Kenneth G. Liu
Paul E. Levin
<p>General orthopedics, nonoperative management of musculoskeletal conditions, fracture surgery and complications of fractures</p>
<p>Patient/physician communication and patient autonomy</p>
<p> </p>Paul E. Levin, MD, joined Montefiore and our Albert Einstein College of Medicine in 2004 and is the Vice Chair of the Department of Orthopedics as well as the Director of the Department of Orthopedics, Moses Campus. At Einstein, he serves as Professor of Orthopedic Surgery. He is a board-certified orthopedic specialist with expertise in general orthopedics, the nonoperative management of musculoskeletal conditions, fracture surgery and complications of fractures.<br /><br />He received his medical degree from SUNY Downstate Medical Center in 1980 and completed his orthopedic residency at Montefiore in 1985. He subsequently completed a fellowship in orthopedic traumatology at the University of Texas and a second fellowship in fracture care at the Kantosspital in Basel, Switzerland.<br /><br />Dr. Levin teaches classes in bioethics and a course in Patients, Doctors and Communities, both of which focus on collaboration among patients and professionals regarding healthcare delivery. Known for exploring treatment options with his patients along with the desire to identify a strategy for successful care without surgical intervention, he has been called on to lecture on patient-clinician communication and surgical safety. Dr. Levin is a fellow of the American Academy of Orthopedic Surgeons (AAOS) and chairman of the organization's Committee on Ethics and Lectures.<p> </p>
Roy G. Kulick
<p>Dr Kulick is Director of the Orthopaedic Hand Service at Montefiore Medical Center. He has a special interest in reconstructive hand surgery, arthritis,Dupuytren's disease nerve compression, including carpal tunnel syndrome. He attended Cornell University Medical College, and trained at Columbia-Presbyterian Medical Center, and The Hospital For Special Surgery. He is board certified in orthopaedic surgery and holds the sub-specialy Certificate of Added Qualifications for Surgery of the Hand.</p>
Reconstructive hand surgery, arthritis, Dupuytren's disease, nerve compression including carpal tunnel syndrome
<p>Roy G. Kulick, MD, Director of Hand and Upper Extremity surgery, specializes in reconstructive hand surgery, arthritis, Dupuytren’s disease and nerve compression, including carpal tunnel syndrome. He is board certified and holds a Sub-Specialty Certificate of Added Qualification for Surgery of the Hand. Dr. Kulick also serves as an Associate Professor at our Albert Einstein College of Medicine.</p><p>Dr. Kulick received his bachelor’s degree from New York University and his medical degree from Weill Cornell Medical College. He completed his residency at Columbia University Medical Center, an internship at St. Luke’s-Roosevelt Hospital Center during his first year of residency, and a fellowship at Hospital for Special Surgery.</p><p><em>New York</em> magazine has recognized Dr. Kulick as a “Best Doctor” in New York and America.</p>
Alexa J. Karkenny
<p>Operative and non-operative treatment of pediatric and adolescent musculoskeletal problems with a focus on neuromuscular diseases affecting the extremities and the spine, complex pediatric and adolescent hip disorders, bone deformities, limb length discrepancies, scoliosis and traumatic injuries</p>
<p>Neuromuscular scoliosis, adolescent idiopathic scoliosis, intra-operative navigation in orthopaedic surgery, hip dysplasia, slipped capital femoral epiphysis, Legg-Calvé-Perthes disease, vitamin D deficiency and pediatric fractures, pediatric injury prevention, occupational radiation exposure</p>
<p>Alexa J. Karkenny, MD, is an attending physician in the pediatric division of orthopedic surgery and Clinical Instructor at Montefiore-Einstein. Dr. Karkenny’s clinical interest is in the treatment of pediatric and adolescent musculoskeletal problems. She has particular focus on neuromuscular diseases affecting the extremities and the spine, complex pediatric and adolescent hip disorders, bone deformities, limb length discrepancies, scoliosis and traumatic injuries.</p><p>Her medical education began at Drexel University, earning her Bachelor of Science in biomedical engineering in 2010 followed by her Doctor of Medicine in 2014. Dr. Karkenny started her postgraduate training at Montefiore-Einstein with an internship and residency in orthopedic surgery from 2014 to 2019. She then went to the Children’s Hospital of Philadelphia to pursue a yearlong fellowship in pediatric orthopedic surgery, which she completed in 2020.</p><p>Dr. Karkenny’s research interests include neuromuscular scoliosis, adolescent idiopathic scoliosis, intraoperative navigation in orthopedic surgery, hip dysplasia, slipped capital femoral epiphysis, Legg-Calvé-Perthes disease, vitamin D deficiency and pediatric fractures, pediatric injury prevention and occupational radiation exposure. She has shared her research through publication in peer-reviewed journals, poster presentations and podium presentations.</p><p>Dr. Karkenny is a member of the Pediatric Orthopedic Society of North America, the American Academy of Orthopedic Surgeons, and the Ruth Jackson Orthopedic Society.</p>
Mahsa Kanzali
Mani D. Kahn
