Hemochromatosis

Harold D. Keiser

Submitted by Anonymous (not verified) on
Full Name
Harold D. Keiser
Profile Image URL
https://assets.montefioreeinstein.org/profiles/images/physphoto/Keiser_Harold_D_MD_3821.jpg
Type
Faculty
First Name
Harold
Last Name
Keiser
NPI
1245320951
Faculty ID
4585
CMO Specialties
Clinical Terms
Employment Status
Per Diem
Patient Type
Adult
Department
einstein-dept-medicine
Gender
Male
Email
harold.keiser@einsteinmed.edu
Titles
Type
Academic
Department
Department of Medicine
Department Link
Rank
Professor Emeritus
Division
Rheumatology
Locations
Is Primary
On
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.84154 40.84612)
Address Line 1
1250 Waters Place
City
Bronx
State
NY
Zip
10461-2720
Location Title
Montefiore at 1250 Waters Place
Is Primary
Off
Type
Academic
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.839137 40.8526781)
Address Line 1
Montefiore Medical Center
Address Line 3
1250 Waters Place
City
Bronx
State
NY
Zip
10461
Location Title
Montefiore Medical Center
Education and Trainings
Education Type Label
Medical Education
Education Institution
New York University School of Medicine
Education Type Label
Fellowship
Education Institution
Albert Einstein College of Medicine
Education Type Label
Residency
Education Institution
Cleveland Metropolitan General Hospital
Professional Interests

<p>In years of clinical practice Dr. Harold Keiser has acquired experience over the broad range of problems referred to rheumatologists. Dr. Keiser takes special interest in the diagnosis and management of connective tissue disorders, gout, and the spondyloarthropathies.</p>

CHAM Provider
Off
Professional Title
M.D.
EMR ID
3340
Visit Type ID
2528
Is Open Scheduling
On

Sanjeev Gupta

Submitted by Anonymous (not verified) on
Full Name
Sanjeev Gupta
Profile Image URL
https://documentapi-fargate-documentbucket-15qi4tpdvnhlz.s3.amazonaws.com/218/320e3550-5d55-11ef-82d4-99c0ef58f445.jpg
Type
Provider
Faculty
Expert
First Name
Sanjeev
Last Name
Gupta
NPI
1831274315
Faculty ID
8041
Employment Status
Full Time
Patient Type
Adult
Department
einstein-dept-medicine
einstein-dept-pathology
Gender
Male
Email
sanjeev.gupta@einsteinmed.edu
Phone
718-430-3309
Titles
Type
Academic
Department
Department of Medicine
Department Link
Rank
Professor
Division
Hepatology
Type
Academic
Department
Department of Pathology
Department Link
Rank
Professor
Type
Administrative
Title
The Eleazar & Feige Reicher Chair in Translational Medicine, Department of Medicine
Tags
me-patientcare-cancer-research-stem-cell-cancer-biology
Locations
Is Primary
On
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.84154 40.84612)
Address Line 1
1250 Waters place
City
Bronx
State
NY
Zip
10461-2720
Location Title
Montefiore at 1250 Waters Place
Is Primary
Off
Type
Academic
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.8459022 40.8504961)
Building
Ullmann Building
Room
625
Address Line 1
Albert Einstein College of Medicine
Address Line 2
Jack and Pearl Resnick Campus
Address Line 3
1300 Morris Park Avenue
City
Bronx
State
NY
Zip
10461
Location Title
Albert Einstein College of Medicine
Education and Trainings
Education Type Label
Medical Education
Education Institution
University of Rajasthan, Sardar Patel Med Coll
Education Type Label
Fellowship
Education Institution
Hammersmith Hospital
Education Type Label
Fellowship
Education Institution
Los Angeles County and Univ of Southern CA
Education Type Label
Fellowship
Education Institution
Jacobi Medical Center
Education Type Label
Residency
Education Institution
Jacobi Medical Center
Education Type Label
Residency
Education Institution
Postgraduate Institute of Medical Educ. & Research
Education Type Label
Residency
Education Institution
Hammersmith Hospital
Professional Interests

<p>Liver regeneration is critical for health. We focus on physiology of liver regeneration during development, early childhood and adulthood to inform mechanistic disruptions in diseases. The latter ranges from acute liver failure, effects of drugs, toxins, alcohol, virus hepatitis, obesity-related metabolic (or nonalcoholic) liver disease, chronic hepatitis, e.g., Wilson disease with copper toxicosis, and allograft rejection. The mechanisms concerning DNA damage response directed by ATM gene and downstream partners are of considerable interest to us.&nbsp; &nbsp; &nbsp;</p>
<p>These aspects are joined with study of cell type-specific contributions as well as aspects of stem cell biology for liver regeneration. We apply cell transplantation approaches to better understand the biology and regenerative potential of various cell types. Expression of therapeutic constructs and transplantation of those cells is another area of investigative interest. We address the role of endogenous stem/progenitor cells in therapeutic development. Tissue engineering to generate auxiliary liver has potential in these areas and is also advancing liver regenerartion in experimental models.</p>
<p>We use a variety of methods, including microarrays or deep sequencing for gene expression, cell and molecular biology methods, and multiple small and large animal models. The findings are integrated with analyses of human tissue and blood samples.</p>
<p>Unique aspects of our work include use of established drugs for mechanistic interrogations and therapeutic applications, and an uncommon depth and breadth of multidisciplinary tools. We collaborate with leading investigators at Einstein or elsewhere as appropriate.</p>

Research Areas
Liver regeneration in health and disease
Biology and differentiation of hepatic stem cells
DNA damage response involving ATM and downstream pathways
Translational studies using liver cell and animal models
Therapeutics including cell and gene therapy
Areas of Expertise
Stem cell research
Expert Summary

<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt;">Dr. Gupta is a pioneer in the development of cell therapy &ndash; treating disease by introducing healthy cells into the body.&nbsp; He has discovered various mechanisms for coaxing transplanted cells to attach to host tissue and multiply, paving the way for treating health problems such as&nbsp; high cholesterol, hemophilia, liver failure, and hepatitis.&nbsp;</span></p>
<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt;">Dr. Gupta has successfully manipulated human stem cells to generate liver cells and defined some of the fundamental ways by which gene expression is regulated in stem cells. Dr. Gupta serves as an expert for the National Institutes of Health, U.S. Department of Veterans Affairs, U.S. Department of Defense, Wellcome Trust, and national scientific bodies in over ten countries.</span></p>
<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt;">In the 1990s, Dr. Gupta contributed to the first ever clinical trial of a cell/gene therapy for familial hypercholesterolemia (high cholesterol), which results from a gene defect. He also showed that Wilson&rsquo;s disease (a genetic condition characterized by excessive accumulation of copper in the liver and brain) could potentially be cured by use of cell therapy.&nbsp;</span></p>

