutic approaches in neuroblastoma</strong>.&nbsp; With expected outcomes lagging behind those of more common childhood cancers, children with neuroblastoma require new approaches to treatment. Our lab works with multiple international clinical and research consortium groups to perform preclinical studies that substantiate human clinical trials.&nbsp;</p>
<p><strong>+ Detection of circulating tumor DNA in osteosarcoma</strong>. With no reliable non-invasive approach for disease monitoring during and after treatment, we are applying cutting edge next-generation sequencing approaches to identify solid tumors with a blood-based &ldquo;liquid&rdquo; biopsies. This will allow clinicians to assess tumor responsiveness to chemotherapy and predict likelihood of recurrence.</p>
<p><strong>+ Assessment of accelerated aging using miRNA-seq in survivors of childhood cancer</strong>. Chemotherapy has many untoward effects on healthy cells and leads to many signs of accelerated aging in children treated for cancer. Using a known microRNA &ldquo;aging&rdquo; signature discovered at Albert Einstein College of Medicine, we are studying what causes this phenotype in childhood cancer, with a goal of offering improved intervention to minimize long-term toxicity of treatment.</p>
<p><strong><span style="text-decoration: underline;">Physician Summary</span></strong></p>
<p>Daniel A. Weiser, MD, is board-certified in pediatric hematology/oncology with clinical expertise in neuroblastoma and other tumors of the adrenal glands, kidneys, liver, and gonads. He is the medical director of the intra-abdominal solid tumor program at the Children&rsquo;s Hospital at Montefiore and brings together a highly specialized multi-disciplinary care team to provide comprehensive treatment for diverse pediatric malignancies. In addition, Dr. Weiser directs a childhood cancer research laboratory that focuses on the identification of new targeted agents for cancer therapy, especially in the treatment of rare and aggressive malignancies such as neuroblastoma. His research goals are to understand the role of certain genes in the risk, development, and treatment of cancer. The approaches taken and agents studied hold promise for improving management of all patients with solid tumors.</p>
<p>Dr. Weiser participates in the efforts of a number of professional organizations including the Children&rsquo;s Oncology Group (COG), American Association for Cancer Research (AACR), American Society of Clinical Oncology (ASCO), Advances in Neuroblastoma Research Association (ANRA), National Pediatric Cancer Foundation (NPCF), and the American Academy of Pediatrics (AAP). He has received numerous awards including the Brigid Leventhal Special Merit Award from ASCO and the Conquer Cancer Foundation, and a prestigious K12 from the National Cancer Institute for the training of the next generation of physician-scientists in pediatric cancer. Dr. Weiser is actively involved in teaching and mentorship of trainees, and takes great pride in providing advanced and compassionate care to his patients and their families.</p>
<p><strong>Clinical Expertise</strong></p>
<ul>
<li>Neuroblastoma (adrenal tumors)</li>
<li>Wilms tumor (renal tumors)</li>
<li>Hepatoblastoma (liver tumors)</li>
<li>Germ cell tumors (including testicular and ovarian tumors)</li>
<li>Thyroid and other rare tumors</li>
<li>Experimental therapeutics</li>
<li>Cancer genetics and biomarkers</li>
</ul>
<p><strong>Board Certifications</strong></p>
<ul>
<li>Pediatrics</li>
<li>Pediatric Hematology/Oncology</li>
</ul>
<p><strong>Professional Education</strong></p>
<ul>
<li>M.D. &ndash; Stony Brook University, NY</li>
<li>Residency &ndash; Children&rsquo;s Hospital of NY-Presbyterian, Columbia University, NY</li>
<li>Chief Residency &ndash; Children&rsquo;s Hospital of NY-Presbyterian, Columbia University, NY</li>
<li>Fellowship &ndash; The Children&rsquo;s Hospital of Philadelphia, PA</li>
</ul>