<p>Fracture repair of the pelvis and hip bone sockets; complex limb reconstruction; limb lengthening procedures; infected or failed fracture correction</p>
<p>Enhancing the future of fracture care</p>
<p></p>Mani Kahn, MD, is a board certified, fellowship-trained orthopedic surgeon specializing in the treatment of injuries to the upper and lower extremities as well as to the pelvis. He has a particular interest in treating periarticular fractures, fractures of the pelvis and acetabulum, performing complex limb reconstruction, and the correction of failed or infected fractures.<br /><br />Dr. Kahn attended the University of Maryland for his undergraduate degree, where he pursued research in biochemistry and was awarded several research fellowships, including the Rollinson Fellowship and the famed Howard Hughes Medical Institute's fellowship. He went on to obtain a Masters of Science in physiology and biophysics from Georgetown University. Dr. Kahn continued his studies at New York Medical College, where he obtained his Doctor of Medicine and Masters in Public Health. Dr. Kahn completed his residency training at Montefiore Medical Center. While a resident, he received two of the highest awards given to residents: the Anatomy Award and the Richard Selznick Memorial Research Award.<br /><br />Following his residency, Dr. Kahn continued his training at Duke University with a fellowship in trauma surgery, where he received an AOTrauma research fellowship. He was also privileged to continue his training with two sought-after traveling fellowships. Dr. Kahn received a travelling fellowship award in limb lengthening and reconstructive surgery, and he travelled across the country to work with the best limb reconstruction surgeons in the world. He was also selected as the recipient of the prestigious Jack McDaniel AO Travelling Fellowship, and studied under the guidance of Dr. Marcel Jakob at University of Basel Hospital in Switzerland.<br /><br />Dr. Kahn has authored several publications in peer-reviewed journals and book chapters, and has been invited as faculty in a national course for the training of residents in the principles of fracture care.<p></p>
Kira Gritsman
<p><strong>The Roles of Signaling Pathways in Adult Blood Development and Leukemia</strong></p>
<p><span style="font-size: 10.5pt; font-family: Verdana, sans-serif;">The Gritsman lab studies the signal transduction pathways that affect the early fate decisions of adult hematopoietic stem cells (HSCs) as they progress from an undifferentiated multipotent state to the generation of differentiated blood cells. When these early fate decisions go awry, this can lead to the formation of leukemia-initiating cells. We are interested in</span><span style="font-size: 10.5pt; font-family: Verdana, sans-serif;"> how signaling pathways affect the self-renewal and differentiation of HSCs and malignant or pre-malignant stem cells in myeloid malignancies, such as acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), and myeloproliferative neoplasms (MPN).</span></p>
<p><strong>Roles of the PI3 kinase isoforms in adult blood development</strong></p>
<p>PI3 kinase (PI3K) is a lipid kinase that is important for the regulation of metabolism, the cell cycle, apoptosis, and protein synthesis. In hematopoietic cells, there are four isoforms of the catalytic subunit of PI3K, each encoded by a separate gene. Emerging evidence suggests that these isoforms have unique functions in normal and cancer cells, but may substitute for each other in some contexts. We have generated a series of mouse knockout models that allow us to study the roles of each of these isoforms individually in adult hematopoiesis. For example, we have found that the p110alpha isoform is most important for red cell development, but is not required in normal blood stem cells. We have now also generated compound knockout mice to determine the redundant roles of the PI3K isoforms in blood development. We recently reported that PI3K isoforms play important redundant roles during the hematopoietic stress response, such as after chemotherapy. However, deletion of all 3 Class IA PI3K isoforms leads to a phenotype with impaired HSC differentiation, resembling myelodysplastic syndrome (MDS). We are studying how deletion of PI3K will impact normal HSC function, including self-renewal, proliferation, and differentiation along different blood lineages by affecting processes such as autophagy and epigenetic regulation in HSCs.</p>
<p><strong>Roles of the PI3 kinase isoforms in leukemia</strong></p>
<p>Acute myeloid leukemia (AML) is a genetically diverse disease, but activation of the PI3K pathway has been reported in up to 80% of cases. A subset of AML cell lines and AML patient samples respond to PI3K pathway inhibitors, but it is unclear how patients should be selected for potential response to these inhibitors. We found that RAS-mutated myeloid leukemias are particularly dependent on the p110alpha isoform of PI3K, and that pharmacologic inhibition of p110alpha can be used to treat both RAS-mutated cell lines and RAS-mutated leukemia in mice. Furthermore, we use cell lines, patient samples, and mouse models of leukemia to investigate the mechanisms of resistance to PI3K inhibition, with the goal of identifying new drug targets and designing new combination treatments for leukemia that incorporate PI3K inhibitors.</p>
<p><strong>RON Kinase in Myeloproliferative Neoplasms</strong></p>