CHAM Provider
Off
Professional Title
M.B.,B.S.
M.D.
Selected Publications

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<li>Thirunavukkarasu C, Sharma Y, Tchaikovskaya T, Maslov AY, Gupta S. Transcriptional profiling reveals ataxia telangiectasia mutated pathways regulate joint copper and arsenic toxicity for hepatic metalloplasia and anti-cancer therapies. Life Sci. 2022 Jul 6;120787. doi: 10.1016/j.lfs.2022.120787.&nbsp;</li>
<li>Chang CJ, Ge EJ Bush AI, Casini A, Cobine PA, Cross JR, DeNicola GM, Dou Q, Franz KJ, Gohil VM, Gupta S, Kaler SG, Lutsenko S, Mittal V, Petris MJ, Polishchuk R, Ralle M, Schilsky ML, Tonks NK, Vahdat LK, Van Aelst L, Xi D, Yuan P, Brady DC. Connecting copper and cancer from transition metal signaling to metalloplasia in the clinic. Nat Rev Cancer 2022 Feb;22(2):102-113. doi: 10.1038/s41568-021-00417-2. Epub 2021 Nov 11. PMID: 34764459</li>
<li>Viswanathan P, Gupta P, Sharma Y, Maisuradze L, Bandi S, Gupta S. Caffeine disrupts ataxia telangiectasia mutated gene-related pathways and exacerbates acetaminophen toxicity in human fetal immortalized hepatocytes. Toxicology. 2021 May 7;457:152811. doi: 10.1016/j.tox.2021.152811. PMID: 33971260</li>
<li>Viswanathan P, Sharma Y, Jaber FL, Tchaikovskaya T, Gupta S. Transplanted hepatocytes rescue mice in acetaminophen-induced acute liver failure through paracrine signals for hepatic ATM and STAT3 pathways. FASEB J 2021 Apr;35(4):e21471. doi: 10.1096/fj.202002421R. PMID: 33683737</li>
<li>Jaber FL, Sharma Y, Mui BG, Kapoor S, Gupta S. Tumor necrosis factor directs allograft-related innate responses and its neutralization improves hepatocyte engraftment in rats. Am J Pathol 2021; 191(1):79-89. doi: 10.1016/j.ajpath.2020.09.014. Epub 2020 Oct 27. PMID: 33127336</li>
<li>Viswanathan P, Sharma Y, Gupta S. Ataxia telangiectasia mutated pathway disruption affects hepatic DNA and tissue damage in nonalcoholic fatty liver disease. Exp Mol Pathol. 2020 Apr; 113:104369. doi: 10.1016/j.yexmp.2020.104369. Epub 2020 Jan 7. PMID: 31917286</li>
<li>Gupta P, Sharma Y, Viswanathan P, Gupta S. Cellular receptor signaling and ATM pathway intersections regulate hepatic DNA repair. Cytokine 2020 Mar; 127:154946. doi: 10.1016/j.cyto.2019.154946. Epub 2019 Dec 11. PMID: 31837586</li>
<li>Bandi S, Tchaikovskaya T, Gupta S. Hepatic differentiation in human pluripotent stem cells by developmental stage-specific metabolomics products. Differentiation 2019; 105:54-70. Jan 28;105:54-70. doi: 10.1016/j.diff.2019.01.005. PMID: 30776728.</li>
<li>Kakabadze Z, Karalashvili L, Chakhunashvili D, Havlioglu N, Janelidze M, Kakabadze A, Sharma Y, Gupta S. Decellularized bovine placentome for portacavally-interposed heterotopic liver transplantation in rats. Mater Sci Eng C Mater Biol Appl. 2019 Apr; 97:293-301. doi: 10.1016/j.msec.2018.12.025. Epub 2018 Dec 10. PMID: 30678914.</li>
<li>Yadav N, Jaber FL, Sharma Y, Viswanathan P, Gupta S. Efficient reconstitution of hepatic microvasculature by endothelin receptor antagonism in liver sinusoidal endothelial cells. Hum Gene Ther 2018; Sep 28. doi: 10.1089/hum.2018.166. PMID: 30266073,&nbsp;</li>
<li>Sharma Y, Liu J, Kristian KE, Follenzi A, Gupta S. In Atp7b-/- mice modeling Wilson's disease liver repopulation with bone marrow-derived myofibroblasts or inflammatory cells and not hepatocytes is delterious.&nbsp;<span title="Gene expression">Gene Expr</span>. 2018 Jul 20. doi: 10.3727/105221618X15320123457380. PMID: 30029699</li>
<li>Bandi S, Gupta S, Tchaikovskaya T, Gupta S. Differentiation in stem/progenitor cells along fetal or adult hepatic stages requires transcriptional regulators independently of oscillations in microRNA expression.&nbsp;<span title="Experimental cell research">Exp Cell Res</span>. 2018 Sep 1;370(1):1-12. doi: 10.1016/j.yexcr.2018.06.004. Epub 2018 Jun 6.</li>
<li>Benten D, Kluwe J, Wirth JW, Thiele ND, Follenzi A, Bhargava KK, Palestro CJ, Koepke M, Tjandra R, Volz T, Lutgehetmann M, Gupta S. A humanized mouse model with liver fibrosis following expansion of transplanted hepatic stellate cells in injury and inflammation. Lab Invest 2018 Apr;98(4):525-536. doi: 10.1038/s41374-017-0010-7. Epub 2018 Jan 19.PMID: 29352225.</li>
<li>Viswanathan P, Sharma Y, Gupta P, Gupta S. Replicative stress and alterations in cell cycle checkpoint controls following acetaminophen hepatotoxicity restrict hepatic regeneration. Cell Prolif 2018; Jun;51(3):e12445. doi: 10.1111/cpr.12445. Epub 2018 Mar 5. PMID: 29504225.</li>
<li>Kakabadze Z, Kakabadze A, Chakhunashvili D, Karalashvili L, Berishvili E, Sharma Y, Gupta S. Decellularized human placenta supports hepatic tissue and allows rescue in acute liver failure. Hepatology 2018 May;67(5):1956-1969.&nbsp;PMID: 29211918.&nbsp;</li>
</ul>

EMR ID
3601
Is Open Scheduling
Off

Kira Gritsman

Submitted by Anonymous (not verified) on
Full Name
Kira Gritsman
Profile Image URL
https://documentapi-fargate-documentbucket-15qi4tpdvnhlz.s3.amazonaws.com/218/6b993220-5d55-11ef-92db-0be6da54f487.jpg
Type
Provider
Faculty
First Name
Kira
Last Name
Gritsman
NPI
1174598148
Faculty ID
14128
Clinical Terms
Employment Status
part-time
Patient Type
Adult
Department
einstein-dept-oncology
einstein-dept-medicine
einstein-dept-cell-biology
Gender
Female
Email
kira.gritsman@einsteinmed.edu
Phone
929-246-6707
Titles
Type
Academic
Department
Department of Oncology
Rank
Associate Professor
Division
Medical Oncology
Type
Academic
Department
Department of Medicine
Department Link
Rank
Associate Professor
Division
Oncology & Hematology
Type
Academic
Department
Department of Cell Biology
Department Link
Rank
Associate Professor
Type
Clinical
Title
Assistant Director of Correlative Clinical Research
Type
Administrative
Title
Co-Leader, Montefiore Einstein Comprehensive Cancer Center, Stem Cell & Cancer Biology Program
Tags
me-patientcare-cancer-clinical-aids-malignancies
me-patientcare-cancer-research-stem-cell-cancer-biology
Type
Administrative
Title
Betty and Sheldon Feinberg Senior Faculty Scholar in Cancer Research
Locations
Is Primary
On
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.88072 40.88002)
Address Line 1
111 East 210th Street
City
Bronx
State
NY
Zip
10461-2401
Location Title
Montefiore Medical Center
Is Primary
Off
Type
Academic
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.8459022 40.8504961)
Building
Chanin Building
Room
410A
Address Line 1
Albert Einstein College of Medicine
Address Line 2
Jack and Pearl Resnick Campus
Address Line 3
1300 Morris Park Avenue
City
Bronx
State
NY
Zip
10461
Location Title
Albert Einstein College of Medicine
Education and Trainings
Education Type Label
Medical Education
Education Institution
New York University School of Medicine
Education Type Label
Medical Education
Education Institution
New York University School of Medicine
Education Type Label
Medical Education
Education Institution
New York University School of Medicine
Education Type Label
Fellowship
Education Institution
Dana Farber Cancer Institute
Education Type Label
Fellowship
Education Institution
Dana-Farber Cancer Institute
Education Type Label
Residency
Education Institution
Columbia University Medical Center
Professional Interests

