Sarah E. Norris

Submitted by Anonymous (not verified) on
Full Name
Sarah E. Norris
Profile Image URL
https://assets.montefioreeinstein.org/profiles/images/Norris_Sarah_MD_2x.jpg
Type
Provider
Faculty
First Name
Sarah
Last Name
Norris
NPI
1386765139
Faculty ID
15253
Clinical Terms
Employment Status
Full Time
Patient Type
Pediatric
Department
einstein-dept-pediatrics
einstein-dept-neurology
Gender
Female
Email
sanorri@montefiore.org
Phone
718-741-2342
Titles
Type
Academic
Department
Department of Pediatrics
Department Link
Rank
Associate Professor
Division
Pediatric Hematology-Oncology
Type
Academic
Department
The Saul R. Korey Department of Neurology
Department Link
Rank
Assistant Professor
Division
Pediatric Neurology
Type
Clinical
Title
Director of the Quality in Life Team
Type
Clinical
Title
Associate Professor of Pediatrics
Type
Clinical
Type
Administrative
Locations
Is Primary
On
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.87885 40.88037)
Address Line 1
3415 Bainbridge Avenue
City
Bronx
State
NY
Zip
10467-2403
Location Title
The Children's Hospital at Montefiore
Is Primary
Off
Type
Academic
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.8791698 40.880273)
Address Line 1
Montefiore Medical Center
Address Line 2
3415 Bainbridge Avenue
City
Bronx
State
NY
Zip
10467
Location Title
Montefiore Medical Center
Education and Trainings
Education Type Label
Medical Education
Education Institution
Universidad Autonoma de Guadalajara
Education Type Label
Fellowship
Education Institution
Childrens Hospital Medical Center of Cincinnati
Education Type Label
Fellowship
Education Institution
Medical College of Georgia
Education Type Label
Residency
Education Institution
Medical College of Georgia
CHAM Provider
On
Professional Title
M.D.
M.Ed.
Clinical Focus

Pediatrics Hospice &amp; Palliative Medicine<span style="box-sizing:inherit;color:#252525;font-family:Arial, Helvetica, sans-serif;font-size:20px;background-color:#ffffff;"></span>

Research Focus

Dr. Norris's research focus is on primary palliative care education and family decision making regarding medical technology.

EMR ID
78710
Biography

<p>Sarah Evans Norris, MD, MEd, is Director of the Quality in Life Team and Director of Pediatric Palliative Care at Children?s Hospital at Montefiore. She is an Assistant Professor of Pediatrics and of Neurology at the Albert Einstein College of Medicine. </p><p>Dr. Norris earned her Bachelor of Science in Nursing at Loyola University Chicago in 1993 receiving the Gladys Kinnery Clinical Excellence award. As a nurse she worked around the globe including as a Peace Corps volunteer in Morocco before pursuing medical school at the Universidad Autonoma de Guadalajara in Mexico. She completed the Fifth Pathway Program through New York Medical College and embarked on her pediatrics internship at the University of Medicine & Dentistry New Jersey. She finished her residency at the Medical College of Georgia where she was named Resident of the Year. Following residency she completed a fellowship in pediatric critical care medicine and a masters in medical education at Cincinnati Children?s Medical Center. After several years in practice she returned to Cincinnati Children?s to complete a second fellowship in hospice and palliative medicine. Dr. Norris is Board Certified in General Pediatrics and in Hospice and Palliative Medicine.</p> <p>Dr. Norris? research focus is on primary palliative care education and family decision making regarding medical technology. She has given numerous presentations nationally and has a wide range of teaching experience with both adults and children internationally. In 2018 she received the Lewis Fraad Excellence in Resident Teaching Award. When she is not at CHAM you can find her running.</p>

Is Open Scheduling
Off

Irina Murakhovskaya

Submitted by Anonymous (not verified) on
Full Name
Irina Murakhovskaya
Profile Image URL
https://documentapi-fargate-documentbucket-15qi4tpdvnhlz.s3.amazonaws.com/218/4f602dc0-4e1f-11ee-8db1-bb4c384b05c4.jpg
Type
Provider
Faculty
First Name
Irina
Last Name
Murakhovskaya
NPI
1235180464
Faculty ID
13953
CMO Specialties
Clinical Terms
Employment Status
Full Time
Patient Type
Adult
Department
einstein-dept-oncology
einstein-dept-medicine
Gender
Female
Email
imurakho@montefiore.org
Phone
718-920-4137
Titles
Type
Academic
Department
Department of Oncology
Rank
Associate Professor
Division
Hematology
Type
Academic
Department
Department of Medicine
Department Link
Rank
Associate Professor
Division
Oncology & Hematology
Type
Administrative
Title
Chief, Division of Hematology
Tags
me-patientcare-hematology
Locations
Is Primary
Off
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.84544 40.84518)
Address Line 1
1621 Eastchester Road
City
Bronx
State
NY
Zip
10461-2301
Location Title
Montefiore Medical Group-Comprehensive Family Care Center (CFCC)
Is Primary
Off
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.84563 40.84596)
Address Line 1
1575 Blondell Avenue
City
Bronx
State
NY
Zip
10461-2601
Location Title
Montefiore Medical Park at 1575 Blondell
Is Primary
Off
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.88133 40.88109)
Address Line 1
3444 Kossuth Avenue
City
Bronx
State
NY
Zip
10467-2241
Location Title
Montefiore Medical Group-Family Care Center (FCC)
Is Primary
On
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.84475 40.84623)
Address Line 1
1695 Eastchester Road
City
Bronx
State
NY
Zip
10461
Location Title
Montefiore Medical Park at Eastchester
Is Primary
Off
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.88263 40.87994)
Address Line 1
60 East 208th Street
City
Bronx
State
NY
Zip
10467
Location Title
Montefiore at 60 East 208th Street
Is Primary
Off
Type
Academic
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.8782381 40.8799784)
Address Line 1
Montefiore Medical Center
Address Line 3
3411 Wayne Avenue
City
Bronx
State
NY
Zip
10467
Location Title
Montefiore Medical Center
Education and Trainings
Education Type Label
Medical Education
Education Institution
Albert Einstein College of Medicine
Education Type Label
Fellowship
Education Institution
Montefiore Medical Center-AECOM
Professional Interests

<p>Dr. Irina Murakhovskaya is an Assistant Professor of Medicine (Hematology). She completed a medical degree at Albert Einstein College of Medicine and residency and fellowship training at Montefiore Health System. Her clinical interests focus on monoclonal gammopathy, low-grade lymphoma, and hematologic issues in pregnancy.</p>
<p>Dr. Murakhovskaya is currently chairman of the fellowship Clinical Competency Committee and assistant course director for the Albert Einstein of Medicine Hematology Course.&nbsp;</p>

