Dr. Brust is a Professor of Medicine, with joint appointments in the Divisions of General Internal Medicine and Infectious Diseases. He graduated from the College of Physicians & Surgeons at Columbia University and completed both a residency in Internal Medicine and a fellowship in Infectious Diseases at the Columbia University Medical Center. 
Dr. Brust's research is focused on the dual epidemics of multidrug-resistant tuberculosis (MDR TB) and HIV in South Africa. With multiple US and international collaborators, his multidisciplinary research group is studying treatment outcomes of MDR TB/HIV co-infected patients, transmission patterns of drug-resistant TB, pharmacology of new and repurposed TB medications, and genetic mechanisms of drug-resistance. He has funding from NIAID to examinine the emergence of resistance to the new TB medication bedaquiline in patients with MDR and XDR TB.

Research Areas

Epidemiology and treatment outcomes of drug-resistant tuberculosis and HIV in South Africa. A particular focus is on novel therapeutics and emergence of resistance as drugs are introduced into the South African TB program.

Research Profile

https://einsteinmed.edu/faculty/11307/James-Brust

Clinical Profile

https://montefioreeinstein.org/profiles/1508998485/james-cm-brust

CHAM Provider

Off

Professional Title

M.D.

Elsevier Profile

https://einstein.pure.elsevier.com/en/persons/57be43a3-1a8c-4da6-8762-881ca6b78…

Selected Publications

Selected Publications
 
Brust JCM, Gandhi NR, Carrara H, Osburn G and Padayatchi N. High Treatment Failure and Default Rates for Patients with MDR TB in KwaZulu-Natal, South Africa, 2000-2003. Int J Tuberc Lung Dis. 2010;14(4):413-9
 
Brust JCM, Shah NS, Scott M, Chaiyachati K, Lygizos M, van der Merwe TL, Bamber S, Radebe Z, Loveday M, Moll AP, Margot B, Lalloo UG, Friedland GH, Gandhi NR. Integrated, home-based treatment for MDR-TB and HIV in rural South Africa: an alternate model of care. Int J Tuberc Lung Dis 2012; 16:998-1004.
 
Brust JCM, Shah NS, van der Merwe TL, Bamber S, Ning Y, Heo M, Moll AP, Loveday M, Lalloo UG, Friedland GH, Gandhi NR. Adverse events in an integrated, home-based treatment program for MDR-TB and HIV in KwaZulu-Natal, South Africa. J Acquir Immune Defic Syndr 2013; 62:436-440.
 
Brust JCM, Berman AR, Zalta B, Haramati LB, Ning Y, Heo H, van der Merwe TL, Bamber S, Moll AP, Friedland GH, Shah NS, Gandhi NR.Chest radiograph findings and time to culture conversion in patients with multidrug-resistant tuberculosis and HIV in Tugela Ferry, South Africa.PLoS One 2013; 8(9): e73975. doi:10.1371/journal.pone.0073975
 
Gandhi NR, Brust JCM, Moodley P, Weissman D, Heo M, Ning Y, Moll AP, Friedland GH, Sturm W, Shah NS. Low M. tuberculosis strain diversity among multidrug- and extensively drug-resistant tuberculosis isolates from Tugela Ferry, South Africa, 2005-2006. Emerg Infect Dis 2014; 20(3):394-401.
 
Loveday M, Wallengren K, Brust J, Roberts J, Voce A, Margot B, Ngozo J, Master I, Cassell G, Padayatchi N. Community-based care vs. centralised hospitalisation for MDR-TB patients, KwaZulu-Natal, South Africa. Int J Tuberc Lung Dis. 2015 Feb;19(2):163-71.
 
Niehaus AJ, Gandhi NR, Mathema B, Mlisana K, Brust JCM. High prevalence of inhA promoter mutations among patients with drug-resistant tuberculosis in KwaZulu-Natal, South Africa. PLoS One 2015; 10(9):e0135003. doi: 10.1371/journal.pone.0135003
 
Shah NS, Auld S, Brust JCM, Mathema B, Ismail N, Moodley P, Mlisana K, Allana S, Campbell A, Mthiyane T, Morris N, Mpangase P, Vally Omar S, Brown T, Narenchania A, Shaskina E, Kapwata T, Kreiswirth B, Gandhi NR. Transmission of Extensively Drug-Resistant Tuberculosis in South Africa. N Engl J Med 2017; 376(3):243-253
 
Brust JCM, Shah NS, Mlisana K, Moodley P, Allana S, Campbell A, Johnson BA, Master I, Mthiyane T, Lachman S, Larkan L-M, Ning Y, Malik A, Smith JP, Gandhi NR. Improved survival and cure rates with concurrent treatment for MDR-TB/HIV co-infection in South Africa. Clin Infect Dis. 2018; 66(8):1246-1253.
 
