Kate R. Steinberg

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Kate

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Steinberg

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16973

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Tihomir Stefanec

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Tihomir

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Stefanec

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1396729976

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11731

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<p>I am interested in Internal Medicine, Critical Care Medicine and Pulmonary Medicine. &nbsp;My current interest is Critical Care Medicine. &nbsp;</p>

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Multidisciplinary Critical Care Medicine (Medical, Surgical, Neurologic, Cardiothoracic).<quillbot-extension-portal></quillbot-extension-portal>

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Role of the endothelium and its progenitors in the pathogenesis of disease.<quillbot-extension-portal></quillbot-extension-portal>

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EMR ID

5176

Biography

<p>Tihomir Stefanec, MD, is Attending Physician, Critical Care Medicine, Assistant Professor, Medicine and Neurology at Montefiore Einstein. His clinical focus is multidisciplinary critical care medicine including medical, surgical, neurologic and cardiothoracic critical care.</p><p>After earning his Doctor of Medicine from the University of Zagreb Medical School in Zagreb, Croatia in 1992, Dr. Stefanec completed an internal medicine internship and residency at Long Island College Hospital in 1997. He then completed a critical care medicine fellowship at Saint Vincent&rsquo;s Hospital and Medical Center in 1999. Following this, Dr. Stefanec completed a pulmonary medicine fellowship at Memorial Sloan Kettering Cancer Center in 2001.</p><p>Dr. Stefanec&rsquo;s past research focuses on the role of the endothelium and its progenitors in the pathogenesis of disease. His work has been published in peer-reviewed original publications, reviews, editorials and abstracts, and he has presented nationally.</p><p>Dr. Stefanec is board certified in Internal Medicine, Critical Care Medicine and Pulmonary Medicine by the American Board of Internal Medicine, as well as in Neurocritical Care by the United Council for Neurologic Subspecialties. He has been a Fellow of the American College of Chest Physicians since 2003, and is a member of the American Thoracic Society, the American College of Chest Physicians and the European Respiratory Society.</p>

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Brian D. Spund

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Brian

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Spund

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1629377320

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15059

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part-time

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Luke R. Sponholz

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Luke

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Sponholz

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1679837579

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18058

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Simon D. Spivack

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Simon

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Spivack

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1366438475

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11003

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<p>&nbsp;</p>
<p>Focusing diagnostics and therapeutics on those most likely to benefit is a key to successful intervention&nbsp;at both the public health and clinical levels. The translational goal of the Spivack laboratory is to identify individuals at particularly high risk for lung malignancy, and selected non-malignant lung diseases, upon whom to focus smoking/toxin exposure cessation (primary prevention), chemoprevention (secondary prevention), and early disease detection efforts (disease screening, tertiary prevention).</p>
<p>The laboratory is currently exploring individual Gene x Environment signatures as susceptibility markers by exploring quantitative gene (mRNA) expression phenotypes, and the DNA sequence, methylation, microRNA, and other epigenetic features potentially underlying these expression phenotypes, <em>in vitro</em> and in human populations. This is performed in the setting of defined tobacco, diet, and other exposures. There are both mechanistic and translational components to the studies.&nbsp;</p>
<p><br /><strong>Mechanistically</strong>, the role of epigenetic variation in promoter regions in the 5' and 3' regulatory regions of carcinogenesis and oxidant pathway genes is being explored <em>in vitro</em>, using human genomic DNA reporter constructs, and native gene regulation models. High resolution technologies include the realtime quantitation of native mRNA and microRNA by the laboratory's RNA-specific strategy (<em>patented</em>); the&nbsp;tagged-bisulfite genomic sequencing strategy to determine single base resolution CpG methylation status (tBGS, <em>patented</em>);&nbsp;&nbsp;an experimental strategy for assaying microRNA binding to mRNA, for determining the role of miRNA in candidate gene regulation&nbsp;(<em>patented</em>); and evaluation of functional consequences of DNA&nbsp;methylation detail, using a novel patch reporter construct (<em>patented</em>).&nbsp; A new method to engineer methyl-cytosines into the epigenome has recently been developed.</p>
<p>Whole (epi)genome approaches to identify molecular events unique to lung cancer&nbsp;are being completed, which will represent one of the initial cross-platform 'omics level discovery examinations of&nbsp;lung&nbsp;tissues.&nbsp; The execution of each individual discovery platform involves&nbsp;expert local collaborators and cores&nbsp;in (epi)genetics and genomics, and the "integromics" is critically reliant on Einstein strengths in informatics and biostatistical analyses.</p>
<p>&nbsp;</p>
<p><strong>Translationally</strong>, human lung carcinogenesis biomarkers are being established by pairing laser capture microdissected lung with several unique, non-invasively collected surrogate specimens developed in the laboratory. These include mRNA expression signatures from brush-exfoliated buccal mucosa cells, microRNAs detected in exhaled breath condensate representing first reports for a new exhaled airway biomarker class, and exhaled metabolomic signatures. These airway-derived specimens continue to accrue from a sampling (currently n&gt;1000) of a population assembled in a lung cancer case-control context.&nbsp; The specimens are being studied with a view toward developing non-invasive assays in populations.</p>
<p>&nbsp;</p>
<p>The overall aim is to develop informative non-invasive risk profiling, preventive, and early disease detection strategies for the lung in human populations.</p>
<p>&nbsp;</p>
<p>&nbsp;<em>Work is funded by ongoing NIH,</em><em> DoD,&nbsp;and&nbsp;Foundation support.</em></p>
<p>&nbsp;</p>
<p><strong>Clinical Specialties</strong></p>
<ul style="font-size: 1em; color: #333333; padding: 0px; margin: 20px 0px 25px 38px;">
<li style="padding: 0px; margin: 12px 0px 5px 0px;">lung nodule evaluation</li>
<li style="padding: 0px; margin: 12px 0px 5px 0px;">lung cancer diagnostics and screening</li>
<li style="padding: 0px; margin: 12px 0px 5px 0px;">interstitial lung disease</li>
<li style="padding: 0px; margin: 12px 0px 5px 0px;">environmental lung disease</li>
<li style="padding: 0px; margin: 12px 0px 5px 0px;">refractory asthma</li>
<li style="padding: 0px; margin: 12px 0px 5px 0px;">general pulmonary medicine</li>
</ul>