CHAM Provider
Off
Professional Title
M.D.
EMR ID
4308
Is Open Scheduling
Off

Kerry A. Morrone

Submitted by Anonymous (not verified) on
Full Name
Kerry A. Morrone
Profile Image URL
https://documentapi-fargate-documentbucket-15qi4tpdvnhlz.s3.amazonaws.com/218/66099180-ee0e-11ee-a60f-4f2b57adc1a2.jpg
Type
Provider
Faculty
First Name
Kerry
Last Name
Morrone
NPI
1265734297
Faculty ID
12909
Clinical Terms
Employment Status
Full Time
Patient Type
Pediatric
Department
einstein-dept-pediatrics
Gender
Female
Email
kmorrone@montefiore.org
Phone
718-741-2342
Titles
Type
Academic
Department
Department of Pediatrics
Department Link
Rank
Associate Professor
Division
Pediatric Hematology-Oncology
Type
Clinical
Title
Director of the Sickle Cell Program
Type
Clinical
Title
Assistant Professor of Pediatrics
Type
Administrative
Locations
Is Primary
On
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.87885 40.88037)
Address Line 1
3415 Bainbridge Avenue
City
Bronx
State
NY
Zip
10467-2403
Location Title
The Children's Hospital at Montefiore
Is Primary
Off
Type
Academic
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.8790253 40.8803163)
Address Line 1
Children's Hospital at Montefiore
Address Line 2
3415 Bainbridge Avenue
City
Bronx
State
NY
Zip
10467
Location Title
Children's Hospital at Montefiore
Education and Trainings
Education Type Label
Medical Education
Education Institution
Albert Einstein College of Medicine
Education Type Label
Fellowship
Education Institution
Montefiore Medical Center
Education Type Label
Residency
Education Institution
Montefiore Medical Center
Professional Interests

<p>Anemia, hospitalist medicine, general pediatrics</p>

CHAM Provider
On
Professional Title
M.D.
Clinical Focus

Dr. Morrone focuses on classical hematology, particularly sickle cell disease and hemoglobinopathies, platelet disorders, thrombosis, and bone marrow failure syndromes.

Research Focus

Dr. Morrone is committed to improving quality of care and health care utilization in chronic illness, particularly sickle cell disease, and thalassemia through her research

EMR ID
4700
Biography

<p>Kerry Morrone, MD, is an Assistant Professor of Pediatrics at the Albert Einstein College of Medicine, the Director of the Sickle Cell Program and the Director of the Pediatric Hematology Oncology Fellowship Program at Montefiore. Dr. Morrone focuses on classical hematology, particularly sickle cell disease and hemoglobinopathies, platelet disorders, thrombosis, and bone marrow failure syndromes.</p><p>Dr. Morrone graduated from New York University, earning her Bachelor of Arts in Biology in 2003. She then attended the Albert Einstein College of Medicine, where she received her Doctor of Medicine in 2007 and was inducted into the Alpha Omega Alpha Honor Medical Society. Dr. Morrone completed her pediatric residency, chief residency, and pediatric hematology oncology fellowship all at the Albert Einstein College of Medicine. She has also been recognized for her teaching efforts many times and won the Leo M. Davidoff Society &ndash; Albert Einstein College of Medicine Teaching Award in 2010 and 2015.</p><p>Dr. Morrone is committed to improving quality of care and health care utilization in chronic illness, particularly sickle cell disease, and thalassemia through her research. Other current research interests include pulmonary complications of sickle cell disease particularly asthma and acute chest syndrome, in addition to infectious complications and thrombotic complications of sickle cell disease.</p>

Is Open Scheduling
Off

Michael Miksa

Submitted by Anonymous (not verified) on
Full Name
Michael Miksa
Profile Image URL
https://assets.montefioreeinstein.org/profiles/images/Miksa_Michael_MD_2x.jpg
Type
Provider
Faculty
First Name
Michael
Last Name
Miksa
NPI
1881854735
Faculty ID
14249
Clinical Terms
Employment Status
Full Time
Patient Type
Pediatric
Department
einstein-dept-pediatrics
einstein-dept-neurology
Gender
Male
Email
mmiksa@montefiore.org
Phone
718-741-2432
Titles
Type
Academic
Department
Department of Pediatrics
Department Link
Rank
Assistant Professor
Division
Pediatric Critical Care
Type
Academic
Department
The Saul R. Korey Department of Neurology
Department Link
Rank
Assistant Professor
Type
Clinical
Title
Attending Pediatric Intensivist, The Children's Hospital at Montefiore
Type
Clinical
Title
Assistant Professor, Department of Pediatrics, Albert Einstein College of Medicine
Type
Administrative
Locations
Is Primary
On
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.87885 40.88037)
Address Line 1
3415 Bainbridge Avenue
City
Bronx
State
NY
Zip
10467-2403
Location Title
The Children's Hospital at Montefiore
Is Primary
Off
Type
Academic
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.8782381 40.8799784)
Address Line 1
Montefiore Medical Center
Address Line 3
3411 Wayne Avenue
City
Bronx
State
NY
Zip
10467
Location Title
Montefiore Medical Center
Education and Trainings
Education Type Label
Medical Education
Education Institution
Freie Universitat Berlin
Education Type Label
Fellowship
Education Institution
Yale University School of Medicine
Education Type Label
Residency
Education Institution
St. Clemens Hospital
Education Type Label
Residency
Education Institution
SUNY Downstate
CHAM Provider
On
Professional Title
M.D.
Ph.D.
Clinical Focus

Pediatric critical care

EMR ID
5832
Biography

<p>Physician-Scientist, Michael Miksa, MD, PhD received his medical degree from the Free University of Berlin in Germany and his academic degree magna cum laude from The Charit&eacute; &ndash; Universit&auml;tsmedizin Berlin. He completed his pediatric residency training at State University of New York (SUNY) Downstate, a critical care fellowship at Yale and had worked in the pediatric emergency department for the Boston Children&rsquo;s Hospital.</p><p>Dr. Miksa presented his work at several meetings both nationally and abroad and is Site Investigator for NEAR4KIDS, a multi-center quality improvement study to limit adverse events during intubations.</p>

