Daniel N. Lax
<p style="font-family: 'Times New Roman'; font-size: medium;">Daniel Noam Lax, MD, is an attending physician and Assistant Professor of Neurology and Pediatrics at Montefiore Einstein. As the Director of Pediatric Headache, Dr. Lax’s clinical focus is on the diagnosis and treatment of common and rare headache disorders as well as other neurologic conditions in children and adolescents. Dr. Lax’s research focuses on rare neurologic disorders and newer therapies for migraine in youth as well as quality improvement and medical education. His work has been shared through peer-reviewed journals, book chapters, abstracts, poster presentations and invited national and international lectures. He also serves on the editorial board of <em>Cephalalgia</em> and <em>Cephalalgia Reports</em>, the official journals of the International Headache Society.</p>
<p style="font-family: 'Times New Roman'; font-size: medium;">Dr. Lax received his medical degree from the Albert Einstein College of Medicine in 2015 with special distinction in Child Neurology. He continued at Einstein and Children’s Hospital at Montefiore for his pediatrics training through 2017, followed by his residency with Einstein’s Isabelle Rapin Division of Child Neurology in 2020. He completed his fellowship in Headache Medicine at Cincinnati Children’s Hospital Medical Center in 2022 and has been pursuing his Masters in Medical Education at the University of Cincinnati College of Education, Criminal Justice and Human Services.</p>
<p style="font-family: 'Times New Roman'; font-size: medium;">Dr. Lax is board certified in Neurology with special qualification in Child Neurology. He is additionally board certified in Headache Medicine through the United Council for Neurologic Subspecialties. He is a member of the American Academy of Neurology, the Child Neurology Society and the American Headache Society where he was selected to participate in the Emerging Leaders Program in 2022. He has received several awards in recognition of his excellence in teaching, including the Leo M. Davidoff Society Resident Award in 2017, The Saul R. Korey Department of Neurology Resident Teaching Award in 2020 and the Al Spiro M.D. Pediatric Neurology Faculty Teacher of the Year Award in 2021.</p>
Dr. Lax focuses on the diagnosis and treatment of common and rare headache disorders in children and adolescents.
Dr. Lax’s research is focused on rare headache disorders and newer therapies for migraine in youth as well as Quality Improvement and medical education.
Elissa G. Yozawitz
<p>Pediatric neurology, epilepsy, neonatal neurology.</p>
Dr. Yozawitz focuses on the management of neonatal neurology and pediatric epilepsy, particularly children and adolescents with difficult-to-treat seizures. She specializes in a variety of neurological conditions diagnosed in the newborn period, including hypoxic-ischemic encephalopathy, stroke, and seizures. She has expertise in EEG and advanced medical treatments. She provides care from the neonatal period through adolescence.
Dr. Yozawitz’s research is focused on neonatal seizures and early-life epilepsies, including infantile spasms. She is involved in multicenter studies to improve the diagnosis, treatment, and outcomes for children with epilepsy. She is also involved in assessing EEG changes during anesthesia.
<p>Elissa G. Yozawitz, MD, is Director of Neonatal Neurology at Children’s Hospital at Montefiore Einstein and Professor of Neurology and Pediatrics at our Albert Einstein College of Medicine. Dr. Yozawitz focuses on the neurological management of children, from the neonatal period through adolescence, particularly those with difficult-to-treat seizures. She also specializes in the diagnosis and treatment of hypoxic-ischemic encephalopathy, stroke and seizures in the newborn. Dr. Yozawitz’s expertise includes electroencephalography (EEG) and state-of-the-art treatments.</p><p>After obtaining a Bachelor of Arts in psychology and in health and society from the University of Rochester in 2001, Dr. Yozawitz earned a Doctor of Medicine from the State University of New York Upstate Medical University in 2005. She completed a pediatric residency at Schneider Children’s Hospital in 2007, followed by a residency in pediatric neurology at Montefiore Einstein in 2010. Dr. Yozawitz remained at Montefiore Einstein to complete a fellowship in clinical neurophysiology in 2011.</p><p>Dr. Yozawitz’s research focuses on improving the identification and efficacy of treating early-life epilepsies, including infantile spasms. Her research also explores EEG changes during anesthesia. Dr. Yozawitz participated in multicenter studies, functioned as site principal investigator and co-investigator for multiple research projects, presented her research findings at national and international scientific meetings, published in numerous peer-reviewed journals and authored several book chapters. She served as a reviewer for medical journals including <em>Epilepsia, Epileptic Disorders, Neurology</em> and the <em>New England Journal of Medicine</em>, among others. For several years, Dr. Yozawitz participated in the work of international committees tasked to revise nosology and treatment guidelines for neonatal and childhood epilepsy.</p><p>Dr. Yozawitz is board certified by the American Board of Psychiatry and Neurology in Epilepsy and Neurology, with special certification in Child Neurology. She is a member of the American Academy of Neurology, the American Epilepsy Society and the Child Neurology Society. Dr. Yozawitz repeatedly has been named in Castle Connolly’s “Regional Top Doctor,” “Top Doctors: New York Metro Area.” She additionally has been listed in <em>New York Magazine’s</em> “Top Doctors” for multiple years.</p>
Mitchell Steinschneider