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<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt;">A researcher and clinician, Dr. Spivack is developing tests for detecting lung cancer at the earliest possible stage&mdash;before it becomes fatal by spreading to other parts of the body. In one of several NIH-funded studies, his laboratory is working on a noninvasive, early-diagnosis test for lung cancer that detects particular genetic elements and chemicals in exhaled breath.</span></p>
<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt;">In addition to general pulmonary medicine, Dr. Spivack&rsquo;s clinical practice focuses on lung nodule and lung cancer diagnosis, diffuse interstitial lung diseases, and environmental lung diseases.</span></p>

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Dr. Spivack specializes in consultative pulmonary medicine, with an emphasis on the evaluation of lung nodules, lung cancer screening, asthma, and environmental and interstitial lung disease.<span style="color:#4d4d4d;font-family:Arial, Helvetica, source-code-pro, Menlo, Monaco, Consolas, 'Courier New', monospace;font-size:16px;background-color:#ffffff;"><strong></strong></span>

Research Focus

Dr. Spivack&rsquo;s research focuses on the development of non-invasive early detection airway biomarkers of lung cancer risk, as well as epigenetics, gene regulation, gene-environment interaction and non-invasive measurement of deep lung phenomena in humans.

Elsevier Profile

Selected Publications

<p>&nbsp;</p>
<p><strong><span style="text-decoration: underline;">Selected Publications, as of April, 2023</span>:</strong></p>
<p class="MsoNormal"><span style="text-indent: -0.25in;">Shi M, Han W, Loudig O, Shah C, Dobkin J, Keller S, Sadoughi A, Patel D, Desai A, Gombar S, Suh Y, Fernandez MK, DeLaRosa L, Wang T, Hosgood D, Pradhan K, Ye K, </span><strong style="text-indent: -0.25in;">Spivack SD.</strong><span style="text-indent: -0.25in;">&nbsp; </span><span style="text-indent: -0.25in;">(2023) Initial development and testing of an exhaled microRNA detection strategy for lung cancer case-control discrimination</span><em style="text-indent: -0.25in;">. [accepted, Scientific Reports, NPG]</em></p>
<p class="MsoNormal" style="margin-bottom: 1.7pt; background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;">&nbsp;</p>
<p class="MsoNormal" style="margin-bottom: 1.7pt; background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;"><span style="color: #212121; background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;">Huang Z, Sun S, Lee M, Maslov AY, Shi M, Waldman S, Marsh A, Siddiqui T, Dong X, Peter Y, Sadoughi A, Shah C, Ye K, *<strong>Spivack SD</strong>, *Vijg J. Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking. Nat Genet. 2022 Apr;54(4):492-498. doi: 10.1038/s41588-022-01035-w. Epub 2022 Apr 11. PMID: 35410377. (*co-senior authors).</span></p>
<p class="MsoNormal" style="margin-bottom: 1.7pt; background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;">&nbsp;</p>
<p class="MsoNormal"><span style="font-variant-numeric: normal; font-variant-east-asian: normal; font-stretch: normal; font-size: 7pt; line-height: normal; font-family: 'Times New Roman';">&nbsp;</span><!--[endif]--><span lang="EN">Cleven KL, Ye K, Zeig-Owens R, Hena KM, Montagna C, Shan J, Hosgood HD 3rd, Jaber N, Weiden MD, Colbeth HL, Goldfarb DG, <strong>Spivack SD</strong>++, Prezant DJ++ (++co-senior authors). </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/31126090"><span lang="EN" style="color: windowtext; text-decoration-line: none;">Genetic Variants Associated with FDNY WTC-Related Sarcoidosis.</span></a><span lang="EN"> Int J Environ Res Public Health. 2019 May 23;16(10). pii: E1830. doi: 10.3390/ijerph16101830. PMID:31126090</span>.</p>
<p>Dong X, ShiN, LeeM, ToroR, Gravina S, Han W, Yasuda S, Wang T, Zhang Z, Vijg J, Suh Y, <strong>Spivack SD.</strong> (2018) Global, integrated analysis of methylomes and transcriptomes from laser capture microdissected bronchial and alveolar cells in human lung. <em>Epigenetics </em>10.1080/15592294.2018.1441650, 2018.</p>
<p>Mullapudi N, Ye B, Suzuki M, Wang T, Fazarri M,&nbsp;Han W, Shi M, Marquardt G, Lin J, Wang T,&nbsp;Keller S, Zhu C, Locker&nbsp;J, &nbsp;<strong>Spivack SD.</strong> Genome-wide methylome alterations in lung cancer&nbsp;<em> PLoS ONE, </em>Dec. 2015.</p>
<p>Lin J, Marquardt G, Mullapudi N,&nbsp;Wang, T,&nbsp;Han W, Shi W, Zhu C, Keller S,&nbsp;Zhu C,&nbsp;Locker J, <strong>Spivack SD. </strong>Lung cancer transcriptomes refined with laser capture microdissection.<em>&nbsp;Am J Pathology </em>06.028.&nbsp;2014 .</p>
<p>Han W, Shi M, <strong>Spivack SD</strong>. Site-specific methylated reporter constructs for functional analysis of DNA methylation.<em> Epigenetics </em>4; 8(11), 2013.</p>
<p>Shi M, Han W, <strong>Spivack SD</strong>. A quantitative method to identify miRNAs targeting an mRNA using a 3'UTR RNA affinity technique.<em> Analytic Biochem</em>&nbsp;1;443(1):1-12, 2013<em>.</em></p>
<p>Alberg AJ, Brock MV, Ford JG, Samet JM, <strong>Spivack, SD.</strong>&nbsp;&nbsp;Epidemiology of lung cancer.&nbsp; In Evidence-based Practice Guidelines. Diagnosis and Management of Lung Cancer (ACCP position statement). <em>CHEST</em>.&nbsp;&nbsp;May 2013;143(5 Suppl):e1S-e29S. doi: 10.1378/chest.12-2345. PMID: 23649439.</p>