Is Open Scheduling
Off

Deepa G. Manwani

Submitted by Anonymous (not verified) on
Full Name
Deepa G. Manwani
Profile Image URL
https://documentapi-fargate-documentbucket-15qi4tpdvnhlz.s3.amazonaws.com/218/ef575e50-ee0d-11ee-904c-09056fc0ef1f.jpg
Type
Provider
Expert
First Name
Deepa
Last Name
Manwani
NPI
1922077544
Faculty ID
11847
Clinical Terms
Employment Status
Full Time
Patient Type
Pediatric
Department
einstein-dept-pediatrics
Languages
Hindi
Gender
Female
Email
dmanwani@montefiore.org
Phone
718-741-2342
Titles
Type
Academic
Department
Department of Pediatrics
Department Link
Rank
Professor
Division
Pediatric Hematology-Oncology
Type
Clinical
Title
Director of Hematology, Department of Pediatrics
Type
Clinical
Title
Professor, Department of Pediatrics, Albert Einstein College of Medicine
Type
Administrative
Locations
Is Primary
Off
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.84154 40.84612)
Address Line 1
1250 Waters place
City
Bronx
State
NY
Zip
10461-2720
Location Title
Montefiore at 1250 Waters Place
Is Primary
On
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.87885 40.88037)
Address Line 1
3415 Bainbridge Avenue
City
Bronx
State
NY
Zip
10467-2403
Location Title
The Children's Hospital at Montefiore
Is Primary
Off
Type
Academic
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.8791698 40.880273)
Building
Rosenthal Pavilion
Room
312
Address Line 1
Montefiore Medical Center
Address Line 2
3415 Bainbridge Avenue
City
Bronx
State
NY
Zip
10467
Location Title
Montefiore Medical Center
Education and Trainings
Education Type Label
Medical Education
Education Institution
B.J. Medical College
Education Type Label
Fellowship
Education Institution
Mount Sinai School of Medicine
Education Type Label
Residency
Education Institution
North Shore University Hospital - Manhasset
Education Type Label
Residency
Education Institution
B.J. Medical College
Specialties
Expert Tags
Areas of Expertise
Sickle cell disease
Expert Summary

<p>Dr. Manwani is a pediatric hematologist who leads the sickle cell team at CHAM. The team offers treatment and support for young children and teens with sickle cell disease and their families, including weekly support groups and an annual Sickle Cell Awareness Day event focused on new research and strategies for living with this disease.</p>

CHAM Provider
On
Professional Title
M.B.,B.S.
Clinical Focus

<p>Benign hematology, anemia, sickle cell disease, thalassemia, hemophilia, bleeding disorders, thrombosis, neutropenia, thrombocytopenia, ITP, erythrocytosis, thrombocytosis, leukocytosis.</p>

Research Focus

<p>Sickle Cell Disease: Novel therapies, Role of adhesion and neutrophils, Alloimmunization, Transition to adult care, Fetal hemoglobin induction, Gut Microbiome, Pain, Chronic Pain, Quality Improvement.</p>

EMR ID
5141
Biography

<p>Deepa Manwani, MD, is Director, Pediatric Hematology at Children?s Hospital at Montefiore, as well as a Professor in the Department of Pediatrics at Albert Einstein College of Medicine. Dr. Manwani?s clinical focus is on benign hematology, anemia, sickle cell disease, thalassemia, hemophilia, bleeding disorders, thrombosis, neutropenia, thrombocytopenia, ITP, erythrocytosis and leukocytosis. </p><p>Dr. Manwani graduated from B.J. Medical College, Poona University, India, in 1991, earning her Doctor of Medicine. She became a Research Assistant at the Children?s Hospital Oakland in 1991 before beginning an internship in Pediatrics at NSUH-Cornell University Med Center in 1993. Following her internship, Dr. Manwani completed a residency in Pediatrics at the same institution. In 1996, she began a fellowship in Pediatrics Hematology/Oncology at Mount Sinai School of Medicine in New York. </p><p>Dr. Manwani?s research focuses on fetal hemoglobin activating agents, adhesive cellular interactions in vaso-occlusion in sickle cell disease (SCD) and contribution of neutrophils to SCD pathophysiology. She completed the R01 funded Phase 1 study of IVIG in the treatment of SCD vaso-occlusive crises and is currently leading the R01 funded Phase II study. Dr. Manwani is currently participating in studies aimed at increased adherence to hydroxyurea and improved transition to adult care. She is also collaborating with investigators at Case Western Reserve University on an NHLBI R01 funded study to standardize monitoring of cellular adhesion in SCD patients using a novel microfluidic assay. Her contributions have been recognized by the Sickle Cell Thalassemia Patient Network of New York in the form of the Distinguished Service Award in March 2015. Dr. Manwani?s studies have been published nationally in various reviewed journals and books. </p><p>Dr. Manwani has received many awards, including Castle Connolly Top Doctor in 2016, New York Magazine Best Doctor and New York Metro Area?s Top Doctors in 2017. </p>

Is Open Scheduling
Off

Ioannis Mantzaris

Submitted by Anonymous (not verified) on
Full Name
Ioannis Mantzaris
Profile Image URL
https://documentapi-fargate-documentbucket-15qi4tpdvnhlz.s3.amazonaws.com/218/b67e5d80-3938-11ed-a06a-83625b154202.jpg
Type
Provider
Faculty
First Name
Ioannis
Last Name
Mantzaris
NPI
1871865519
Faculty ID
14586
Clinical Terms
Employment Status
Full Time
Patient Type
Adult
Department
einstein-dept-oncology
einstein-dept-medicine
Gender
Male
Email
imantzar@montefiore.org
Phone
718-920-4826
Titles
Type
Academic
Department
Department of Oncology
Rank
Associate Professor
Tags
me-patientcare-cancer-clinical-aids-malignancies
me-patientcare-cancer-clinical-blood-bone-marrow
me-patientcare-cancer-research-therapeutics
Division
Medical Oncology
Type
Academic
Department
Department of Medicine
Department Link
Rank
Associate Professor
Division
Oncology & Hematology
Type
Administrative
Locations
Is Primary
On
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.88072 40.88002)
Address Line 1
111 East 210th Street
City
Bronx
State
NY
Zip
10461-2401
Location Title
Montefiore Medical Center
Is Primary
Off
Type
Academic
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.8798833 40.8799447)
Building
Hofheimer Main
Room
100
Address Line 1
Montefiore Medical Center
Address Line 3
111 East 210th Street
City
Bronx
State
NY
Zip
10467
Location Title
Montefiore Medical Center
Education and Trainings
Education Type Label
Medical Education
Education Institution
University of Athens Medical School
Education Type Label
Fellowship
Education Institution
Montefiore Medical Center
Education Type Label
Residency
Education Institution
Jacobi Medical Center
Education Type Label
Residency
Education Institution
General Hospital of Trikala
Education Type Label
Residency
Education Institution
Agios Savvas Anticancer-Oncology Hospital Athens
CHAM Provider
Off
Professional Title
M.D.
M.S.
EMR ID
57027
Is Open Scheduling
Off

