Denise J. Nunez

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First Name

Denise

Last Name

Nunez

NPI

1023276433

Faculty ID

10111

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Full Time

Patient Type

Pediatric

Department

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Female

Provider Type

Primary Care

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Professional Interests

<p>My major area of interest is cardiac critical care.</p>

Research Profile

Clinical Profile

CHAM Provider

On

Professional Title

Elsevier Profile

EMR ID

4683

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Sarah E. Norris

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First Name

Sarah

Last Name

Norris

NPI

1386765139

Faculty ID

15253

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Full Time

Patient Type

Pediatric

Department

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Female

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CHAM Provider

On

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Clinical Focus

Pediatrics Hospice &amp; Palliative Medicine<span style="box-sizing:inherit;color:#252525;font-family:Arial, Helvetica, sans-serif;font-size:20px;background-color:#ffffff;"></span>

Research Focus

Dr. Norris's research focus is on primary palliative care education and family decision making regarding medical technology.

Elsevier Profile

EMR ID

78710

Biography

<p>Sarah Evans Norris, MD, MEd, is Director of the Quality in Life Team and Director of Pediatric Palliative Care at Children?s Hospital at Montefiore. She is an Assistant Professor of Pediatrics and of Neurology at the Albert Einstein College of Medicine. </p><p>Dr. Norris earned her Bachelor of Science in Nursing at Loyola University Chicago in 1993 receiving the Gladys Kinnery Clinical Excellence award. As a nurse she worked around the globe including as a Peace Corps volunteer in Morocco before pursuing medical school at the Universidad Autonoma de Guadalajara in Mexico. She completed the Fifth Pathway Program through New York Medical College and embarked on her pediatrics internship at the University of Medicine & Dentistry New Jersey. She finished her residency at the Medical College of Georgia where she was named Resident of the Year. Following residency she completed a fellowship in pediatric critical care medicine and a masters in medical education at Cincinnati Children?s Medical Center. After several years in practice she returned to Cincinnati Children?s to complete a second fellowship in hospice and palliative medicine. Dr. Norris is Board Certified in General Pediatrics and in Hospice and Palliative Medicine.</p> <p>Dr. Norris? research focus is on primary palliative care education and family decision making regarding medical technology. She has given numerous presentations nationally and has a wide range of teaching experience with both adults and children internationally. In 2018 she received the Lewis Fraad Excellence in Resident Teaching Award. When she is not at CHAM you can find her running.</p>

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Deepa G. Manwani

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First Name

Deepa

Last Name

Manwani

NPI

1922077544

Faculty ID

11847

CMO Specialties

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Full Time

Patient Type

Pediatric

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Female

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Expert Summary

<p>Dr. Manwani is a pediatric hematologist who leads the sickle cell team at CHAM. The team offers treatment and support for young children and teens with sickle cell disease and their families, including weekly support groups and an annual Sickle Cell Awareness Day event focused on new research and strategies for living with this disease.</p>

Clinical Profile

CHAM Provider

On

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Clinical Focus

<p>Benign hematology, anemia, sickle cell disease, thalassemia, hemophilia, bleeding disorders, thrombosis, neutropenia, thrombocytopenia, ITP, erythrocytosis, thrombocytosis, leukocytosis.</p>

Research Focus

<p>Sickle Cell Disease: Novel therapies, Role of adhesion and neutrophils, Alloimmunization, Transition to adult care, Fetal hemoglobin induction, Gut Microbiome, Pain, Chronic Pain, Quality Improvement.</p>