<p>The myeloproliferative neoplasms (MPNs) are a group of diseases that are caused by kinase mutations in HSCs, which lead to uncontrolled proliferation of myeloid cells. The Philadelphia chromosome-negative MPNs are characterized by mutations in the JAK/STAT signaling pathway, and respond to JAK inhibitors, but resistance often develops. We recently discovered that the receptor Tyrosine kinase RON can physically interact with JAK2 in MPN cells, leading to potentiation of JAK/STAT signaling in resistant cells. Furthermore, we found that pharmacologic or genetic inactivation of RON can inhibit proliferation of MPN cells and re-sensitize resistant cells to JAK inhibitors.</p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif;"><strong><span style="font-size: 10.5pt; font-family: Verdana, sans-serif; color: #201f1e;">Member of the Cancer Dormancy and Tumor Microenvironment Institute </span></strong></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif;"> </p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif;"><span style="font-size: 10.5pt; font-family: Verdana, sans-serif;"> </span><span style="font-size: 10.5pt; font-family: Verdana, sans-serif;">The Gritsman lab’s research interests include the contributions of signaling pathways to leukemic and pre-leukemic stem cell dormancy in minimal residual disease, which includes mechanisms of immune evasion. Furthermore, the Gritsman lab is interested in the roles of inflammatory signaling pathways and of the local microenvironment in bone marrow fibrosis, and in the evolution of myeloid neoplasms from the pre-malignant to malignant state. Our major goals are to identify opportunities for therapeutic targeting to prevent the transition from the pre-leukemic state to leukemia, or to eliminate minimal residual disease to prevent relapse.</span></p>
<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;"><a name="_GoBack"></a><span style="font-size: 11pt; font-family: Arial, sans-serif;">Ames, K., <sup> </sup>Kaur,<sup> </sup>I., Shi, Y., Tong, M., Sinclair, T., Hemmati, S., Glushakow-Smith, S.G., Tein, E., Gurska, L., Steidl, U., Dubin, R., Shan, J., Montagna, C., Pradhan, K., Verma, A., and <strong><u>Gritsman, K.</u></strong>, Deletion of PI3-Kinase Promotes Myelodysplasia Through Dysregulation of Autophagy in Hematopoietic Stem Cells, <strong><em>Science Advances</em></strong><em> 2023. </em>doi: <a href="https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fdoi.o…; target="_blank" rel="noopener"><span style="color: black; text-decoration: none;">10.1126/sciadv.ade8222</span></a><u>, </u>PMID: 36812307</span></p>
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<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;"><span style="font-size: 11pt; font-family: Arial, sans-serif;">Folgado Marco, V., Ames, K., Chuen, J., <strong><u>Gritsman, K.</u></strong> & Baker, N., Haploinsufficiency of the essential gene <em>RpS12</em> causes defects in erythropoiesis and hematopoietic stem cell maintenance, <em> <strong>eLife</strong> </em>2023 Jun 5;12:e69322. doi: 10.7554/eLife.69322. PMID: 37272618</span></p>
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<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;"><span style="font-size: 11pt; font-family: Arial, sans-serif;">Gurska, L.M., Okabe, R., Schurer, A., Tong, M.M., Soto, M., Choi, D., Ames, K., Glushakow-Smith, S., Montoya, A., Tein, E., Miles, L.A., Cheng, H., Hankey-Giblin, P., Levine, R.L., Goel, S., Halmos, B., and <strong><u>Gritsman, K.</u></strong> Crizotinib has Preclinical Efficacy in Philadelphia-negative Myeloproliferative Neoplasms, <strong><em>Clinical Cancer Research</em></strong> 2022 Dec 20:CCR-22-1763. doi: 10.1158/1078-0432.CCR-22-1763. PMID: 36537918</span></p>
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<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;"><span style="font-size: 11pt; font-family: Arial, sans-serif;">Gurska, L., Ames, K., and <strong><u>Gritsman, K</u></strong>, Signaling Pathways in Leukemic Stem Cells, </span><span style="font-size: 11pt; font-family: Arial, sans-serif; color: #333333; letter-spacing: 0.2pt; background-color: #fcfcfc;">In: Zhang H., Li S. (eds) Leukemia Stem Cells in Hematologic Malignancies. <strong>Advances in Experimental Medicine and Biology</strong>, vol 1143. Springer, Singapore</span><span style="font-size: 11pt; font-family: Arial, sans-serif;">, July 24, 2019, doi: <a href="https://doi.org/10.1007/978-981-13-7342-8_1"><span style="color: black; letter-spacing: 0.2pt; background-color: #fcfcfc; text-decoration: none;">https://doi.org/10.1007/978-981-13-7342-8_1</span></a><span style="letter-spacing: 0.2pt; background-color: #fcfcfc;">; </span>PMID: 31338813, PMCID: <a href="http://www.ncbi.nlm.nih.gov/pmc/articles/pmc7249489/" target="_blank" rel="noopener"><span style="color: black; text-decoration: none;">PMC7249489</span></a></span></p>
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<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;"><span style="font-size: 11pt; font-family: Arial, sans-serif;">Hemmati, S., Sinclair, T., Tong, M., Bartholdy, B., Okabe, R.O., Ames, K., Ostrodka, L., Haque, T., Kaur, I., Mills, T. S., Agarwal, A., Pietras, E.M., Zhao, J.J., Roberts, T.M., and <strong><u>Gritsman, K.</u></strong>, PI3 kinase alpha and delta promote hematopoietic stem cell activation, <strong><em>JCI Insight </em></strong>2019 doi.org/10.1172/jci.insight.125832</span></p>