Kenneth G. Liu

Submitted by Anonymous (not verified) on
Full Name
Kenneth G. Liu
Profile Image URL
https://documentapi-fargate-documentbucket-15qi4tpdvnhlz.s3.amazonaws.com/218/62a47410-3938-11ed-9b41-f32856b0701a.jpg
Type
Provider
Faculty
First Name
Kenneth
Last Name
Liu
NPI
1174840888
Faculty ID
15135
Clinical Terms
Employment Status
Full Time
Patient Type
Adult
Department
einstein-dept-oncology
einstein-dept-medicine
Gender
Male
Email
kliu@montefiore.org
Phone
718-405-1700
Titles
Type
Academic
Department
Department of Oncology
Rank
Assistant Professor
Division
Medical Oncology
Type
Academic
Department
Department of Medicine
Department Link
Rank
Assistant Professor
Division
Oncology & Hematology
Type
Administrative
Locations
Is Primary
On
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.88263 40.87994)
Address Line 1
60 East 208th Street
City
Bronx
State
NY
Zip
10467
Location Title
Montefiore at 60 East 208th Street
Is Primary
Off
Type
Academic
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.8822305 40.8791652)
Address Line 1
Montefiore Medical Center
Address Line 3
60 East 208th Street
City
Bronx
State
NY
Zip
10467
Location Title
Montefiore Medical Center
Education and Trainings
Education Type Label
Medical Education
Education Institution
University of Cincinnati College of Medicine
Education Type Label
Fellowship
Education Institution
Montefiore Medical Center
Education Type Label
Residency
Education Institution
Harbor UCLA Medical Center
CHAM Provider
Off
Professional Title
M.D.
EMR ID
57009
Is Open Scheduling
Off

Joseph J. Hong

Submitted by Anonymous (not verified) on
Full Name
Joseph J. Hong
Profile Image URL
https://documentapi-fargate-documentbucket-15qi4tpdvnhlz.s3.amazonaws.com/218/bb016ac0-7e92-11ec-8207-c982689cc96c.jpg
Type
Provider
Faculty
First Name
Joseph
Last Name
Hong
NPI
1821437815
Faculty ID
16999
CMO Specialties
Clinical Terms
Employment Status
Full Time
Patient Type
Adult
Department
einstein-dept-medicine
Gender
Male
Email
johong@montefiore.org
Phone
718-920-9259
Titles
Type
Academic
Department
Department of Medicine
Department Link
Rank
Assistant Professor
Division
Hospital Medicine
Locations
Is Primary
On
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.8608 40.89439)
Address Line 1
600 East 233rd Street
City
New York
State
NY
Zip
10466-2604
Location Title
Montefiore Wakefield Campus
Is Primary
Off
Type
Academic
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.861005 40.8939411)
Address Line 1
Montefiore Medical Center - Wakefield
Address Line 2
600 East 233rd Street
City
Bronx
State
NY
Zip
10466
Location Title
Montefiore Medical Center - Wakefield
Education and Trainings
Education Type Label
Medical Education
Education Institution
Icahn School of Medicine at Mt. Sinai
Education Type Label
Residency
Education Institution
Montefiore Medical Center
CHAM Provider
Off
Professional Title
M.D.
EMR ID
56395
Is Open Scheduling
Off

Betsy Herold

Submitted by Anonymous (not verified) on
Full Name
Betsy Herold
Profile Image URL
https://assets.montefioreeinstein.org/profiles/images/physphoto/Herold_Betsey_MD_420x504.jpg
Type
Provider
Faculty
Expert
First Name
Betsy
Last Name
Herold
NPI
1619938206
Faculty ID
10991
Clinical Terms
Employment Status
Full Time
Patient Type
Pediatric
Department
einstein-dept-pediatrics
einstein-dept-microbiology-immunology
einstein-dept-obstetrics-gynecology-womens-health
Gender
Female
Email
betsy.herold@einsteinmed.edu
Phone
718-839-7460
Titles
Type
Academic
Department
Department of Pediatrics
Department Link
Rank
Professor
Division
Pediatric Infectious Disease
Type
Academic
Department
Department of Microbiology & Immunology
Department Link
Rank
Professor
Type
Academic
Department
Department of Obstetrics & Gynecology and Women's Health
Department Link
Rank
Professor
Type
Clinical
Title
Chief, Division of Pediatric Infectious Disease
Type
Clinical
Title
Harold and Muriel Block Chair in Pediatrics
Type
Clinical
Title
Vice Chair, Research
Type
Clinical
Title
Director, Translational Prevention Research Center, Children's Hospital at Montefiore
Type
Clinical
Title
Professor of Pediatrics, Albert Einstein College of Medicine
Type
Administrative
Title
Harold and Muriel Block Chair in Pediatrics
Type
Administrative
Title
Vice Chair for Research, Department of Pediatrics
Type
Administrative
Title
Chief, Division of Pediatric Infectious Diseases, Department of Pediatrics
Type
Administrative
Title
Director, Translational Prevention Research Center
Locations
Is Primary
On
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.87885 40.88037)
Address Line 1
3415 Bainbridge Avenue
City
Bronx
State
NY
Zip
10467-2403
Location Title
The Children's Hospital at Montefiore
Is Primary
Off
Type
Academic
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.8459022 40.8504961)
Building
Van Etten
Room
6A04A
Address Line 1
Albert Einstein College of Medicine
Address Line 3
1225 Morris Park Avenue
City
Bronx
State
NY
Zip
10461
Location Title
Albert Einstein College of Medicine
Education and Trainings
Education Type Label
Medical Education
Education Institution
University of Pennsylvania School of Dental Med
Education Type Label
Fellowship
Education Institution
Northwestern University/ Children's Memorial Hosp.
Education Type Label
Residency
Education Institution
Northwestern University/ Children's Memorial Hosp.
Professional Interests