<p>The goal of my research is to delineate the multiple fields of auditory and auditory-related cortex, identify their functional connectivity, and clarify the roles that each of these regions play in the neural processing of speech and other complex hearing phenomena. The three arms of my research career, coupled to my clinical career arms, make me ideally suited to contribute to this academic endeavor. Pertaining to the first arm, I was among the first investigators to rigorously examine auditory cortical mechanisms of speech processing in an animal model. Previously, it had been thought that animals would make poor models for this uniquely human process. My colleagues and I demonstrated that auditory cortical activity could explain many of features of speech processing, such as the neural events associated with the categorical representation of the voice onset time parameter, in the non-human primate model. This line of research has expanded over the years to address many of the key issues in auditory neuroscience, including clarifying neural mechanisms underlying auditory scene analysis, musical consonance and dissonance, pitch, and the mismatch negativity component of the human auditory evoked potential. We have also been among the first to demonstrate the close correspondence between monkey auditory cortical activity and that recorded directly from the human auditory cortex using intracranial electrodes. While I have retired from this research arm to increase my role on this project and pursue my mandate to help lead the new program of intracranial recordings in children at U Iowa, my animal research background helps ground this project in tenets of basic auditory cortical physiology.</p>
<p>The second arm of my research has been as co-investigator on this long-standing project. Working with the University of Iowa investigative team, I have been a major contributor to their intracranial studies that have helped delineate fundamental features of human auditory cortical physiology. In the last several years, working with Dr. Nourski as co-first author on multiple papers, we have identified the relative modulations of core and non-core auditory cortex by attention, and the role of these fields and auditory-related cortex including the middle temporal gyrus, supramarginal gyrus, and prefrontal cortex in word object formation and selection and in predictive coding mechanisms.</p>
<p>The third arm of my research, in collaboration with Dr. Elyse Sussman, and more recently, Dr. Monica Wagner, has focused on clarifying the maturation of cortical auditory evoked potentials and the effects of language experience on cortical speech processing. Finally, my 30 years of clinical experience in child neurology and clinical electrophysiology has made me keenly aware of multiple types of developmental language disorders and normal and aberrant features of the electroencephalogram. These experiences allow me to frame research questions in a translationally relevant way.</p>
<p><strong>Steinschneider, M.</strong>, & Fishman, Y.I. (2011). Enhanced physiologic discriminability of stop consonants with prolonged formant transitions in awake monkeys based on the tonotopic organization of primary auditory cortex. Hearing Research, 271, 103-114. PMCID: PMC2945626</p>
<p><strong>Steinschneider, M.</strong>, Nourski, K., Kawasaki, H., Oya, H., Brugge, J.F., & Howard, M.A. III. (2011). Intracranial study of speech-elicited activity on the human posterolateral superior temporal gyrus. Cerebral Cortex, 21, 2332-2347. PMCID: PMC3169661</p>
<p><strong>Steinschneider, M.</strong>, Nourski, K.V., & Fishman, Y.I. (2013). Representation of speech in human auditory cortex: Is it special? Hearing Research, 305, 57-73. Invited Paper for Special Issue: Communication Sounds and the Brain: New Directions and Perspectives. PMCID: PMC3818517.</p>
<p>Fishman, Y.I., Micheyl, C., & <strong>Steinschneider, M.</strong> (2012). Neural mechanisms of rhythmic masking release in monkey primary auditory cortex: Implications for models of auditory scene analysis. Journal of Neurophysiology, 107, 2366-2382. PMCID: PMC3362241</p>
<p>Fishman, Y.I., Micheyl, C., & <strong>Steinschneider, M.</strong> (2014). Neural representation of concurrent harmonic sounds in monkey primary auditory cortex: Implications for models of auditory scene analysis. Journal of Neuroscience, 34, 12425-12443. PMICD: PMC4160777.</p>
<p>Fishman, Y.I., Kim, M., <strong>Steinschneider, M.</strong> (2017). A Crucial Test of the Population Separation Model of Auditory Stream Segregation in Macaque Primary Auditory Cortex. Journal of Neuroscience, 37 10645-10655. PMID: 28954867.</p>
<p>Nourski, K.V., <strong>Steinschneider, M.</strong>, Rhone, A.E. Electrocorticographic activation within human auditory cortex during dialog-based language and cognitive testing. Frontiers in Human Neuroscience (2016) May 4;10:20. PMID: 27199720. K.V.N. and M.S. contributed equally to this work.</p>
<p>Nourski, K.V., <strong>Steinschneider, M.</strong>, Rhone, A.E., Howard, M.A. Intracranial electrophysiology of auditory selective attention associated with speech classification tasks. Frontiers in Human Neuroscience (2017) Jan 10:691. doi:10.3389/fnhum.2016.00691 K.V.N. and M.S. contributed equally to this work.</p>
<p>Nourski, K.V., <strong>Steinschneider, M.</strong>, Rhone, A.E., Kawasaki, H., Todd, M.M., Howard, M.A., Banks, M.I. Processing of auditory novelty across the cortical hierarchy: An intracranial electrophysiology study. NeuroImage 183 (2018) 412-424. PMID: 30114466.</p>
<p>Sussman, E., <strong>Steinschneider, M.</strong>, Gumenyuk, V., Grushko, J., & Lawson, K. (2008). The maturation of human evoked brain potentials to sounds presented at different stimulus rates. Hearing Research, 236, 61-79. PMCID: PMC2567844</p>