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<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;"><span style="font-size: 11pt; font-family: Arial, sans-serif;">Mitchell, K., Barreyro, L., Todorova, T., Taylor, S., Antony-Debre, I., Narayanagari, S., Carvajal, L., Leite, J., Piperdi, Z., Pendurti, G., Mantzaris, I., Paietta, E., Verma, A., <strong><u>Gritsman, K., </u></strong>and Steidl, U. IL1RAP potentiates multiple oncogenic signaling pathways in AML, <strong><em>Journal of Experimental Medicine</em></strong><em>. </em>2018 May 17. doi: 10.1084/jem.20180147, PMID: 29773641</span></p>
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<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;"><span style="font-size: 11pt; font-family: Arial, sans-serif;">Hemmati, S., Haque, T., and <strong><u>Gritsman, K</u>, </strong>Inflammatory Signaling Pathways in Pre-leukemic and Leukemic Stem Cells, <strong><em>Frontiers in Oncology</em></strong><em> </em>2017 Nov 13;7:265. doi: 10.3389/fonc.2017.00265</span></p>
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<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;"><span style="font-size: 11pt; font-family: Arial, sans-serif;">Bhagat, T.D., Chen, S., Bartenstein, M., Barlowe, A.T., Von Ahrens, D., Choudhary, G.S., Tivnan, P., Amin, E., Marcondes, M., Sanders, M.A., Hoogenboezem, R.M., Kambhampati, S., Ramanchandra, N., Mantzaris, I., Sukrithan, V., Laurence, R., Lopez, R. Bhagat, P., Giricz, O., Sohal, D., Wickrema, A., Yeung, C., <strong><u>Gritsman, K.,</u></strong> Aplan, P., Hochedlinger, K., Yu, Y., Pradhan, K., Zhang, J., Greally, J.M., Mukherjee, S., Pellagatti, A., Boultwood, J., Will, B., Steidl, U., Raaijmakers, M.H.G.P., Deeg, H.J., Kharas, M.G. and Verma, A. Epigenetically Aberrant Stroma in MDS Propagates Disease Via Wnt/b-Catenin Activation, 2017 <strong><em>Cancer Research</em></strong> 2017 Jul 6. pii: canres.0282.2017. doi: 10.1158/0008-5472</span></p>
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<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;"><span style="font-size: 11pt; font-family: Arial, sans-serif;">Yuzugullu, H., Baitsch, L., Von, T., Steiner, A., Tong, H., Ni, J., Clayton, L., Bronson, R., Roberts, T., <strong><u>Gritsman, K</u></strong><u>.</u>, and Zhao, J.J. A p110b-Rac signaling loop mediates Pten-loss-induced perturbation of hematopoiesis and leukemogenesis. <strong><em>Nature Communication</em></strong><em>s </em>October 7,2015, doi:10.1038/NCOMMS9501</span></p>
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<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;"><span style="font-size: 11pt; font-family: Arial, sans-serif;">Yoda, A., Adelmant, G., Tamburini, J., Chapuy, B., Shindoh, N., Yoda, Y., Weigert, O., Kopp, N., Wu, S-C., Kim, S., Liu, H., Tivey, T., Christie, A.L., <strong><u>Gritsman, K.</u></strong>, Gotlib, J., Deininger, M., Turley, S., Tyner, J., Marto, J., Weinstock, D.M., and Lane, A.A. Mutations in G-protein beta subunits promote transformation and kinase inhibitor resistance <strong><em>Nature Medicine</em></strong><em> </em>2015 (1):71-5.</span></p>
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<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;"><strong><u><span style="font-size: 11pt; font-family: Arial, sans-serif;">Gritsman, K</span></u></strong><strong><span style="font-size: 11pt; font-family: Arial, sans-serif;">.</span></strong><span style="font-size: 11pt; font-family: Arial, sans-serif;">, Yuzugullu, H., Von, T., Yan, H., Clayton, L., Fritsch, C., Maira, S.-M., Hollingworth, G., Choi, C., Khandan, T., Paktinat, M., Okabe, R.O., Roberts, T.M., and Zhao, J.J. Hematopoiesis and RAS-driven myeloid leukemia differentially require PI3K isoform p110alpha<strong>. <em>Journal of Clinical Investigation </em></strong>2014;124(4):1794–1809. http://www.jci.org/articles/view/69927</span></p>
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<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;"><span style="font-size: 11pt; font-family: Arial, sans-serif;">Kharas, M.G. and <strong><u>Gritsman, K</u></strong>. Akt: A Double-Edged Sword for Hematopoietic Stem Cells. <strong><em>Cell Cycle</em> </strong>2010; Vol 9; Issue 7</span></p>
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<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;"><span style="font-size: 11pt; font-family: Arial, sans-serif;">Kharas, M.G., Okabe, R., Ganis, J.J., Gozo,M., Khandan,T., Paktinat, M., Gilliland, D.G., and <strong><u>Gritsman, K</u>.</strong> Constitutively Active AKT Depletes Hematopoietic Stem Cells and Induces Leukemia in Mice. <strong><em>Blood </em></strong>2010; 115(7): 140615 http://www.bloodjournal.org/content/115/7/1406</span></p>
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Jaime A. Gomez
<p>Dr. Gomez moved to New York City from Bogota-Colombia after earning his medical degree from the Pontificia Universidad Javeriana. He completed his internship and residency in Orthopaedic Surgery at Columbia University where he obtained the prestigious <em>“Rosamond Kane Award for Excellence in Pediatric Orthopaedic Surgery”</em>. Following residency, Dr. Gomez graduated from the Pediatric Orthopaedic Fellowship at Harvard’s Boston Children’s Hospital. Then he went on to pursue a Spinal Surgery Fellowship at NYU/Hospital for Joint Diseases.</p>