<p><strong>Betsy Herold, M.D.</strong> directs a basic and translational research program, which focuses on virus host interactions. Projects in the lab include studies designed to identify the cellular signaling pathways that herpes simplex viruses (HSV) usurp to promote viral entry and infection. The lab uncovered a previously unappreciated paradigm associated with activation of phospholipid scramblases, which are known to catalyze the movement of phosphatidylserine lipids between the inner and outer leaflet of the plasma membrane. Surprisingly, they found that the exofacial movement of phospholipids is associated with concomitant translocation of intracellular proteins, including the master kinase Akt to the outside, where Akt becomes phosphorylated to activate an &ldquo;outside-inside&rdquo; signaling cascade that promotes viral entry. This pathway is also usurped by SARS-CoV-2 and is important for cellular processes including apoptosis. In collaboration with the Almo lab, they have engineered cell impermeable kinase inhibitors. These compounds block viral entry and prevent induction of apoptosis by select TNF ligands.</p>
<p> Serendipitously, in studying this signaling pathway, the lab identified a novel candidate vaccine for the prevention and treatment of HSV infections.  Most efforts to develop a vaccine have focused on neutralizing antibodies that target HSV glycoprotein D (gD), but all of these have failed in clinical trials. Instead, the lab (in collaboration with the Jacobs lab), engineered a virus completely deleted in gD. Glycoprotein D is required for viral entry and cell-to-cell spread, thus the deletion virus (DgD-2) is restricted a single cycle and will not spread. This candidate vaccine elicits T cell responses and high titer, polyfunctional antibodies that protect through antibody-dependent cell mediated cytotoxicity (ADCC). The vaccine prevents the establishment of latency in mice and is significantly more protective in multiple small animal models than prior vaccines that have failed in clinical trials. The lab has subsequently isolated monoclonal antibodies (mAbs) that have this protective ADCC activity and both the vaccine and the mAbs are being advanced for preclinical development.  Studies to understand why this vaccine elicits ADCC-mediating antibodies whereas gD vaccines and primary HSV infection only elicit neutralizing antibodies led to the identification of a key role for TNFRSF14 (aka HVEM) in generating and mediating ADCC responses. HVEM is an immune cell surface protein that functions in signal transduction pathways that regulate inflammatory or inhibitory immune responses but its role in shaping the B cell repertoire and in providing a second signal for ADCC had not been previously described and has implications for vaccine development and oncolytic therapies. </p>
<p> The third major area of basic research involves defining the molecular mechanisms underlying the HIV-HSV syndemic. Epidemiological studies have consistently demonstrated that being HSV seropositive is associated with an increased risk for HIV acquisition, replication, higher plasma viral loads and more frequent episodes of HIV reactivation.  Using primary cells from patients and HIV latently infected cell lines, the lab has identified several mechanisms by which HSV promotes HIV latency reversal and replication including upregulation of the noncoding RNA, <em>Malat1</em>, and downregulation of IL-32. Defining these pathways may lead to identification of new strategies to &ldquo;shock and kill&rdquo; or &ldquo;block and lock&rdquo; HIV.</p>
<p> Clinical studies include prevention of infectious disease complications in transplantation. Members of the research group are involved in studies to optimize pre-emptive prophylaxis for CMV and EBV, vaccine responses in transplantation recipients, and others</p><p>Studies with vaginal microbicides have resulted in the expnasion of studies to focus on soluble mucosal immunity in the genital tract. We found that .female genital tract secretions collected from healthy women provide variable, but significant protection against both HSV and HIV. Mechanistic studies suggest that this endogenous activity is mediated by defensins and other antimicrobial peptides. This endogenous activity may serve as a biomarker of a "healthy mucosal immune environment" and thus provide a surrogate marker to evaluate the safety of vaginal microbicides. In addition, identification of the mediators that contribute to this endogenous activity could lead to development of new strategies to boost this host defense and help protect against infection. These studies are being conducted in collaboration with the proteomics core facility at AECOM. Additionally, we are testing the hypothesis that HSV triggers changes in the mucosal environment, which allow it to escape cervical secretion defenses, enhance its own infectivity and facilitate HIV co-infection. Our preliminary observations support the paradigm that HSV disrupts the epithelial barrier by targeting tight junction and adherens junction proteins, and interferes with host defenses by triggering an inflammatory response and a loss in protective proteins such as SLPI. These changes could facilitate both its own infectivity and enhance HIV co-infection.<br /><br /></p>
<p>Results obtained from this bench research are critical to the laboratory's translational studies. The focus of the Translational Microbicide Research Program is to identify optimal combinations of topical microbicides that are safe and target different steps in HIV life cycle, thus reducing the risks of drug resistance and providing greater protection than could be achieved with a single agent, and also target HSV infection. Candidate combinations are evaluated using a multi-tiered approach for anti-viral activity and safety using human cervical cultures, as well as primary T cells and macrophages, in the presence of cervicovaginal secretions and seminal plasma. Leading combinations are then evaluated in human explant cultures (cervical, vaginal) and in murine genital models and a new cotton rat model for anti-viral activity and for the impact on mucosal immunity. If results of these pre-clinical studies suggest that candidate microbicides are safe and effective, the drugs are advanced for regulatory testing, and undergo evaluation in Phase I clinical studies.<br /><br /></p>
<p>Clinical research interests also include prevention of infectious disease complications in transplantation. Members of the research group are involved in studies to optimize pre-emptive prophylaxis for CMV and EBV, vaccine responses in transplantation recipients, and other related infectious complications.<br /><br /></p>

Research Areas
Herpes simplex virus (HSV) infection; synergy between HSV and HIV; microbicide development; genital tract mucosal immunity
Areas of Expertise
Antibiotic resistance
Antimicrobial resistance
Community-acquired MRSA (Methicillin-resistant Staphylococcus aureus)
HSV (herpes simplex virus)
Transplant infectious diseases
Expert Summary

<div>Dr. Herold directs a translational research program focused on the interactions between viruses and their host and using that knowledge to develop novel treatment and prevention strategies. Through her basic science studies, Dr. Herold has developed a unique candidate vaccine to prevent herpes simplex virus (HSV) infections, which is being advanced for phase I clinical trials. Studies of this vaccine uncovered a previously unappreciated immune evasion strategy; this knowledge may accelerate the development of drugs to bolster vaccine and monoclonal antibody efficacy against a range of pathogens.&nbsp;</div>
<div><span style="white-space: pre;"> </span>&nbsp;</div>
<div>Her studies on HIV focus on the development of safe and effective pre-exposure prophylactic strategies and on investigating how HSV interacts with HIV to reactivate HIV. Dr. Herold's team also has discovered a previously unrecognized phenomenon in cell biology in which HSV and other viruses activate a mechanism that helps them gain entry and infect healthy cells. This provides a novel target for the development of new antiviral drugs.&nbsp;<br /><br /></div>
<div>Most recently, her lab has studied why children respond differently and are relatively protected from severe COVID-19. Defining the differences in the immune response in children compared to adults will provide insights into protective immunity against this virus and future pandemic viruses.&nbsp;<br /><br /></div>
<div>Her clinical research focuses on infections in pediatric transplant recipients. Dr. Herold helped established and is co-chair of the Pediatric Infectious Diseases Society Transplant Research Network (PIDTRAN), which supports and promotes projects to prevent and treat infectious diseases among child transplant recipients. Dr. Herold has served on the Office of AIDS Research Advisory Council and on the Pediatric Infectious Diseases Society Council. She has been continuously funded by the NIH since 1989. Dr. Herold has over 180 publications in peer-reviewed journals and has presented her work internationally.</div>

CHAM Provider
On
Professional Title
M.D.
Clinical Focus

Pediatric Infectious Diseases.

Research Focus

Prevention and treatment of infections in solid and stem cell transplant patients and other immunocompromised patients.

