<p class="MsoNormal" style="margin: 0in 0in 0in 0.5in; font-size: medium; font-family: Calibri, sans-serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in; background-color: white;"><!-- [if !supportLists]--><span style="font-size: 10.5pt; font-family: Verdana, sans-serif;"> 1. Zhang WB, Ye K, Barzilai N, <strong>Milman S</strong>. The antagonistic pleiotropy of insulin-like growth factor 1. <em>Aging Cell </em>2021; </span><span style="font-size: 10.5pt; font-family: Verdana, sans-serif; color: #231f20; letter-spacing: -0.05pt; background-color: white;">20(9), e13443</span><span style="font-size: 10.5pt; font-family: Verdana, sans-serif;">; </span><span class="id-label"><span style="font-size: 10.5pt; font-family: Verdana, sans-serif; color: black;">PMCID: PMC8441393</span></span><span class="apple-converted-space"><span style="font-size: 10.5pt; font-family: Verdana, sans-serif; color: black;"> </span></span></p>
<p class="MsoNormal" style="margin: 0in 0in 0in 0.5in; font-size: medium; font-family: Calibri, sans-serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in; background-color: white;"><!-- [if !supportLists]--><span class="docsum-authors"><span style="font-size: 10.5pt; font-family: Verdana, sans-serif; color: #212121;"> </span></span></p>
<p class="MsoNormal" style="margin: 0in 0in 0in 0.5in; font-size: medium; font-family: Calibri, sans-serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in; background-color: white;"><span class="docsum-authors"><span style="font-size: 10.5pt; font-family: Verdana, sans-serif; color: #212121;"> 2. DeVito LM, Barzilai N, Cuervo AM, Niedernhofer LJ, <strong>Milman S</strong>, Levine M, Promislow D, Ferrucci L, Kuchel GA, Mannick J, Justice J, Gonzales MM, Kirkland JL, Cohen P, Campisi J. Extending human healthspan and longevity: a symposium report. <em>Ann NY Acad Sci </em>2021</span></span></p>
<p class="MsoNormal" style="margin: 0in 0in 0in 0.5in; font-size: medium; font-family: Calibri, sans-serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in; background-color: white;"> </p>
<p class="MsoNormal" style="margin: 0in 0in 0in 0.5in; font-size: medium; font-family: Calibri, sans-serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in; background-color: white;"><span style="font-size: 10.5pt; font-family: Verdana, sans-serif; color: black;"> 3. Zhang WB, Aleksic S, Gao T, Weiss EF, Demetriou E, Verghese J, Holtzer R, Barzilai N,<strong> Milman S. </strong><a href="https://pubmed.ncbi.nlm.nih.gov/32492897/?from_term=sofiya+milman&f… style="color: black; text-decoration: none;">Insulin-like Growth Factor-1 and IGF Binding Proteins Predict All-Cause Mortality and Morbidity in Older Adults.</span></a> <em>Cells</em> 2020; 9(6):E1368, PMCID:<a href="http://www.ncbi.nlm.nih.gov/pmc/articles/pmc7349399/" target="_blank" rel="noopener"><span style="color: black; text-decoration: none;">PMC7349399</span></a></span></p>
<p class="MsoNormal" style="margin: 0in 0in 0in 0.5in; font-size: medium; font-family: Calibri, sans-serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in; background-color: white;"> </p>
<p class="MsoNormal" style="margin: 0in 0in 0in 0.5in; font-size: medium; font-family: Calibri, sans-serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in; background-color: white;"><!-- [if !supportLists]--><span style="font-size: 10.5pt; font-family: Verdana, sans-serif; color: black;"> 4. Zhang ZD, <strong>Milman S</strong>, Lin J, Barzilai N, Gorbunova V, Ladiges WC, Niedernhofer LF, Suh Y, Robbins PD, Vijg J. Genetics of extreme human longevity to guide drug discovery for healthy ageing. <em>Nat Metab </em>2020; 2(8)663-672.</span></p>
<p class="MsoNormal" style="margin: 0in 0in 0in 0.5in; font-size: medium; font-family: Calibri, sans-serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in; background-color: white;"> </p>
