Daorong Feng

Daorong Feng, Ph.D.

Area of research

  • Adipocyte cell death in pathology and physiology condition, intercellular crosstalk within adipose tissue

Email

Phone

Location

  • Albert Einstein College of Medicine Michael F. Price Center 1301 Morris Park Avenue 379 Bronx, NY 10461


Research Profiles

Selected Publications

 

1.         Fu XR, Ng C, Feng DR, Liang C. Cdc48p is required for the cell cycle commitment point at start via degradation of the G1-CDK inhibitor Far1p. J Cell Biol. 2003;163(1):21-6. doi: DOI 10.1083/jcb.200307025. PubMed PMID: WOS:000185956800002.

 

2.         Feng D, Tu Z, Wu W, Liang C. Inhibiting the expression of DNA replication-initiation proteins induces apoptosis in human cancer cells. Cancer research. 2003;63(21):7356-64. PubMed PMID: 14612534.

 

3.         Yu Z, Feng D, Liang C. Pairwise interactions of the six human MCM protein subunits. Journal of molecular biology. 2004;340(5):1197-206. doi: 10.1016/j.jmb.2004.05.024. PubMed PMID: 15236977.

 

4.         Senee V, Chelala C, Duchatelet S, Feng D, Blanc H, Cossec JC, Charon C, Nicolino M, Boileau P, Cavener DR, Bougneres P, Taha D, Julier C. Mutations in GLIS3 are responsible for a rare syndrome with neonatal diabetes mellitus and congenital hypothyroidism. Nature genetics. 2006;38(6):682-7. doi: 10.1038/ng1802. PubMed PMID: 16715098.

 

5.         Zhang W, Feng D*, Li Y, Iida K, McGrath B, Cavener DR. PERK EIF2AK3 control of pancreatic beta cell differentiation and proliferation is required for postnatal glucose homeostasis. Cell metabolism. 2006;4(6):491-7. doi: 10.1016/j.cmet.2006.11.002. PubMed PMID: 17141632 (*co-first author).

 

6.         Wei J, Sheng X, Feng D, McGrath B, Cavener DR. PERK is essential for neonatal skeletal development to regulate osteoblast proliferation and differentiation. Journal of cellular physiology. 2008;217(3):693-707. doi: 10.1002/jcp.21543. PubMed PMID: 18683826.

 

7.         Feng D, Wei J, Gupta S, McGrath BC, Cavener DR. Acute ablation of PERK results in ER dysfunctions followed by reduced insulin secretion and cell proliferation. BMC cell biology. 2009; 10:61. doi: 10.1186/1471-2121-10-61. PubMed PMID: 19732428; PubMed Central PMCID: PMC2749809.

 

8.         Ma L, Zhai Y, Feng D, Chan TC, Lu Y, Fu X, Wang J, Chen Y, Li J, Xu K, Liang C. Identification of novel factors involved in or regulating initiation of DNA replication by a genome-wide phenotypic screen in Saccharomyces cerevisiae. Cell cycle. 

2010;9(21):4399-410. PubMed PMID: 20980819.

 

9.         Li P, Lu M, Nguyen MT, Bae EJ, Chapman J, Feng D, Hawkins M, Pessin JE, Sears DD, Nguyen AK, Amidi A, Watkins SM, Nguyen U, Olefsky JM. Functional heterogeneity of CD11c-positive adipose tissue macrophages in diet-induced obese mice. The Journal of biological chemistry. 2010;285(20):15333-45. doi: 14.1074/jb.M110.100263. PubMed PMID: 20308074; PubMed Central PMCID: PMC2865288.

 

10.      Feng D, Tang Y, Kwon H, Zong H, Hawkins M, Kitsis RN, Pessin JE. High-fat diet-induced adipocyte cell death occurs through a cyclophilin D intrinsic signaling pathway independent of adipose tissue inflammation. Diabetes. 2011;60(8):2134-43. doi: 10.2337/db10-1411. PubMed PMID: 21734017; PubMed Central PMCID: PMC3142076.