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Research Profile

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Clinical Focus

DR. Weiser's clinical focuses are neuroblastoma and adrenal tumors, Wilms tumor and other kidney (renal) tumors, hepatoblastoma, and other liver tumors, germ cell tumors (including testicular and ovarian tumors), Thyroid and other rare tumors, experimental therapeutics, and cancer genetics and biomarkers.&nbsp;

Research Focus

Dr. Weiser&rsquo;s research goals are to understand the role of certain genes in the risk, development, and treatment of cancer. The approaches taken and agents studied hold promise in the treatment of all solid tumors. Dr. Weiser&rsquo;s laboratory focuses on childhood cancer research with a goal of elucidating the underlying biology of the most aggressive malignancies. He has multiple ongoing projects, such as identification of biologic drivers of neuroblastoma at ultra-high risk for treatment failure, characterization of neuroblastoma development from neural crest cells, and evaluation of novel combinatorial targeted therapeutic approaches in neuroblastoma, among others.

Elsevier Profile

EMR ID

5755

Biography

<p>Daniel A. Weiser, MD, is a Medical Director of the Intra-abdominal Solid Tumor Program in the Pediatrics Hematology/Oncology department at Children&rsquo;s Hospital at Montefiore. He is also Associate Professor in the Pediatrics and Genetics departments at the Albert Einstein College of Medicine. His clinical focuses are neuroblastoma and adrenal tumors, Wilms tumor and other kidney (renal) tumors, hepatoblastoma and other liver tumors, germ cell tumors (including testicular and ovarian tumors), Thyroid and other rare tumors, experimental therapeutics, and cancer genetics and biomarkers. Dr. Weiser is actively involved in teaching and mentorship of trainees and takes great pride in his active participation in patient care.</p><p>Dr. Weiser received his Bachelor of Science in Neurobiology in 1995 at Haverford College, PA. In 2004, he received his Doctor of Medicine at Stony Brook University School of Medicine, NY. He is currently earning his Master of Science in Translational Research at the University of Pennsylvania. He began a residency in Pediatrics at the New York-Presbyterian, Columbia University in 2007. Dr. Weiser then completed a three-year fellowship in Pediatric Hematology/Oncology at The Children&rsquo;s Hospital of Philadelphia. </p><p>Dr. Weiser&rsquo;s research goals are to understand the role of certain genes in the risk, development, and treatment of cancer. The approaches taken and agents studied hold promise in the treatment of all solid tumors. Dr. Weiser&rsquo;s laboratory focuses on childhood cancer research with a goal of elucidating the underlying biology of the most aggressive malignancies. He has multiple ongoing projects, such as identification of biologic drivers of neuroblastoma at ultra-high risk for treatment failure, characterization of neuroblastoma development from neural crest cells, and evaluation of novel combinatorial targeted therapeutic approaches in neuroblastoma, among others. His research has been published in many reviewed journals. </p><p>Dr. Weiser participates in the efforts of a number of professional organizations including the Children&rsquo;s Oncology Group (COG), American Association for Cancer Research (AACR), American Society of Clinical Oncology (ASCO), and the American Academy of Pediatrics (AAP). He has received many awards including the Brigid Leventhal Special Merit Award through ASCO, and he has been awarded a prestigious K12 from the NCI for the training of the next generation of physician-scientists in pediatric cancer.</p><p>He is board certified in Pediatric Hematology/Oncology and General Pediatrics.</p>