<p class="MsoNormal" style="margin: 0in 0in 0in 0.5in; font-size: medium; font-family: Calibri, sans-serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in; background-color: white;"><!-- [if !supportLists]--><span style="font-size: 10.5pt; font-family: Verdana, sans-serif; color: black;"> 5. Lehallier B, Gate D, Schaum N, Nanasi T, Lee SE, Yousef H, Moran Losada P, Berdnik D, Keller A, Verghese J, Sathyan S, Franceschi C, <strong>Milman S</strong>, Barzilai N, Wyss-Coray T. Undulating changes in human plasma proteome profiles across the lifespan. <em>Nat Med</em> 2019; 25(12):1843-1850; PMCID: <a href="http://www.ncbi.nlm.nih.gov/pmc/articles/pmc7062043/" target="_blank" rel="noopener"><span style="color: black;">PMC7062043</span></a></span></p>
<p class="MsoNormal" style="margin: 0in 0in 0in 0.5in; font-size: medium; font-family: Calibri, sans-serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in; background-color: white;"> </p>
<p class="MsoNormal" style="margin: 0in 0in 0in 0.5in; font-size: medium; font-family: Calibri, sans-serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in; background-color: white;"><!-- [if !supportLists]--><span style="font-size: 10.5pt; font-family: Verdana, sans-serif; color: black;"> 6. Gubbi S, Quipildor GF, Barzilai N, Huffman DM, <strong>Milman S</strong>. 40 Years of IGF-1: IGF-1: the Jekyll and Hyde of the aging brain. <em>J Mol Endocrinol </em>2018; 61(1):T171-T185. PMCID: PMC5988994</span></p>
<p class="MsoNormal" style="margin: 0in 0in 0in 0.5in; font-size: medium; font-family: Calibri, sans-serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in; background-color: white;"> </p>
<p class="MsoNormal" style="margin: 0in 0in 0in 0.5in; font-size: medium; font-family: Calibri, sans-serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in; background-color: white;"><!-- [if !supportLists]--><span style="font-size: 10.5pt; font-family: Verdana, sans-serif; color: black;"> 7. Gubbi S, Schwartz E, Crandall JP, Verghese J, Holtzer R, Atzmon G, Braunstein R, Barzilai N, <strong>Milman S</strong>. Effect of Exceptional Parental Longevity and Lifestyle Factors on Prevalence of Cardiovascular Disease in Offspring. <em>Am J Cardiol</em> 2017</span></p>
<p class="MsoNormal" style="margin: 0in 0in 0in 0.5in; font-size: medium; font-family: Calibri, sans-serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in; background-color: white;"> </p>
<p class="MsoNormal" style="margin: 0in 0in 0in 0.5in; font-size: medium; font-family: Calibri, sans-serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in; background-color: white;"><!-- [if !supportLists]--><span style="font-size: 10.5pt; font-family: Verdana, sans-serif; color: black;"> 8. Ismail K, Nussbaum L, Sebastiani P, Andersen S, Perls T, Barzilai N, <strong>Milman S</strong>. Compression of Morbidity is Observed Across Cohorts with Exceptional Longevity. <em>J Am Geriatr Soc</em> 2016; 64(8):1583-91. PMCID: <a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4988893/"><span style="color: black;">PMC4988893</span></a></span></p>
<p class="MsoNormal" style="margin: 0in 0in 0in 0.5in; font-size: medium; font-family: Calibri, sans-serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in; background-color: white;"> </p>
<p class="MsoNormal" style="margin: 0in 0in 0in 0.5in; font-size: medium; font-family: Calibri, sans-serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in; background-color: white;"><!-- [if !supportLists]--><span style="font-size: 10.5pt; font-family: Verdana, sans-serif; color: black;"> 9.</span><strong><span style="font-size: 10.5pt; font-family: Verdana, sans-serif; color: black;"> Milman S</span></strong><span style="font-size: 10.5pt; font-family: Verdana, sans-serif; color: black;">, Huffman DM, Barzilai N. The Somatotropic Axis in Human Aging: Framework for the Current State of Knowledge and Future Research. <em>Cell Metab</em> 2016; 23(6):980-9. PMCID: <a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919980/"><span style="color: black;">PMC4919980</span></a></span></p>
