Jennifer M. McKenna
Adult Medicine<quillbot-extension-portal></quillbot-extension-portal>
Adult Medicine<quillbot-extension-portal></quillbot-extension-portal>
<p>My research interests include pancreatic and colonic carcinogenesis and causes of fatty liver disease. Clinical expertise is in the area of gastrointestinal and liver pathology including liver transplantation. </p>
<span style="font-size:11.0pt;line-height:107%;font-family:'Calibri',sans-serif;">Dr. Laurini's clinical focus is on the study of tissue to diagnose inflammatory and neoplastic diseases of the breast, gynecologic tract and bone and soft tissues.</span>
<span style="font-size:11.0pt;line-height:107%;font-family:'Calibri',sans-serif;">Dr. Laurini's research focus follows his clinical interests in breast and gynecologic pathology.</span>
<p>Javier Ariel Laurini, MD, is Associate Professor, Pathology at Montefiore Einstein. Dr. Laurini's clinical focus is on the study of tissue to diagnose inflammatory and neoplastic diseases of the breast, gynecologic tract and bone and soft tissues.</p>
<p>After earning his Doctor of Medicine in 1995 from the University Of Salvador, School Of Medicine in Buenos Aires, Argentina, Dr. Laurini completed a residency in anatomic pathology in 1999 at the Center of Medical Education and Clinical Investigations (CEMIC) in Buenos Aires. Following this, he completed a three-month internship in hematopathology service at Massachusetts General Hospital. Dr. Laurini became Administrative Chief Resident in the department of pathology at CEMIC for one year before completing a surgical pathology fellowship at British Hospital in Buenos Aires in 2002. He then became a visiting clinician in the Department of Pathology, Mayo Clinic in Rochester before undergoing a combined anatomic and clinical pathology residency at the University of South Alabama College of Medicine, which he completed in 2010. Dr. Laurini then finished a fellowship in surgical pathology at the Mayo Clinic in 2011 before completing another fellowship in hematopathology at the University of Nebraska Medical Center in 2012.</p>
<p>Dr. Laurini's research focus follows his clinical interests in breast and gynecologic pathology. His work has been published in numerous original communications and peer-reviewed journals, articles and abstracts.</p>
<p>Dr. Laurini is board certified in Hematology and Anatomic and Clinical Pathology by the American Board Of Pathology. He is a Fellow of the College of American Pathologists and the American Society of Clinical Pathologists, and a member of the United States and Canadian Academy of Pathology. He is also part of the Mayo Clinic Alumni Association. Dr. Laurini has won multiple faculty teaching awards from the University of South Alabama and Wake Forest School of Medicine. In 2022 he won the Attending Teaching Award from Einstein.</p>
<p>Neil D. Herbsman, MD, FAGA, FACP, is an attending physician and Clinical Assistant Professor, Medicine at Montefiore Einstein. Dr. Herbsman’s clinical focus is in colon cancer screening, peptic ulcer disease, diverticular disease, reflux, colonoscopy, endoscopy and diseases of the esophagus, stomach, intestines and colon.</p><p>After receiving his Bachelor of Arts from Yale University in 1985, Dr. Herbsman attended Mount Sinai School of Medicine, earning his Doctor of Medicine in 1989. He completed his internal medicine residency at Mount Sinai Hospital in 1992, and his gastroenterology fellowship at Memorial Sloan Kettering in 1995.</p><p>Dr. Herbsman’s research focuses on colon cancer screening. His research has been published in peer-reviewed journals.</p><p>Dr. Herbsman is board certified in Internal Medicine and Gastroenterology, and is a Fellow of the American Gastroenterological Association and the American College of Physicians. He is a member of the American Society of Gastrointestinal Endoscopy, the American College of Gastroenterology and the New York State Medical Society. In 2015, he was the president of the Bronx County Medical Society.</p>
Dr. Hametz's clinical focus is on providing family-centered care for all hospitalized children and on developing and implementing systems of care for children with medical complexities.
Dr. Hametz’s research focuses on improving care and the systems in which care is provided to hospitalized children and adolescents, and their families.