EMR ID
4968
Biography

<p>Betsy Herold, MD, is Chief of the Division of Pediatric Infectious Diseases and Vice Chair for Research at Children's Hospital at Montefiore. Dr. Herold is also a Professor of Pediatrics, Microbiology &amp; Immunology, and Obstetrics &amp; Gynecology and Women's Health at our Albert Einstein College of Medicine. She specializes in pediatric infectious diseases. </p><p>Dr. Herold received her Bachelor of Arts in Biology in 1978 from Brown University and went on to receive her Doctor of Medicine from the University of Pennsylvania Medical School in 1982. Dr. Herold completed an internship and residency in pediatrics at Children's Memorial Hospital, where she became a Chief Resident in 1985. She then began a fellowship in research at Hagedorn Research Laboratory in Gentofte, Denmark. In 1987, Dr. Herold began a fellowship in pediatric infectious diseases at Children's Memorial Hospital, followed by a Research Associate/Postdoctoral Virology Fellowship in the Department of Microbiology and Immunology at Northwestern University in Chicago. </p><p>Dr. Herold's clinical research focuses on the prevention and treatment of infections in solid and stem cell transplant patients and other immunocompromised patients. Dr. Herold has also been involved in research in Kawasaki disease and the emergence of methicillin-resistant staphylococcus aureus (MRSA) in the community. Dr. Herold directs a basic and translational research program on the prevention of herpes simplex virus (HSV) and HIV infections through the development of vaccines and novel antivirals. The current major focus of her lab is on a novel, paradigm-shifting, single-cycle vaccine to prevent HSV-1 and HSV-2. She has been continuously funded by the NIH since 1989. Dr. Herold has over 150 peer reviewed publications in peer-reviewed journals and has presented her work internationally. </p><p>In 2012, Dr. Herold received the Clinical Science Faculty Mentor Award from the Albert Einstein College of Medicine. She has also been awarded the Henry and Jacob Lowenberg Prize in Pediatrics and the Pediatric Infectious Disease Young Investigator Award. Dr. Herold is board certified by the American Board of Pediatrics in Pediatrics and in Pediatric Infectious Diseases. </p>

Is Open Scheduling
Off

Kira Gritsman

Submitted by Anonymous (not verified) on
Full Name
Kira Gritsman
Profile Image URL
https://documentapi-fargate-documentbucket-15qi4tpdvnhlz.s3.amazonaws.com/218/6b993220-5d55-11ef-92db-0be6da54f487.jpg
Type
Provider
Faculty
First Name
Kira
Last Name
Gritsman
NPI
1174598148
Faculty ID
14128
Clinical Terms
Employment Status
part-time
Patient Type
Adult
Department
einstein-dept-oncology
einstein-dept-medicine
einstein-dept-cell-biology
Gender
Female
Email
kira.gritsman@einsteinmed.edu
Phone
929-246-6707
Titles
Type
Academic
Department
Department of Oncology
Rank
Associate Professor
Division
Medical Oncology
Type
Academic
Department
Department of Medicine
Department Link
Rank
Associate Professor
Division
Oncology & Hematology
Type
Academic
Department
Department of Cell Biology
Department Link
Rank
Associate Professor
Type
Clinical
Title
Assistant Director of Correlative Clinical Research
Type
Administrative
Title
Co-Leader, Montefiore Einstein Comprehensive Cancer Center, Stem Cell & Cancer Biology Program
Tags
me-patientcare-cancer-clinical-aids-malignancies
me-patientcare-cancer-research-stem-cell-cancer-biology
Type
Administrative
Title
Betty and Sheldon Feinberg Senior Faculty Scholar in Cancer Research
Locations
Is Primary
On
Type
Clinical
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.88072 40.88002)
Address Line 1
111 East 210th Street
City
Bronx
State
NY
Zip
10461-2401
Location Title
Montefiore Medical Center
Is Primary
Off
Type
Academic
Location (Address, State, City, Zip)
Not used, will be deleted
Coordinates
POINT (-73.8459022 40.8504961)
Building
Chanin Building
Room
410A
Address Line 1
Albert Einstein College of Medicine
Address Line 2
Jack and Pearl Resnick Campus
Address Line 3
1300 Morris Park Avenue
City
Bronx
State
NY
Zip
10461
Location Title
Albert Einstein College of Medicine
Education and Trainings
Education Type Label
Medical Education
Education Institution
New York University School of Medicine
Education Type Label
Medical Education
Education Institution
New York University School of Medicine
Education Type Label
Medical Education
Education Institution
New York University School of Medicine
Education Type Label
Fellowship
Education Institution
Dana Farber Cancer Institute
Education Type Label
Fellowship
Education Institution
Dana-Farber Cancer Institute
Education Type Label
Residency
Education Institution
Columbia University Medical Center
Professional Interests

<p><strong>The Roles of Signaling Pathways in Adult Blood Development and Leukemia</strong></p>
<p><span style="font-size: 10.5pt; font-family: Verdana, sans-serif;">The Gritsman lab studies the signal transduction pathways that affect the early fate decisions of adult hematopoietic stem cells (HSCs) as they progress from an undifferentiated multipotent state to the generation of differentiated blood cells.&nbsp; When these early fate decisions go awry, this can lead to the formation of leukemia-initiating cells. We are interested in</span><span style="font-size: 10.5pt; font-family: Verdana, sans-serif;">&nbsp;how signaling pathways affect the self-renewal and differentiation of HSCs and malignant or pre-malignant stem cells in myeloid malignancies, such as acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), and myeloproliferative neoplasms (MPN).</span></p>
<p><strong>Roles of the PI3 kinase isoforms in adult blood development</strong></p>
<p>PI3 kinase (PI3K) is a lipid kinase that is important for the regulation of metabolism, the cell cycle, apoptosis, and protein synthesis. &nbsp;In hematopoietic cells, there are four isoforms of the catalytic subunit of PI3K, each encoded by a separate gene. &nbsp;Emerging evidence suggests that these isoforms have unique functions in normal and cancer cells, but may substitute for each other in some contexts.&nbsp; We have generated a series of mouse knockout models that allow us to study the roles of each of these isoforms individually in adult hematopoiesis.&nbsp; For example, we have found that the p110alpha isoform is most important for red cell development, but is not required in normal blood stem cells. We have now also generated compound knockout mice to determine the redundant roles of the PI3K isoforms in blood development. &nbsp;We recently reported that PI3K isoforms play important redundant roles during the hematopoietic stress response, such as after chemotherapy. However, deletion of all 3 Class IA PI3K isoforms leads to a phenotype with impaired HSC differentiation, resembling myelodysplastic syndrome (MDS). We are studying how deletion of PI3K will impact normal HSC function, including self-renewal, proliferation, and differentiation along different blood lineages by affecting processes such as autophagy and epigenetic regulation in HSCs.</p>
<p><strong>Roles of the PI3 kinase isoforms in leukemia</strong></p>
<p>Acute myeloid leukemia (AML) is a genetically diverse disease, but activation of the PI3K pathway has been reported in up to 80% of cases.&nbsp; A subset of AML cell lines and AML patient samples respond to PI3K pathway inhibitors, but it is unclear how patients should be selected for potential response to these inhibitors. &nbsp;We found that RAS-mutated myeloid leukemias are particularly dependent on the p110alpha isoform of PI3K, and that pharmacologic inhibition of p110alpha can be used to treat both RAS-mutated cell lines and RAS-mutated leukemia in mice. Furthermore, we use cell lines, patient samples, and mouse models of leukemia to investigate the mechanisms of resistance to PI3K inhibition, with the goal of identifying new drug targets and designing new combination treatments for leukemia that incorporate PI3K inhibitors.</p>
<p><strong>RON Kinase in Myeloproliferative Neoplasms</strong></p>
<p>The myeloproliferative neoplasms (MPNs) are a group of diseases that are caused by kinase mutations in HSCs, which lead to uncontrolled proliferation of myeloid cells. The Philadelphia chromosome-negative MPNs are characterized by mutations in the JAK/STAT signaling pathway, and respond to JAK inhibitors, but resistance often develops. We recently discovered that the receptor Tyrosine kinase RON can physically interact with JAK2 in MPN cells, leading to potentiation of JAK/STAT signaling in resistant cells. Furthermore, we found that pharmacologic or genetic inactivation of RON can inhibit proliferation of MPN cells and re-sensitize resistant cells to JAK inhibitors.</p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif;"><strong><span style="font-size: 10.5pt; font-family: Verdana, sans-serif; color: #201f1e;">Member of the Cancer Dormancy and Tumor Microenvironment Institute&nbsp;</span></strong></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif;">&nbsp;</p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size: medium; font-family: 'Times New Roman', serif;"><span style="font-size: 10.5pt; font-family: Verdana, sans-serif;">&nbsp;</span><span style="font-size: 10.5pt; font-family: Verdana, sans-serif;">The Gritsman lab&rsquo;s research interests include the contributions of signaling pathways to leukemic and pre-leukemic stem cell dormancy in minimal residual disease, which includes mechanisms of immune evasion. Furthermore, the Gritsman lab is interested in the roles of inflammatory signaling pathways and of the local microenvironment in bone marrow fibrosis, and in the evolution of myeloid neoplasms from the pre-malignant to malignant state. Our major goals are to identify opportunities for therapeutic targeting to prevent the transition from the pre-leukemic state to leukemia, or to eliminate minimal residual disease to prevent relapse.</span></p>