<p><strong>The Roles of Signaling Pathways in Adult Blood Development and Leukemia</strong></p>
<p><span style="font-size: 10.5pt; font-family: Verdana, sans-serif;">The Gritsman lab studies the signal transduction pathways that affect the early fate decisions of adult hematopoietic stem cells (HSCs) as they progress from an undifferentiated multipotent state to the generation of differentiated blood cells.&nbsp; When these early fate decisions go awry, this can lead to the formation of leukemia-initiating cells. We are interested in</span><span style="font-size: 10.5pt; font-family: Verdana, sans-serif;">&nbsp;how signaling pathways affect the self-renewal and differentiation of HSCs and malignant or pre-malignant stem cells in myeloid malignancies, such as acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), and myeloproliferative neoplasms (MPN).</span></p>
<p><strong>Roles of the PI3 kinase isoforms in adult blood development</strong></p>
<p>PI3 kinase (PI3K) is a lipid kinase that is important for the regulation of metabolism, the cell cycle, apoptosis, and protein synthesis. &nbsp;In hematopoietic cells, there are four isoforms of the catalytic subunit of PI3K, each encoded by a separate gene. &nbsp;Emerging evidence suggests that these isoforms have unique functions in normal and cancer cells, but may substitute for each other in some contexts.&nbsp; We have generated a series of mouse knockout models that allow us to study the roles of each of these isoforms individually in adult hematopoiesis.&nbsp; For example, we have found that the p110alpha isoform is most important for red cell development, but is not required in normal blood stem cells. We have now also generated compound knockout mice to determine the redundant roles of the PI3K isoforms in blood development. &nbsp;We recently reported that PI3K isoforms play important redundant roles during the hematopoietic stress response, such as after chemotherapy. However, deletion of all 3 Class IA PI3K isoforms leads to a phenotype with impaired HSC differentiation, resembling myelodysplastic syndrome (MDS). We are studying how deletion of PI3K will impact normal HSC function, including self-renewal, proliferation, and differentiation along different blood lineages by affecting processes such as autophagy and epigenetic regulation in HSCs.</p>
<p><strong>Roles of the PI3 kinase isoforms in leukemia</strong></p>
<p>Acute myeloid leukemia (AML) is a genetically diverse disease, but activation of the PI3K pathway has been reported in up to 80% of cases.&nbsp; A subset of AML cell lines and AML patient samples respond to PI3K pathway inhibitors, but it is unclear how patients should be selected for potential response to these inhibitors. &nbsp;We found that RAS-mutated myeloid leukemias are particularly dependent on the p110alpha isoform of PI3K, and that pharmacologic inhibition of p110alpha can be used to treat both RAS-mutated cell lines and RAS-mutated leukemia in mice. Furthermore, we use cell lines, patient samples, and mouse models of leukemia to investigate the mechanisms of resistance to PI3K inhibition, with the goal of identifying new drug targets and designing new combination treatments for leukemia that incorporate PI3K inhibitors.</p>
<p><strong>RON Kinase in Myeloproliferative Neoplasms</strong></p>
<p>The myeloproliferative neoplasms (MPNs) are a group of diseases that are caused by kinase mutations in HSCs, which lead to uncontrolled proliferation of myeloid cells. The Philadelphia chromosome-negative MPNs are characterized by mutations in the JAK/STAT signaling pathway, and respond to JAK inhibitors, but resistance often develops. We recently discovered that the receptor Tyrosine kinase RON can physically interact with JAK2 in MPN cells, leading to potentiation of JAK/STAT signaling in resistant cells. Furthermore, we found that pharmacologic or genetic inactivation of RON can inhibit proliferation of MPN cells and re-sensitize resistant cells to JAK inhibitors.</p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif;"><strong><span style="font-size: 10.5pt; font-family: Verdana, sans-serif; color: #201f1e;">Member of the Cancer Dormancy and Tumor Microenvironment Institute&nbsp;</span></strong></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif;">&nbsp;</p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif;"><span style="font-size: 10.5pt; font-family: Verdana, sans-serif;">&nbsp;</span><span style="font-size: 10.5pt; font-family: Verdana, sans-serif;">The Gritsman lab&rsquo;s research interests include the contributions of signaling pathways to leukemic and pre-leukemic stem cell dormancy in minimal residual disease, which includes mechanisms of immune evasion. Furthermore, the Gritsman lab is interested in the roles of inflammatory signaling pathways and of the local microenvironment in bone marrow fibrosis, and in the evolution of myeloid neoplasms from the pre-malignant to malignant state. Our major goals are to identify opportunities for therapeutic targeting to prevent the transition from the pre-leukemic state to leukemia, or to eliminate minimal residual disease to prevent relapse.</span></p>

Research Areas
roles of signaling pathways in hematopoietic stem cell self-renewal and differentiation, leukemic stem cells, targeting signaling pathways in hematologic malignancies
CHAM Provider
Off
Professional Title
M.D.
Ph.D.
Selected Publications

<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;"><a name="_GoBack"></a><span style="font-size: 11pt; font-family: Arial, sans-serif;">Ames, K.,&nbsp;<sup>&nbsp;</sup>Kaur,<sup>&nbsp;</sup>I., Shi, Y., Tong, M., Sinclair, T., Hemmati, S., Glushakow-Smith, S.G., Tein,&nbsp;&nbsp;E., Gurska, L., Steidl, U., Dubin, R., Shan, J., Montagna, C., Pradhan, K., Verma, A., and&nbsp;<strong><u>Gritsman, K.</u></strong>, Deletion of PI3-Kinase Promotes Myelodysplasia Through Dysregulation of Autophagy in Hematopoietic Stem Cells,&nbsp;<strong><em>Science Advances</em></strong><em>&nbsp;2023.&nbsp;</em>doi:&nbsp;<a href="https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fdoi.o…; target="_blank" rel="noopener"><span style="color: black; text-decoration: none;">10.1126/sciadv.ade8222</span></a><u>,&nbsp;</u>PMID:&nbsp;36812307</span></p>
<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;"><em><span style="font-size: 11pt; font-family: Arial, sans-serif;">&nbsp;</span></em></p>
<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;"><span style="font-size: 11pt; font-family: Arial, sans-serif;">Folgado Marco, V., Ames, K., Chuen, J.,&nbsp;<strong><u>Gritsman, K.</u></strong>&nbsp;&amp; Baker, N.,&nbsp;Haploinsufficiency of the essential gene&nbsp;<em>RpS12</em>&nbsp;causes defects in erythropoiesis and hematopoietic stem cell maintenance,&nbsp;<em>&nbsp;<strong>eLife</strong>&nbsp;</em>2023&nbsp;Jun 5;12:e69322. doi: 10.7554/eLife.69322.&nbsp;PMID:&nbsp;37272618</span></p>
<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;"><span style="font-size: 11pt; font-family: Arial, sans-serif;">&nbsp;</span></p>
<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;"><span style="font-size: 11pt; font-family: Arial, sans-serif;">Gurska, L.M., Okabe, R., Schurer, A., Tong, M.M., Soto, M., Choi, D., Ames, K., Glushakow-Smith, S., Montoya, A., Tein, E., Miles, L.A., Cheng, H., Hankey-Giblin, P., Levine, R.L., Goel, S., Halmos, B., and&nbsp;<strong><u>Gritsman, K.</u></strong>&nbsp;Crizotinib has Preclinical Efficacy in Philadelphia-negative Myeloproliferative Neoplasms,&nbsp;<strong><em>Clinical Cancer Research</em></strong>&nbsp;2022&nbsp;Dec 20:CCR-22-1763. doi: 10.1158/1078-0432.CCR-22-1763. PMID:&nbsp;36537918</span></p>
<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;"><span style="font-size: 11pt; font-family: Arial, sans-serif;">&nbsp;</span></p>
<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;"><span style="font-size: 11pt; font-family: Arial, sans-serif;">Gurska, L., Ames, K., and&nbsp;<strong><u>Gritsman, K</u></strong>, Signaling Pathways in Leukemic Stem Cells,&nbsp;</span><span style="font-size: 11pt; font-family: Arial, sans-serif; color: #333333; letter-spacing: 0.2pt; background-color: #fcfcfc;">In: Zhang H., Li S. (eds) Leukemia Stem Cells in Hematologic Malignancies.&nbsp;<strong>Advances in Experimental Medicine and Biology</strong>, vol 1143. Springer, Singapore</span><span style="font-size: 11pt; font-family: Arial, sans-serif;">, July 24, 2019, doi:&nbsp;<a href="https://doi.org/10.1007/978-981-13-7342-8_1"><span style="color: black; letter-spacing: 0.2pt; background-color: #fcfcfc; text-decoration: none;">https://doi.org/10.1007/978-981-13-7342-8_1</span></a><span style="letter-spacing: 0.2pt; background-color: #fcfcfc;">;&nbsp;</span>PMID:&nbsp;31338813, PMCID:&nbsp;<a href="http://www.ncbi.nlm.nih.gov/pmc/articles/pmc7249489/&quot; target="_blank" rel="noopener"><span style="color: black; text-decoration: none;">PMC7249489</span></a></span></p>
<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;">&nbsp;</p>
<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;"><span style="font-size: 11pt; font-family: Arial, sans-serif;">Hemmati, S., Sinclair, T., Tong, M., Bartholdy, B., Okabe, R.O., Ames, K., Ostrodka, L., Haque, T., Kaur, I., Mills, T. S., Agarwal, A., Pietras, E.M., Zhao, J.J., Roberts, T.M., and&nbsp;<strong><u>Gritsman, K.</u></strong>, PI3 kinase alpha and delta promote hematopoietic stem cell activation,&nbsp;<strong><em>JCI Insight&nbsp;</em></strong>2019&nbsp;doi.org/10.1172/jci.insight.125832</span></p>
<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;">&nbsp;</p>
<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;"><span style="font-size: 11pt; font-family: Arial, sans-serif;">Mitchell, K., Barreyro, L., Todorova, T., Taylor, S., Antony-Debre, I., Narayanagari, S., Carvajal, L., Leite, J., Piperdi, Z., Pendurti, G., Mantzaris, I., Paietta, E., Verma, A.,&nbsp;<strong><u>Gritsman, K.,&nbsp;</u></strong>and Steidl, U. IL1RAP potentiates multiple oncogenic signaling pathways in AML,&nbsp;<strong><em>Journal of&nbsp;Experimental Medicine</em></strong><em>.&nbsp;</em>2018 May 17. doi: 10.1084/jem.20180147,&nbsp;PMID: 29773641</span></p>
<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;">&nbsp;</p>
<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;"><span style="font-size: 11pt; font-family: Arial, sans-serif;">Hemmati, S., Haque, T., and&nbsp;<strong><u>Gritsman, K</u>,&nbsp;</strong>Inflammatory Signaling Pathways in Pre-leukemic and Leukemic Stem Cells,&nbsp;<strong><em>Frontiers in Oncology</em></strong><em>&nbsp;</em>2017 Nov 13;7:265. doi: 10.3389/fonc.2017.00265</span></p>
<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;">&nbsp;</p>
<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;"><span style="font-size: 11pt; font-family: Arial, sans-serif;">Bhagat, T.D., Chen, S., Bartenstein, M., Barlowe, A.T., Von Ahrens, D., Choudhary, G.S., Tivnan, P., Amin, E., Marcondes, M., Sanders, M.A., Hoogenboezem, R.M., Kambhampati, S., Ramanchandra, N., Mantzaris, I., Sukrithan, V., Laurence, R., Lopez, R. Bhagat, P., Giricz, O., Sohal, D., Wickrema, A., Yeung, C.,&nbsp;<strong><u>Gritsman, K.,</u></strong>&nbsp;Aplan, P., Hochedlinger, K., Yu, Y., Pradhan, K., Zhang, J., Greally, J.M., Mukherjee, S., Pellagatti, A., Boultwood, J., Will, B., Steidl, U., Raaijmakers, M.H.G.P., Deeg, H.J., Kharas, M.G. and Verma, A. Epigenetically Aberrant Stroma in MDS Propagates Disease Via Wnt/b-Catenin Activation, 2017&nbsp;<strong><em>Cancer Research</em></strong>&nbsp;2017 Jul 6. pii: canres.0282.2017. doi: 10.1158/0008-5472</span></p>
<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;">&nbsp;</p>
<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;"><span style="font-size: 11pt; font-family: Arial, sans-serif;">Yuzugullu, H., Baitsch, L., Von, T., Steiner, A., Tong, H., Ni, J., Clayton, L., Bronson, R., Roberts, T.,&nbsp;<strong><u>Gritsman, K</u></strong><u>.</u>, and Zhao, J.J. A p110b-Rac signaling loop mediates Pten-loss-induced perturbation of hematopoiesis and leukemogenesis.&nbsp;<strong><em>Nature Communication</em></strong><em>s&nbsp;</em>October 7,2015, doi:10.1038/NCOMMS9501</span></p>
<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;">&nbsp;</p>
<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;"><span style="font-size: 11pt; font-family: Arial, sans-serif;">Yoda, A., Adelmant, G., Tamburini, J., Chapuy, B., Shindoh, N., Yoda, Y., Weigert, O., Kopp, N., Wu, S-C., Kim, S., Liu, H., Tivey, T., Christie, A.L.,&nbsp;<strong><u>Gritsman, K.</u></strong>,&nbsp; Gotlib, J., Deininger, M., Turley, S., Tyner, J., Marto, J., Weinstock, D.M., and Lane, A.A. Mutations in G-protein beta subunits promote transformation and kinase inhibitor resistance&nbsp;<strong><em>Nature Medicine</em></strong><em>&nbsp;</em>2015 (1):71-5.</span></p>
<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;">&nbsp;</p>
<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;"><strong><u><span style="font-size: 11pt; font-family: Arial, sans-serif;">Gritsman, K</span></u></strong><strong><span style="font-size: 11pt; font-family: Arial, sans-serif;">.</span></strong><span style="font-size: 11pt; font-family: Arial, sans-serif;">, Yuzugullu, H., Von, T., Yan, H., Clayton, L., Fritsch, C., Maira, S.-M., Hollingworth, G., Choi, C., Khandan, T., Paktinat, M., Okabe, R.O., Roberts, T.M., and Zhao, J.J. &nbsp;Hematopoiesis and RAS-driven myeloid leukemia differentially require PI3K isoform p110alpha<strong>.&nbsp;<em>Journal of Clinical Investigation&nbsp;</em></strong>2014;124(4):1794&ndash;1809.&nbsp;http://www.jci.org/articles/view/69927</span></p&gt;
<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;">&nbsp;</p>
<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;"><span style="font-size: 11pt; font-family: Arial, sans-serif;">Kharas, M.G. and&nbsp;<strong><u>Gritsman, K</u></strong>. Akt: A Double-Edged Sword for Hematopoietic Stem Cells.&nbsp;<strong><em>Cell Cycle</em>&nbsp;</strong>2010; Vol 9; Issue 7</span></p>
<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;">&nbsp;</p>
<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;"><span style="font-size: 11pt; font-family: Arial, sans-serif;">Kharas, M.G., Okabe, R., Ganis, J.J., Gozo,M., Khandan,T., Paktinat, M., Gilliland, D.G., and&nbsp;<strong><u>Gritsman, K</u>.</strong>&nbsp;Constitutively Active AKT Depletes Hematopoietic Stem Cells and Induces Leukemia in Mice.&nbsp;<strong><em>Blood&nbsp;</em></strong>2010; 115(7): 140615&nbsp;http://www.bloodjournal.org/content/115/7/1406</span></p&gt;
<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;"><span style="font-size: 10.5pt; font-family: Verdana, sans-serif;">&nbsp;</span></p>
<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;"><span style="font-size: 10.5pt; font-family: Verdana, sans-serif;">&nbsp;</span></p>
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<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;">&nbsp;</p>