Elsevier Profile

EMR ID

5141

Biography

<p>Deepa Manwani, MD, is Director, Pediatric Hematology at Children?s Hospital at Montefiore, as well as a Professor in the Department of Pediatrics at Albert Einstein College of Medicine. Dr. Manwani?s clinical focus is on benign hematology, anemia, sickle cell disease, thalassemia, hemophilia, bleeding disorders, thrombosis, neutropenia, thrombocytopenia, ITP, erythrocytosis and leukocytosis. </p><p>Dr. Manwani graduated from B.J. Medical College, Poona University, India, in 1991, earning her Doctor of Medicine. She became a Research Assistant at the Children?s Hospital Oakland in 1991 before beginning an internship in Pediatrics at NSUH-Cornell University Med Center in 1993. Following her internship, Dr. Manwani completed a residency in Pediatrics at the same institution. In 1996, she began a fellowship in Pediatrics Hematology/Oncology at Mount Sinai School of Medicine in New York. </p><p>Dr. Manwani?s research focuses on fetal hemoglobin activating agents, adhesive cellular interactions in vaso-occlusion in sickle cell disease (SCD) and contribution of neutrophils to SCD pathophysiology. She completed the R01 funded Phase 1 study of IVIG in the treatment of SCD vaso-occlusive crises and is currently leading the R01 funded Phase II study. Dr. Manwani is currently participating in studies aimed at increased adherence to hydroxyurea and improved transition to adult care. She is also collaborating with investigators at Case Western Reserve University on an NHLBI R01 funded study to standardize monitoring of cellular adhesion in SCD patients using a novel microfluidic assay. Her contributions have been recognized by the Sickle Cell Thalassemia Patient Network of New York in the form of the Distinguished Service Award in March 2015. Dr. Manwani?s studies have been published nationally in various reviewed journals and books. </p><p>Dr. Manwani has received many awards, including Castle Connolly Top Doctor in 2016, New York Magazine Best Doctor and New York Metro Area?s Top Doctors in 2017. </p>

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Chhavi Katyal

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First Name

Chhavi

Last Name

Katyal

NPI

1508942442

Faculty ID

10252

CMO Specialties

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Employment Status

Per Diem

Patient Type

Pediatric

Department

Languages

Gender

Female

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Education and Trainings

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Clinical Profile

CHAM Provider

Off

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Elsevier Profile

EMR ID

4752

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Daphne T. Hsu

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First Name

Daphne

Last Name

Hsu

NPI

1689653321

Faculty ID

11172

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Employment Status

Full Time

Patient Type

Pediatric

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Female

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<p>Dr. Hsu&rsquo;s main research efforts focus on improving outcomes in children and young adults with congenital heart disease and acquired heart diseases of childhood. She has published extensively in the fields of pediatric cardiomyopathy and pediatric heart transplantation. She has conducted outcomes research in drug therapies in the treatmen of pediatric heart failure. She also has a strong interest in the emerging field of adult congenital heart disease. She has served in leadership positions in the American Heart Association, American College of Cardiology, International Society for Heart and Lung Transplantation, American Academy of Pediatrics, American Board of Pediatrics and is a member of the American Pediatric Society.</p>

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Expert Summary

<p>Dr. Hsu is one of the nation's leading experts in children's heart failure and heart transplant. Dr. Hsu brings specialized medical skills, decades of experience-and extraordinary commitment-to the care of children with complex heart disease. She conducts ongoing clinical research and has participated in many US multi-center studies on children's cardiomyopathies, medical and catheter-based therapy for heart disease in children and heart transplant. She is a nationally recongized pediatric cardiologic thought-leader.</p>