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Jacqueline Weingarten-Arams

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First Name

Jacqueline

Last Name

Weingarten-Arams

NPI

1558447409

Faculty ID

4831

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Full Time

Patient Type

Pediatric

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Female

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Elsevier Profile

Lab Website Link

EMR ID

3961

Biography

<p>Jacqueline Weingarten-Arams, MD, is an attending physician and Professor, Pediatrics at Montefiore Einstein. Dr. Weingarten-Arams&rsquo; pediatric critical care expertise focuses on cardiac critical care, acute hypoxemic respiratory failure, nutrition in critical illness and energy expenditure, cardiopulmonary resuscitation (quality CPR) and extracorporeal life support (ECMO).</p><p>After obtaining her Bachelor of Science in nutritional biochemistry at Cornell University in 1982, Dr. Weingarten-Arams earned her Doctor of Medicine at the same institution in 1986. She then completed her pediatric residency at Columbia University in 1990, where she was Chief Resident in her final year. Following this, Dr. Weingarten-Arams completed a fellowship in pediatric critical care medicine at New York Hospital Cornell University Medical College in 1996.</p><p>Dr. Weingarten-Arams research focus includes the use of deliberate simulated practice in improving outcomes in pediatric critical illness, pediatric resuscitation and pediatric airway management. Her other projects involve chronic critical illness, bioethics in pediatric critical care and oxidative injury in respiratory failure. She has been principal investigator and co-investigator on several research projects, and her work has been shared through numerous peer-reviewed publications and invited presentations.</p><p>Dr. Weingarten-Arams is a Diplomate of the National Board of Medical Examiners and the American Board of Pediatrics. She is a Fellow of the American Academy of Pediatrics and the American College of Chest Physicians. She is also a member of several professional organizations, including the American Medical Association, the Pediatric Cardiac Intensive Care Society and the Society of Critical Care Medicine. Dr. Weingarten-Arams has been named in Castle Connolly&rsquo;s &ldquo;Top Doctors: New York Metro Area&rdquo; for multiple years. In 2006, she was inducted into the Leo M. Davidoff Society and in 2019, Dr. Weingarten-Arams won the William Obrinsky Award for Excellence in Medical Student Education.</p>

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Henry Michael Ushay

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First Name

Henry

Last Name

Ushay

NPI

1558332007

Faculty ID

10275

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Full Time

Patient Type

Pediatric

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Male

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Pediatric critical care medicine with a special emphasis on respiratory failure; shock resuscitation; cardiac intensive care; intensive care of pediatric oncology patients; extracorporeal support for children with respiratory and cardiovascular failure

Research Focus

Leadership and direction of the 16-bed Pediatric Critical Care Unit of The Children&rsquo;s Hospital at Montefiore; improving medication safety; respiratory physiology; advances in the management of respiratory failure in children; shock; medical ethics

Elsevier Profile

EMR ID

4763

Biography

<p>Dr. Ushay is Professor of Clinical Pediatrics in the Albert Einstein College of Medicine. He is a Fellow of the American Academy of Pediatrics as well as a Fellow of the American College of Critical Care Medicine. </p><p>After obtaining a PhD in Chemistry from Columbia University, Dr. Ushay received his MD from UMDNJ-New Jersey Medical School and completed a Pediatrics residency in the Montefiore-Jacobi-Einstein program. After serving as Chief Resident and a Fellow in Pediatric Pulmonology at Montefiore, he completed a Pediatric Critical Care Fellowship at New York Hospital/Cornell Medical Center in 1993. He was a faculty member at NewYork-Presbyterian and Memorial Sloan-Kettering Hospitals from 1993 to 2005, and he served as Pediatric Critical Care Medicine Fellowship Program Director and Medical Director of the Pediatric Observation Unit at Memorial Sloan-Kettering Cancer Center. </p><p>In 2005 Dr. Ushay became Director of the Pediatric Critical Care Unit in The Children&rsquo;s Hospital at Montefiore. Dr. Ushay is involved in increasing pediatric ICU surge capacity through the New York City Pediatric Disaster Coalition, serving on its Central Leadership Council and teaching the Pediatric Fundamental Critical Care Support Course. Through the National Institute of Child Health and Human Development, Dr. Ushay works on employing medical countermeasures safely for children in the event of chemical, biological or radiological disaster. Sponsored by Surgeons of Hope and Children&rsquo;s HeartLink, Dr. Ushay has worked as a cardiac intensivist in Cambodia, Africa, China and Nicaragua. </p>