EMR ID
73180
Is Open Scheduling
Off

David S. Geller

Submitted by Anonymous (not verified) on
Full Name
David S. Geller
Profile Image URL
https://assets.montefioreeinstein.org/profiles/images/Geller_David_S_MD_2x.jpg
Type
Provider
Faculty
Expert
First Name
David
Last Name
Geller
NPI
1467437764
Faculty ID
10675
Clinical Terms
Employment Status
Full Time
Patient Type
Adult
Department
einstein-dept-orthopaedic-surgery
einstein-dept-pediatrics
Languages
Hebrew
Gender
Male
Email
dgeller@montefiore.org
Phone
718-920-2060
Titles
Type
Academic
Department
Department of Orthopaedic Surgery
Department Link
Rank
Professor
Type
Academic
Department
Department of Pediatrics
Department Link
Rank
Professor
Division
Pediatric Hematology-Oncology
Type
Clinical
Title
Co-Director, Orthopedic Oncology
Tags
me-patientcare-cancer-research-therapeutics
me-patientcare-cancer-clinical-aids-malignancies
me-patientcare-orthopedics-about-team-chiefs
Type
Clinical
Title
Vice-Chairman, Strategy and Innovation
Tags
me-patientcare-orthopedics-orthopediconcology
me-patientcare-orthopedics-about-team
Type
Clinical
Title
Associate Director, Musculoskeletal Oncology Lab
Type
Clinical
Title
Professor, Orthopedic Surgery and Pediatrics
Type
Administrative
Locations
Is Primary
On
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.87862 40.88032)
Address Line 1
3400 Bainbridge Avenue
City
Bronx
State
NY
Zip
10467-2404
Location Title
Montefiore Greene Medical Arts Pavilion
Is Primary
Off
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.88072 40.88002)
Address Line 1
111 East 210th Street
City
Bronx
State
NY
Zip
10467-2401
Location Title
Montefiore Medical Center
Is Primary
Off
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.99671 40.75115)
Address Line 1
435 W 31st Street, Suite 30
City
New York
State
NY
Zip
10001
Location Title
MEAC Manhattan West
Is Primary
Off
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.8820619 40.879953)
Address Line 1
111 East 210th Street
Address Line 2
Third Floor
City
Bronx
State
NY
Zip
10467
Location Title
Pediatric Oncology - Rosenthal 3
Is Primary
Off
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.7681117 41.0268898)
Address Line 1
122 Maple Avenue
City
White Plains
State
NY
Zip
10601
Location Title
White Plains Hospital Center for Advanced Medicine & Surgery
Is Primary
Off
Type
Academic
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.8785732 40.879979)
Building
MMC-MAP
Address Line 1
Montefiore Medical Center
Address Line 2
Medical Arts Pavilion
Address Line 3
3400 Bainbridge Avenue
City
Bronx
State
NY
Zip
10467
Location Title
Montefiore Medical Center
Education and Trainings
Education Type Label
Medical Education
Education Institution
Sackler School of Medicine, New York
Education Type Label
Fellowship
Education Institution
Massachusetts General Hospital
Education Type Label
Residency
Education Institution
Montefiore Medical Center
Professional Interests