<p>Dr. Gomez’ premier training enables him to provide superior care to children, adolescents and adults undergoing spinal surgery with the proficiency of a spine surgeon and the perspective of a pediatric orthopaedic surgeon. He has trained and applied cutting edge growth friendly techniques for young children with scoliosis such as “MAGEC” which is a magnetic growing rod that allows for growth of young children with early onset scoliosis avoiding repeat surgical procedures. He has significant interest in less invasive techniques such a scoliosis casting as well as the most complex deformity correction osteotomies for scoliosis both in children and adults. He treats a wide array of musculoskeletal pathology with special interest in the treatment of:</p>
<ul>
<li>Early Onset, Congenital and Adolescent Idiopathic Scoliosis</li>
<li>Spondylolisthesis</li>
<li>Pediatric Cervical Spine Pathology</li>
<li>Cerebral Palsy</li>
<li>Hip Dysplasia</li>
<li>Pediatric Fractures and Trauma</li>
</ul>
<p>Dr. Gomez has also volunteered to perform complex surgeries in developing countries. He worked with “Butterfly Foundation” in Dominican Republic and with “Healing the Children” in Colombia providing orthopedic surgical care and training to local orthopaedists. Being a native Spanish speaker, he is particularly attuned to the different cultural backgrounds of the city of New York. Dr. Gomez is an active member of the American Academy of Orthopedic Surgeons (AAOS), North American Spine Society (NASS) and the Pediatric Orthopedic Society of North America (POSNA).</p>
<p>Operative and nonoperative treatment of pediatric orthopedics, adult and pediatric complex spinal problems; scoliosis treatment in children and adults using techniques ranging from less invasive scoliosis casting to complex osteotomies for deformity correction</p>
<p>Clinical outcomes in pediatric orthopedics and scoliosis</p>
<p><strong>PEER REVIEW ARTICLES</strong></p>
<ol>
<li>Lowenstein JE, Matsumoto H, Vitale MG, Weidenbaum M, <strong>Gomez JA, </strong>Lee FY, Hyman JE, Roye DP Jr. <em>Coronal and sagittal plane correction in adolescent idiopathic scoliosis: a comparison between all pedicle screw versus hybrid thoracic hook lumbar screw constructs. </em><strong>Spine. 2007 Feb 15; 32(4):448-52. </strong>
</li>
<li>Vitale MG, Privitera DM, Matsumoto H, <strong>Gomez JA</strong>, Waters LM, Hyman JE, Roye DP Jr. <em>Efficacy of preoperative erythropoietin administration in pediatric neuromuscular scoliosis patients. </em><strong>Spine. 2007 Nov 15;32(24):2662-7. </strong>
</li>
<li>Vitale MG, Matsumoto H, Roye DP Jr, <strong>Gomez JA</strong>, Betz RR, Emans JB, Skaggs DL, Smith JT, Song KM, Campbell RM Jr. <em>Health-related quality of life in children with thoracic insufficiency syndrome. </em><strong>J Pediatr Orthop. 2008 Mar;28(2):239-43. </strong>
</li>
<li>Vitale MG, Matsumoto H, Bye MR, <strong>Gomez JA</strong>, Booker WA, Hyman JE, Roye DP Jr. <em>A retrospective cohort study of pulmonary function, radiographic measures, and quality of life in children with congenital scoliosis: an evaluation of patient outcomes after early spinal fusion. </em><strong>Spine. 2008 May 15;33(11):1242-9. </strong>
</li>
<li>Matsumoto H, Vitale MG, Clayton-Krasinski D, Hyman JE, Klinge SA, <strong>Gomez JA</strong>, Avendano J, Roye DP. <em>Quantifying the ‘burden of care’ for parents with children with neuromuscular disease. </em><strong>Developmental Medicine & Child Neurology. 2008:50:S21. </strong>
</li>
<li>Vitale MG, Moore D, Roye DP, Matsumoto H, <strong>Gomez JA</strong>, Hyman JE<em>. MEP/SSEP monitoring in spinal deformity surgery: incidence and factors leading to significant electrophysiological events. </em><strong>J Child Orthop. 2008;2 (Suppl 1): S55. </strong>
</li>
<li>Vitale MG, Klinge SA, Matsumoto H, Clayton-Krasinski D, Hyman JE, <strong>Gomez JA</strong>, Avendano J Roye DP. <em>A rapid comprehensive quality of life assessment in children with neuromuscular disease</em>. <strong>Developmental Medicine & Child Neurology. 2008:50: S73. </strong>
</li>
<li>Ahmad CS, Moira, <strong>Gomez JA</strong>, Shubinstein B. <em>The Moving Patella Apprehension Test for Lateral Patella Instability. </em><strong>Am J Sports Med, 2009 Feb 3 </strong>
</li>
<li>Roye DP, Privetera DM, <strong>Gomez JA</strong>, Matsumoto H, Klinge SA, Hyman JE, Vitale MG. <em>Pedicle screw placement in pediatric scoliosis surgery: do non-idiopathic patients have higher misplacment rates? </em><strong>Journal of Child Orthopaedics. </strong>2009;3:S52. 
</li>
<li><strong>Gomez JA</strong>, Roye, DP Jr., Vitale MG, Hyman JE, Matsumoto H, van Bosse H JP, Marangoz S, Sala DA, Stein MI, Feldman DS. <em>Articulated Hip Distraction Arthroplasty: A Treatment Option for Avascular Necrosis of the Child and Adolescent Femoral Head</em><strong>. J Pediatr Orthop 2009 </strong>March 29: 163-169</li>
<li>Matsumoto H, Roye DP, Vitale MG, Clayton-Krasinski D, <strong>Gomez JA</strong>, Hyman JE. Impact on personal time in parents of children with neuromuscular disease. <strong>Journal of Child Orthopaedics. 2009</strong>:3;S14</li>
