Jose M. Taveras

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Jose M. Taveras
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Type
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Faculty
First Name
Jose
Last Name
Taveras
NPI
1205072881
Faculty ID
13893
Clinical Terms
Employment Status
Full Time
Patient Type
Adult
Department
einstein-dept-medicine
Gender
Male
Email
jostaver@montefiore.org
Phone
718-920-4116
Titles
Type
Academic
Department
Department of Medicine
Department Link
Rank
Assistant Professor
Division
Cardiology
Locations
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Off
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Location (Address, State, City, Zip)
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POINT (-73.83054 40.84461)
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1620 Crosby Avenue
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Bronx
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NY
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St. Joseph's Medical Practice, PC
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St. Joseph's Medical Practice, PC
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Montefiore Medical Center
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111 East 210th Street
City
Bronx
State
NY
Zip
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Montefiore Medical Center
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Universidad Autonoma de Guadalajara
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M.D.
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5738
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Sarah Sungurlu

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Sarah Sungurlu
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Type
Provider
Faculty
First Name
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NPI
1174819478
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17214
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Employment Status
Full Time
Patient Type
Adult
Department
einstein-dept-medicine
Gender
Female
Email
ssungurlu@montefiore.org
Phone
718-920-6474
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Type
Academic
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Rank
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Pulmonary Medicine
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1825 Eastchester Road
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NY
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10467-2404
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Asli S. Sucu

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Asli S. Sucu
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Asli
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Sucu
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einstein-dept-medicine
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Female
Email
asucu@montefiore.org
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718-920-9269
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Academic
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600 East 233rd Street
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New York
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NY
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10466-2604
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Montefiore Medical Center - Wakefield
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600 East 233rd Street
City
Bronx
State
NY
Zip
10466
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Montefiore Medical Center - Wakefield
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Uludag Universitesi
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Montefiore Medical Center
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M.D.
EMR ID
55869
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Kate R. Steinberg

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Kate R. Steinberg
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Kate
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Steinberg
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1528488459
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Department
einstein-dept-medicine
Gender
Female
Email
ksteinberg@montefiore.org
Phone
718-920-6054
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Type
Academic
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Pulmonary Medicine
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111 East 210th Street
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NY
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10461-2401
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Montefiore Medical Center
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Montefiore Medical Center
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3411 Wayne Avenue
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NY
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10467
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Boston Medical Center
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University of Wisconsin Hospital and Clinics
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Off
Professional Title
M.D.
EMR ID
141643
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2542
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Brian D. Spund

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Brian D. Spund
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Brian
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Spund
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1629377320
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Clinical Terms
Employment Status
part-time
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Department
einstein-dept-medicine
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Male
Email
bspund@montefiore.org
Phone
718-920-5057
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Type
Academic
Department
Department of Medicine
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Rank
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On
Type
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POINT (-73.88072 40.88002)
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111 East 210th Street
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Bronx
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NY
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10461-2401
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Montefiore Medical Center
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Academic
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Montefiore Medical Center
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111 East 210th Street
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Bronx
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NY
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10467
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Montefiore Medical Center
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SUNY Downstate College of Medicine
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Residency
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North Shore Long Island Jewish Health System
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M.D.
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68828
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Luke R. Sponholz

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Luke R. Sponholz
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First Name
Luke
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Sponholz
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1679837579
Faculty ID
18058
CMO Specialties
Clinical Terms
Employment Status
Full Time
Patient Type
Adult
Department
einstein-dept-medicine
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Male
Email
lsponhol@montefiore.org
Phone
718-904-4138
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Type
Academic
Type
Academic
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Department of Medicine
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Rank
Assistant Professor
Division
Hospital Medicine
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Is Primary
On
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Location (Address, State, City, Zip)
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POINT (-73.845 40.85026)
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1825 Eastchester Road
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Bronx
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NY
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10467-2404
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Jack D. Weiler Hospital
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1825 Eastchester Road
City
Bronx
State
NY
Zip
10461
Location Title
Jack D. Weiler Hospital
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Virginia Commonwealth University
Education Type Label
Residency
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Montefiore Medical Center
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Off
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M.D.
EMR ID
55833
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Simon D. Spivack