<p>Patricia A. Hametz, MD, MPH, is Chief of the Division of Pediatric Hospital Medicine at Children’s Hospital at Montefiore Einstein (CHAM). As Chief, she oversees the care of children admitted to the general pediatrics service, consultation service and co-management of patients on the pediatric surgery and surgical subspecialty services. She is also an Attending Physician at CHAM and an Associate Professor of Pediatrics at Albert Einstein College of Medicine. Her clinical focus is on providing family-centered care for all hospitalized children and on developing and implementing systems of care for children with medical complexities.</p><p>Dr. Hametz received her Doctor of Medicine in 1995 from Columbia University College of Physicians and Surgeons in New York. In 2008, she received her Master of Public Health from Columbia University Mailman School of Public Health. Dr. Hametz completed an internship and residency in Pediatrics at Morgan Stanley Children's Hospital of New York from 1995 to 1999 and became Chief Resident in 1998.</p><p>Dr. Hametz’s research focuses on improving care and the systems in which care is provided to hospitalized children and adolescents, and their families. Her original communications have been published in numerous peer-reviewed journals, as well as invited publications. She has been an invited speaker to regional and local presentations.</p><p>Dr. Hametz has been recognized as an outstanding teacher, was nominated for the Attending Teacher of the Year Award several times and also won the Pediatric Residency Appreciation Award in 2015. Dr. Hametz is board certified by the American Board of Pediatrics and is a Resident Member of the American Academy of Pediatrics.</p>
<p>Liver regeneration is critical for health. We focus on physiology of liver regeneration during development, early childhood and adulthood to inform mechanistic disruptions in diseases. The latter ranges from acute liver failure, effects of drugs, toxins, alcohol, virus hepatitis, obesity-related metabolic (or nonalcoholic) liver disease, chronic hepatitis, e.g., Wilson disease with copper toxicosis, and allograft rejection. The mechanisms concerning DNA damage response directed by ATM gene and downstream partners are of considerable interest to us. </p>
<p>These aspects are joined with study of cell type-specific contributions as well as aspects of stem cell biology for liver regeneration. We apply cell transplantation approaches to better understand the biology and regenerative potential of various cell types. Expression of therapeutic constructs and transplantation of those cells is another area of investigative interest. We address the role of endogenous stem/progenitor cells in therapeutic development. Tissue engineering to generate auxiliary liver has potential in these areas and is also advancing liver regenerartion in experimental models.</p>
<p>We use a variety of methods, including microarrays or deep sequencing for gene expression, cell and molecular biology methods, and multiple small and large animal models. The findings are integrated with analyses of human tissue and blood samples.</p>
<p>Unique aspects of our work include use of established drugs for mechanistic interrogations and therapeutic applications, and an uncommon depth and breadth of multidisciplinary tools. We collaborate with leading investigators at Einstein or elsewhere as appropriate.</p>
<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt;">Dr. Gupta is a pioneer in the development of cell therapy – treating disease by introducing healthy cells into the body. He has discovered various mechanisms for coaxing transplanted cells to attach to host tissue and multiply, paving the way for treating health problems such as high cholesterol, hemophilia, liver failure, and hepatitis. </span></p>
<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt;">Dr. Gupta has successfully manipulated human stem cells to generate liver cells and defined some of the fundamental ways by which gene expression is regulated in stem cells. Dr. Gupta serves as an expert for the National Institutes of Health, U.S. Department of Veterans Affairs, U.S. Department of Defense, Wellcome Trust, and national scientific bodies in over ten countries.</span></p>
<p class="MsoNormal" style="line-height: 15.6pt;"><span style="font-size: 9.0pt;">In the 1990s, Dr. Gupta contributed to the first ever clinical trial of a cell/gene therapy for familial hypercholesterolemia (high cholesterol), which results from a gene defect. He also showed that Wilson’s disease (a genetic condition characterized by excessive accumulation of copper in the liver and brain) could potentially be cured by use of cell therapy. </span></p>
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<ul type="disc">