Wasserman S, Denti P, Brust JCM, Abdelwahab M, Hlungulu S, Wiesner L, Norman J, Sirgel FA, Warren RM, Esmail A, Dheda K, Gandhi NR, Meintjes G, Maartens G. Linezolid pharmacokinetics in South African patients with drug resistant tuberculosis and a high prevalence of HIV co-infection. Antimicrob Agents Chemother 2019 63(3):e02164-18
 
Meintjes G, Brust JCM, Nutall J, Maartens G. Management of active tuberculosis in adults with HIV. Lancet HIV 2019; 6: e463–74
 
Smith JP, Gandhi NR, Shah NS, Mlisana K, Moodley P, Johnson BA, Allana S, Campbell A, Nelson KN, Master I, Brust JCM. The impact of concurrent antiretroviral therapy and MDR-TB treatment on adverse events. J Acquir Immune Defic Syndr 2020; 83(1):47-55
 
Ngwalero P*, Brust JCM*, van Beek SW, Wasserman S, Maartens G, Meintjes G, Joubert A, Norman J, Castel S, Gandhi NR, Denti P, McIlleron H, Svensson EM, Wiesner L. Relationship between plasma and intracellular concentrations of bedaquiline and its M2 metabolite in South African patients with rifampin-resistant TB. Antmicrob Agents Chemother. 2021; 65(11):e0239920. doi: 10.1128/AAC.02399-20
 
Brust JCM, Gandhi NR, Wasserman S, Maartens G, Omar SV, Ismail NA, Campbell A, Joseph L, Hahn A, Allana S, Hernandez-Romieu AC, Zhang C, Mlisana K, Viljoen CA, Zalta B, Ebrahim I, Franczek M, Master I, Ramangoaela L, Te Riele J, Meintjes G; PROBeX Study Team. Effectiveness and cardiac safety of bedaquiline-based therapy for drug-resistant tuberculosis: a prospective cohort study. Clin Infect Dis. 2021; 73(11):2083-2092

EMR ID

5132

Is Open Scheduling

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Larry Jay Bernstein

Read more about Larry Jay Bernstein

Larry Jay Bernstein

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Provider

Faculty

First Name

Larry

Last Name

Bernstein

NPI

1851380950

Faculty ID

963

CMO Specialties

Clinical Terms

Hypertensive Emergency

Chronic Bronchitis

Cough

Complex Regional Pain Syndrome

Allergic Conjunctivitis

Anaphylactic Reaction

Allergic Reactions

Shortness Of Breath

Viral Conjunctivitis

Bacterial Conjunctivitis

Seborrheic Dermatitis

Reactive Airway Disease

Lower Respiratory Tract Infection

Employment Status

part-time

Patient Type

Pediatric

Department

einstein-dept-pediatrics

Gender

Male

labernst@montefiore.org

Phone

718-405-8530

Titles

Type

Academic

Department

Department of Pediatrics

Department Link

Rank

Associate Professor

Division

Pediatric Allergy & Immunology

Type

Clinical

Title

Attending Physician, Division of Allergy & Immunology, Children’s Hospital at Montefiore Einstein

Type

Clinical

Title

Associate Professor of Pediatrics, Albert Einstein College of Medicine

Locations

Is Primary

Off

Type

Clinical

Location (Address, State, City, Zip)

Not used, will be deleted

Coordinates

POINT (-73.84907 40.85098)

Address Line 1

1180 Morris Park Avenue

City

Bronx

State

Zip

10461-1925

Location Title

Montefiore Wellness Center

Is Primary

Type

Clinical

Location (Address, State, City, Zip)

Not used, will be deleted

Coordinates

POINT (-73.84521 40.84556)

Address Line 1

1525 Blondell Avenue

City

Bronx

State

Zip

10461-2601

Location Title

Montefiore CFCC at Blondell

Is Primary

Off

Type

Clinical

Location (Address, State, City, Zip)

Not used, will be deleted

Coordinates

POINT (-73.87811 40.87956)

Address Line 1

3411 Wayne Avenue

City

Bronx

State

Zip

10467-2509

Location Title

Montefiore At 3411 Wayne Avenue

Is Primary

Off

Type

Academic

Location (Address, State, City, Zip)

Not used, will be deleted

Coordinates

POINT (-73.8457528 40.845826)

Address Line 1

Montefiore Medical Park

Address Line 2

1525 Blondell Avenue

City

Bronx

State

Zip

10461

Location Title

Montefiore Medical Park

Education and Trainings

Education Type Label

Medical Education

Education Institution

Albert Einstein College of Medicine

Education Type Label

Fellowship

Education Institution

Albert Einstein College of Medicine

Education Type Label

Residency

Education Institution

Jacobi Medical Center

Research Profile

https://einsteinmed.edu/faculty/963/Larry-Bernstein

Clinical Profile

https://montefioreeinstein.org/profiles/1851380950/larry-jay-bernstein

CHAM Provider

Off

Professional Title

M.D.

EMR ID

3195

Biography

Larry J. Bernstein, MD, is Associate Program Director, Allergy and Clinical Immunology at the Children’s Hospital at Montefiore Einstein and Associate Clinical Professor, Pediatrics at our Albert Einstein College of Medicine. Dr. Bernstein’s clinical focus is in chronic urticaria, asthma, and primary and acquired immunodeficiencies.After receiving his Bachelor of Arts from Yeshiva University in 1973, Dr. Bernstein came to Einstein for his medical education, earning his Doctor of Medicine in 1977. He completed his internship and residency in pediatrics at Bronx Municipal Hospital Center in 1981, taking on the role of Chief Resident in his final year. In 1983, Dr. Bernstein completed a two-year fellowship in allergy and immunology at Einstein.Dr. Bernstein’s research focus is in clinical service grants for HIV care. He has shared his work through peer-reviewed journals, abstracts, poster presentations and book chapters.Dr. Bernstein is a Diplomate of the American Board of Pediatrics and the American Board of Allergy and Immunology. He is a Fellow of the American College of Allergy and Immunology and a member of the American Academy of Allergy and Immunology and the Clinical Immunology Society. In 1981, he received the Leo M. Davidoff Certificate of Distinction for excellence in medical student teaching.

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Zocdoc Link

https://www.zocdoc.com/wl/montefiore/doctor/larry-bernstein-md-186323