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Jamie T. Twaite

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First Name

Jamie

Last Name

Twaite

NPI

1003390972

Faculty ID

16241

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Full Time

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Adult

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Female

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Clinical Focus

Dr. Twaite&rsquo;s clinical focus is on the neuropsychological evaluation and rehabilitation of individuals with cognitive and emotional concerns related to neurologic, medical, and psychiatric illness. She has a particular interest in the diagnosis and management of dementias and acquired brain injury(ABI), as well as in the rehabilitation of of spinal cord injury (both with and without concurrent ABI).<quillbot-extension-portal></quillbot-extension-portal>

Research Focus

Dr. Twaite&rsquo;s research interests include cognitive and emotional functioning following stroke, TBI, and other acquired brain injury, as well as in individuals with Parkinson&rsquo;s disease and in healthy populations, such as musicians.<quillbot-extension-portal></quillbot-extension-portal>

Elsevier Profile

EMR ID

16191

Biography

<p>Jamie Twaite, PhD, is a Neuropsychologist, Co-Director, Burke Rehabilitation Hospital&rsquo;s Concussion Management Program, Director, Neuropsychology Externship and Assistant Professor, Physical Medicine and Rehabilitation at Montefiore Einstein. Her clinical focus is on the neuropsychological evaluation and rehabilitation of individuals with cognitive and emotional concerns related to neurologic, medical and psychiatric illnesses. She has a particular interest in the diagnosis and management of dementia and acquired brain injury (ABI), as well as in the rehabilitation of spinal cord injury (both with and without concurrent ABI).</p><p>After completing her Master of Psychology at Columbia University in 2008, Dr. Twaite pursued her Doctor of Philosophy in psychology at City University of New York (CUNY), earning the degree in 2016. That same year, she completed an APA-accredited predoctoral internship in clinical psychology-adult neuropsychology track with the Henry Ford Health System. She then went on to complete her postdoctoral fellowship in clinical neuropsychology with the Institute of Living, Hartford Hospital, with focused training in the assessment of memory disorders/dementias, acquired brain injuries, and severe and persistent mental illness.</p><p>Dr. Twaite&rsquo;s research interests include cognitive and emotional functioning following stroke, traumatic brain injury (TBI) and other acquired brain injury in individuals with Parkinson&rsquo;s disease as well as in healthy populations, such as in musicians. Her work has been published in numerous peer-reviewed journals and she has given paper and poster presentations at scientific meetings nationally and internationally. Dr. Twaite is a reviewer for the <em>Journal of Clinical and Experimental Neuropsychology</em> and the <em>Journal of Psycholinguistic Research</em>.</p><p>Dr. Twaite is a member of several professional associations, including the American Psychological Association (APA), the Society for Clinical Neuropsychology and the International Neuropsychological Society. In 2013, Dr. Twaite received the Graduate Center Doctoral Student Research Grant from CUNY.</p>

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Ivy Tam

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First Name

Ivy

Last Name

Tam

NPI

1427494269

Faculty ID

15947

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Full Time

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Pediatric

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Female

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Pediatric Medicine

Research Focus

Dr. Tam&rsquo;s research aims to improve care and communication for patients with limited English proficiency, as well as standardizing pain practices for children.&nbsp;

Elsevier Profile

EMR ID

14829

Biography

<p>Ivy Tam, MD, FAAP, is an Attending Physician and a Non-neonatal Emergency Transport Coordinator at Children&rsquo;s Hospital at Montefiore. She is also an Assistant Professor of Pediatrics at our Albert Einstein College of Medicine. </p><p>In 2009, Dr. Tam received her Bachelor of Arts in Biological Sciences at Cornell University. She then attended SUNY Upstate Medical University, where she received her Doctor of Medicine in 2013. Dr. Tam began her postgraduate training with a residency in pediatrics at New York University School of Medicine, followed by a fellowship in pediatric hospital medicine in 2018 at the University of California San Diego. </p><p>Dr. Tam&rsquo;s research aims to improve care and communication for patients with limited English proficiency, as well as standardizing pain practices for children. She has shared her work through presentations in academic forums and scientific meetings, and is currently in the process of being submitted for publication. </p><p>2017, Dr. Tam received the CARES Award from hospital staff at Rady Children&rsquo;s Hospital for her support during the medical director&rsquo;s absence. Dr. Tam is board certified by the American Board of Pediatrics and is a member of the American Academy of Pediatrics. </p>