<li>Thirunavukkarasu C, Sharma Y, Tchaikovskaya T, Maslov AY, Gupta S. Transcriptional profiling reveals ataxia telangiectasia mutated pathways regulate joint copper and arsenic toxicity for hepatic metalloplasia and anti-cancer therapies. Life Sci. 2022 Jul 6;120787. doi: 10.1016/j.lfs.2022.120787. </li>
<li>Chang CJ, Ge EJ Bush AI, Casini A, Cobine PA, Cross JR, DeNicola GM, Dou Q, Franz KJ, Gohil VM, Gupta S, Kaler SG, Lutsenko S, Mittal V, Petris MJ, Polishchuk R, Ralle M, Schilsky ML, Tonks NK, Vahdat LK, Van Aelst L, Xi D, Yuan P, Brady DC. Connecting copper and cancer from transition metal signaling to metalloplasia in the clinic. Nat Rev Cancer 2022 Feb;22(2):102-113. doi: 10.1038/s41568-021-00417-2. Epub 2021 Nov 11. PMID: 34764459</li>
<li>Viswanathan P, Gupta P, Sharma Y, Maisuradze L, Bandi S, Gupta S. Caffeine disrupts ataxia telangiectasia mutated gene-related pathways and exacerbates acetaminophen toxicity in human fetal immortalized hepatocytes. Toxicology. 2021 May 7;457:152811. doi: 10.1016/j.tox.2021.152811. PMID: 33971260</li>
<li>Viswanathan P, Sharma Y, Jaber FL, Tchaikovskaya T, Gupta S. Transplanted hepatocytes rescue mice in acetaminophen-induced acute liver failure through paracrine signals for hepatic ATM and STAT3 pathways. FASEB J 2021 Apr;35(4):e21471. doi: 10.1096/fj.202002421R. PMID: 33683737</li>
<li>Jaber FL, Sharma Y, Mui BG, Kapoor S, Gupta S. Tumor necrosis factor directs allograft-related innate responses and its neutralization improves hepatocyte engraftment in rats. Am J Pathol 2021; 191(1):79-89. doi: 10.1016/j.ajpath.2020.09.014. Epub 2020 Oct 27. PMID: 33127336</li>
<li>Viswanathan P, Sharma Y, Gupta S. Ataxia telangiectasia mutated pathway disruption affects hepatic DNA and tissue damage in nonalcoholic fatty liver disease. Exp Mol Pathol. 2020 Apr; 113:104369. doi: 10.1016/j.yexmp.2020.104369. Epub 2020 Jan 7. PMID: 31917286</li>
<li>Gupta P, Sharma Y, Viswanathan P, Gupta S. Cellular receptor signaling and ATM pathway intersections regulate hepatic DNA repair. Cytokine 2020 Mar; 127:154946. doi: 10.1016/j.cyto.2019.154946. Epub 2019 Dec 11. PMID: 31837586</li>
<li>Bandi S, Tchaikovskaya T, Gupta S. Hepatic differentiation in human pluripotent stem cells by developmental stage-specific metabolomics products. Differentiation 2019; 105:54-70. Jan 28;105:54-70. doi: 10.1016/j.diff.2019.01.005. PMID: 30776728.</li>
<li>Kakabadze Z, Karalashvili L, Chakhunashvili D, Havlioglu N, Janelidze M, Kakabadze A, Sharma Y, Gupta S. Decellularized bovine placentome for portacavally-interposed heterotopic liver transplantation in rats. Mater Sci Eng C Mater Biol Appl. 2019 Apr; 97:293-301. doi: 10.1016/j.msec.2018.12.025. Epub 2018 Dec 10. PMID: 30678914.</li>
<li>Yadav N, Jaber FL, Sharma Y, Viswanathan P, Gupta S. Efficient reconstitution of hepatic microvasculature by endothelin receptor antagonism in liver sinusoidal endothelial cells. Hum Gene Ther 2018; Sep 28. doi: 10.1089/hum.2018.166. PMID: 30266073, </li>
<li>Sharma Y, Liu J, Kristian KE, Follenzi A, Gupta S. In Atp7b-/- mice modeling Wilson's disease liver repopulation with bone marrow-derived myofibroblasts or inflammatory cells and not hepatocytes is delterious. <span title="Gene expression">Gene Expr</span>. 2018 Jul 20. doi: 10.3727/105221618X15320123457380. PMID: 30029699</li>
<li>Bandi S, Gupta S, Tchaikovskaya T, Gupta S. Differentiation in stem/progenitor cells along fetal or adult hepatic stages requires transcriptional regulators independently of oscillations in microRNA expression. <span title="Experimental cell research">Exp Cell Res</span>. 2018 Sep 1;370(1):1-12. doi: 10.1016/j.yexcr.2018.06.004. Epub 2018 Jun 6.</li>
<li>Benten D, Kluwe J, Wirth JW, Thiele ND, Follenzi A, Bhargava KK, Palestro CJ, Koepke M, Tjandra R, Volz T, Lutgehetmann M, Gupta S. A humanized mouse model with liver fibrosis following expansion of transplanted hepatic stellate cells in injury and inflammation. Lab Invest 2018 Apr;98(4):525-536. doi: 10.1038/s41374-017-0010-7. Epub 2018 Jan 19.PMID: 29352225.</li>
<li>Viswanathan P, Sharma Y, Gupta P, Gupta S. Replicative stress and alterations in cell cycle checkpoint controls following acetaminophen hepatotoxicity restrict hepatic regeneration. Cell Prolif 2018; Jun;51(3):e12445. doi: 10.1111/cpr.12445. Epub 2018 Mar 5. PMID: 29504225.</li>
<li>Kakabadze Z, Kakabadze A, Chakhunashvili D, Karalashvili L, Berishvili E, Sharma Y, Gupta S. Decellularized human placenta supports hepatic tissue and allows rescue in acute liver failure. Hepatology 2018 May;67(5):1956-1969. PMID: 29211918. </li>
</ul>
<p><strong>Education</strong></p>
<p>Medical School: Lady Hardinge Medical College, University of Delhi, New Delhi, India<br />Residency: Bronx-Lebanon Hospital Center (Family Medicine)</p>