Shlomo Shinnar
<p>Dr. Shlomo Shinnar is a neurologist, pediatrician and epidemiologist. His expertise focuses on comprehensive epilepsy management, child neurology and epilepsy with a focus on long term studies the prognosis of childhood seizures disorders. He is also an experienced clinical trialist and is the co-director of the Einstein NeuroNEXT cener of Excellence for Clinical Trials in Neurology.<br /><br />Dr. Shinnar conducts research on a variety of topics relating to childhood seizures, including when to initiate and discontinue antiepileptic drug therapy, prognosis following a first seizure, and prognosis following discontinuation of medications in children with seizures. He is also interested in the comorbidities of epilepsy and its impact on chilren and families. He current studies focus on status epilepticus, a life-threatening condition of persistent continuous and unremitting brain seizure lasting longer than 30 minutes. He is also involved in research in autism, an increasingly common neurological condition in childhood.<br /><br />His current research focuses on the consequences of prolonged febrile seizures, the most common seizure seen in children and on the long term outcomes of childhood absence (petit-mal) seizures which are the most common form of epilepsy in children. He is also on the executive commitee of the recentlyfunded ESETT (Established Status Epilepticus Treatment Trial) trial which seeks to determine the optimal therapy for convulsive status epilepticus inchildren and adults when first line therapy with a benzodiazepine has failed.</p>
<p>Dr. Shinnar is the senior editor of the book <em>Childhood Seizures</em> and co-editor of the book <em>Febrile Seizures</em>. He has published over 185 original papers and over 125 reviews and chapters. He is the recipient of the prestigious Research Recognition Award of the American Epilepsy Society and the CURE research award. His continuing research on the Consequences of Prolonged Febrile Seizures in Children (FEBSTAT) study was recently recognized with the prestigious Javits award by the NINDS.<br /><br /></p>
<p>Most recent publications:</p>
<p>ORIGINAL PAPERS:</p>
<p>Sillanpaa M, Shinnar S. SUDEP and other causes of mortality in childhood-onset epilepsy<span style="text-decoration: underline;">. Epilepsy & Behavior</span> 2013;28:249-255. PMID: 23746924</p>
<p> Hesdorffer DC, Shinnar S, Lewis DV, Nordli DR Jr, Pellock JM, Moshe SL, Shinnar RC, Litherand C, Bagiella E, Frank LM, BelloJA, Chan S, Masur D, Macfall J, Sun S and the Consequences of Prolonged Febrile Seizures (FEBSTAT) Study Team. Risk Factors for Febrile Status Epilepticus: A case control study. <span style="text-decoration: underline;">J Pediatr</span> 2013; 163:1147-1151. PMID: 23809042 PMCID: PMC3989363</p>
<p> Masur D, Shinnar S, Cnaan A, Shinnar RC, Clark P, Wang J, Weiss EF, Hirtz DG, Glauser TA, Childhood Absence Epilepsy Study Group. Pretreatment cognitive deficits and treatment effects on attention in childhood absence epilepsy. <span style="text-decoration: underline;">Neurology</span> 2013; 81:1572-1580. PMID: 24089388. PMCID: PMC3980500</p>
<p> Brown FC, Westerveld M, Langfitt JT, Hamberger M, Hamid H, Shinnar S, Sperling MR, Devinsky O, Barr W, Tracy J, Masur M, Bazil CW, Spencer SS. Influence of anxiety on memory performance in temporal lobe epilepsy. <span style="text-decoration: underline;">Epilepsy & Behavior</span> 2014; 31:19-24. PMID: 24291525 PMCID: PMC3946774.</p>
<p> Lewis DV, Shinnar S, Hesdorffer DC, Bagiella E, Bello JA, Chan S, Xu Y, MacFall J, Gomes WA, Moshe SL, Mathern GW, Pellock JM, Nordli DR Jr, Frank LM, Provenzale J, Shinnar RC, Epstein LG, Masur D, Litherand C, Sun S; FEBSTAT Study Team. Hippocampal sclerosis after febrile status epilepticus: The FEBSTAT study<span style="text-decoration: underline;">. Ann Neurol</span> 2014;75:178-185. PMID# 24318290 NIHMSID# 569823 PMCID: PMC3980500</p>
<p> Hussain SA, Shinnar S, Kwong G, Lerner JT, Matsumoto JH, Wu JY, Sields WD, Sankar R. Treatment of infantile spasms with very high dose prednisolone before high dose adrenocorticotropic hormone. Epilepsia 2014;55:103-107. PMID 24446954 OMCID: PMC3904676</p>
<p> Hamid H, Blackmon K, Cong X, Dziura J, Atlas LY, Vickrey BG, Berg AT, Bazil CW, Langfitt JT, Walczak TS, Sperling MR, Shinnar S, Devinsky O. Mood anxiety and incomplete seizure control affect quality of life after epilepsy surgery. <span style="text-decoration: underline;">Neurology</span> 2014; 82:887-894. PMID 24489129 PMCID: PMC3959755.</p>
<p> Seinfeld S, Shinnar S, Sun S, Hesdorffer DC, Deng X, Shinnar RC, O’Hara K, Nordli DR Jr, Frank LM, Gallentine W, Moshe SL, Pellock JM and FEBSTAT Study Team. Emergency management of febrile status epilepticus: results of the FEBSTAT study<span style="text-decoration: underline;">. Epilepsia</span> 2014; 55:388-395. PMID 24502379 PMCID: PMC3937844.</p>
<p> Mendley SR, Matheson MB, Shinnar S, Lande MB, Gerson AC, Butler RW, Warady BA, Furth SL, Hooper SR. Duration of chronic kidney disease reduces attention and executive function in pediatric patients. <span style="text-decoration: underline;">Kidney Int</span> 2014; 87:800-806.] PMID 25252026</p>
<p> Valicenti-McDermott M, Lawson K, Hottinger K, Seijo R, Schechtman M, Shulman L, Shinnar S. Parental Stress in Families of Children with Autism and Other Developmental Disabilities. <span style="text-decoration: underline;">J Child Neurol</span> 2015 April 10 [epub ahead of print). PMID: 25862740.</p>
<p> Krumholz A, Wiebe S, Groseth GS, Gloss DS, Sanchez AM, Kabir AA, Liferidge AT, Martello JP, Kanner AM, Shinnar S, Hopp JL, French JA. Evidence-based guideline: Management of an unprovoked first seizure in adults: report of the Guideline Development Subcommittee of the American Academy of Neurology and the American Epilepsy Society. <span style="text-decoration: underline;">Neurology</span> 2015;84:1805-1713. PMIDL 25901057</p>