<p>Tan XT, Marquardt G, Shi M, Han W, <strong>Spivack SD.</strong> High throughput library screening identifies phytochemical inducers of phase II mutagen/oxidant metabolism enzymes GSTP1 and NQO1 in human lung cells.<em> Am J Resp Cell Molec Biol, </em>46(3): 365-71, 2012.</p>
<p>Brock GJ,&nbsp;Moschos S, <strong>Sp</strong><strong>ivack SD,</strong> Hurteau GJ.&nbsp;The 3' prime paradigm of the miR-200 family and other microRNAs. <em>Epigenetics</em> (6:3, 1-5), 2011.</p>
<p>Tan XT, &nbsp;Shi M, &nbsp;Minna JD,&nbsp; Han W,&nbsp; <strong>Spivack SD.</strong> Candidate phytopreventive agent modulation of phase II metabolism enzymes <em>GSTP1</em> and <em>NQO1</em> in human bronchial cells<em>. J Nutrition,&nbsp;</em>140(8): 1404-10, 2010<em>.</em></p>
<p>Tan, XT, &nbsp;&nbsp;Wang T,&nbsp; Xiong S,&nbsp; Kumar SV,<strong>&nbsp;</strong> Han W, &nbsp;<strong>Spivack SD.</strong> &nbsp;Smoking-related gene expression in laser capture microdissected human lung. <em>Clin Cancer Res,</em> 15(24): 7562-70, 2009.</p>
<p>Han W, Tang T, Reilly AA, Keller S, <strong>Spivack SD</strong>. Gene promoter methylation analyses from exhaled breath, with differences in smokers and lung cancer cases.&nbsp; <em>Resp Res,</em> 10:86 epubl, 2009.</p>
<p>Tan X-L,&nbsp; Moslehi R, Han W, <strong>Spivack SD</strong>. Haplotype tagging single nucleotide polymorphisms in the glutathione S-transferase P1 gene promoter and susceptibility to lung cancer. <em>Cancer Detection Prev,</em>32:403-415, 2009<em>.</em></p>
<p>Tan X-L,&nbsp;&nbsp;<strong>Spivack SD</strong>. Dietary chemoprevention strategies for&nbsp;induction of phase II metabolism: a review. <em>Lung Cancer,</em>65(2):129-37, 2009.</p>
<p>Hurteau GJ, Carlson AJ, <strong>Spivack, SD,</strong> Brock GJ. Restoration of E-Cadherin expression by over-expression of the microRNA <em>hsa-miR-200c</em> via reduced expression of the transcription factor TCF8. <em>Cancer Res.</em> 67:7972-76, 2007.</p>
<p>Hurteau, GJ, <strong>Spivack</strong> <strong>SD</strong>, Brock G.&nbsp; Parallel identification of miRNA and target mRNA by combined informatics and qRT-PCR approaches: application to <em>has-miR-200c.</em>&nbsp; <em>Cell Cycle</em> 5(17):1951-56, 2006.</p>
<p>Han W, Cauchi S, Herman JG, <strong>Spivack SD</strong>.&nbsp; Methylation mapping of DNA by tag-modified bisulfite genomic DNA sequencing. <em>Analytic Biochem. 355: 50-61,</em> 2006.</p>
<p>Cauchi S, Han W, Kumar SV, <strong>Spivack SD</strong>. Haplotype-environment interactions regulating the human <em>GSTP1</em> promoter <em>Cancer Res</em>. 66(12): 6439-6448, 2006.</p>
<p>Kumar SV, Hurteau GJ, <strong>Spivack SD.</strong> Validity of mRNA expression analyses of human saliva. <em>Clin. Cancer Res.</em> 12: 5033-39, 2006.</p>
<p><strong>Spivack SD</strong>, Hurteau GJ, Jain R, Kumar SV, Aldous KM, Gierthy JF, Kaminsky LS.&nbsp; Gene-environment interaction signatures by quantitative mRNA profiling in exfoliated buccal mucosal cells. <em>Cancer Res,</em> 64:6805-6813, 2004.</p>
<p><strong>Spivack SD</strong>, Hurteau GJ, Fasco MJ, Kaminsky LS.&nbsp; Phase I and II carcinogen metabolism gene expression in human lung tissue and tumors.&nbsp; <em>Clinical Cancer Research</em>, 9:6002-6011, 2003.</p>
<p>&nbsp;</p>

EMR ID

4969

Biography

<p>Simon D. Spivack, MD, MPH, is Professor, Medicine, Epidemiology and Genetics at Montefiore Einstein. He is also former Emeritus Chief, Pulmonary Medicine. Clinically, Dr. Spivack specializes in consultative pulmonary medicine, with an emphasis on the evaluation of lung nodules, lung cancer screening, asthma, and environmental and interstitial lung disease. </p><p>After obtaining his Bachelor of Science in Psychobiology from McGill University in Montreal, Canada in 1980, Dr. Spivack earned his Doctor of Medicine from the State University of New York Upstate Medical University in 1985. He then completed an internship and residency in internal medicine at the University of Massachusetts Medical Center in 1988. Dr. Spivack then earned his Master of Public Health at Harvard University, School of Public Health in 1989. He completed a clinical pulmonary and critical care medicine and lung research fellowship at the University of Vermont in 1992. </p><p>Dr. Spivack&rsquo;s research focuses on the development of non-invasive early detection airway biomarkers of lung cancer risk, as well as epigenetics, gene regulation, gene-environment interaction and non-invasive measurement of deep lung phenomena in humans. His work has been published in numerous peer-reviewed journals, articles, chapters and books, and he has given many national/international presentations, organized symposia and visiting professorships. Dr. Spivack is on the Editorial Board for Scientific Reports and is a reviewer for journals such as <em>PLoS Genetics</em>, <em>Genetics in Medicine</em>, <em>Nature Protocols</em>, <em>American Journal of Respiratory &amp; Critical Care Medicine</em>, <em>Carcinogenesis</em>, <em>Cancer Research</em> and others. He holds multiple United States patents. He has been continually funded by the National Institutes of Health (NIH) for research for over 25 years.
</p><p>Dr. Spivack is board certified in internal medicine, pulmonary medicine and critical care medicine. He is a member of the American Thoracic Society (ATS), the American Association for Cancer Research (AACR) and the American Lung Association (ALA). He is a frequent peer-reviewer on various NIH study sections. In the past, Dr. Spivack won the Excellence in Research Award from ALA and the NIH/National Institute of Environmental Health Sciences (NIEHS) Clinical Scientist Development Award.