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Full Name
Simon D. Spivack
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Type
Provider
Faculty
Expert
First Name
Simon
Last Name
Spivack
NPI
1366438475
Faculty ID
11003
Clinical Terms
Employment Status
Full Time
Patient Type
Adult
Department
einstein-dept-medicine
einstein-dept-epidemiology-population-health
einstein-dept-genetics
Gender
Male
Email
simon.spivack@einsteinmed.edu
Phone
718-678-1040
Titles
Type
Academic
Department
Department of Medicine
Department Link
Rank
Professor
Division
Pulmonary Medicine
Type
Academic
Department
Department of Epidemiology & Population Health
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Professor
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Epidemiology
Type
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Department
Department of Genetics
Department Link
Rank
Professor
Type
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Title
Chief Emeritus, Division of Pulmonary Medicine, Department of Medicine
Tags
me-patientcare-cancer-research-stem-cell-cancer-biology
Locations
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Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.82894 41.05873)
Address Line 1
555 Taxter Road
City
Elmsford
State
NY
Zip
10523
Location Title
Montefiore Einstein Advanced Care -Westchester
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On
Type
Clinical
Location (Address, State, City, Zip)
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POINT (-73.84154 40.84612)
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1250 Waters place
City
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NY
Zip
10461-2720
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Montefiore at 1250 Waters Place
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Type
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Location (Address, State, City, Zip)
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Coordinates
POINT (-73.845838 40.8516937)
Room
301
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Albert Einstein College of Medicine
Address Line 2
Michael F. Price Center
Address Line 3
1301 Morris Park Avenue
City
Bronx
State
NY
Zip
10461
Location Title
Albert Einstein College of Medicine
Education and Trainings
Education Type Label
Medical Education
Education Institution
SUNY Upstate Medical Center
Education Type Label
Fellowship
Education Institution
Medical Center Hospital of Vermont
Education Type Label
Residency
Education Institution
UMASS Memorial Medical Center - University Campus
Professional Interests

<p>Focusing diagnostics and therapeutics on those most likely to benefit is a key to successful intervention&nbsp;at both the public health and clinical levels. The translational goal of the Spivack laboratory is to identify individuals at particularly high risk for lung malignancy, and selected non-malignant lung diseases, upon whom to focus smoking/toxin exposure cessation (primary prevention), chemoprevention (secondary prevention), and early disease detection efforts (disease screening, tertiary prevention).</p>
<p>The laboratory is currently exploring individual Gene x Environment signatures as susceptibility markers by exploring quantitative gene (mRNA) expression phenotypes, and the DNA sequence, methylation, microRNA, and other epigenetic features potentially underlying these expression phenotypes, <em>in vitro</em> and in human populations. This is performed in the setting of defined tobacco, diet, and other exposures. There are both mechanistic and translational components to the studies.&nbsp;</p>
<p><br /><strong>Mechanistically</strong>, the role of epigenetic variation in promoter regions in the 5' and 3' regulatory regions of carcinogenesis and oxidant pathway genes is being explored <em>in vitro</em>, using human genomic DNA reporter constructs, and native gene regulation models. High resolution technologies include the realtime quantitation of native mRNA and microRNA by the laboratory's RNA-specific strategy (<em>patented</em>); the&nbsp;tagged-bisulfite genomic sequencing strategy to determine single base resolution CpG methylation status (tBGS, <em>patented</em>);&nbsp;&nbsp;an experimental strategy for assaying microRNA binding to mRNA, for determining the role of miRNA in candidate gene regulation&nbsp;(<em>patented</em>); and evaluation of functional consequences of DNA&nbsp;methylation detail, using a novel patch reporter construct (<em>patented</em>).&nbsp; A new method to engineer methyl-cytosines into the epigenome has recently been developed.</p>
<p>Whole (epi)genome approaches to identify molecular events unique to lung cancer&nbsp;are being completed, which will represent one of the initial cross-platform 'omics level discovery examinations of&nbsp;lung&nbsp;tissues.&nbsp; The execution of each individual discovery platform involves&nbsp;expert local collaborators and cores&nbsp;in (epi)genetics and genomics, and the "integromics" is critically reliant on Einstein strengths in informatics and biostatistical analyses.</p>
<p>&nbsp;</p>
<p><strong>Translationally</strong>, human lung carcinogenesis biomarkers are being established by pairing laser capture microdissected lung with several unique, non-invasively collected surrogate specimens developed in the laboratory. These include mRNA expression signatures from brush-exfoliated buccal mucosa cells, microRNAs detected in exhaled breath condensate representing first reports for a new exhaled airway biomarker class, and exhaled metabolomic signatures. These airway-derived specimens continue to accrue from a sampling (currently n&gt;1000) of a population assembled in a lung cancer case-control context.&nbsp; The specimens are being studied with a view toward developing non-invasive assays in populations.</p>
<p>&nbsp;</p>
<p>The overall aim is to develop informative non-invasive risk profiling, preventive, and early disease detection strategies for the lung in human populations.</p>
<p>&nbsp;</p>
<p>&nbsp;<em>Work is funded by ongoing NIH,</em><em> DoD,&nbsp;and&nbsp;Foundation support.</em></p>
<p>&nbsp;</p>
<p><strong>Clinical Specialties</strong></p>
<ul style="font-size: 1em; color: #333333; padding: 0px; margin: 20px 0px 25px 38px;">
<li style="padding: 0px; margin: 12px 0px 5px 0px;">lung nodule evaluation</li>
<li style="padding: 0px; margin: 12px 0px 5px 0px;">lung cancer diagnostics and screening</li>
<li style="padding: 0px; margin: 12px 0px 5px 0px;">interstitial lung disease</li>
<li style="padding: 0px; margin: 12px 0px 5px 0px;">environmental lung disease</li>
<li style="padding: 0px; margin: 12px 0px 5px 0px;">refractory asthma</li>
<li style="padding: 0px; margin: 12px 0px 5px 0px;">general pulmonary medicine</li>
</ul>