<p>RECENT REVIEWS:</p>
<p> Gomes WA, Shinnar S. Prospects for imaging-related biomarkers of human epileptogenesis: A critical review. <span style="text-decoration: underline;">Biomark Med</span> 2011;5:599-606. PMID:22003908. PMCID: 3235417.</p>
<p> Shinnar S. Prognostic factors for recurrence after a first unprovoked seizure in childhood. In Arts WF, Arzimanoglou A, Brouwer OF, Camfield C, Camfield P eds. <span style="text-decoration: underline;">Outcome of Childhood Epilepsies.</span> Progress in Epileptic Disorders 2013;12:25-31.</p>
<p> Bleck T, Cock H, Chamberlain J Cloyd J, Connor J, Elm J, Fountain N, Jones E, Lowenstein D, Shinnar S, Silbergleit R, Treiman D, Trinka E, Kapur J. The established status epilepticus trial 2013. <span style="text-decoration: underline;">Epilepsia</span> 2013 54 (suppl 6): 89-92. PMID 24001084 PMCID: PMC4048827</p>
<p> Patterson KP, Baram TZ, Shinnar S. Origins of Temporal Lobe Epilepsy: Febrile seizures and Febrile Status Epilepticus. <span style="text-decoration: underline;">Neurotherapeutics</span> 2014; 11:242-250. PMID: 24604424 PMCID: PMC3996115</p>
Aparna V.R. Polavarapu
Solomon L. Moshe
<p class="MsoBodyText" style="margin: 1.95pt 8.45pt 0.0001pt 0in; font-size: 12pt; font-family: Calibri, sans-serif;"><strong>Solomon L. Moshé, M.D., </strong>is the Charles Frost Chair in Neurosurgery and Neurology, and Professor of Neurology, Neuroscience, and Pediatrics at the Albert Einstein College of Medicine/Montefiore Medical Center in the Bronx, New York. He is also the Vice Chair of the Saul R. Korey Department of Neurology, Director of the Isabelle Rapin Child Neurology Division and Director of Clinical Neurophysiology. His area of expertise is in epilepsy and related disorders.</p>
<p class="MsoBodyText" style="margin: 1.95pt 8.45pt 0.0001pt 6pt; font-size: 12pt; font-family: Calibri, sans-serif;"> </p>
<p class="MsoNormal" style="margin: 0in; font-size: 11pt; font-family: Calibri, sans-serif;"><span style="font-size: 12pt;">Since 1979, his research has focused on understanding the mechanisms underlying age and sex-related differences in epilepsy in humans and animal models. Current research interests include studies on the role of subcortical circuitries involved in the control of seizures as a function of age and sex; the consequences of seizures on the developing brain and the development of models of catastrophic epilepsies. His laboratory has patented a model of infantile spasms that can be used to identify novel treatments. He is co principal investigator of a Center Without Walls grant on interdisciplinary research aimed at accelerating the development of disease modifying or prevention therapies for epilepsy following traumatic brain injuries. He is also involved in a large multicenter study examining the consequences of prolonged febrile seizures. He has over 600 publications as well as He has over 600 publications as well over 35 books and monographs.</span></p>
<p class="MsoNormal" style="margin: 0in; font-size: 11pt; font-family: Calibri, sans-serif;"><span style="font-size: 12pt;">over 35 books and monographs.</span></p>
<p class="MsoBodyText" style="margin: 0.55pt 0in 0in; font-size: 12pt; font-family: Calibri, sans-serif;"> </p>
<p class="MsoBodyText" style="margin: 0.05pt 5.85pt 0.0001pt 0in; font-size: 12pt; font-family: Calibri, sans-serif;"> He has served as President of the International League Against Epilepsy (2009-2013), the American Epilepsy Society (2000-2001), the American Clinical Neurophysiology Society (1996-1997) and the Eastern Association of EEGers (1992-1994). He is the recipient of many awards and honors, including the Teacher-Investigator Development Award from NINDS; the 1995 Jacob Javits Neuroscience Investigator Award from NINDS; the 1984 Michael Prize for Achievements in Epilepsy Research; the 1990 American Epilepsy Society Research Award; the 1999 Ambassador for Epilepsy Award from the International League Against Epilepsy; the 2005 Gloor Award from the American Clinical Neurophysiology Society; the 2007 J.E. Purkyne Honorary Medal in Biomedical Research by the Czech Academy of Sciences; the 2008 Mentor of the Year Award from Albert Einstein College of Medicine; the 2010 Global and Awareness Award from CURE, Citizens United for Research in Epilepsy; the First 2012 Saul R. Korey Award in Translational Science and Medicine, Albert Einstein College of Medicine and the 2017 Bernard Sachs Award from the Child Neurology Society, <span style="background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;">and the 2023 Lifetime Achievement Award from the International League against Epilepsy.</span></p>
<p class="MsoBodyText" style="margin: 0.05pt 5.85pt 0.0001pt 0in; font-size: 12pt; font-family: Calibri, sans-serif;"> </p>
<p class="MsoBodyText" style="margin: 0.05pt 5.85pt 0.0001pt 0in; font-size: 12pt; font-family: Calibri, sans-serif;">He has been asked to deliver over 50 several keynote lectures.</p>
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<p class="MsoBodyText" style="margin: 0.05pt 5.85pt 0.0001pt 0in; font-size: 12pt; font-family: Calibri, sans-serif;">Clinical Focus:</p>
<p class="MsoBodyText" style="margin: 0.05pt 5.85pt 0.0001pt 0in; font-size: 12pt; font-family: Calibri, sans-serif;">Dr. Moshé focuses on helping people with epilepsy and related conditions with a special emphasis on children and adolescents.</p>
<p class="MsoBodyText" style="margin: 0.05pt 5.85pt 0.0001pt 0in; font-size: 12pt; font-family: Calibri, sans-serif;"><span style="color: red;"> </span></p>