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Clinical Profile

CHAM Provider

On

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Elsevier Profile

PubMed.gov URL

EMR ID

4960

Biography

<p>Dr. Daphne Hsu, is one of the nation's leading experts in children's heart failure and heart transplant. Dr. Hsu has treated more than 600 children with heart failure and more than 250 children undergoing heart transplant. Past director of Pediatric Heart Failure at New York-Presbyterian Hospital, Dr. Hsu brings unique specialized medical skills, decades of experience-and extraordinary commitment-to the care of your child with complex heart disease.</p><p>When your child is being considered for a heart transplant, Dr. Hsu provides expert evaluation. Before, during and after surgery, she manages the full-spectrum, customized medical therapy-and hands-on specialized care-your child needs for successful heart transplant.</p><p>In addition to managing her busy practice, Dr. Hsu conducts ongoing clinical research and is a nationally recognized pediatric cardiologic thought-leader.</p><p>Since beginning her career in 1987, Dr. Hsu has participated in many important US multi-center studies on children's cardiomyopathies, medical and catheter-based therapy for heart disease in children and heart transplant. Dr. Hsu served on the end-point and steering committee of the only multi-centered, placebo-controlled trial studying the effect of Carvedilol in pediatric heart failure patients.</p><p>Past president and board member of the Pediatric Heart Transplant Study Group, Dr. Hsu also sits on the boards of the Pediatric Cardiomyopathy Registry and the Adult Congenital Heart Disease Committee for the American Heart Association. In addition to authoring dozens of peer-reviewed cardiologic studies (link: p. 41), Dr. Hsu reviews pediatric cardiologic-related grants for the Food and Drug Administration and the National Institutes of Health and is a member of the Sub Board of Pediatric Cardiology of the American Board of Pediatrics.</p><p>Dr. Hsu was drawn to pediatric cardiology early in her career. "I like being able to care for the sickest children," she explains. Children with heart failure "have a terrible disease," says Dr. Hsu. "You have to figure out what it is. You have to treat it quickly. And you have to do it well-and then you can follow them for the rest of their lives." Lasting relationships with her patients-and their families-are for Dr. Hsu among the most rewarding aspects her work. "You can share with the family the joy of this child who is doing so beautifully because you know where they've come from."</p>

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Manoj Gupta

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First Name

Manoj

Last Name

Gupta

NPI

1780817460

Faculty ID

16086

CMO Specialties

Clinical Terms

Employment Status

Full Time

Patient Type

Pediatric

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Male

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Phone

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On

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Elsevier Profile

EMR ID

102348

Biography

<p>Manoj Gupta, MBBS, MD, is an Attending Physician in the Division of Pediatric Cardiology at Children&rsquo;s Hospital at Montefiore and an Assistant Professor at Albert Einstein College of Medicine. He specializes in noninvasive pediatric cardiology, with special interests in sports cardiology and congenital heart disease in young patients. Dr. Gupta joined Montefiore in 2018.</p><p>Dr. Gupta received his Bachelor of Medicine and Bachelor of Surgery at Lokmarya Tilak Municipal Medical College, Sion Hospital in Mumbai, India in 2003. He completed a junior residency at DDU Hospital in Delhi, India from 2003 to 2004 and then completed a residency in Pediatrics in 2008 at Maharaja Agrasen Hospital. In 2009, Dr. Gupta started another residency in Pediatrics at Sparrow Hospital, Michigan State University and completed that in 2012. In 2015, he completed a fellowship in Pediatric Cardiology at Case Medical Center. </p><p>Dr. Gupta treats all cardiac conditions for inpatient, ICU and outpatients, ranging from infancy through young adults. This spans everything from complex congenital heart disease to acquired heart conditions. He has extensive teaching experience from medical students to residents at various institutions over last 10 years.</p><p>Dr. Gupta has had his clinical research work on pediatric health published in numerous journals.</p><p>Dr. Gupta is board certified in both Pediatrics and Pediatric Cardiology by the American Board of Pediatrics and is a member of numerous professional societies, including the American College of Cardiology and the American Academy of Pediatrics. </p>