<li>Matsumoto H, Vitale MG, <strong>Gomez JA</strong>, Hyman JE, Kaufman B, Roye DP. <em>Femoral valgus osteotomy for advanced femoral head osteonecrosis and perthes disease in children and adolescents. </em><strong>J Bone Joint Surg Br 2010 </strong>vol. 92-B no. SUPP I 11</li>
<li>Vitale MG, Moore DW, Matsumoto H, Emerson RG, Booker WA, <strong>Gomez JA</strong>, Gallo EJ, Hyman JE, Roye DP Jr. <em>Risk factors for spinal cord injury during surgery for spinal deformity. </em><strong>J Bone Joint Surg Am. 2010 </strong>Jan;92(1):64-71.</li>
<li>Privitera DM, Matsumoto H, <strong>Gomez JA</strong>, Roye DP, Hyman JE, Vitale MG. <em>Are Breech Rates for Pedicle Screws Higher in the Upper Thoracic Spine? </em><strong>Spine Deformity 05/2013</strong>; 1(3):189– 195.</li>
<li>Matsumoto H, Krasinski DA, Klinge SA, <strong>Gomez JA</strong>, Booker WA, Hyman JE, Roye DP, Vitale MG. <em>Development and Initial Validation of the Assessment of Caregiver Experience with Neuromuscular Disease (ACEND). </em><strong>J Pediatr Orthop. 2011</strong>;31:284-92.</li>
<li>Vitale MG, <strong>Gomez JA</strong>, Matsumoto H, Roye DP Jr; Chest Wall and Spine Deformity Study Group. <em>Variability of expert opinion in treatment of early-onset scoliosis. </em><strong>Clin Orthop Relat Res. 2011 May;</strong>469(5):1317-22.</li>
<li>Miller DJ, Franzone JM, Matsumoto HM, <strong>Gomez JA</strong>, Avendano J, Hyman JE, Roye DP, Vitale MG. <em>Electronic Monitoring Improves Brace Wearing Compliance in Patients with Adolescent Idiopathic Scoliosis- A Randomized Clinical Trial. </em><strong>Spine 2012 </strong>Apr 20;37(9):717- 21.</li>
<li>Lee JK, <strong>Gomez JA</strong>, Gardner T, Michelsen C, Yongjung KJ. <em>In vitro Biomechanical Study to Quantify Range of Motion, Intradiscal Pressure, and Facet Force of Three-level Dynamic Stabilization Constructs with Decreased Stiffness. </em><strong>Spine 2013 </strong>Aug 5. PMID: 23921330</li>
<li>Prince DE, Matsumoto H, Chan CM, <strong>Gomez JA</strong>, Hyman JE, Roye DP Jr, Vitale MG. <em>The Effect of Rod Diameter on Correction of Adolescent Idiopathic Scoliosis at Two Years Follow Up. </em><strong>J Pediatr Orthop. 2013 </strong>Jul 16. PMID: 23863413</li>
<li><strong>Gomez JA</strong>, Matsumoto H, Colacchio ND, Roye DP, Sucato DJ, Richards BS, Emans JB, Erickson MA, Sanders JO, Lenke LG, Vitale MG. <em>Risk Factors for Coronal Decompensation After Posterior Spinal Instrumentation and Fusion in Adolescent Idiopathic Scoliosis. </em><strong>Spine Deformity 09/2014; </strong>2(5):380–385. </li>
</ol>
<p><strong>BOOK CHAPTERS & REVIEW ARTICLES </strong></p>
<p>1.David Roye, <strong>Jaime Gómez</strong>. <em>Cavus Foot</em>. In Skaggs D.L., Tolo V.T. <strong>Master Techniques in </strong>
<strong>Orthopaedic Surgery: Pediatrics. </strong>Lippincott Williams & Wilkins, 2008. 
</p>
<p>2.<strong>Gomez JA</strong>, Lee JK, Kim PD, Roye DP, Vitale MG. "Growth Friendly" Spine Surgery: management options for the young child with scoliosis. <strong>J Am Acad Orthop Surg. 2011 Dec;19(12):722-7. </strong>
</p>
<p>3.<strong>Gómez J</strong>, Ludwig SC. Minimally invasive techniques for thoracolumbar spinal trauma. <strong>Contemp Spine Surg 2012;13(5):1-7. </strong>
</p>
<p>4.<strong>Gomez JA, </strong>Vitale MG. Measuring Outcomes in Children with Early-Onset Scoliosis. <strong>Semin Spine Surg 2012 Sept; 24(3):140-143 </strong>
</p>
<p>5.<strong>Gomez JA</strong>, Makhni MC, Vitale MG. Recurrent Spinal Deformity After Scoliosis Surgery in Children. <strong>AAOS Instr Course Lect. 2014;63:345-51. </strong>
</p>
<p>6.<strong>Gomez JA, </strong>Park, H, Vitale MG. <em>Early Onset Scoliosis: The North American Experience</em>. In Nnadi C. <strong>Early Onset Scoliosis: A Comprehensive Guide from the Oxford Meetings</strong>. Chapter 26, Stuttgart: Thieme Publishers; 2015. <em>In Print </em>
</p>
<p>7.<strong>Gomez JA, </strong>Ramirez F, Hedequist D. <em>Hemivertebrae Excision; Technique for Congenital Spine Deformity. </em>In Wang, Boachie, Lenke. <strong>Spinal Osteotomy. Springer 2015 . </strong><em>In Print </em>
</p>
<p>8.<strong>Gomez JA, </strong>Hedequist D. <em>Posterior Cervical Arthrodesis Occiput to C2 and C1-C2; </em>In Wiesel S. <strong>Operative Techniques in Orthopaedic Surgery 2nd Edition</strong>, 2015. In Print 
</p>
<p>Jaime A. Gomez, MD, is a board-certified orthopedic surgeon with expertise in the nonoperative and operative treatment of scoliosis, pediatric orthopedics and spinal surgery. He has trained and applied cutting-edge, growth-friendly techniques for young children with scoliosis. He has significant interest in less invasive techniques, such as scoliosis casting, as well as the most complex deformity correction osteotomies for scoliosis in both children and adults. Dr. Gomez joined Montefiore in 2015 and serves as an Assistant Professor of Orthopedic Surgery and Co-Director of Pediatric Orthopedic Research at our Albert Einstein College of Medicine.</p><p>After earning his medical degree from Pontificia Universidad Javeriana in Bogota, Colombia, Dr. Gomez served his internship and residency in orthopedic surgery at Columbia University in New York City, where he was honored with the prestigious Rosamond Kane Award for Excellence in Pediatric Orthopedic Surgery. He also completed a pediatric orthopedic fellowship at Harvard Medical School?s Boston Children?s Hospital and a spinal surgery fellowship at New York University?s Hospital for Joint Diseases.