</p>

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Sumeet Singh-Tan

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Sumeet

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Singh-Tan

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Ariel L. Shiloh

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Ariel

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Shiloh

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1346561891

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12325

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<p class="MsoNormal" style="background: white;">Dr. Shiloh is the Director of the Critical Care Medicine Consult Service and Professor of Medicine at Montefiore Medical Center/Albert Einstein College of Medicine. As a clinician-educator he serves as the director of critical care ultrasonography.&nbsp;&nbsp;</p>
<p class="MsoNormal" style="background: white;">After receiving his medical degree from the Medical School for International Health at Ben Gurion University of the Negev in 2005, he completed both his Internal Medicine residency and Critical Care Medicine fellowship at Montefiore Medical Center/Albert Einstein College of Medicine. Dr. Shiloh joined the Montefiore/Einstein Critical Care faculty in 2010.&nbsp;</p>
<p class="MsoNormal" style="background: white;">&nbsp;Dr. Shiloh is board-certified in:&nbsp;</p>
<p class="MsoNormal" style="background: white;">&middot;&nbsp; &nbsp; &nbsp; &nbsp; &nbsp;Internal Medicine</p>
<p class="MsoNormal" style="background: white;">&middot;&nbsp; &nbsp; &nbsp; &nbsp; &nbsp;Critical Care Medicine</p>
<p class="MsoNormal" style="background: white;">&middot;&nbsp; &nbsp; &nbsp; &nbsp; &nbsp;Neurocritical Care</p>
<p class="MsoNormal" style="background: white;">&middot;&nbsp; &nbsp; &nbsp; &nbsp; &nbsp;Hospice and Palliative Medicine</p>
<p class="MsoNormal" style="background: white;">As an active member of CHEST, Dr. Shiloh serves as faculty leader and co-chair for the Critical Care Ultrasound: Integration Into Clinical Practice course.&nbsp; He is an active contributor to CHEST&rsquo;s &ldquo;Better with Ultrasound&rdquo; and &ldquo;Ultrasound Corner&rdquo; series and a recipient of the &ldquo;Distinguished Chest Educator&rdquo; award.&nbsp;<span style="color: #262626; font-family: Verdana;">Award recipients represent the top 4% of CHEST&rsquo;s international faculty and are recognized for their achievements and long-term contributions to the design and delivery of CHEST education.</span></p>
<p class="MsoNormal" style="background: white;">Dr. Shiloh has authored over 50 original articles, co-edited the &ldquo;The 5-Minute ICU Consult&rdquo; published by Lippincott Williams &amp; Wilkins, and has authored over 15 book chapters. His areas of interest and research include use of point of care ultrasonography, early identification of critical illness, and critical care education and simulation training.&nbsp;</p>
<p class="MsoNormal" style="background: white;">&nbsp;</p>
<p class="MsoNormal" style="background: white;">&nbsp;</p>
<p class="MsoNormal" style="background: white;">&nbsp;</p>

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Early Detection and Treatment of Critical Illness, Point Of Care Ultrasonography For The Evaluation Of Critical Illness, Advanced Airway Management

Research Focus

Dr. Shiloh's research includes the clinical use of point-of-care ultrasonography in critical illness, improvement of airway management, and cardiopulmonary resuscitation.