<p class="MsoBodyText" style="margin: 0.05pt 5.85pt 0.0001pt 0in; font-size: 12pt; font-family: Calibri, sans-serif;"><span style="color: #002060;">Research focus</span></p>
<p class="MsoBodyText" style="margin: 0.05pt 5.85pt 0.0001pt 0in; font-size: 12pt; font-family: Calibri, sans-serif;">Dr Moshé has focused on translational research to understand the mechanisms underlying age and sex-related differences in epilepsy in humans and animal models. The main goals are to develop individualized treatments today and to prevent and cure epilepsy tomorrow. Current projects include the development of effective means to predict and treat epilepsy after traumatic brain injury and the development of specialized treatments for infants and children with epilepsy.</p>
<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt; font-family: "Arial","sans-serif";">Dr. Moshé is an authority on the mechanisms that underlie the development of epilepsy and on the consequences of the disease in infants and children.</span></p>
<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt; font-family: "Arial","sans-serif";">A translational scientist, Dr. Moshé has developed and patented an animal model that replicates human infantile spasms, which can be used to identify novel treatments of this devastating condition. Dr. Moshé has served as President of the International League Against Epilepsy, American Epilepsy Society, the American Clinical Neurophysiology Society, and the Eastern Association of Electroencephalographers.</span></p>
<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt; font-family: "Arial","sans-serif";">Dr. Moshé is actively involved in several large, multicenter studies examining the outcomes of prolonged febrile seizure to identify predictive biomarkers of the course of these conditions and response to treatment.</span></p>
<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt; font-family: "Arial","sans-serif";">Dr. Moshé has received numerous honors and awards, including the American Epilepsy Society Research Recognition Award, Jacob Javitz Neuroscience Investigator Award from the National Institutes of Health, the Michael Prize, American Epilepsy Society research award, the CURE (Citizens United for Research in Epilepsy) Global Awareness Award for leadership in raising the international profile of epilepsy<strong>, </strong>the Pierre Gloor Award of the American Clinical Neurophysiology Society, and the J.E. Purkyne Honorary Medal for Merit in the BioMedical Sciences of the Czech Academy of Sciences. He is an elected member of the American Neurological Association and the American Pediatric Society. </span></p>
Dr. Moshé focuses on helping people with epilepsy and related conditions with a special emphasis on children and adolescents
Dr. Moshé has focused on translational research to understand the mechanisms underlying age and sex-related differences in epilepsy in human and animal models. The main goals are to develop individualized treatments today and to prevent and cure epilepsy tomorrow. Current projects include the development of effective means to predict and treat epilepsy after traumatic brain injury and the development of specialized treatments for infants and children with epilepsy.
<ol>
<li> <span style="font-size: 11pt; font-family: Arial, sans-serif;">Katsarou A, Moshé SL, Galanopoulou AS. Interneuronopathies and their role in early life epilepsies and neurodevelopmental disorders. Epilepsia Open 3: 284-306 (2017). PMID: 29062978</span></li>
<li><span style="font-size: 11pt; font-family: Arial, sans-serif;">Moshe SL. The 2017 Sachs lecture: Kindling knowledge in Epilepsy. Pediatric Neurology 85: 5-12 (2018). PMID: 29958806</span></li>
<li>Saletti PG, Ali I, Casillas-Espinonsa PM, Semple BD, Lisgaras C, Moshe SL, Galanopoulou AS. In search of antiepileptogenic treatments for post-traumatic epilepsy. Neurobiology of Disease 123: 86-99 (2019). PMID: 29936231</li>
<li>Correa DJ, Kwon C, Connors S, Fureman B, Whittemore V, Jette N, Mathern G and Moshe SL. For the EpiBioS4RX Public Engagement Core. Applying participatory action research in traumatic brain injury studies to prevent post-traumatic epilepsy. Neurobiology of Disease 123: 137-144 (2019). PMID: 30031158</li>
<li><span style="font-size: 11pt; font-family: Arial, sans-serif;">Molinero I, Galanopoulou AS and Moshe SL. Rodent models: Where it all started with these “truths”. European Journal of Paediatric Neurology 61-65 (2020) PMID: 31875833</span></li>
<li><span style="font-size: 11pt; font-family: Arial, sans-serif;">Ozlem A, Briggs S, Mowrey W, Moshe SL, Galanopoulou AS Antiepiletogenic effects of rapamycin in a model of infantile spasms due to structural lesions. Epilepsia, 62,1985-1999, (2021) PMID: 34212374</span></li>
<li>
<p class="MsoNormal" style="margin: 0in; font-size: 10pt; font-family: 'Times New Roman', serif; background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;"><span style="font-size: 11pt; font-family: Arial, sans-serif;">Zuberi S, Wirrell E, Yozawitz E, Wilmshurst J, Specchi N, Riney K, Pressler R, Auvin S, Samia P, Hirsch E, Galicchio S, Triki C, Snead O, Wiebe S, Cross H, Tinuper P, Scheffer I, Perucca E and Moshe SL. ILAE classification and definition of epilepsy syndromes with onset in neonates and infants: Position statement by the ILAE Task Force on Nosology and Definitions. Epilepsia, 63, 1349-1397 (2022) PMID: 35503712</span></p>
</li>
<li>
<p class="MsoNormal" style="margin: 0in; font-size: 10pt; font-family: 'Times New Roman', serif; background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;"><span style="font-size: 11pt; font-family: Arial, sans-serif;">Hirsch E, French J, Scheffer I, Bogacz A, Alsaadi T, Sperling M, Abdulla F, Zuberi S, Trinka E, Specchio N, Somerville E, Samia P, Riney K, Nabbout R, Jain S, Wilmshurst J, Auvin S, Wiebe S, Perucca E, Moshe SL, Tinuper P and Wirrell E. ILAE definition of the Idiopathic Generalized Epilepsy Syndromes: Position statement by the ILAE Task Force on Nosology and Definitions. Epilepsia, 63, 1475-1499 (2022) PMID: 35503716</span></p>