</p><p>Dr. Gomez's research is focused on clinical outcomes in pediatric orthopedics and scoliosis. As a member of the largest international multicenter study group on early-onset scoliosis, the Children Spine Study Group, he has presented his research in multiple national and international conferences and has contributed to more than 30 peer-reviewed publications and book chapters. He is a member of several orthopedic societies, including the Pediatric Orthopedic Society of North America (POSNA) and the American Academy of Pediatrics (AAP), and he is a diplomat of the American Board of Orthopedic Surgeons. He has also worked with the Butterfly Foundation in the Dominican Republic and with Healing the Children in Colombia, providing orthopedic surgical care and training to local orthopedists.</p><p>Dr. Gomez is a native Spanish speaker.</p>
David S. Geller
<p>Dr. Geller is a full-time faculty member of the Orthopaedic Surgery Department at Montefiore Medical Center and serves as the director of the Orthopaedic Oncology Service, managing both pediatric and adult patients. He is the co-director of Orthopaedic Surgery at the Montefiore Medical Center Moses Campus and currently serves as the Quality Improvement Officer for the Montefiore Cancer Committee. His clinical focus involves primary and metastatic bone and soft tissue tumors, with a secondary interest in joint replacement in the setting of extensive bone loss. He has experience in navigation-guided surgery, allograft reconstruction, endoprosthetic reconstruction, and use of custom or patient-tailored reconstructive prostheses. His research interests include expression patterns in osteosarcoma, surgical margins in osteosarcoma, novel drug screening methods and targeted therapy for osteosarcoma using novel therapeutic modalities. He is extensively involved in resident and medical student education.</p>
<p>Dr. Geller is an orthopaedic surgeon specializing in musculoskeletal oncology and joint replacement, and his practice encompasses adult and pediatric patients. Dr. Geller’s research interests include surface receptor expression in osteosarcoma and potential targeted therapies for the treatment of osteosarcoma. He has developed a novel murine xenograft model for osteosarcoma for the evaluation of surgical margins in osseous tumor surgery. His research additionally includes allograft bone reconstruction techniques, resonance frequency changes during joint reconstruction and pain management in the elderly orthopaedic population.</p>
<p>Orthopedic oncology, orthopedic surgery, bone and soft tissue sarcomas, benign bone and soft-tissue tumors, metastatic carcinoma on the bone </p>
<p>Osteosarcoma, with an interest in innovative treatment strategies for both local disease control and metastatic disease; evaluation of expression patterns in osteosarcoma and surgical margins using a xenograft osteosarcoma murine model; the functional role of bone morphogenetic proteins in osteosarcoma surgery; use of intraoperative navigation techniques for tumor surgery; tumorigenesis of osteosarcoma </p>
<ul>
<li>Morris J, Dutcher J, <strong>Geller DS</strong>. Revisiting the Orhtopaedic Management of Metastatic Renal Cell Carcinoma: Rationale for a More Aggressive Approach. <em>Current Orthopaedic Practice. </em>2013 Sept/Oct; 24(5):547-551.</li>
<li>Bekarev M, Elsinger EC, Villanueva-Siles E, Borzykowski RM, <strong>Geller DS.</strong> Synovial Sarcoma of the Foot. <em>Journal of Foot and Ankle Surgery</em>. 2013 Jul-Aug; 52(4):513-7. doi: 10.1053</li>
<li>Capogna BM, Lovy A, Blum Y, Kim SJ, Flesen UR, <strong>Geller DS.</strong> Infection Rate Following Total Joint Arthroplasty in the HIV Population. <em>Journal of Arthroplasty</em>. 2013 Sep; 28(8):1254-8. doi: 10.1016</li>
<li>Lall A, Hohn E, Kim M, Gorlick R, Abraham J, <strong>Geller DS</strong>. Comparison of Surface Area Across the Allograft-Host Junction Site Using Conventional and Navigated Osteotomy Technique. <em>Sarcoma</em>. 2012; 2012:197540. </li>
<li>Piperdi S, Austin-Page L, <strong>Geller DS</strong>, Ahluwalia M, Gorlick S, Gill J, Sellers R, Zhang W, Li N, Ching Sohak, Gorlick R. Beta-Catenin Does Not Confer Tumorigenicity when Introduced into Partially Transformed Human Mesenchymal Stem Cells.<em> Sarcoma</em>. 2012. Epub 2012 Oct 18.</li>
<li>Crocco L, Gorlick R,<strong> Geller DS</strong>. Current Practice Management Regarding Thromboembolic Prophylaxis Within the Pediatric Sarcoma Patient Population, <em>Journal of Pediatric Hematology/Oncology</em>.2012 Sep 19. [Epub ahead of print]</li>
<li> Hall GL, Villanueva-Siles E, Borzykowski RM, Gruson KI, Dorfman HD, <strong>Geller</strong> <strong>DS</strong>. Aspergillus osteomyelitis of the proximal humerus: a case report. <em>Skeletal Radiology</em>. 2012 Aug; 41(8):1021-5. Epub 2012 Mar 31.</li>
<li>Sambaziotis C, Plymale M, Lovy A, O’Halloran K, McCulloch K, <strong>Geller DS</strong>. Pseudoaneurysm of the Distal Thigh after Manipulation of a Total Knee Arthroplasty. <em>Journal of Arthroplasty</em>. 2012 Aug; 27(7); 1414.</li>
<li>Shakked RJ, <strong>Geller DS</strong>, Gorlick R, Dorfman HD. Mesenchymal chondrosarcoma: Clinicopathologic study of 20 cases. <em>The Archives of Pathology & Laboratory Medicine</em>. 2012 Jan; 136(1):61-75.</li>
<li>Hohn E, Garfein ES, Mehta KJ, <strong>Geller DS. </strong>Quadriceps Tendon Allograft Augmentation after Wide Excision of a Soft Tissue Sarcoma. <em>Current Orthopaedic Practice</em>. 2012 Jan/Feb; 23(1):68-71.</li>