<p>Dr. Geller is a full-time faculty member of the Orthopaedic Surgery Department at Montefiore Medical Center and serves as the director of the Orthopaedic Oncology Service, managing both pediatric and adult patients.&nbsp; He is the co-director of Orthopaedic Surgery at the Montefiore Medical Center Moses Campus and currently serves as the Quality Improvement Officer for the Montefiore Cancer Committee.&nbsp; His clinical focus involves primary and metastatic bone and soft tissue tumors, with a secondary interest in joint replacement in the setting of extensive bone loss.&nbsp; He has experience in navigation-guided surgery, allograft reconstruction, endoprosthetic reconstruction, and use of custom or patient-tailored reconstructive prostheses.&nbsp; His research interests include expression patterns in osteosarcoma, surgical margins in osteosarcoma, novel drug screening methods and targeted therapy for osteosarcoma using novel therapeutic modalities.&nbsp; He is extensively involved in resident and medical student education.</p>

Specialties
Expert Tags
Areas of Expertise
Musculoskeletal oncology and joint replacement (adult and pediatric)
Limb sparing surgical techniques
Innovative surgical treatments and patient-tailored implants for those who suffer from osteosarcoma and other primary bone tumors
Expert Summary

<p>Dr. Geller is an orthopaedic surgeon specializing in musculoskeletal oncology and joint replacement, and his practice encompasses adult and pediatric patients. Dr. Geller’s research interests include surface receptor expression in osteosarcoma and potential targeted therapies for the treatment of osteosarcoma. He has developed a novel murine xenograft model for osteosarcoma for the evaluation of surgical margins in osseous tumor surgery. His research additionally includes allograft bone reconstruction techniques, resonance frequency changes during joint reconstruction and pain management in the elderly orthopaedic population.</p>

CHAM Provider
Off
Professional Title
M.D.
Clinical Focus

<p>Orthopedic oncology, orthopedic surgery, bone and soft tissue sarcomas, benign bone and soft-tissue tumors, metastatic carcinoma on the bone </p>

Research Focus

<p>Osteosarcoma, with an interest in innovative treatment strategies for both local disease control and metastatic disease; evaluation of expression patterns in osteosarcoma and surgical margins using a xenograft osteosarcoma murine model; the functional role of bone morphogenetic proteins in osteosarcoma surgery; use of intraoperative navigation techniques for tumor surgery; tumorigenesis of osteosarcoma </p>

PubMed.gov URL
Selected Publications

<ul>
<li>Morris J, Dutcher J, <strong>Geller DS</strong>. Revisiting the Orhtopaedic Management of Metastatic Renal Cell Carcinoma: Rationale for a More Aggressive Approach. <em>Current Orthopaedic Practice. </em>2013 Sept/Oct; 24(5):547-551.</li>
<li>Bekarev M, Elsinger EC, Villanueva-Siles E, Borzykowski RM, <strong>Geller DS.</strong> Synovial Sarcoma of the Foot. <em>Journal of Foot and Ankle Surgery</em>. 2013 Jul-Aug; 52(4):513-7. doi: 10.1053</li>
<li>Capogna BM, Lovy A, Blum Y, Kim SJ, Flesen UR, <strong>Geller DS.</strong> Infection Rate Following Total Joint Arthroplasty in the HIV Population. <em>Journal of Arthroplasty</em>. 2013 Sep; 28(8):1254-8. doi: 10.1016</li>
<li>Lall A, Hohn E, Kim M, Gorlick R, Abraham J, <strong>Geller DS</strong>. Comparison of Surface Area Across the Allograft-Host Junction Site Using Conventional and Navigated Osteotomy Technique. <em>Sarcoma</em>. 2012; 2012:197540.&nbsp;</li>
<li>Piperdi S, Austin-Page L, <strong>Geller DS</strong>, Ahluwalia M, Gorlick S, Gill J, Sellers R, Zhang W, Li N, Ching Sohak, Gorlick R. Beta-Catenin Does Not Confer Tumorigenicity when Introduced into Partially Transformed Human Mesenchymal Stem Cells.<em> Sarcoma</em>. 2012. Epub 2012 Oct 18.</li>
<li>Crocco L, Gorlick R,<strong> Geller DS</strong>. Current Practice Management Regarding Thromboembolic Prophylaxis Within the Pediatric Sarcoma Patient Population, <em>Journal of Pediatric Hematology/Oncology</em>.2012 Sep 19. [Epub ahead of print]</li>
<li>&nbsp;Hall GL, Villanueva-Siles E, Borzykowski RM, Gruson KI, Dorfman HD, <strong>Geller</strong> <strong>DS</strong>. Aspergillus osteomyelitis of the proximal humerus: a case report. <em>Skeletal Radiology</em>. 2012 Aug; 41(8):1021-5. Epub 2012 Mar 31.</li>
<li>Sambaziotis C, Plymale M, Lovy A, O&rsquo;Halloran K, McCulloch K, <strong>Geller DS</strong>. Pseudoaneurysm of the Distal Thigh after Manipulation of a Total Knee Arthroplasty. <em>Journal of Arthroplasty</em>. 2012 Aug; 27(7); 1414.</li>
<li>Shakked RJ, <strong>Geller DS</strong>, Gorlick R, Dorfman HD. Mesenchymal chondrosarcoma: Clinicopathologic study of 20 cases. <em>The Archives of Pathology &amp; Laboratory Medicine</em>.&nbsp; 2012 Jan; 136(1):61-75.</li>
<li>Hohn E, Garfein ES, Mehta KJ, <strong>Geller DS. </strong>Quadriceps Tendon Allograft Augmentation after Wide Excision of a Soft Tissue Sarcoma. <em>Current Orthopaedic Practice</em>. 2012 Jan/Feb; 23(1):68-71.</li>
<li>Singh CK, <strong>Geller DS. </strong>The Telescopic Mating Technique for Bulk Allograft Reconstruction. <em>Orthopaedics</em>. 2012 Feb; 35(2):118-124.</li>
<li>Sambaziotis C, Lovy A, Moadel RM, Chamarthy M, Glaser J, Jaini S, Villanueva-Siles E, <strong>Geller DS</strong>. Florine-18 Fluorodeoxyglucose Positron Emission Tomography for Osteochondromas Utilizing a Triple-Time Point Protocol.&nbsp; <em>Open Journal of Medical Imaging</em>. 2011 Dec; 1(2):15-20.</li>
<li>Hassan SE, Bekarev M, Kim MY, Lin J, Piperdi S, Gorlick R, <strong>Geller DS. </strong>Cell Surface Receptor Expression Patterns in Osteosarcoma. <em>Cancer.</em> 2011 Feb 1; 118(3):740-9.</li>
<li>Plymale M, Lovy A, Villanueva-Siles E, <strong>Geller DS.</strong> Isolated intra-articular pseudorheumatoid nodule of the knee.<em> Skeletal Radiology</em>. 2011 Apr; 40(4):463-6.</li>
<li>Green MC, Dorfman HD, Villanueva-Siles E, Gorlick RG, Thornhill BA, Weber RV, <strong>Geller DS. </strong>Aggressively Recurrent Infantile Myofibroma of the Axilla and Shoulder Girdle. A Case Report. <em>Skeletal Radiology</em>.2010 Mar; 40(3):357-61.</li>
<li><strong>Geller DS</strong>, Pope JB, Thornhill BA, Dorfman, HD. Cryptococcal pyarthrosis and sarcoidosis. <em>Skeletal Radiol</em>. 2009 Jul; 38(7):721-7.</li>
<li>Sah A, <strong>Geller DS</strong>, Mankin HJ, Delaney T, Rosenberg A, Wright C, Hornicek FJ. Malignant Transformation of Synovial Chondromatosis of the Shoulder to Chondrosarcoma - A Case Report," <em>Journal of Bone and Joint Surgery. </em>2007 Jun; 89(6):1321-8.</li>
<li><strong>Geller DS</strong>, Hornicek FJ, Mankin HJ, Raskin KA. &ldquo;Soft Tissue Sarcoma Resection Volume Associated with Wound-Healing Complications,&rdquo; <em>Clinical Orthopaedics and Related Research.</em> 2007; 457:182-5.</li>
<li>Ames JA, Abraham JA, <strong>Geller DS</strong>, Goldsmith J, Gebhardt MC.&nbsp; Proximal Tibial Lesion in a Young Adult: Early Diagnosis Allowing Unique Reconstruction.&nbsp; <em>The Orthopaedic Journal at Harvard Medical School.</em> 2006 Aug: 143-7.</li>
<li>Gardner MJ, Yacoubian S, <strong>Geller DS</strong>, Pode M, Mintz D, Helfet&nbsp; DL,&nbsp; Lorich DG. &ldquo;Prediction of Soft-Tissue Injuries in Schatzker II Tibial Plateau Fractures based on Measurements of Plain Radiographs,&rdquo; <em>Journal of Trauma-Injury Infection &amp; Critical Care</em>. 2006; 60(2):319-324.</li>
<li>Steinberg EL, <strong>Geller DS</strong>, Yacoubian SV, Shasha N, Dekel S, Lorich DG. &ldquo;Intramedullary Fixation of Tibial Shaft Fractures Using an Expandable Nail,&rdquo; <em>Journal of Orthopaedic Trauma.&nbsp; </em>2006 May; 20(5):303-9.</li>
<li>Gardner, MJ, Yacoubian S, <strong>Geller DS</strong>, Suk M, Mintz D, Potter H, Helfet DL, Lorich DG. &ldquo; The Incidence of Soft Tissue Injury in Operative Tibial Plateau Fractures,&rdquo; <em>Journal of Orthopaedic Trauma</em>.&nbsp; 2005; 19:79-84.</li>
<li>Lorich DG, Yacoubian SV, <strong>Geller DS</strong>. &ldquo;Intramedullary Fixation of Humeral Shaft Fractures Using an Inflatable Nail,&rdquo; <em>Orthopaedics</em>. 2003 Oct; 26(10):1011-4.</li>
<li>Lorich DG, <strong>Geller DS</strong>, Yacoubian SV, Leo AJ, Helfet DL. &ldquo;An Innovative Mode of Intramedullary Fixation,&rdquo; <em>International Review of Modern Surgery</em>, March 2002.</li>
<li>Westrich GH, <strong>Geller DS</strong>, O&rsquo;Malley MJ, Deland JT, Helfet DL. &ldquo;Anterior Iliac Crest Bone Graft Harvesting Using the Cortico-Cancellous Reamer System,&rdquo; <em>Journal of Orthopaedic Trauma</em>. 2001 Sep-Oct; 15(7):500-6.</li>
</ul>