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Mitchell Steinschneider

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First Name

Mitchell

Last Name

Steinschneider

NPI

1629032016

Faculty ID

2598

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Full Time

Patient Type

Pediatric

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Male

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<p>The goal of my research is to delineate the multiple fields of auditory and auditory-related cortex, identify their functional connectivity, and clarify the roles that each of these regions play in the neural processing of speech and other complex hearing phenomena. The three arms of my research career, coupled to my clinical career arms, make me ideally suited to contribute to this academic endeavor. Pertaining to the first arm, I was among the first investigators to rigorously examine auditory cortical mechanisms of speech processing in an animal model. Previously, it had been thought that animals would make poor models for this uniquely human process. My colleagues and I demonstrated that auditory cortical activity could explain many of features of speech processing, such as the neural events associated with the categorical representation of the voice onset time parameter, in the non-human primate model. This line of research has expanded over the years to address many of the key issues in auditory neuroscience, including clarifying neural mechanisms underlying auditory scene analysis, musical consonance and dissonance, pitch, and the mismatch negativity component of the human auditory evoked potential. We have also been among the first to demonstrate the close correspondence between monkey auditory cortical activity and that recorded directly from the human auditory cortex using intracranial electrodes. While I have retired from this research arm to increase my role on this project and pursue my mandate to help lead the new program of intracranial recordings in children at U Iowa, my animal research background helps ground this project in tenets of basic auditory cortical physiology.</p>
<p>The second arm of my research has been as co-investigator on this long-standing project. Working with the University of Iowa investigative team, I have been a major contributor to their intracranial studies that have helped delineate fundamental features of human auditory cortical physiology. In the last several years, working with Dr. Nourski as co-first author on multiple papers, we have identified the relative modulations of core and non-core auditory cortex by attention, and the role of these fields and auditory-related cortex including the middle temporal gyrus, supramarginal gyrus, and prefrontal cortex in word object formation and selection and in predictive coding mechanisms.</p>
<p>The third arm of my research, in collaboration with Dr. Elyse Sussman, and more recently, Dr. Monica Wagner, has focused on clarifying the maturation of cortical auditory evoked potentials and the effects of language experience on cortical speech processing. Finally, my 30 years of clinical experience in child neurology and clinical electrophysiology has made me keenly aware of multiple types of developmental language disorders and normal and aberrant features of the electroencephalogram. These experiences allow me to frame research questions in a translationally relevant way.</p>