Research Areas
roles of signaling pathways in hematopoietic stem cell self-renewal and differentiation, leukemic stem cells, targeting signaling pathways in hematologic malignancies
CHAM Provider
Off
Professional Title
M.D.
Ph.D.
Selected Publications

<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;"><a name="_GoBack"></a><span style="font-size: 11pt; font-family: Arial, sans-serif;">Ames, K.,&nbsp;<sup>&nbsp;</sup>Kaur,<sup>&nbsp;</sup>I., Shi, Y., Tong, M., Sinclair, T., Hemmati, S., Glushakow-Smith, S.G., Tein,&nbsp;&nbsp;E., Gurska, L., Steidl, U., Dubin, R., Shan, J., Montagna, C., Pradhan, K., Verma, A., and&nbsp;<strong><u>Gritsman, K.</u></strong>, Deletion of PI3-Kinase Promotes Myelodysplasia Through Dysregulation of Autophagy in Hematopoietic Stem Cells,&nbsp;<strong><em>Science Advances</em></strong><em>&nbsp;2023.&nbsp;</em>doi:&nbsp;<a href="https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fdoi.o…; target="_blank" rel="noopener"><span style="color: black; text-decoration: none;">10.1126/sciadv.ade8222</span></a><u>,&nbsp;</u>PMID:&nbsp;36812307</span></p>
<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;"><em><span style="font-size: 11pt; font-family: Arial, sans-serif;">&nbsp;</span></em></p>
<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;"><span style="font-size: 11pt; font-family: Arial, sans-serif;">Folgado Marco, V., Ames, K., Chuen, J.,&nbsp;<strong><u>Gritsman, K.</u></strong>&nbsp;&amp; Baker, N.,&nbsp;Haploinsufficiency of the essential gene&nbsp;<em>RpS12</em>&nbsp;causes defects in erythropoiesis and hematopoietic stem cell maintenance,&nbsp;<em>&nbsp;<strong>eLife</strong>&nbsp;</em>2023&nbsp;Jun 5;12:e69322. doi: 10.7554/eLife.69322.&nbsp;PMID:&nbsp;37272618</span></p>
<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;"><span style="font-size: 11pt; font-family: Arial, sans-serif;">&nbsp;</span></p>
<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;"><span style="font-size: 11pt; font-family: Arial, sans-serif;">Gurska, L.M., Okabe, R., Schurer, A., Tong, M.M., Soto, M., Choi, D., Ames, K., Glushakow-Smith, S., Montoya, A., Tein, E., Miles, L.A., Cheng, H., Hankey-Giblin, P., Levine, R.L., Goel, S., Halmos, B., and&nbsp;<strong><u>Gritsman, K.</u></strong>&nbsp;Crizotinib has Preclinical Efficacy in Philadelphia-negative Myeloproliferative Neoplasms,&nbsp;<strong><em>Clinical Cancer Research</em></strong>&nbsp;2022&nbsp;Dec 20:CCR-22-1763. doi: 10.1158/1078-0432.CCR-22-1763. PMID:&nbsp;36537918</span></p>
<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;"><span style="font-size: 11pt; font-family: Arial, sans-serif;">&nbsp;</span></p>
<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;"><span style="font-size: 11pt; font-family: Arial, sans-serif;">Gurska, L., Ames, K., and&nbsp;<strong><u>Gritsman, K</u></strong>, Signaling Pathways in Leukemic Stem Cells,&nbsp;</span><span style="font-size: 11pt; font-family: Arial, sans-serif; color: #333333; letter-spacing: 0.2pt; background-color: #fcfcfc;">In: Zhang H., Li S. (eds) Leukemia Stem Cells in Hematologic Malignancies.&nbsp;<strong>Advances in Experimental Medicine and Biology</strong>, vol 1143. Springer, Singapore</span><span style="font-size: 11pt; font-family: Arial, sans-serif;">, July 24, 2019, doi:&nbsp;<a href="https://doi.org/10.1007/978-981-13-7342-8_1"><span style="color: black; letter-spacing: 0.2pt; background-color: #fcfcfc; text-decoration: none;">https://doi.org/10.1007/978-981-13-7342-8_1</span></a><span style="letter-spacing: 0.2pt; background-color: #fcfcfc;">;&nbsp;</span>PMID:&nbsp;31338813, PMCID:&nbsp;<a href="http://www.ncbi.nlm.nih.gov/pmc/articles/pmc7249489/&quot; target="_blank" rel="noopener"><span style="color: black; text-decoration: none;">PMC7249489</span></a></span></p>
<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;">&nbsp;</p>
<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;"><span style="font-size: 11pt; font-family: Arial, sans-serif;">Hemmati, S., Sinclair, T., Tong, M., Bartholdy, B., Okabe, R.O., Ames, K., Ostrodka, L., Haque, T., Kaur, I., Mills, T. S., Agarwal, A., Pietras, E.M., Zhao, J.J., Roberts, T.M., and&nbsp;<strong><u>Gritsman, K.</u></strong>, PI3 kinase alpha and delta promote hematopoietic stem cell activation,&nbsp;<strong><em>JCI Insight&nbsp;</em></strong>2019&nbsp;doi.org/10.1172/jci.insight.125832</span></p>
<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;">&nbsp;</p>
<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;"><span style="font-size: 11pt; font-family: Arial, sans-serif;">Mitchell, K., Barreyro, L., Todorova, T., Taylor, S., Antony-Debre, I., Narayanagari, S., Carvajal, L., Leite, J., Piperdi, Z., Pendurti, G., Mantzaris, I., Paietta, E., Verma, A.,&nbsp;<strong><u>Gritsman, K.,&nbsp;</u></strong>and Steidl, U. IL1RAP potentiates multiple oncogenic signaling pathways in AML,&nbsp;<strong><em>Journal of&nbsp;Experimental Medicine</em></strong><em>.&nbsp;</em>2018 May 17. doi: 10.1084/jem.20180147,&nbsp;PMID: 29773641</span></p>