EMR ID
4324
Biography

<p>David S. Geller is a board-certified orthopedic oncologist who specializes in the treatment of both pediatric and adult patients with bone and soft-tissue tumors. He has been a full-time faculty member at Montefiore since 2006. He is an Associate Professor of Orthopedic Surgery and Pediatrics at our Albert Einstein College of Medicine.</p><p>Dr. Geller is known for his expertise in musculoskeletal tumor surgery, with specific experience in bone and soft-tissue sarcomas, such as osteosarcoma, Ewing's sarcoma, liposarcoma and synovial sarcoma. He has extensive experience in managing patients with metastatic carcinoma of the bone as well. He routinely offers limb-salvage surgery using a wide array of reconstructive tools.</p><p>Dr. Geller earned his medical degree from Tel Aviv University's Sackler School of Medicine and completed an orthopedic surgery residency at Montefiore. He received his fellowship training from the Harvard Combined Orthopedic Oncology Program, which included Massachusetts General Hospital, Boston Children's Hospital, and Beth Israel Deaconess Medical Center.</p><p>Dr. Geller serves as the Associate Director of the Musculoskeletal Oncology Research Laboratory at Montefiore. He leads numerous translational research efforts designed to investigate the pathophysiology and molecular mechanisms of bone and soft tissue cancers. He is interested in improved surgical techniques and novel therapeutic approaches for primary malignant bone tumors. He is actively involved in collaborative clinical trials both nationally and internationally.</p><p>Dr. Geller is an active member of the American Academy of Orthopedic Surgeons, Muskuloskeletal Tumor Society, Connective Tissue Oncology Society, Children's Oncology Group, American Orthopedic Association, and the American Association for Cancer Research.</p>

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Ellen Wolkin Friedman

Submitted by Anonymous (not verified) on
Full Name
Ellen Wolkin Friedman
Profile Image URL
https://documentapi-fargate-documentbucket-15qi4tpdvnhlz.s3.amazonaws.com/218/5f748650-3937-11ed-a06a-83625b154202.jpg
Type
Provider
Faculty
First Name
Ellen
Last Name
Friedman
NPI
1215026539
Faculty ID
2007
CMO Specialties
Clinical Terms
Employment Status
part-time
Patient Type
Adult
Department
einstein-dept-oncology
einstein-dept-medicine
Gender
Female
Email
elfriedm@montefiore.org
Phone
718-920-4137
Titles
Type
Academic
Department
Department of Oncology
Rank
Associate Professor
Division
Hematology
Type
Academic
Department
Department of Medicine
Department Link
Rank
Associate Professor
Division
Oncology & Hematology
Type
Clinical
Title
Acting Director, Sickle Cell Program
Tags
me-patientcare-sicklecell-about-team
Type
Administrative
Locations
Is Primary
On
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.88072 40.88002)
Address Line 1
111 East 210th Street
City
Bronx
State
NY
Zip
10461-2401
Location Title
Montefiore Medical Center
Is Primary
Off
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.84563 40.84596)
Address Line 1
1575 Blondell Avenue
City
Bronx
State
NY
Zip
10461-2601
Location Title
Montefiore Medical Park at 1575 Blondell
Is Primary
Off
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.88263 40.87994)
Address Line 1
60 East 208th Street
City
Bronx
State
NY
Zip
10467
Location Title
Montefiore at 60 East 208th Street
Is Primary
Off
Type
Academic
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.8782381 40.8799784)
Address Line 1
Montefiore Medical Center
Address Line 3
3411 Wayne Avenue
City
Bronx
State
NY
Zip
10467
Location Title
Montefiore Medical Center
Education and Trainings
Education Type Label
Medical Education
Education Institution
New York University School of Medicine
Education Type Label
Fellowship
Education Institution
New York University Medical Center
Education Type Label
Residency
Education Institution
Bellevue Hospital
Professional Interests

<p>Dr. Ellen Friedman&rsquo;s passion is the study of the blood (hematology) and ensuring that the next generation of medical practitioners are prepared to analyze and treat blood-related problems.</p>
<p>Dr. Friedman has been the Hematology Fellowship Director of Montefiore Medical Center/Albert Einstein College of Medicine since 2005. She completed a fellowship in hematology at New York University, specializing in the conditions of red cells, platelets and hematologic malignancies. She has been engaged in diagnosing and treating these conditions while simultaneously teaching medical students, medical residents and fellows in the skills and knowledge required. She trained at New York Hospital/Cornell, Bellevue, New York University and has been an attending physician in teaching programs in New York City her entire career. She has 40 years of experience in caring for patients in the Bronx both in the city hospitals and at Montefiore/Albert Einstein College of Medicine. Dr. Friedman also educates patients, lecturing nationally for National Organization of Rare Diseases and the Aplastic Anemia &amp; MDS International Foundation.</p>
<p>Dr. Friedman was elected Fellow in the American College of Physicians and is an Associate Professor of Clinical Medicine at Einstein. Her teaching has been recognized with the Best Teacher Award by the hematology-oncology fellows. Her research has focused on a variety of blood conditions including anemia, thrombocytopenia, myelodysplastic syndrome, and the safe performance of the bone marrow procedure.</p>

CHAM Provider
Off
Professional Title
M.D.
Selected Publications

<ol>
<li>Dai, T, Friedman E, Barta S. Ruxolitinib Withdrawal Syndrom Leading to Tumor Lysis. JCO 2013 June 10.</li>
<li>Lam A, Guandabolu K, Sridharan A, Jain R, Pavlos M, Chrysofakis G, Yu Y, Friedman, E, Price E, Schrier S, Verma A. Multiplicative Interaction Between Mean Corpuscular Volume and Red Cell Distribution Width in Predicting Mortality of Elderly Patients with and without Anemia. American Journal of Hematology, 2013 July 5.</li>
<li>Bhavana Konda, Swati Pathak, Inga Edwin, Priti Mishall, Sherry A. Downie, Todd R. Olson, Louis J. Reed and Ellen W. Friedman. Safe and Successful Bone Marrow Biopsy: An Anatomical and CT-Based Cadaver Study. Am. J. Hematol. 00:000-000, June 2014.</li>
</ol>

EMR ID
3276
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Daniel T. Friedman