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Samuel V. Gorstein

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First Name

Samuel

Last Name

Gorstein

NPI

1285878652

Faculty ID

15800

CMO Specialties

Clinical Terms

Employment Status

Full Time

Patient Type

Pediatric

Department

Gender

Male

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Phone

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Education and Trainings

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CHAM Provider

On

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Elsevier Profile

EMR ID

12106

Biography

<p>Samuel Gorstein, MD, is Director, Resident Education, Pediatric Intensive Care Unit (PICU) at the Children&rsquo;s Hospital at Montefiore Einstein (CHAM) and Assistant Professor, Pediatrics at our Albert Einstein College of Medicine. Dr. Gorstein&rsquo;s clinical focus is on the care of critically ill infants, children and adolescents, focusing on conditions requiring intensive monitoring, life support and complex interventions, such as respiratory failure, sepsis, trauma and post-surgical recovery.
</p><p>After obtaining a Bachelor of Science in Biophysics from Brown University, Dr. Gorstein attended the University of Massachusetts Medical School, where he received his Doctor of Medicine in 2009. He then began his postgraduate training with an internship and residency in Pediatrics at Baystate Medical Center from 2009 to 2012. In 2015, he completed a fellowship in Pediatric Critical Care at Massachusetts General Hospital. </p><p>Dr. Gorstein oversees resident education in the PICU and has developed a didactic curriculum for residents rotating through the PICU at CHAM. His research aligns with his clinical expertise, and his work has been shared through peer-reviewed publications, invited presentations, abstracts, and poster presentations at professional meetings. </p><p>Dr. Gorstein is board-certified in Pediatrics and Pediatric Critical Care Medicine. He is a member of the American Academy of Pediatrics and the Society of Critical Care Medicine.

</p>

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David L. Goldman

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First Name

David

Last Name

Goldman

NPI

1730245671

Faculty ID

5923

CMO Specialties

Clinical Terms

Employment Status

Full Time

Patient Type

Pediatric

Department

Gender

Male

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Phone

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Locations

Education and Trainings

Professional Interests

<p>The medical community has long recognized fungi as important allergens for patients with asthma. Interestingly, fungal sensitization is more common in children and has been linked to severe asthma resulting in death. The accepted paradigm is that fungal sensitization occurs as a result of recurrent, transient environmental exposures. Yet, increasing evidence suggests that fungi may interact with people in unrecognized ways to promote asthma. My lab is interested in understanding the role of subclinical fungal infections in asthma and their potential contribution to the high prevalence of asthma in urban areas.<br /><br /></p>
<p><em>Cryptococcus neoformans</em> is an encapsulated fungus that is well suited to serve as co-factor in urban asthma. <em>C. neoformans</em> colonizes pigeon droppings and is endemic to urban areas. Once inhaled, this fungus causes persistent, subclinical infections. We have demonstrated that the majority of Bronx children older than 2 years have serologic evidence of cryptococcal infection. Cryptococcal infection induces TH2 inflammation in animal models. In a rat model, we have shown that cryptococcal pulmonary infection acts a co-factor to enhance allergic inflammation to allergen challenge and promotes airway hyper-responsiveness, both hallmark features of asthma. Pulmonary cryptococcosis also induces chitinase expression, which has recently been implicated as an essential mediator of allergic inflammation.<br /><br /></p>
<p>To study this phenomenon, we have established collaborations with Pulmonary Medicine, Critical Care and Emergency Medicine at the Children&Atilde;&cent;&acirc;&sbquo;&not;&acirc;&bdquo;&cent;s Hospital of Montefiore. These collaborations provide access to the large number of children with asthma in the Bronx. Current studies underway include a characterization of chitinase expression among asthmatics and a comparison of cryptococcal infection prevalence among asthmatics and non-asthmatics. Animal experimentation directed at understanding the mechanisms and variables related to fungal induced asthma are also underway.<br /><br /></p>
<p>In addition to fungal studies, my lab is interested in anthrax pathogenesis. <em>Bacillus anthracis</em> is widely recognized as a potential agent of bioterrorism as evidenced by the 2001 anthrax attack. The toxins of <em>B. anthracis</em> are essential to virulence. In collaborations with Drs. Arturo Casadevall and Jurgen Brojatsch, we have studied the mechanisms by which <em>Bacillus anthracis</em> toxins contribute to host death. We have identified a previously unrecognized protease in human serum that inactivates the protective antigen component of lethal toxin <em>in vitro</em>. The precise protease and its role in the host response and susceptibility to anthrax remain to be determined. We have also identified a potential role for platelet activating factor (PAF) in mediating the lethal effects of toxin, including the alterations in vascular permeability which is characteristic of anthrax. Together, these observations may have important implications in developing new approaches to the treatment of anthrax.</p>

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Research Profile

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Professional Title

Clinical Focus

Dr. Goldman has a special interest in fungal infections in children, including hospital and community acquired mycoses.