</li>
<li>
<p class="MsoNormal" style="margin: 0in; font-size: 10pt; font-family: 'Times New Roman', serif; background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;"><span style="font-size: 11pt; font-family: Arial, sans-serif;">Specchio N, Wirrell E, Scheffer I, Nabbout R, Riney K, Samia P, Guerreiro M, Gwer S, Zuberi S, Wilmshurst J, Yozawitz E, Pressler R, Hirsch E, Wiebe S, Cross H, Perucca E, Moshe SL, Tinuper P and Auvin S. International League Against Epilepsy classification and definition of epilepsy syndromes with onset in childhood: Position paper by the ILAE Task Force on Nosology and Definitions. Epilepsia, 63, 1398-1442 (2022) PMID: 35503717</span></p>
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<p class="MsoNormal" style="margin: 0in; font-size: 10pt; font-family: 'Times New Roman', serif; background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;"><span style="font-size: 11pt; font-family: Arial, sans-serif;"> Riney K, Bogacz A, Somerville E, Hirsch E, Nabbout R, Scheffer I, Zuberi S, Alsaadi T, Jain S, French J, Specchio N, Trinka E, Wiebe S, Auvin S, Cabral-Lin L, Naiddo A, Perucca E, Moshe SL, Wirrell E and Tinuper P. International League Againist Epilepsy classification and definition of epilepsy syndromes with onset at a variable age: position statement by the ILAE Task Force on Nosology and Definitions. Epilespia, 63, 1443-1474 (2022) PMID: 35503725</span></p>
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<p class="MsoNormal" style="margin: 0in; font-size: 10pt; font-family: 'Times New Roman', serif; background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;"><span style="font-size: 11pt; font-family: Arial, sans-serif;">Wirrell E, Nabbout R, Scheffer I, Alsaadi T, Bogacz A, French J, Hirsch E, Jain S, Kaneko S, Riney K, Samia P, Snead O, Somerville E, Specchio N, Trinka E, Zuberi S, Balestrini S, Wiebe S, Cross H, Perucca E, Moshe SL and Tinuper P. Methodology for classification and definition of epilepsy syndromes with list of syndroms: Report of the ILAE Task Force on Nosology and Definitions. Epilepsia, 63, 1333-1348 (2022) PMID: 35503715</span></p>
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<p class="MsoNormal" style="margin: 0in; font-size: 10pt; font-family: 'Times New Roman', serif;"><span style="font-size: 11pt; font-family: Arial, sans-serif;">Saletti P, Casillas-Espinosa P, Lisgaras C, Mowrey W, Li Q, Liu W, Brady R, Ali I, Silva J, Yamakawa G, Hudson M, Li C, Braine E, Coles L, Cloyd J, Shultz S, Moshé SL, O’Brien T, Galanopoulou AS for the EpiBioS4RX Group. TAU phosphorylation patterns in the rat cerebral cortex after traumatic brain injury and sodium selenate effects: An EpiBioS4Rx Project 2 study. Journal of Neurotrauma pgs 1-22, (2023.) PMID: 36950806</span></p>
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<p class="MsoNormal" style="margin: 0in; font-size: 10pt; font-family: 'Times New Roman', serif;"><span style="font-size: 11pt; font-family: Arial, sans-serif;">Saletti P, Mowrey W, Liu W, Li Q, McCullough J, Aniceto R, Lin I-H, Eklund M, Casillas-Espinosa P, Ali I, Santana-Gomez C, Coles L, Shultz S, Jones N, Staba R, O’Brien T, Moshé SL, Agoston D, Galanopoulou AS for the EpiBioS4RX Study Group. Early preclinical plasma protein biomarkers of brain trauma are influenced by early seizures and levetiracetam. Epilepsia Open pgs. 586-608 (2023) PMID: 37026764</span></p>
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<p class="MsoNormal" style="margin: 0in; font-size: 10pt; font-family: 'Times New Roman', serif;"><span style="font-size: 11pt; font-family: Arial, sans-serif;">Coles L, Saletti P, Lisgaras C, Casillas-Espinosa P, Liu W, Li Q, Jones N, Shultz S, Ali I, Brady R, Yamakawa G, Hudson M, Silva J, Braine E, Mishra U, Cloyd J, O’Brien T, Moshé SL, Galanopoulou AS for the EpiBioS4RX Study Group. Levetiracetam Pharmacokinetics and Brain Uptake in a Lateral Fluid Percussion Injury Rat Model. <span style="background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;">Journal of Pharmacology and Experimental Therapeutics pgs 1-30, (2023). PMID:</span> </span><span style="font-size: 11pt; font-family: Arial, sans-serif; color: #212121;">37316328</span></p>
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<p>Solomon L. Moshé, MD, is Vice Chair of Neurology, Director of the Isabelle Rapin Child Neurology Division and Director of Clinical Neurophysiology at Montefiore. He is also the Charles Frost Chair in Neurosurgery and Neurology, Vice Chair, Saul R. Korey Department of Neurology, and Professor of Neurology, Neuroscience and Pediatrics at the Albert Einstein College of Medicine (Einstein). Dr. Moshé’s clinical focus is on epilepsy and electroencephalography with special emphasis on age-related influences on the expression, control and consequences of seizures.</p><p>After receiving his Doctor of Medicine from the National University of Athens School of Medicine in Greece in 1972, Dr. Moshé began his post-doctoral training at the University Hospital of Maryland. He completed his internship and residency there in pediatrics in 1975. Following this, he pursued a pediatric neurology fellowship at Einstein from 1975 to 1978. He was a visiting epilepsy research fellow at the University of California Los Angeles in 1978, then completed a neurology and neuroscience research fellowship at Einstein in 1979. He was a guest scholar with the EEG department at Columbia Presbyterian Medical Center from 1980 to 198, and with the seizure unit at Children’s Hospital in Boston in 1980.