<li>Singh CK, <strong>Geller DS. </strong>The Telescopic Mating Technique for Bulk Allograft Reconstruction. <em>Orthopaedics</em>. 2012 Feb; 35(2):118-124.</li>
<li>Sambaziotis C, Lovy A, Moadel RM, Chamarthy M, Glaser J, Jaini S, Villanueva-Siles E, <strong>Geller DS</strong>. Florine-18 Fluorodeoxyglucose Positron Emission Tomography for Osteochondromas Utilizing a Triple-Time Point Protocol. <em>Open Journal of Medical Imaging</em>. 2011 Dec; 1(2):15-20.</li>
<li>Hassan SE, Bekarev M, Kim MY, Lin J, Piperdi S, Gorlick R, <strong>Geller DS. </strong>Cell Surface Receptor Expression Patterns in Osteosarcoma. <em>Cancer.</em> 2011 Feb 1; 118(3):740-9.</li>
<li>Plymale M, Lovy A, Villanueva-Siles E, <strong>Geller DS.</strong> Isolated intra-articular pseudorheumatoid nodule of the knee.<em> Skeletal Radiology</em>. 2011 Apr; 40(4):463-6.</li>
<li>Green MC, Dorfman HD, Villanueva-Siles E, Gorlick RG, Thornhill BA, Weber RV, <strong>Geller DS. </strong>Aggressively Recurrent Infantile Myofibroma of the Axilla and Shoulder Girdle. A Case Report. <em>Skeletal Radiology</em>.2010 Mar; 40(3):357-61.</li>
<li><strong>Geller DS</strong>, Pope JB, Thornhill BA, Dorfman, HD. Cryptococcal pyarthrosis and sarcoidosis. <em>Skeletal Radiol</em>. 2009 Jul; 38(7):721-7.</li>
<li>Sah A, <strong>Geller DS</strong>, Mankin HJ, Delaney T, Rosenberg A, Wright C, Hornicek FJ. Malignant Transformation of Synovial Chondromatosis of the Shoulder to Chondrosarcoma - A Case Report," <em>Journal of Bone and Joint Surgery. </em>2007 Jun; 89(6):1321-8.</li>
<li><strong>Geller DS</strong>, Hornicek FJ, Mankin HJ, Raskin KA. “Soft Tissue Sarcoma Resection Volume Associated with Wound-Healing Complications,” <em>Clinical Orthopaedics and Related Research.</em> 2007; 457:182-5.</li>
<li>Ames JA, Abraham JA, <strong>Geller DS</strong>, Goldsmith J, Gebhardt MC. Proximal Tibial Lesion in a Young Adult: Early Diagnosis Allowing Unique Reconstruction. <em>The Orthopaedic Journal at Harvard Medical School.</em> 2006 Aug: 143-7.</li>
<li>Gardner MJ, Yacoubian S, <strong>Geller DS</strong>, Pode M, Mintz D, Helfet DL, Lorich DG. “Prediction of Soft-Tissue Injuries in Schatzker II Tibial Plateau Fractures based on Measurements of Plain Radiographs,” <em>Journal of Trauma-Injury Infection & Critical Care</em>. 2006; 60(2):319-324.</li>
<li>Steinberg EL, <strong>Geller DS</strong>, Yacoubian SV, Shasha N, Dekel S, Lorich DG. “Intramedullary Fixation of Tibial Shaft Fractures Using an Expandable Nail,” <em>Journal of Orthopaedic Trauma. </em>2006 May; 20(5):303-9.</li>
<li>Gardner, MJ, Yacoubian S, <strong>Geller DS</strong>, Suk M, Mintz D, Potter H, Helfet DL, Lorich DG. “ The Incidence of Soft Tissue Injury in Operative Tibial Plateau Fractures,” <em>Journal of Orthopaedic Trauma</em>. 2005; 19:79-84.</li>
<li>Lorich DG, Yacoubian SV, <strong>Geller DS</strong>. “Intramedullary Fixation of Humeral Shaft Fractures Using an Inflatable Nail,” <em>Orthopaedics</em>. 2003 Oct; 26(10):1011-4.</li>
<li>Lorich DG, <strong>Geller DS</strong>, Yacoubian SV, Leo AJ, Helfet DL. “An Innovative Mode of Intramedullary Fixation,” <em>International Review of Modern Surgery</em>, March 2002.</li>
<li>Westrich GH, <strong>Geller DS</strong>, O’Malley MJ, Deland JT, Helfet DL. “Anterior Iliac Crest Bone Graft Harvesting Using the Cortico-Cancellous Reamer System,” <em>Journal of Orthopaedic Trauma</em>. 2001 Sep-Oct; 15(7):500-6.</li>
</ul>
<p>David S. Geller is a board-certified orthopedic oncologist who specializes in the treatment of both pediatric and adult patients with bone and soft-tissue tumors. He has been a full-time faculty member at Montefiore since 2006. He is an Associate Professor of Orthopedic Surgery and Pediatrics at our Albert Einstein College of Medicine.</p><p>Dr. Geller is known for his expertise in musculoskeletal tumor surgery, with specific experience in bone and soft-tissue sarcomas, such as osteosarcoma, Ewing's sarcoma, liposarcoma and synovial sarcoma. He has extensive experience in managing patients with metastatic carcinoma of the bone as well. He routinely offers limb-salvage surgery using a wide array of reconstructive tools.</p><p>Dr. Geller earned his medical degree from Tel Aviv University's Sackler School of Medicine and completed an orthopedic surgery residency at Montefiore. He received his fellowship training from the Harvard Combined Orthopedic Oncology Program, which included Massachusetts General Hospital, Boston Children's Hospital, and Beth Israel Deaconess Medical Center.</p><p>Dr. Geller serves as the Associate Director of the Musculoskeletal Oncology Research Laboratory at Montefiore. He leads numerous translational research efforts designed to investigate the pathophysiology and molecular mechanisms of bone and soft tissue cancers. He is interested in improved surgical techniques and novel therapeutic approaches for primary malignant bone tumors. He is actively involved in collaborative clinical trials both nationally and internationally.</p><p>Dr. Geller is an active member of the American Academy of Orthopedic Surgeons, Muskuloskeletal Tumor Society, Connective Tissue Oncology Society, Children's Oncology Group, American Orthopedic Association, and the American Association for Cancer Research.</p>