Submitted by Anonymous (not verified) on
Full Name
Daniel T. Friedman
Profile Image URL
https://documentapi-fargate-documentbucket-15qi4tpdvnhlz.s3.amazonaws.com/218/880f93d0-7e92-11ec-9d5a-db3fba8c54fb.jpg
Type
Provider
Faculty
First Name
Daniel
Last Name
Friedman
NPI
1538180252
Faculty ID
14639
Clinical Terms
Employment Status
Full Time
Patient Type
Adult
Department
einstein-dept-oncology
einstein-dept-medicine
Gender
Male
Email
dfriedma@montefiore.org
Phone
718-405-1700
Titles
Type
Academic
Department
Department of Oncology
Rank
Assistant Professor
Tags
me-patientcare-cancer-research-therapeutics
Division
Medical Oncology
Type
Academic
Department
Department of Medicine
Department Link
Rank
Assistant Professor
Division
Oncology & Hematology
Type
Administrative
Locations
Is Primary
On
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.88263 40.87994)
Address Line 1
60 East 208th Street
City
Bronx
State
NY
Zip
10467
Location Title
Montefiore at 60 East 208th Street
Is Primary
Off
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.84563 40.84596)
Address Line 1
1575 Blondell Avenue
City
Bronx
State
NY
Zip
10461-2601
Location Title
Montefiore Medical Park at 1575 Blondell
Is Primary
Off
Type
Academic
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.8822305 40.8791652)
Address Line 1
Montefiore Medical Center
Address Line 3
60 East 208th Street
City
Bronx
State
NY
Zip
10467
Location Title
Montefiore Medical Center
Education and Trainings
Education Type Label
Medical Education
Education Institution
Cornell University Medical College
Education Type Label
Fellowship
Education Institution
Montefiore Medical Center
Education Type Label
Residency
Education Institution
Montefiore Medical Center
CHAM Provider
Off
Professional Title
M.D.
EMR ID
4745
Biography

<p>Daniel T. Friedman, MD, is Director, Community Hematology/Oncology at Montefiore Einstein and Assistant Professor, Medical Oncology at our Albert Einstein College of Medicine. He delivers community-focused care for hematology and medical oncology patients in the Bronx and Yonkers.</p><p>After earning his Doctor of Medicine from Cornell University Medical College in 1999, Dr. Friedman completed his internship and residency in internal medicine at Montefiore Einstein in 2002. He remained at Montefiore Einstein to complete an oncology fellowship in 2005.</p><p>Dr. Friedman's research has been focused on treatment outcomes and access to care. His work has been published in peer-reviewed journals and abstracts.</p><p>Dr. Friedman is board certified in Medical Oncology and Hematology.</p>

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Joseph D. Frager

Submitted by Anonymous (not verified) on
Full Name
Joseph D. Frager
Profile Image URL
https://documentapi-fargate-documentbucket-15qi4tpdvnhlz.s3.amazonaws.com/218/c3767690-0092-11ee-908e-e75af2693d3a.jpg
Type
Provider
Faculty
First Name
Joseph
Last Name
Frager
NPI
1992705974
Faculty ID
6662
CMO Specialties
Clinical Terms
Employment Status
Full Time
Patient Type
Adult
Department
einstein-dept-medicine
Languages
Hebrew
French
Spanish
Gender
Male
Email
jfrager@montefiore.org
Phone
718-239-0115
Titles
Type
Academic
Department
Department of Medicine
Department Link
Rank
Assistant Professor
Tags
me-patientcare-transplant-pediatric
Division
Gastroenterology
Type
Clinical
Title
Attending Physician
Type
Clinical
Title
Assistant Professor of Medicine
Type
Administrative
Locations
Is Primary
Off
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.84286 40.84649)
Address Line 1
1200 Waters Place
City
Bronx
State
NY
Zip
10461
Location Title
New York GI Center, LLC
Is Primary
On
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.84154 40.84612)
Address Line 1
1250 Waters place
City
Bronx
State
NY
Zip
10461-2720
Location Title
Montefiore at 1250 Waters Place
Is Primary
Off
Type
Academic
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.839137 40.8526781)
Building
Tower 1
Room
1201
Address Line 1
Montefiore Medical Center
Address Line 3
1250 Waters Place
City
Bronx
State
NY
Zip
10461
Location Title
Montefiore Medical Center
Education and Trainings
Education Type Label
Medical Education
Education Institution
University of Pennsylvania
Education Type Label
Fellowship
Education Institution
Montefiore Medical Center
Education Type Label
Residency
Education Institution
Montefiore Medical Center
CHAM Provider
Off
Professional Title
M.D.
Clinical Focus

<p>Dr. Frager specializes in disorders of the Colon and Upper GI Tract including: Colon Polyps, Diverticulitis, Peptic Ulcer Disease, Gastroesophageal Reflux and Gallstones.</p>

Research Focus

<p>Immunology of the GI Tract</p>

EMR ID
3272
Biography

<p>Joseph Frager, MD, is an Attending Physician in Gastroenterology and Assistant Professor of Medicine at Montefiore Einstein. Dr. Frager specializes in the diagnosis and treatment of disorders of the colon and upper gastrointestinal tract including colon polyps, diverticulitis, peptic ulcer disease, gastroesophageal reflux and gallstones.</p><p>After earning his Doctor of Medicine from University of Pennsylvania School of Medicine in 1980, Dr. Frager came to Montefiore for his postgraduate training. He completed his internal medicine internship and residency in 1983, followed by his fellowship in gastroenterology in 1985.</p><p>Dr. Frager&rsquo;s research focus is on the immunology of the gastrointestinal tract. He has shared his work through peer-reviewed journals and abstracts.</p><p>Dr. Frager is board certified in Internal Medicine by the American Board of Internal Medicine. He is a member of the American College of Gastroenterology, the American Gastroenterology Association and the New York Society for Gastrointestinal Endoscopy.</p>

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Brett E. Fortune

Submitted by Anonymous (not verified) on
Full Name
Brett E. Fortune
Profile Image URL
https://documentapi-fargate-documentbucket-15qi4tpdvnhlz.s3.amazonaws.com/218/bd026af0-c49b-11ec-b83c-ebcf060bac15.jpeg
Type
Provider
Faculty
First Name
Brett
Last Name
Fortune
NPI
1720121585
Faculty ID
17475
CMO Specialties
Employment Status
Full Time
Patient Type
Adult
Department
einstein-dept-medicine
Gender
Male
Email
bfortune@montefiore.org
Phone
718-920-7561
Titles
Type
Academic
Department
Department of Medicine
Department Link
Rank
Associate Professor
Tags
me-patientcare-transplant-pediatric
Division
Hepatology
Type
Clinical
Title
Medical Director, Liver Transplant Program
Tags
me-patientcare-transplant-team
Type
Clinical
Title
Associate Professor of Medicine
Type
Administrative
Locations
Is Primary
On
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.88072 40.88002)
Address Line 1
111 East 210th Street
City
Bronx
State
NY
Zip
10461-2401
Location Title
Montefiore Medical Center
Is Primary
Off
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.84544 40.84518)
Address Line 1
1621 Eastchester Road
City
Bronx
State
NY
Zip
10461-2301
Location Title
Montefiore Medical Group-Comprehensive Family Care Center (CFCC)
Is Primary
Off
Type
Academic
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.8798833 40.8799447)
Building
Rosenthal Pavilion
Room
218
Address Line 1
Montefiore Medical Center
Address Line 3
111 East 210th Street
City
Bronx
State
NY
Zip
10467
Location Title
Montefiore Medical Center
Education and Trainings
Education Type Label
Medical Education
Education Institution
Wake Forest University School of Medicine
Education Type Label
Fellowship
Education Institution
University of Colorado
Education Type Label
Residency
Education Institution
Ohio State University Medical Center
Professional Interests

<p>Brett E. Fortune, MD, MSc, is Medical Director, Liver Transplant Program, and Associate Professor, Medicine at Montefiore Einstein. His clinical focus centers on providing care for patients with advanced liver disease and those who need or have received liver transplantation.</p>
<p>After obtaining his Bachelor of Science in biological sciences in 1999 from North Carolina State University, Dr. Fortune earned his Doctor of Medicine from Wake Forest University School of Medicine in 2004. He then completed an internship and residency in internal medicine at The Ohio State University Medical Center in 2007. After this, he participated in a gastroenterology fellowship at the University of Colorado Denver, where he also earned his Master of Science in clinical sciences, completing both in 2011. Dr. Fortune remained there for another year to participate in a transplant hepatology fellowship, which he completed in 2012.</p>
<p>Dr. Fortune&rsquo;s research focuses on clinical outcomes related to cirrhosis and portal hypertension complications as well as quality improvement in the care of patients with cirrhosis or those who have received a liver transplant. His work has been published in numerous peer-reviewed journals or books. He is currently Associate Editor for Liver Transplantation and Liver Section Editor for Digestive Disease Interventions, and has sat on the editorial board for Hepatology.</p>
<p>Dr. Fortune is board certified in Internal Medicine, Gastroenterology and Transplant Hepatology by the American Board of Internal Medicine. He is a member of many professional organizations, such as the American Association for the Study of Liver Diseases (AASLD), the American Gastroenterology Association (AGA) and the American Liver Foundation. Dr. Fortune won the Kushlan Junior Faculty Award, Section of Digestive Diseases in 2015 and the Howard M. Spiro Digestive Disease Fellowship Teaching Award in 2016 from Yale School of Medicine.</p>