<p class="MsoNormal" style="margin: 0in 0in 0in 0.5in; font-size: medium; font-family: Calibri, sans-serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in; background-color: white;"> </p>
<p class="MsoNormal" style="margin: 0in 0in 0in 0.5in; font-size: medium; font-family: Calibri, sans-serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in; background-color: white;"><!-- [if !supportLists]--><span style="font-size: 10.5pt; font-family: 'Verdana',sans-serif; mso-fareast-font-family: Verdana; mso-bidi-font-family: Verdana; color: black; mso-themecolor: text1;"><span style="mso-list: Ignore;"> 10.<span style="font: 7.0pt 'Times New Roman';"> </span></span></span><!--[endif]--><span style="font-size: 10.5pt; font-family: Verdana, sans-serif; color: black;">Perice L, Barzilai N, Verghese J, Weiss EF, Holtzer R, Cohen P, <strong>Milman S</strong>. Lower Circulating Insulin-like Growth Factor-I is Associated with Better Cognition in Females with Exceptional Longevity Without Compromise to Muscle Mass and Function. <em>Aging </em>Albany NY) 2016; 8(10): 2414-2424. PMCID: <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5115897/"><span style="color: black;">PMC5115897</span></a></span></p>
<p class="MsoNormal" style="margin: 0in 0in 0in 0.5in; font-size: medium; font-family: Calibri, sans-serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in; background-color: white;"> </p>
<p class="MsoNormal" style="margin: 0in 0in 0in 0.5in; font-size: medium; font-family: Calibri, sans-serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in; background-color: white;"><span style="font-size: 10.5pt; font-family: 'Verdana',sans-serif; mso-fareast-font-family: Verdana; mso-bidi-font-family: Verdana; color: black; mso-themecolor: text1;"><span style="mso-list: Ignore;"> 11.<span style="font: 7.0pt 'Times New Roman';"> </span></span></span><!--[endif]--><strong><span style="font-size: 10.5pt; font-family: Verdana, sans-serif; color: black;">Milman S</span></strong><span style="font-size: 10.5pt; font-family: Verdana, sans-serif; color: black;">, Barzilai N. Dissecting the Mechanisms Underlying Unusually Successful Human Health Span and Life Span. <em>Cold Spring Harb Perspect Med</em> 2015 Dec 4. PMCID: <a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691799/"><span style="color: black;">PMC4691799</span></a> </span></p>
<p class="MsoNormal" style="margin: 0in 0in 0in 0.5in; font-size: medium; font-family: Calibri, sans-serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in; background-color: white;"> </p>
<p class="MsoNormal" style="margin: 0in 0in 0in 0.5in; font-size: medium; font-family: Calibri, sans-serif; caret-color: #000000; color: #000000; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; text-indent: -0.25in; background-color: white;"><span style="font-size: 10.5pt; font-family: Verdana, sans-serif;"> 12.<span style="font-stretch: normal; font-size: 7pt; line-height: normal; font-family: 'Times New Roman';"> </span></span><!--[endif]--><strong><span style="font-size: 10.5pt; font-family: Verdana, sans-serif;">Milman S</span></strong><span style="font-size: 10.5pt; font-family: Verdana, sans-serif;">, Atzmon G, Huffman DM, Wan J, Crandall JP, Cohen P, Barzilai N. Low Insulin-like Growth Factor-1 Level Predicts Survival in Humans with Exceptional Longevity. <em>Aging Cell</em> 2014; 13(4):769-71</span></p>