Research Focus

Dr. Goldman has two primary research interests: the contribution of fungi to the development of asthma in children and the pathogenesis of C. difficile infection in children

Elsevier Profile

Selected Publications

<div id="pmid_19708853" class="rprt">
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<p>1.&nbsp; Fungal sensitization in childhood persistent asthma is associated with disease severity.&nbsp; Vicencio AG, Santiago MT, Tsirilakis K, Stone A, Worgall S, Foley EA, Bush D, Goldman DL.&nbsp; Pediatr Pulmonol. 2013 Feb 8. doi: 10.1002/ppul.22779. [Epub ahead of print]</p>
<p>&nbsp;</p>
<p>2.&nbsp; Increased chitinase expression and fungal-specific antibodies in the bronchoalveolar lavage fluid of asthmatic children.&nbsp; Goldman DL, Li X, Tsirilakis K, Andrade C, Casadevall A, Vicencio AG.&nbsp; Clin Exp Allergy. 2012 Apr;42(4):523-30. doi: 10.1111/j.1365-2222.2011.03886.x. Epub 2011 Oct 10.</p>
<p>&nbsp;</p>
<p>3.&nbsp; CHIT1 mutations: genetic risk factor for severe asthma with fungal sensitization?&nbsp; Vicencio AG, Chupp GL, Tsirilakis K, He X, Kessel A, Nandalike K, Veler H, Kipperman S, Young MC, Goldman DL.</p>
<p>Pediatrics. 2010 Oct;126(4):e982-5. doi: 10.1542/peds.2010-0321. Epub 2010 Sep 6.</p>
<p>&nbsp;</p>
<p>4.&nbsp; Proteasome inhibitors prevent caspase-1-mediated disease in rodents challenged with anthrax lethal toxin.Muehlbauer SM, Lima H Jr, Goldman DL, Jacobson LS, Rivera J, Goldberg MF, Palladino MA, Casadevall A, Brojatsch J.&nbsp; Am J Pathol. 2010 Aug;177(2):735-43. doi: 10.2353/ajpath.2010.090828. Epub 2010 Jul 1. Erratum in: Am J Pathol. 2010 Oct;177(4):2145.</p>
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EMR ID

4147

Biography

<p>David L. Goldman, MD, is Fellowship Director, Pediatric Infectious Diseases; Associate Professor, Pediatrics, and Associate Professor, Microbiology and Infectious Diseases at Montefiore Einstein. He has a special interest in fungal infections in children, including hospital and community acquired mycoses.</p><p>After earning his Bachelor of Arts from Brandeis University in 1983, Dr. Goldman attended Jefferson Medical College, earning his Doctor of Medicine in 1987. He began his postdoctoral education at St. Vincent&rsquo;s Hospital. Yale University, New York Medical College, completing a yearlong internship before coming to Einstein&rsquo;s Jacobi Medical Center, where he completed a residency in pediatrics in 1991, a fellowship in academic pediatrics in 1992 and a fellowship in pediatric infectious diseases in 1996.</p><p>Dr. Goldman has two primary research interests: the contribution of fungi to the development of asthma in children and the pathogenesis of C. difficile infection in children. He has shared his work through conferences, symposia, books, peer-reviewed journals, review articles, abstracts and poster presentations. He has also been an ad hoc reviewer for several journals including <em>Infection and Immunity, Microbes and Infection</em>, and <em>Medical Mycology</em>.</p><p>Dr. Goldman is board certified in pediatrics and pediatric infectious diseases. He is a member of the American Society of Microbiology, the Infectious Diseases Society of America and the Pediatric Infectious Diseases Society.</p>

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