CHAM Provider
Off
Professional Title
M.D.
EMR ID
P1004568
Biography

<p>Brett E. Fortune, MD, MSc, is Medical Director, Liver Transplant Program, and Associate Professor, Medicine at Montefiore Einstein. His clinical focus centers on providing care for patients with advanced liver disease and those who need or have received liver transplantation.</p><p>After obtaining his Bachelor of Science in biological sciences in 1999 from North Carolina State University, Dr. Fortune earned his Doctor of Medicine from Wake Forest University School of Medicine in 2004. He then completed an internship and residency in internal medicine at The Ohio State University Medical Center in 2007. After this, he participated in a gastroenterology fellowship at the University of Colorado Denver, where he also earned his Master of Science in clinical sciences, completing both in 2011. Dr. Fortune remained there for another year to participate in a transplant hepatology fellowship, which he completed in 2012.</p><p>Dr. Fortune&rsquo;s research focuses on clinical outcomes related to cirrhosis and portal hypertension complications as well as quality improvement in the care of patients with cirrhosis or those who have received a liver transplant. His work has been published in numerous peer-reviewed journals or books. He is currently Associate Editor for <em>Liver Transplantation</em> and Liver Section Editor for <em>Digestive Disease Interventions</em>, and has sat on the editorial board for <em>Hepatology</em>.</p><p>Dr. Fortune is board certified in Internal Medicine, Gastroenterology and Transplant Hepatology by the American Board of Internal Medicine. He is a member of many professional organizations, such as the American Association for the Study of Liver Diseases (AASLD), the American Gastroenterology Association (AGA) and the American Liver Foundation. Dr. Fortune won the Kushlan Junior Faculty Award, Section of Digestive Diseases in 2015 and the Howard M. Spiro Digestive Disease Fellowship Teaching Award in 2016 from Yale School of Medicine.</p>

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Barry J. Fomberstein

Submitted by Anonymous (not verified) on
Full Name
Barry J. Fomberstein
Profile Image URL
https://assets.montefioreeinstein.org/profiles/images/physphoto/Fomberstein_Barry_MD-11.jpg
Type
Provider
Faculty
First Name
Barry
Last Name
Fomberstein
NPI
1417007261
Faculty ID
13988
CMO Specialties
Clinical Terms
Employment Status
Full Time
Patient Type
Adult
Department
einstein-dept-medicine
Languages
Spanish
Gender
Male
Email
bfombers@montefiore.org
Phone
718-920-9945
Titles
Type
Academic
Department
Department of Medicine
Department Link
Rank
Associate Professor
Division
Rheumatology
Locations
Is Primary
On
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.84154 40.84612)
Address Line 1
1250 Waters place
City
Bronx
State
NY
Zip
10461-2720
Location Title
Montefiore at 1250 Waters Place
Is Primary
Off
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.86049 40.89552)
Address Line 1
4234 Bronx Boulevard
City
Bronx
State
NY
Zip
10466-2611
Location Title
Montefiore Medical Group-Wakefield Ambulatory Care Center
Is Primary
Off
Type
Academic
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.861005 40.8939411)
Address Line 1
Montefiore Medical Center - Wakefield
Address Line 3
600 East 233rd Street
City
Bronx
State
NY
Zip
10466
Location Title
Montefiore Medical Center - Wakefield
Education and Trainings
Education Type Label
Medical Education
Education Institution
Albert Einstein College of Medicine
Education Type Label
Fellowship
Education Institution
Long Island Jewish Medical Center
Education Type Label
Residency
Education Institution
Long Island Jewish Medical Center
Professional Interests

<p>Dr. Barry J. Fomberstein is Associate Professor of Clinical Medicine (Rheumatology) at Albert Einstein College of Medicine and a practicing rheumatologist at Montefiore Medical Center. He graduated from Albert Einstein College of Medicine in 1976, and did his residency and fellowship at Long Island Jewish Medical Center.</p>
<p>Prior to arriving at Our Lady of Mercy Medical Center in 1992, Dr. Fomberstein was a full-time attending for nine years in the Department of Medicine at St John&rsquo;s Episcopal Hospital in Far Rockaway, where he first became actively involved in the process of residency training. He is a fellow of the American College of Physicians (FACP), as well as a fellow of the American College of Rheumatology (FACR).</p>

CHAM Provider
Off
Professional Title
M.D.
EMR ID
4595
Visit Type ID
2528
Is Open Scheduling
On

Jennifer G. Davila

Submitted by Anonymous (not verified) on
Full Name
Jennifer G. Davila
Profile Image URL
https://documentapi-fargate-documentbucket-15qi4tpdvnhlz.s3.amazonaws.com/218/b6cb4d40-5ef8-11ec-a8ce-d9da2e730b48.jpg
Type
Provider
Faculty
First Name
Jennifer
Last Name
Davila
NPI
1417265331
Faculty ID
14331
Clinical Terms
Employment Status
Full Time
Patient Type
Pediatric
Department
einstein-dept-pediatrics
Gender
Female
Email
jedavila@montefiore.org
Phone
718-741-2342
Titles
Type
Academic
Department
Department of Pediatrics
Department Link
Rank
Associate Professor
Division
Pediatric Hematology-Oncology
Type
Clinical
Title
Co-Director, Hemophilia Treatment Center at Montefiore
Type
Clinical
Title
Associate Professor of Pediatrics
Type
Clinical
Type
Administrative
Locations
Is Primary
On
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.87885 40.88037)
Address Line 1
3415 Bainbridge Avenue
City
Bronx
State
NY
Zip
10467-2403
Location Title
The Children's Hospital at Montefiore
Is Primary
Off
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.84154 40.84612)
Address Line 1
1250 Waters place
City
Bronx
State
NY
Zip
10461-2720
Location Title
Montefiore at 1250 Waters Place
Is Primary
Off
Type
Academic
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.8782381 40.8799784)
Address Line 1
Montefiore Medical Center
Address Line 3
3411 Wayne Avenue
City
Bronx
State
NY
Zip
10467
Location Title
Montefiore Medical Center
Education and Trainings
Education Type Label
Medical Education
Education Institution
Ross University School of Medicine
Education Type Label
Fellowship
Education Institution
Memorial Sloan Kettering Cancer Center
Education Type Label
Residency
Education Institution
SUNY Downstate
CHAM Provider
On
Professional Title
M.D.
Clinical Focus

Diagnosis and management of children with thrombosis, hemophilia and rare bleeding disorders.

Research Focus

Her primary areas of academic interest include quality improvement efforts to improve thrombosis risk assessment in the pediatric population, specifically elucidating the thrombosis risk in patients with sickle cell disease.

EMR ID
68832
Biography

<p>Jennifer G. Davila, MD, is Co-Director, Hemophilia Treatment Center at Montefiore Einstein and Associate Professor, Pediatrics at our Albert Einstein College of Medicine. Dr. Davila focuses on the care of children with bleeding and clotting disorders.</p><p>After obtaining her Bachelor of Science in psychobiology from the State University of New York at Binghamton in 2000, Dr. Davila earned her Doctor of Medicine at Ross University School of Medicine in 2007. She completed her pediatrics internship and residency at the State University of New York Downstate Medical Center in 2010. Dr. Davila continued her medical training at Memorial Sloan Kettering Cancer Center/Weill-Cornell Medical College, completing a pediatric hematology/oncology fellowship in 2013 where she was Chief Fellow in her final year. She also completed a research fellowship at the same institution in 2014.</p><p>Dr. Davila's research focuses on thrombosis prevention in children. She has been primary investigator and co-primary investigator on funded research projects, and has shared her work through numerous peer-reviewed publications and presentations.</p><p>Dr. Davila is board certified by the American Board of Pediatrics in General Pediatrics and Pediatric Hematology Oncology. She is a member of several professional organizations, including the American Society of Hematology, the Hemostasis and Thrombosis Research Society and the American Society of Clinical Oncology, among others. She sits on the board of the American Thrombosis and Hemostasis Network, is co-chair of the Pediatric sub-committee of the Venous Thromboembolism Network of the United States and is a member of the Medical and Scientific Advisory Council of the National Bleeding Disorders Foundation.</p>

Is Open Scheduling
Off
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