Elsevier Profile

Selected Publications

<p>1: Shah TE, Vij R, Kim YH, Shiloh AL. Sudden Unilateral Vision Loss in a Patient</p>
<p>Who Received Intravenous Thrombolytic Therapy. Chest. 2021 Dec;160(6):e669-e672.</p>
<p>doi: 10.1016/j.chest.2021.03.074. PMID: 34872684.</p>
<p>&nbsp;</p>
<p>2: Nauka PC, Chen JT, Shiloh AL, Eisen LA, Fein DG. Practice, Outcomes, and</p>
<p>Complications of Emergent Endotracheal Intubation by Critical Care Practitioners</p>
<p>During the COVID-19 Pandemic. Chest. 2021 Dec;160(6):2112-2122. doi:</p>
<p>10.1016/j.chest.2021.06.008. Epub 2021 Jun 15. PMID: 34139207; PMCID:</p>
<p>PMC8204844.</p>
<p>&nbsp;</p>
<p>3: Savel RH, Shiloh AL, Kupfer Y, Hope AA. The Complex Issue of Race and</p>
<p>Coronavirus Disease 2019 in the ICU. Crit Care Med. 2021 Mar 1;49(3):532-535.</p>
<p>doi: 10.1097/CCM.0000000000004766. PMID: 33616353.</p>
<p>&nbsp;</p>
<p>4: Jabbour E, Malik D, Shiloh AL. Sudden Cardiopulmonary Collapse in a Patient</p>
<p>With Coronavirus Disease 2019. Chest. 2021 Feb;159(2):e127-e129. doi:</p>
<p>10.1016/j.chest.2020.05.618. PMID: 33563455; PMCID: PMC7859694.</p>
<p>&nbsp;</p>
<p>5: Savel RH, Kupfer Y, Shiloh AL. Steady As She Goes: Practicing Evidence-Based</p>
<p>Critical Care When the Evidence Is Limited. Chest. 2021 Jan;159(1):7-8. doi:</p>
<p>10.1016/j.chest.2020.09.245. PMID: 33422231; PMCID: PMC7787062.</p>
<p>&nbsp;</p>
<p>6: Tirumandas M, Gendlina I, Figueredo J, Shiloh A, Trachuk P, Jain R, Corpuz M,</p>
<p>Spund B, Maity A, Shmunko D, Garcia M, Barthelemy D, Weston G, Madaline T.</p>
<p>Analysis of catheter utilization, central line associated bloodstream</p>
<p>infections, and costs associated with an inpatient critical care-driven vascular</p>
<p>access model. Am J Infect Control. 2021 May;49(5):582-585. doi:</p>
<p>10.1016/j.ajic.2020.10.006. Epub 2020 Oct 17. PMID: 33080360.</p>
<p>&nbsp;</p>
<p>7: Fein DG, Zhao D, Swartz K, Nauka P, Andrea L, Aboodi M, Shiloh AL, Eisen LA.</p>
<p>The Impact of Nighttime on First Pass Success During the Emergent Endotracheal</p>
<p>Intubation of Critically Ill Patients. J Intensive Care Med. 2021</p>
<p>Dec;36(12):1498-1506. doi: 10.1177/0885066620965166. Epub 2020 Oct 15. PMID:</p>
<p>33054483.</p>
<p>&nbsp;</p>
<p>8: Kapoor S, Chand S, Dieiev V, Fazzari M, Tanner T, Lewandowski DC, Nalla A,</p>
<p>Abdulfattah O, Aboodi MS, Shiloh AL, Gong MN. Thromboembolic Events and Role of</p>
<p>Point of Care Ultrasound in Hospitalized Covid-19 Patients Needing Intensive</p>
<p>Care Unit Admission. J Intensive Care Med. 2021 Dec;36(12):1483-1490. doi:</p>
<p>10.1177/0885066620964392. Epub 2020 Oct 6. PMID: 33021131; PMCID: PMC7539230.</p>
<p>&nbsp;</p>
<p>9: Emami N, Tanner T, Ogundipe F, Hawn VS, Rubin R, Skae CC, Shiloh AL, Keene</p>
<p>AB. Drape to prevent disease transmission during endotracheal intubation. Am J</p>
<p>Infect Control. 2021 Mar;49(3):387-388. doi: 10.1016/j.ajic.2020.06.212. Epub</p>
<p>2020 Jul 3. PMID: 32628982; PMCID: PMC7333628.</p>
<p>&nbsp;</p>
<p>10: Millington SJ, Colvin MO, Shiloh AL, Koenig S. How I Do It: Ultrasound-</p>
<p>Guided Internal Jugular and Femoral Central Venous Catheter Insertion. Chest.</p>
<p>2020 Dec;158(6):2425-2430. doi: 10.1016/j.chest.2020.06.026. Epub 2020 Jun 26.</p>
<p>PMID: 32599065.</p>
<p>&nbsp;</p>
<p>11: Savel RH, Shiloh AL, Saunders PC, Kupfer Y. Mechanical Ventilation During</p>
<p>the Coronavirus Disease 2019 Pandemic: Combating the Tsunami of Misinformation</p>
<p>From Mainstream and Social Media. Crit Care Med. 2020 Sep;48(9):1398-1400. doi:</p>
<p>10.1097/CCM.0000000000004462. PMID: 32496274; PMCID: PMC7302097.</p>
<p>&nbsp;</p>
<p>12: Shiloh AL, McPhee C, Eisen L, Koenig S, Millington SJ. Better With</p>
<p>Ultrasound: Detection of DVT. Chest. 2020 Sep;158(3):1122-1127. doi:</p>
<p>10.1016/j.chest.2020.01.038. Epub 2020 Feb 20. PMID: 32087215.</p>
<p>&nbsp;</p>
<p>13: Islam M, Levitus M, Eisen L, Shiloh AL, Fein D. Lung Ultrasound for the</p>
<p>Diagnosis and Management of Acute Respiratory Failure. Lung. 2020</p>
<p>Feb;198(1):1-11. doi: 10.1007/s00408-019-00309-1. Epub 2020 Jan 1. PMID:</p>
<p>31894411.</p>
<p>&nbsp;</p>
<p>14: Fein DG, Mastroianni F, Murphy CG, Aboodi M, Malik R, Emami N, Abramowitz M,</p>
<p>Shiloh AL, Eisen L. Impact of a Critical Care Specialist Intervention on First</p>
<p>Pass Success for Emergency Airway Management Outside the ICU. J Intensive Care</p>
<p>Med. 2021 Jan;36(1):80-88. doi: 10.1177/0885066619886816. Epub 2019 Nov 10.</p>
<p>PMID: 31707906.</p>
<p>&nbsp;</p>
<p>15: Millington SJ, Hendin A, Shiloh AL, Koenig S. Better With Ultrasound:</p>
<p>Peripheral Intravenous Catheter Insertion. Chest. 2020 Feb;157(2):369-375. doi:</p>
<p>10.1016/j.chest.2019.04.139. Epub 2019 Oct 22. PMID: 31654617.</p>
<p>&nbsp;</p>
<p>16: Wang A, Hendin A, Millington SJ, Koenig S, Eisen LA, Shiloh AL. Better With</p>
<p>Ultrasound: Arterial Line Placement. Chest. 2020 Mar;157(3):574-579. doi:</p>
<p>10.1016/j.chest.2019.08.2209. Epub 2019 Oct 18. PMID: 31634448.</p>
<p>&nbsp;</p>
<p>17: Savel RH, Shiloh AL, Simon RJ, Kupfer Y. Getting It Right for Our Patients:</p>
<p>The Importance of Collaborative Leadership in the ICU. Crit Care Med. 2019</p>
<p>Sep;47(9):1279-1281. doi: 10.1097/CCM.0000000000003880. PMID: 31415316.</p>
<p>&nbsp;</p>
<p>18: Islam M, Bangar M, Shiloh AL. A Woman in Her 70s on Anticoagulation With</p>
<p>Sudden Shock. Chest. 2019 May;155(5):e123-e126. doi:</p>