<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;">&nbsp;</p>
<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;"><span style="font-size: 11pt; font-family: Arial, sans-serif;">Hemmati, S., Haque, T., and&nbsp;<strong><u>Gritsman, K</u>,&nbsp;</strong>Inflammatory Signaling Pathways in Pre-leukemic and Leukemic Stem Cells,&nbsp;<strong><em>Frontiers in Oncology</em></strong><em>&nbsp;</em>2017 Nov 13;7:265. doi: 10.3389/fonc.2017.00265</span></p>
<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;">&nbsp;</p>
<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;"><span style="font-size: 11pt; font-family: Arial, sans-serif;">Bhagat, T.D., Chen, S., Bartenstein, M., Barlowe, A.T., Von Ahrens, D., Choudhary, G.S., Tivnan, P., Amin, E., Marcondes, M., Sanders, M.A., Hoogenboezem, R.M., Kambhampati, S., Ramanchandra, N., Mantzaris, I., Sukrithan, V., Laurence, R., Lopez, R. Bhagat, P., Giricz, O., Sohal, D., Wickrema, A., Yeung, C.,&nbsp;<strong><u>Gritsman, K.,</u></strong>&nbsp;Aplan, P., Hochedlinger, K., Yu, Y., Pradhan, K., Zhang, J., Greally, J.M., Mukherjee, S., Pellagatti, A., Boultwood, J., Will, B., Steidl, U., Raaijmakers, M.H.G.P., Deeg, H.J., Kharas, M.G. and Verma, A. Epigenetically Aberrant Stroma in MDS Propagates Disease Via Wnt/b-Catenin Activation, 2017&nbsp;<strong><em>Cancer Research</em></strong>&nbsp;2017 Jul 6. pii: canres.0282.2017. doi: 10.1158/0008-5472</span></p>
<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;">&nbsp;</p>
<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;"><span style="font-size: 11pt; font-family: Arial, sans-serif;">Yuzugullu, H., Baitsch, L., Von, T., Steiner, A., Tong, H., Ni, J., Clayton, L., Bronson, R., Roberts, T.,&nbsp;<strong><u>Gritsman, K</u></strong><u>.</u>, and Zhao, J.J. A p110b-Rac signaling loop mediates Pten-loss-induced perturbation of hematopoiesis and leukemogenesis.&nbsp;<strong><em>Nature Communication</em></strong><em>s&nbsp;</em>October 7,2015, doi:10.1038/NCOMMS9501</span></p>
<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;">&nbsp;</p>
<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;"><span style="font-size: 11pt; font-family: Arial, sans-serif;">Yoda, A., Adelmant, G., Tamburini, J., Chapuy, B., Shindoh, N., Yoda, Y., Weigert, O., Kopp, N., Wu, S-C., Kim, S., Liu, H., Tivey, T., Christie, A.L.,&nbsp;<strong><u>Gritsman, K.</u></strong>,&nbsp; Gotlib, J., Deininger, M., Turley, S., Tyner, J., Marto, J., Weinstock, D.M., and Lane, A.A. Mutations in G-protein beta subunits promote transformation and kinase inhibitor resistance&nbsp;<strong><em>Nature Medicine</em></strong><em>&nbsp;</em>2015 (1):71-5.</span></p>
<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;">&nbsp;</p>
<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;"><strong><u><span style="font-size: 11pt; font-family: Arial, sans-serif;">Gritsman, K</span></u></strong><strong><span style="font-size: 11pt; font-family: Arial, sans-serif;">.</span></strong><span style="font-size: 11pt; font-family: Arial, sans-serif;">, Yuzugullu, H., Von, T., Yan, H., Clayton, L., Fritsch, C., Maira, S.-M., Hollingworth, G., Choi, C., Khandan, T., Paktinat, M., Okabe, R.O., Roberts, T.M., and Zhao, J.J. &nbsp;Hematopoiesis and RAS-driven myeloid leukemia differentially require PI3K isoform p110alpha<strong>.&nbsp;<em>Journal of Clinical Investigation&nbsp;</em></strong>2014;124(4):1794&ndash;1809.&nbsp;http://www.jci.org/articles/view/69927</span></p&gt;
<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;">&nbsp;</p>
<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;"><span style="font-size: 11pt; font-family: Arial, sans-serif;">Kharas, M.G. and&nbsp;<strong><u>Gritsman, K</u></strong>. Akt: A Double-Edged Sword for Hematopoietic Stem Cells.&nbsp;<strong><em>Cell Cycle</em>&nbsp;</strong>2010; Vol 9; Issue 7</span></p>
<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;">&nbsp;</p>
<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;"><span style="font-size: 11pt; font-family: Arial, sans-serif;">Kharas, M.G., Okabe, R., Ganis, J.J., Gozo,M., Khandan,T., Paktinat, M., Gilliland, D.G., and&nbsp;<strong><u>Gritsman, K</u>.</strong>&nbsp;Constitutively Active AKT Depletes Hematopoietic Stem Cells and Induces Leukemia in Mice.&nbsp;<strong><em>Blood&nbsp;</em></strong>2010; 115(7): 140615&nbsp;http://www.bloodjournal.org/content/115/7/1406</span></p&gt;
<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;"><span style="font-size: 10.5pt; font-family: Verdana, sans-serif;">&nbsp;</span></p>
<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;"><span style="font-size: 10.5pt; font-family: Verdana, sans-serif;">&nbsp;</span></p>
<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;"><span style="font-family: 'Times New Roman', serif;">&nbsp;</span></p>
<p class="MsoNormal" style="margin: 0in; font-size: medium; font-family: Calibri, sans-serif;">&nbsp;</p>

EMR ID
73180
Is Open Scheduling
Off
Subscribe to Aplastic Anemia