Research Areas
Development of early lung cancer detection strategies; exhaled nucleic acid and other airway biomarkers.
Genome-wide surveys of lung epithelia. Translational lung studies. Mechanistic studies in functional epigenetics.
Areas of Expertise
Interstitial lung disease
Lung nodule evaluation
Lung toxicology
Expert Summary

<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt;">A researcher and clinician, Dr. Spivack is developing tests for detecting lung cancer at the earliest possible stage&mdash;before it becomes fatal by spreading to other parts of the body. In one of several NIH-funded studies, his laboratory is working on a noninvasive, early-diagnosis test for lung cancer that detects particular genetic elements and chemicals in exhaled breath.</span></p>
<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt;">In addition to general pulmonary medicine, Dr. Spivack&rsquo;s clinical practice focuses on lung nodule and lung cancer diagnosis, diffuse interstitial lung diseases, and environmental lung diseases.</span></p>

CHAM Provider
Off
Professional Title
M.D.
M.P.H.
Clinical Focus

Dr. Spivack specializes in consultative pulmonary medicine, with an emphasis on the evaluation of lung nodules, lung cancer screening, asthma, and environmental and interstitial lung disease.<span style="color:#4d4d4d;font-family:Arial, Helvetica, source-code-pro, Menlo, Monaco, Consolas, 'Courier New', monospace;font-size:16px;background-color:#ffffff;"><strong></strong></span>

Research Focus

Dr. Spivack&rsquo;s research focuses on the development of non-invasive early detection airway biomarkers of lung cancer risk, as well as epigenetics, gene regulation, gene-environment interaction and non-invasive measurement of deep lung phenomena in humans.