<p>10.1016/j.chest.2018.10.052. PMID: 31060707.</p>
<p>&nbsp;</p>
<p>19: Patrawalla P, Narasimhan M, Eisen L, Shiloh AL, Koenig S, Mayo P. A</p>
<p>Regional, Cost-Effective, Collaborative Model for Critical Care Fellows'</p>
<p>Ultrasonography Education. J Intensive Care Med. 2020 Dec;35(12):1447-1452. doi:</p>
<p>10.1177/0885066619828951. Epub 2019 Feb 12. PMID: 30755062.</p>
<p>&nbsp;</p>
<p>20: Shiloh AL. Smooth Transitions in Critical Care. J Emerg Trauma Shock. 2018</p>
<p>Jul-Sep;11(3):154-155. doi: 10.4103/JETS.JETS_44_17. PMID: 30429619; PMCID:</p>
<p>PMC6182967.</p>
<p>&nbsp;</p>
<p>21: Savel RH, Shiloh AL. Are We Really Doing More With Less: The Value of Half-</p>
<p>Dose Alteplase in Pulmonary Embolism Therapy. Crit Care Med. 2018</p>
<p>Oct;46(10):1696-1697. doi: 10.1097/CCM.0000000000003303. PMID: 30216306.</p>
<p>&nbsp;</p>
<p>22: Savel RH, Borgia D, Shiloh AL. A Path to High-Quality Care: Implementing</p>
<p>Flexible Visitation While Avoiding Staff Burnout. Crit Care Med. 2018</p>
<p>Jul;46(7):1203-1204. doi: 10.1097/CCM.0000000000003167. PMID: 29912108.</p>
<p>&nbsp;</p>
<p>23: Ferenchick HR, Chua AT, Carlese AJ, Shiloh AL. A Woman With Recent Stroke</p>
<p>Presenting With Respiratory Failure and Shock. Chest. 2018 May;153(5):e101-e103.</p>
<p>doi: 10.1016/j.chest.2017.11.048. PMID: 29731049.</p>
<p>&nbsp;</p>
<p>24: Savel RH, Shiloh AL, Simon RJ, Kupfer Y. Using Big Data to See the Big</p>
<p>Picture in Sepsis. Crit Care Med. 2018 Apr;46(4):640-641. doi:</p>
<p>10.1097/CCM.0000000000002976. PMID: 29538113.</p>
<p>&nbsp;</p>
<p>25: Kumarasamy N, Tishbi N, Mukundan S, Shiloh A, Levsky JM, Haramati LB.</p>
<p>Cardiothoracic MRI in the ICU: A 10-Year Experience. Acad Radiol. 2018</p>
<p>Mar;25(3):359-364. doi: 10.1016/j.acra.2017.09.017. Epub 2018 Feb 6. PMID:</p>
<p>29426683.</p>
<p>&nbsp;</p>
<p>26: Lishmanov A, Bellamkonda TT, Shiloh AL. A Woman in Her 20s With</p>
<p>Cardiopulmonary Failure. Chest. 2017 Jun;151(6):e123-e125. doi:</p>
<p>10.1016/j.chest.2017.01.040. PMID: 28599944.</p>
<p>&nbsp;</p>
<p>27: Shiloh AL, Sobolev M, Di Biase L, Slovut DP. A call for safety during</p>
<p>electrophysiological procedures: US in, why not US out? Authors' reply.</p>
<p>Europace. 2017 Dec 1;19(12):2048-2049. doi: 10.1093/europace/eux007. PMID:</p>
<p>28340047.</p>
<p>&nbsp;</p>
<p>28: Sobolev M, Shiloh AL, Di Biase L, Slovut DP. Ultrasound-guided cannulation</p>
<p>of the femoral vein in electrophysiological procedures: a systematic review and</p>
<p>meta-analysis. Europace. 2017 May 1;19(5):850-855. doi: 10.1093/europace/euw113.</p>
<p>PMID: 27207813.</p>
<p>&nbsp;</p>
<p>29: Shiloh AL, Lominadze G, Gong MN, Savel RH. Early Warning/Track-and-Trigger</p>
<p>Systems to Detect Deterioration and Improve Outcomes in Hospitalized Patients.</p>
<p>Semin Respir Crit Care Med. 2016 Feb;37(1):88-95. doi: 10.1055/s-0035-1570352.</p>
<p>Epub 2016 Jan 28. PMID: 26820276.</p>
<p>&nbsp;</p>
<p>30: Patrawalla P, Eisen LA, Shiloh A, Shah BJ, Savenkov O, Wise W, Evans L, Mayo</p>
<p>P, Szyld D. Development and Validation of an Assessment Tool for Competency in</p>
<p>Critical Care Ultrasound. J Grad Med Educ. 2015 Dec;7(4):567-73. doi:</p>
<p>10.4300/JGME-D-14-00613.1. PMID: 26692968; PMCID: PMC4675413.</p>
<p>&nbsp;</p>
<p>31: Hena KM, Eisen LA, Shiloh AL. A Man in His 60s With Renal Failure and Shock</p>
<p>Refractory to Vasopressors. Chest. 2015 Dec;148(6):e171-e174. doi:</p>
<p>10.1378/chest.15-0160. PMID: 26621295.</p>
<p>&nbsp;</p>
<p>32: Bernier-Jean A, Albert M, Shiloh AL, Eisen LA, Williamson D, Beaulieu Y. The</p>
<p>Diagnostic and Therapeutic Impact of Point-of-Care Ultrasonography in the</p>
<p>Intensive Care Unit. J Intensive Care Med. 2017 Mar;32(3):197-203. doi:</p>
<p>10.1177/0885066615606682. Epub 2016 Jul 9. PMID: 26423745.</p>
<p>&nbsp;</p>
<p>33: Shiloh AL, Adrish M. A Man in His 60s With Cirrhosis, Encephalopathy, and</p>
<p>Shock. Chest. 2015 Jul;148(1):e5-e7. doi: 10.1378/chest.14-2201. PMID: 26149567.</p>
<p>&nbsp;</p>
<p>34: Sobolev M, Slovut DP, Lee Chang A, Shiloh AL, Eisen LA. Ultrasound-Guided</p>
<p>Catheterization of the Femoral Artery: A Systematic Review and Meta-Analysis of</p>
<p>Randomized Controlled Trials. J Invasive Cardiol. 2015 Jul;27(7):318-23. PMID:</p>
<p>26136279.</p>
<p>&nbsp;</p>
<p>35: Adrish M, Shiloh AL. A woman in her 50s with recent coronary artery bypass</p>
<p>grafting presenting with right-sided chest pain. Chest. 2015</p>
<p>May;147(5):e171-e174. doi: 10.1378/chest.14-0457. PMID: 25940259.</p>
<p>&nbsp;</p>
<p>36: Shiloh AL, Ari Eisen L, Savel RH. The unplanned intensive care unit</p>
<p>admission. J Crit Care. 2015 Apr;30(2):419-20. doi: 10.1016/j.jcrc.2014.12.010.</p>
<p>Epub 2014 Dec 24. PMID: 25579373.</p>
<p>&nbsp;</p>
<p>37: Eisen LA, Savel RH, Shiloh AL. Video laryngoscopy in the intensive care</p>
<p>unit. A clearer view? Ann Am Thorac Soc. 2014 Oct;11(8):1254-5. doi:</p>
<p>10.1513/AnnalsATS.201408-386ED. PMID: 25343195.</p>
<p>&nbsp;</p>
<p>38: Chung M, Shiloh AL, Carlese A. Monitoring of the adult patient on</p>
<p>venoarterial extracorporeal membrane oxygenation. ScientificWorldJournal.</p>
<p>2014;2014:393258. doi: 10.1155/2014/393258. Epub 2014 Apr 3. PMID: 24977195;</p>
<p>PMCID: PMC3998007.</p>
<p>&nbsp;</p>
<p>39: Karakitsos D, El Barbary M, Gillman LM, Papalois A, Shiloh A. Critical care</p>
<p>and perioperative monitoring. ScientificWorldJournal. 2014;2014:737628. doi:</p>