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Elsevier Profile

Selected Publications

<p><strong>Steinschneider, M.</strong>, &amp; Fishman, Y.I. (2011). Enhanced physiologic discriminability of stop consonants with prolonged formant transitions in awake monkeys based on the tonotopic organization of primary auditory cortex. Hearing Research, 271, 103-114. PMCID: PMC2945626</p>
<p><strong>Steinschneider, M.</strong>, Nourski, K., Kawasaki, H., Oya, H., Brugge, J.F., &amp; Howard, M.A. III. (2011). Intracranial study of speech-elicited activity on the human posterolateral superior temporal gyrus. Cerebral Cortex, 21, 2332-2347. PMCID: PMC3169661</p>
<p><strong>Steinschneider, M.</strong>, Nourski, K.V., &amp; Fishman, Y.I. (2013). Representation of speech in human auditory cortex: Is it special? Hearing Research, 305, 57-73. Invited Paper for Special Issue: Communication Sounds and the Brain: New Directions and Perspectives. PMCID: PMC3818517.</p>
<p>Fishman, Y.I., Micheyl, C., &amp; <strong>Steinschneider, M.</strong> (2012). Neural mechanisms of rhythmic masking release in monkey primary auditory cortex: Implications for models of auditory scene analysis. Journal of Neurophysiology, 107, 2366-2382. PMCID: PMC3362241</p>
<p>Fishman, Y.I., Micheyl, C., &amp; <strong>Steinschneider, M.</strong> (2014). Neural representation of concurrent harmonic sounds in monkey primary auditory cortex: Implications for models of auditory scene analysis. Journal of Neuroscience, 34, 12425-12443. PMICD: PMC4160777.</p>
<p>Fishman, Y.I., Kim, M., <strong>Steinschneider, M.</strong> (2017). A Crucial Test of the Population Separation Model of Auditory Stream Segregation in Macaque Primary Auditory Cortex. Journal of Neuroscience, 37 10645-10655. PMID: 28954867.</p>
<p>Nourski, K.V., <strong>Steinschneider, M.</strong>, Rhone, A.E. Electrocorticographic activation within human auditory cortex during dialog-based language and cognitive testing. Frontiers in Human Neuroscience (2016) May 4;10:20. PMID: 27199720. K.V.N. and M.S. contributed equally to this work.</p>
<p>Nourski, K.V., <strong>Steinschneider, M.</strong>, Rhone, A.E., Howard, M.A. Intracranial electrophysiology of auditory selective attention associated with speech classification tasks. Frontiers in Human Neuroscience (2017) Jan 10:691. doi:10.3389/fnhum.2016.00691 K.V.N. and M.S. contributed equally to this work.</p>
<p>Nourski, K.V., <strong>Steinschneider, M.</strong>, Rhone, A.E., Kawasaki, H., Todd, M.M., Howard, M.A., Banks, M.I. Processing of auditory novelty across the cortical hierarchy: An intracranial electrophysiology study. NeuroImage 183 (2018) 412-424. PMID: 30114466.</p>
<p>Sussman, E., <strong>Steinschneider, M.</strong>, Gumenyuk, V., Grushko, J., &amp; Lawson, K. (2008). The maturation of human evoked brain potentials to sounds presented at different stimulus rates. Hearing Research, 236, 61-79. PMCID: PMC2567844</p>

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Brian D. Spund

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First Name

Brian

Last Name

Spund

NPI

1629377320

Faculty ID

15059

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Adult

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Male

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Elsevier Profile

EMR ID

68828

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Olena Slinchenkova

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First Name

Olena

Last Name

Slinchenkova

NPI

1013205632

Faculty ID

14967

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Female

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EMR ID

55793

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Mark Shlomovich

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First Name

Mark

Last Name

Shlomovich

NPI

1790065910

Faculty ID

15549

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Full Time

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Pediatric

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Male

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Elsevier Profile

EMR ID

29419

Biography

<p>Mark Shlomovich, MD, is Director, Extracorporeal Liver Support and Director, Pediatric Critical Care Transport at Children&rsquo;s Hospital at Montefiore and Assistant Professor, Pediatrics at Montefiore-Einstein. Dr. Shlomovich&rsquo;s clinical focus is on the care of critically ill children with abdominal organ failure, transplantation and post-surgical care. He also focuses on the safe transportation of critically ill children.</p><p>In 2006, Dr. Shlomovich earned his Bachelor of Science in biology from Towson University. He then attended University of Connecticut School of Medicine earning his Doctor of Medicine in 2010. His postgraduate training began at SUNY Downstate Medical Center with a four-year pediatric residency, where he was Chief Pediatric Resident in his final year. He then came to Children's Hospital at Montefiore for a pediatric critical care fellowship, which he completed in 2017.</p><p>Dr. Shlomovich&rsquo;s research interests are in the use of artificial liver support technology, as well as the care of children in liver failure before and after transplantation. In addition, he investigates the safety and efficiency of the transportation of critically ill children. He has shared his research through peer-reviewed journals and abstracts, and is an ad hoc reviewer for BMC Nephrology.</p><p>Dr. Shlomovich is board certified in general pediatrics and pediatric critical care medicine. He is a member of the Society of Critical Care Medicine and the American Academy of Pediatrics.</p>

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