Selected Publications

<ol>
<li>Zhenqiu Huang, Alex Maslov, Xiao Dong, Shixiang Sun, Moonsook Lee, Chirag Shah, Ali Sadoughi, Aditi Desai, Dhruv Patel, Taha Siddiqui, Jaiminkumar Patel, Miao Shi, Spencer Waldman, Ava Marsh, Yakov Peter, <strong>*Simon D Spivack,</strong> *Jan Vijg. Somatic Mutations At Single Base Resolution in Single Bronchial Progenitor Cells Collected From Human Lung. <em>(Nature Genetics, April 2022, </em><a href="https://www.nature.com/articles/s41588-022-01035-w&quot; target="_blank">https://www.nature.com/articles/s41588-022-01035-w</a&gt;). (*co-senior authors).</li>
<li>Shi M, Han W, Loudig O, Shah CD, Dobkin JB, Keller S, Sadoughi A, Zhu C, Siegel RE, Fernandez MK, DeLaRosa L, Patel D, Desai A, Siddiqui T, Gombar S, Suh Y, Wang T, Hosgood HD, Pradhan K, Ye K, <strong>Spivack SD.</strong> Initial development and testing of an exhaled microRNA detection strategy for lung cancer case-control discrimination. Sci Rep. 2023 Apr 24;13(1):6620. doi: 10.1038/s41598-023-33698-8. PMID: 37095155; PMCID: PMC10126132.</li>
<li>Yoo EJ, Kim JS, Stransky S, <strong>Spivack S,</strong> Sidoli S. Advances in proteomics methods for the analysis of exhaled breath condensate. Mass Spectrom Rev. 2024 Jul-Aug;43(4):713-722. doi: 10.1002/mas.21871. Epub 2023 Dec 27. PMID: 38149478.</li>
<li>Zefi O, Waldman S, Marsh A, Shi MK, Sonbolian Y, Khulan B, Siddiqui T, Desai A, Patel D, Okorozo A, Khader S, Dobkin J, Sadoughi A, Shah C, <strong>*Spivack S,</strong> *Peter Y. Distinctive field effects of smoking and lung cancer case-control status on bronchial basal cell growth and signaling. Respir Res. 2024 Aug 19;25(1):317. doi: 10.1186/s12931-024-02924-w. PMID: 39160511; PMCID: PMC11334309. *(co-senior authors)</li>
<li>Mitchell MI, Ben-Dov IZ, Ye K, Liu C, Shi M, Sadoughi A, Shah C, Siddiqui T, Okorozo A, Gutierrez M, Unawane R, Biamonte L, Parikh K, <strong>Spivack S,</strong> Loudig O. Exhaled breath condensate contains extracellular vesicles (EVs) that carry miRNA cargos of lung tissue origin that can be selectively purified and analyzed. J Extracell Vesicles. 2024 Apr;13(4):e12440. doi: 10.1002/jev2.12440. Erratum in: J Extracell Vesicles. 2024 May;13(5):e12453. doi: 10.1002/jev2.12453. PMID: 38659349; PMCID: PMC11043690.</li>
<li>Khulan B, Ye K, Shi MK, Waldman S, Marsh A, Siddiqui T, Okorozo A, Desai A, Patel D, Dobkin J, Sadoughi A, Shah C, Gera S, Peter Y, Liao W, *Vijg J, *<strong>Spivack SD</strong>. Normal bronchial field basal cells show persistent methylome-wide impact of tobacco smoking, including in known cancer genes. Epigenetics. 2025 Dec;20(1):2466382. doi: 10.1080/15592294.2025.2466382. Epub 2025 Feb 20. PMID: 39980243; PMCID: PMC11849931. *(co-senior authors)</li>
</ol>

EMR ID
4969
Biography

<p>Simon D. Spivack, MD, MPH, is Professor, Medicine, Epidemiology and Genetics at Montefiore Einstein. He is also former Emeritus Chief, Pulmonary Medicine. Clinically, Dr. Spivack specializes in consultative pulmonary medicine, with an emphasis on the evaluation of lung nodules, lung cancer screening, asthma, and environmental and interstitial lung disease. </p><p>After obtaining his Bachelor of Science in Psychobiology from McGill University in Montreal, Canada in 1980, Dr. Spivack earned his Doctor of Medicine from the State University of New York Upstate Medical University in 1985. He then completed an internship and residency in internal medicine at the University of Massachusetts Medical Center in 1988. Dr. Spivack then earned his Master of Public Health at Harvard University, School of Public Health in 1989. He completed a clinical pulmonary and critical care medicine and lung research fellowship at the University of Vermont in 1992. </p><p>Dr. Spivack&rsquo;s research focuses on the development of non-invasive early detection airway biomarkers of lung cancer risk, as well as epigenetics, gene regulation, gene-environment interaction and non-invasive measurement of deep lung phenomena in humans. His work has been published in numerous peer-reviewed journals, articles, chapters and books, and he has given many national/international presentations, organized symposia and visiting professorships. Dr. Spivack is on the Editorial Board for Scientific Reports and is a reviewer for journals such as <em>PLoS Genetics</em>, <em>Genetics in Medicine</em>, <em>Nature Protocols</em>, <em>American Journal of Respiratory &amp; Critical Care Medicine</em>, <em>Carcinogenesis</em>, <em>Cancer Research</em> and others. He holds multiple United States patents. He has been continually funded by the National Institutes of Health (NIH) for research for over 25 years.
</p><p>Dr. Spivack is board certified in internal medicine, pulmonary medicine and critical care medicine. He is a member of the American Thoracic Society (ATS), the American Association for Cancer Research (AACR) and the American Lung Association (ALA). He is a frequent peer-reviewer on various NIH study sections. In the past, Dr. Spivack won the Excellence in Research Award from ALA and the NIH/National Institute of Environmental Health Sciences (NIEHS) Clinical Scientist Development Award.