<p>10.1155/2014/737628. Epub 2014 May 4. PMID: 24892082; PMCID: PMC4032705.</p>
<p>&nbsp;</p>
<p>40: Tischenkel BR, Gong MN, Shiloh AL, Pittignano VC, Keschner YG, Glueck JA,</p>
<p>Cohen HW, Eisen LA. Daytime Versus Nighttime Extubations: A Comparison of</p>
<p>Reintubation, Length of Stay, and Mortality. J Intensive Care Med. 2016</p>
<p>Feb;31(2):118-26. doi: 10.1177/0885066614531392. Epub 2014 Apr 24. PMID:</p>
<p>24763118.</p>
<p>&nbsp;</p>
<p>41: Shiloh AL, Kazzi MG, Mathew R, Eisen LA, Carlese AJ. A man in his 40s with a</p>
<p>history of hypertension and alcohol dependency presenting to the ED with</p>
<p>respiratory distress: septic shock in the setting of ARDS. Chest. 2014</p>
<p>Feb;145(2):e3-e6. doi: 10.1378/chest.13-2089. PMID: 24493554.</p>
<p>&nbsp;</p>
<p>42: Shiloh AL, Sobolev M, Eisen LA. A woman in her 30s in respiratory distress</p>
<p>with a history of gestational diabetes and hypertension. Chest. 2014</p>
<p>Jan;145(1):e1-e2. doi: 10.1378/chest.13-1850. PMID: 24394849.</p>
<p>&nbsp;</p>
<p>43: Lahiri S, Boro AD, Shiloh AL, Milstein MJ, Savel RH. Periodic Epileptiform</p>
<p>Discharges Clarified for the Nonneurologist Intensivist: Clinical Implications</p>
<p>and Current Management. J Intensive Care Med. 2015 Oct;30(7):385-91. doi:</p>
<p>10.1177/0885066613513411. Epub 2013 Dec 9. PMID: 24323590.</p>
<p>&nbsp;</p>
<p>44: Eisen LA, Janowski W, Shiloh AL. Ultrasound diagnosis of shock in a woman</p>
<p>with metastatic renal cell carcinoma. Chest. 2013 Sep;144(3):e1-e3. doi:</p>
<p>10.1378/chest.13-0964. PMID: 24008972.</p>
<p>&nbsp;</p>
<p>45: Savel RH, Shiloh AL, Eisen LA. Tackling the tough questions: what was this</p>
<p>patient like before they were critically ill? Crit Care Med. 2013</p>
<p>Jan;41(1):327-8. doi: 10.1097/CCM.0b013e318267a8ad. PMID: 23269133.</p>
<p>&nbsp;</p>
<p>46: Shiloh AL, Eisen LA, Yee M, Langner JB, LeDonne J, Karakitsos D. Ultrasound-</p>
<p>guided subclavian and axillary vein cannulation via an infraclavicular approach:</p>
<p>In the tradition of Robert Aubaniac. Crit Care Med. 2012 Oct;40(10):2922-3. doi:</p>
<p>10.1097/CCM.0b013e31825cea64. PMID: 22986669.</p>
<p>&nbsp;</p>
<p>47: Keene AB, Shiloh AL, Dudaie R, Eisen LA, Savel RH. Online testing from</p>
<p>Google Docs&trade; to enhance teaching of core topics in critical care: a pilot study.</p>
<p>Med Teach. 2012;34(12):1075-7. doi: 10.3109/0142159X.2012.716553. Epub 2012 Aug</p>
<p>30. PMID: 22931149.</p>
<p>&nbsp;</p>
<p>48: Stefanidis K, Pentilas N, Dimopoulos S, Nanas S, Savel RH, Shiloh AL,</p>
<p>Poularas J, Slama M, Karakitsos D. Echogenic Technology Improves Cannula</p>
<p>Visibility during Ultrasound-Guided Internal Jugular Vein Catheterization via a</p>
<p>Transverse Approach. Crit Care Res Pract. 2012;2012:306182. doi:</p>
<p>10.1155/2012/306182. Epub 2012 May 10. PMID: 22649715; PMCID: PMC3357505.</p>
<p>&nbsp;</p>
<p>49: Stefanidis K, Fragou M, Pentilas N, Kouraklis G, Nanas S, Savel RH, Shiloh</p>
<p>AL, Slama M, Karakitsos D. Optimization of Cannula Visibility during Ultrasound-</p>
<p>Guided Subclavian Vein Catheterization, via a Longitudinal Approach, by</p>
<p>Implementing Echogenic Technology. Crit Care Res Pract. 2012;2012:617149. doi:</p>
<p>10.1155/2012/617149. Epub 2012 Apr 23. PMID: 22593825; PMCID: PMC3347863.</p>
<p>&nbsp;</p>
<p>50: Savel RH, Shiloh AL, Eisen LA. Educational impact of continuous chest</p>
<p>compression cardiopulmonary resuscitation: the confidence to "pay it forward"*.</p>
<p>Crit Care Med. 2012 Mar;40(3):992-3. doi: 10.1097/CCM.0b013e31823878b1. PMID:</p>
<p>22343848.</p>
<p>&nbsp;</p>
<p>51: Shiloh AL, Eisen LA, Savel RH. Goal-directed ultrasonography in the</p>
<p>intensive care unit: no more excuses! Crit Care Med. 2011 Apr;39(4):879-80. doi:</p>
<p>10.1097/CCM.0b013e318208e393. PMID: 21613832.</p>
<p>&nbsp;</p>
<p>52: Rosenberg JB, Shiloh AL, Savel RH, Eisen LA. Non-invasive methods of</p>
<p>estimating intracranial pressure. Neurocrit Care. 2011 Dec;15(3):599-608. doi:</p>
<p>10.1007/s12028-011-9545-4. PMID: 21519957.</p>
<p>&nbsp;</p>
<p>53: Kory PD, Pellecchia CM, Shiloh AL, Mayo PH, DiBello C, Koenig S. Accuracy of</p>
<p>ultrasonography performed by critical care physicians for the diagnosis of DVT.</p>
<p>Chest. 2011 Mar;139(3):538-542. doi: 10.1378/chest.10-1479. Epub 2010 Oct 28.</p>
<p>PMID: 21030490.</p>
<p>&nbsp;</p>
<p>54: Shiloh AL, Savel RH, Paulin LM, Eisen LA. Ultrasound-guided catheterization</p>
<p>of the radial artery: a systematic review and meta-analysis of randomized</p>
<p>controlled trials. Chest. 2011 Mar;139(3):524-529. doi: 10.1378/chest.10-0919.</p>
<p>Epub 2010 Aug 19. PMID: 20724734.</p>
<p>&nbsp;</p>
<p>55: Shiloh AL, Eisen LA, Savel RH. Selective decontamination of the digestive</p>
<p>tract: what outcomes matter? Crit Care Med. 2010 May;38(5):1386-7. doi:</p>
<p>10.1097/CCM.0b013e3181da47d1. PMID: 20404637.</p>
<p>&nbsp;</p>
<p>56: Shiloh AL, Eisen LA. Ultrasound-guided arterial catheterization: a narrative</p>
<p>review. Intensive Care Med. 2010 Feb;36(2):214-21. doi:</p>
<p>10.1007/s00134-009-1699-6. Epub 2009 Oct 31. PMID: 19882140.</p>
<p>&nbsp;</p>
<p>57: Li M, Chen D, Shiloh A, Luo J, Nikolaev AY, Qin J, Gu W. Deubiquitination of</p>
<p>p53 by HAUSP is an important pathway for p53 stabilization. Nature. 2002 Apr</p>
<p>11;416(6881):648-53. doi: 10.1038/nature737. Epub 2002 Mar 31. PMID: 11923872.</p>