</p><p>Dr. Moshé’s research focuses on understanding the mechanisms underlying differences in epilepsy in humans and animal models. His laboratory has developed and patented a novel model of human infantile spasms that can be used to identify novel treatments of this devastating condition. He also investigates the consequences of prolonged seizures and methods to accelerate the development of disease modifying or prevention therapies for post-traumatic epilepsy. His extensive body of work has been shared nationally and internationally through peer-reviewed publications, lectures and conferences. He is a member on several editorial boards including Neurobiology of Disease, Pediatric Neurology, Epileptic Disorders, and the Journal of Neurology & Psychology.</p><p>Dr. Moshé has been recognized with numerous national and international honors and awards, including a 1995 Jacob Javits Neuroscience Investigator Award from the National Institute of Health, the first 2012 Saul R. Korey Award in Translational Science and Medicine, Albert Einstein College of Medicine; the 2017 Bernard Sachs Award from the Child Neurology Society, and election as a foreign member of the Russian Academy of Science in 2017. He is a member of many professional societies including the American Academy of Neurology, the Child Neurology Society, the American Epilepsy Society and the American Association for Advancement of Science.</p>
Karen R. Ballaban-Gil
<p>Dr. Karen Ballaban-Gil is Professor of Neurology and Pediatrics, the Director of the Child Neurology Residency Training Program and Director of Outpatient Child Neurology Services at the Albert Einstein College of Medicine. She graduated Magna Cum Laude from Union College and Cum Laude from Albany Medical College, in the 6 year combined B.S- M.D. program. Dr. Ballaban-Gil trained in general pediatrics at The Johns Hopkins Hospital, and trained in child neurology and clinical neurophysiology and epilepsy at the Albert Einstein College of Medicine. She received board certifications in pediatrics, neurology with special competence in child neurology , clinical neurophysiology and in epilepsy.</p>
<p><br />Dr. Ballaban-Gil has a large clinical practice in child neurology, including the evaluation and treatment of children with epilepsy, headaches, sleep disorders, autism and other developmental disabilities. Her research interests include the relationship between epilepsy and language regression in youngsters with Landau-Kleffner Syndrome, autism, and other developmental disorders of higher cognitive functioning. In addition, she runs the Ketogenic Diet program for the management of intractable epilepsy at the Montefiore Medical Center - Comprehensive Epilepsy Center. Her publications include numerous papers on autism, epilepsy related language disorders, and the Ketogenic Diet.</p>
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<p>Karen Ballaban-Gil, MD, is Director, Pediatric Epilepsy Center and Deputy Director, Division of Child Neurology at the Children’s Hospital at Montefiore Einstein, and Professor, Pediatrics and Neurology at our Albert Einstein College of Medicine. Dr. Ballaban-Gil has a large clinical practice in child neurology, including the evaluation and treatment of children with epilepsy, headaches, sleep disorders, autism and other developmental disabilities.</p><p>After receiving her Bachelor of Science at Union College in 1984, Dr. Ballaban-Gil earned her Doctor of Medicine in 1986 at the Albany Medical College. She began her postgraduate training at Johns Hopkins Hospital, completing two years as an intern and assistant resident in pediatrics before coming to Einstein, where she completed a residency in child neurology, followed by a fellowship in epilepsy and electrophysiology in 1991.</p><p>Dr. Ballaban-Gil’s research interests include the relationship between epilepsy and language regression in youngsters with Landau-Kleffner Syndrome, autism and other developmental disorders of higher cognitive functioning. Her publications include numerous papers on autism, epilepsy related language disorders and the Ketogenic Diet. She has shared her work through national and international meetings, and has been a peer reviewer for a variety of medical journals, including <em>Epilepsia</em> and <em>Cephalgia</em>.</p><p>Dr. Ballaban-Gil is board certified by the American Board of Psychiatry and Neurology in Neurology with special competence in Child Neurology and with Certification in Epilepsy.</p>
Susan E. Duberstein Coad
<p>Susan Duberstein, MD, is Associate Professor, Child Neurology and Pediatrics at Montefiore Einstein. Dr. Duberstein is an epileptologist with a special interest in complex care. She is the collaborating neurologist for the Linking Individual Needs of Children with Services (LINCS) clinic, which provides a “medical home” and family-centered care for children with chronic illnesses, multiple conditions and medical technologies. She is also the Associate Director of the Neurocutaneous Clinic, serving children with neurofibromatosis, Sturge-Weber, tuberous sclerosis complex and other neurocutaneous conditions.</p><p>After earning her Doctor of Medicine at the State University of New York Downstate Medical Center in 2008, Dr. Duberstein completed her internship and residency in pediatrics at the same institution in 2010. She then came to Montefiore Einstein to continue her medical training, completing her residency in child neurology in 2013 and a fellowship in clinical neurophysiology and electroencephalography (EEG) in 2014.</p><p>Dr. Duberstein's research focuses include retrospective studies on neurofibromatosis and tuberous sclerosis complex. She is also one of the leaders of a research project investigating the clinical outcomes of autoimmune encephalopathies. Her work has been published in numerous peer-reviewed journals, book chapters and abstracts.</p><p>Dr. Duberstein is board certified by the American Board of Psychiatry and Neurology in Neurology with a special qualification in Child Neurology and holds a subspecialty certificate in Epilepsy. She is a member of the American Academy of Neurology, the Child Neurology Society and the American Epilepsy Society. Dr. Duberstein was elected a Fellow of the American Epilepsy Society in 2022.</p>