</p>

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Olena Slinchenkova

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Olena Slinchenkova
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First Name
Olena
Last Name
Slinchenkova
NPI
1013205632
Faculty ID
14967
CMO Specialties
Clinical Terms
Employment Status
Full Time
Patient Type
Adult
Department
einstein-dept-medicine
Gender
Female
Email
oslinche@montefiore.org
Phone
718-920-9860
Titles
Type
Academic
Department
Department of Medicine
Department Link
Rank
Assistant Professor
Division
Hospital Medicine
Locations
Is Primary
On
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.8608 40.89439)
Address Line 1
600 East 233rd Street
City
New York
State
NY
Zip
10466-2604
Location Title
Montefiore Wakefield Campus
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Type
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Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.86049 40.89552)
Address Line 1
4234 Bronx Boulevard
City
Bronx
State
NY
Zip
10466-2611
Location Title
Montefiore Medical Group-Wakefield Ambulatory Care Center
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Type
Academic
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.861005 40.8939411)
Address Line 1
Montefiore Medical Center - Wakefield
Address Line 2
600 East 233rd Street
City
Bronx
State
NY
Zip
10466
Location Title
Montefiore Medical Center - Wakefield
Education and Trainings
Education Type Label
Medical Education
Education Institution
Dnepropetrovskij Medicinskij Institut
Education Type Label
Residency
Education Institution
Montefiore Medical Center
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55793
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Sumeet Singh-Tan

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Sumeet Singh-Tan
Profile Image URL
https://documentapi-fargate-documentbucket-15qi4tpdvnhlz.s3.amazonaws.com/218/d41fe610-497e-11ec-8149-d1681d4b2362.jpg
Type
Provider
Faculty
First Name
Sumeet
Last Name
Singh-Tan
NPI
1215318001
Faculty ID
16569
CMO Specialties
Clinical Terms
Employment Status
Full Time
Patient Type
Adult
Department
einstein-dept-medicine
Gender
Female
Email
ssinght@montefiore.org
Phone
718-920-5057
Titles
Type
Academic
Department
Department of Medicine
Department Link
Rank
Assistant Professor
Division
Hospital Medicine
Type
Administrative
Locations
Is Primary
On
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.88072 40.88002)
Address Line 1
111 East 210th Street
City
Bronx
State
NY
Zip
10461-2401
Location Title
Montefiore Medical Center
Is Primary
Off
Type
Academic
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.8798833 40.8799447)
Address Line 1
Montefiore Medical Center
Address Line 3
111 East 210th Street
City
Bronx
State
NY
Zip
10467
Location Title
Montefiore Medical Center
Education and Trainings
Education Type Label
Medical Education
Education Institution
A.T. Still University, Arizona School of Health Sciences
Education Type Label
Residency
Education Institution
Rush University Medical Center
CHAM Provider
Off
Professional Title
D.O.
EMR ID
14316
Is Open Scheduling
Off

Chirag D. Shah

Submitted by Anonymous (not verified) on
Full Name
Chirag D. Shah
Profile Image URL
https://assets.montefioreeinstein.org/profiles/images/physphoto/Shah_Chirag_MD_420x504.jpg
Type
Provider
Faculty
First Name
Chirag
Last Name
Shah
NPI
1164629770
Faculty ID
15234
Clinical Terms
Employment Status
Full Time
Patient Type
Adult
Department
einstein-dept-medicine
Gender
Male
Email
cshah@montefiore.org
Phone
718-920-6087
Titles
Type
Academic
Department
Department of Medicine
Department Link
Rank
Associate Professor
Division
Pulmonary Medicine
Type
Administrative
Locations
Is Primary
On
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.88022 40.87856)
Address Line 1
3332 Rochambeau Avenue
City
Bronx
State
NY
Zip
10467
Location Title
Montefiore Centennial
Is Primary
Off
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.91148 40.82878)
Address Line 1
1150 Webster Avenue
City
Bronx
State
NY
Zip
10456
Location Title
Montefiore at 1150 Webster
Is Primary
Off
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.84154 40.84612)
Address Line 1
1250 Waters place
City
Bronx
State
NY
Zip
10461-2720
Location Title
Montefiore at 1250 Waters Place
Is Primary
Off
Type
Academic
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.8782381 40.8799784)
Room
5h
Address Line 1
Montefiore Medical Center
Address Line 3
3411 Wayne Avenue
City
Bronx
State
NY
Zip
10467
Location Title
Montefiore Medical Center
Education and Trainings
Education Type Label
Medical Education
Education Institution
St. Georges University School of Medicine
Education Type Label
Fellowship
Education Institution
State University of New York at Stony Brook Hosp
Education Type Label
Residency
Education Institution
State University of New York at Stony Brook
CHAM Provider
Off
Professional Title
M.D.
EMR ID
5732
Visit Type ID
2542
Is Open Scheduling
On
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