EMR ID

4723

Biography

<p>Ariel L Shiloh, MD, is Director, Critical Care Consult Services, Professor, Medicine and Associate Professor, Neurology at Montefiore Einstein. Dr. Shiloh&rsquo;s clinical interests include the early detection and treatment of critical illness, point-of-care ultrasonography for the evaluation of critical illness and advanced airway management.</p><p>After earning his Bachelor of Arts from Yeshiva University, Dr. Shiloh attended the Medical School for International Health at Ben Gurion University, Be&rsquo;er Sheva, Israel, earning his Doctor of Medicine in 2005. He came to Montefiore for his postdoctoral training, completing his internship and residency in internal medicine in 2008, followed by his fellowship in critical care medicine in 2010.</p><p>Dr. Shiloh's research includes the clinical use of point-of-care ultrasonography in critical illness, improvement of airway management, and cardiopulmonary resuscitation. He has shared his work through peer-reviewed journals, invited presentations, books, abstracts and poster presentations at national conferences. He has also been a reviewer for several journals including <em>Chest</em>, the <em>American Journal of Critical Care</em> and the <em>European Journal of Anesthesiology</em>.</p><p>Dr. Shiloh is board certified in Internal Medicine, Critical Care Medicine and Neurocritical Care and Hospice &amp; Palliative Medicine. He is a Fellow of the American College of Chest Physicians and a member of the Society of Critical Care Medicine. Dr. Shiloh has been recognized by the American College of Chest Physicians as a Distinguished CHEST Educator, among the top 5% of CHEST&rsquo;s international faculty recognized for long-term contributions to the design and delivery of CHEST education</p>

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