Aleksandra Jacobs
<p>Aleksandra Djukic, is Associate Professor of Neurology . She completed her neurology residency at the Albert Einstein College of Medicine. She is a diplomate of the American Board of Psychiatry and Neurology.</p>
<p>Dr. Djukic has Ph.D. in neuropsychology and is especially qualified for evaluations and treatment of children with learning disabilities, addressing both cognitive and neurological problems in children with a variety of hereditary neurological diseases and babies with neonatal neurological problems.</p>
<p>Dr. Djukic gained extensive experience following and treating more than 300 children with traumatic brain injuries.</p>
<p>Currently she is <strong>Director of the Center for Rett Syndrome</strong> which is the only Center for Rett syndrome in the Tri-State area.</p>
<p>Dr. Djukic is member of the International Consortium for Rett Syndrome "RettSearch", Leader of the Working group for development of Treatment Quidelines for Rett Syndrome, Grant reviewer for IRSF, member of the International Committee for the research of bio markers in Rett Syndrome and member of the International Committee for the research of the outcome measures in Rett Syndrome.</p>
<p>Dr. Djukic is member of RE-TT (Rett Education -Transforming Teaching) a group which is actively addressing educational issued and provides support to families .</p>
<p>Dr. Djukic is also Director of the Neonatal Neurology service.</p>
<p>She is a member of the New York State Consortium for Krabbe Disease .<br /><br />Dr. Djukic speaks both English and Serbian.</p>
Neuropsychology
The clinical focus is providing care for patients with Rett syndrome. She founded the Tri-State Rett Center at Montefiore in 2008, which provides comprehensive multidisciplinary care to 380 patients with Rett syndrome, and has been awarded a designation of the National Center of Excellence for Rett syndrome in 2021. Dr. Djukic serves on the Medical Advisory Board of the International Rett Syndrome Foundation. She has published about clinical care and worked with other Rett specialists to develop a better understanding of Rett syndrome and develop better outcome measures and biomarkers that can be used in treatment trials. She was the founder of an international Blue Sky Girls event that raised awareness about Rett syndrome.
Her vision to develop the Rett Syndrome Center at Montefiore originated from the optimism brought by the scientific evidence that several major aspects of the phenotype of the disorder could be fully reversed in an animal model, even in its terminal stages. However, we still do not understand well the full phenotype of the human disease inter-relationship between various symptoms, especially those autonomic and behavioral/cognitive. The main research goals of the Rett Syndrome Center, therefore, entail systematic and uniform documentation of the natural history, development of objective outcome measures, and better treatment strategies. These goals complement our endeavor to implement the best clinical practices in the clinical care of our patients.<br /><br />Dr. Djukic has a special interest in neuropsychology and how those with Rett syndrome communicate and excel in their education. She was the first to implement effective eye tracking technology as a method of cognitive assessment in patients with Rett syndrome and objective neurophysiological techniques to assess their language processing. <br /><br />Her current main research interest is related to the development of more effective therapies for individuals with Rett syndrome. She was the Principal investigator in seven clinical trials of Rett syndrome. She has also published about clinical care and worked with other scientists to develop a better understanding of Rett syndrome and develop better outcome measures and biomarkers that can be used in treatment trials.
<p>Djukic, A., Lado, F. A., Shinnar, S., Moshé, S. L., Are early myoclonic encephalopathy (EME) and the Ohtahara Syndrome (EIEE) independent of each other? Epilepsy Research, 70 (2-3S): 68-76 (2006).</p>
<p>Djukic A. Folate responsive neurological disorders, in Press. Pediatric neurology 2007. Review.</p>
<p>Wilson S, Djukic A, Shinnar S, Dharmani C, Rapin I. (2003) Clinical characteristics of language regression in children. Developmental Medicine Child Neurology 45:508-514.</p>
<p style="text-autospace: none; font-family: 'Times New Roman'; font-size: 12.0pt; margin: 0in 0in .0001pt 0in;"><span style="font-family: Arial; font-size: 11.0pt;">Djukic A.</span><span style="font-family: Arial; font-size: 10.0pt;"> Neurological Abnormalities in newborn , AAP ,Pediatric Primary Care , Chapter 106</span></p>
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<p style="text-autospace: none; font-family: 'Times New Roman'; font-size: 12.0pt; margin: 0in 0in .0001pt 0in;"><span style="font-family: Arial; font-size: 10.0pt;">Djukic A, Vigevano F, Plouin P, Moshe S.L. Early myoclonic encephalopathy (neonatal myoclonic encephalopathy)</span><span style="font-family: 'Times New Roman'; font-size: 11.0pt; color: black;">. Epilepsy: a comprehensive textbook, 2 ed. Engel J, Pedley T eds. Lippincot Williams&Wilkins, Philadelphia 2007. Chapter 224.</span></p>