 

11.      Zhao X, Feng D*, Wang Q, Abdulla A, Xie XJ, Zhou J, Sun Y, Yang ES, Liu LP, Vaitheesvaran B, Bridges L, Kurland IJ, Strich R, Ni JQ, Wang C, Ericsson J, Pessin JE, Ji JY, Yang F. Regulation of lipogenesis by cyclin-dependent kinase 8-mediated control of SREBP-1. The Journal of clinical investigation. 2012; 122(7):2417-27. doi: 11.1172/JCI61462. PubMed PMID: 22684109; PubMed Central PMCID: PMC3386818 (*co-first author).

 

12.      Hasek BE, Boudreau A, Shin J, Feng D, Hulver M, Van NT, Laque A, Stewart LK, Stone KP, Wanders D, Ghosh S, Pessin JE, Gettys TW. Remodeling the integration of lipid metabolism between liver and adipose tissue by dietary methionine restriction in rats. Diabetes. 2013;62(10):3362-72. doi: 10.2337/db13-0501. PubMed PMID: 23801581; PubMed Central PMCID: PMC3781441.

 

13.      Lim J, Liu Z, Apontes P, Feng D, Pessin JE, Sauve AA, Angeletti RH, Chi Y. Dual mode action of mangiferin in mouse liver under high fat diet. PloS one. 2014;9(3): e90137. doi: 10.1371/journal.pone.0090137. PubMed PMID: 24598864; PubMed Central PMCID: PMC3943915.

 

14.      Feng D, Youn DY, Zhao X, Gao Y, Quinn WJ 3rd, Xiaoli AM, Sun Y, Birnbaum MJ, Pessin JE, Yang F. mTORC1 Down-Regulates Cyclin-Dependent Kinase 8 (CDK8) and Cyclin C (CycC). PLoS One. 2015 Jun 4;10(6):e0126240. doi: 10.1371/journal.pone.0126240. PMID: 26042770; PMCID: PMC4456374.

 

15.      Esterson YB, Carey M, Boucai L, Goyal A, Raghavan P, Zhang K, Mehta D, Feng D, Wu L, Kehlenbrink S, Koppaka S, Kishore P, Hawkins M. Diabetes. 2016 Sep;65(9):2569-79. doi: 10.2337/db15-1465.

 

16.      Toledo M, Batista-Gonzalez A, Merheb E, Aoun ML, Tarabra E, Feng D, Sarparanta J, Merlo P, Botrè F, Schwartz GJ, Pessin JE, Singh R. Autophagy Regulates the Liver Clock and Glucose Metabolism by Degrading CRY1. Cell Metab. 2018 Aug 7;28(2):268-281.e4. doi: 10.1016/j.cmet.2018.05.023. Epub 2018 Jun 21. 15 Esterson YB, Carey M, Boucai L, Goyal A, Raghavan P, Zhang K, Mehta D, Feng D, Wu L, Kehlenbrink S, Koppaka S, Kishore P, Hawkins M. Diabetes. 2016 Sep;65(9):2569-79. doi: 10.2337/db15-1465. 

 

17.       Feng D*, Amgalan D, Singh R, Wei J, Wen J, Wei TP, McGraw TE, Kitsis RN, Pessin JE. SNAP23 regulates BAX-dependent adipocyte programmed cell death independently of canonical macroautophagy. J Clin Invest. 2018 Aug 31;128(9):3941-3956. doi: 10.1172/JCI99217. Epub 2018Aug 13. 

 

18.        Liang T, Qin T, Kang F, Kang Y, Xie L, Zhu D, Dolai S, Greitzer-Antes D, Baker RK, Feng D, Tuduri E, Ostenson CG, Kieffer TJ, Banks K, Pessin JE, Gaisano HY. SNAP23 depletion enables more SNAP25/calcium channel excitosome formation to increase insulin exocytosis in type 2 diabetes. JCI Insight. 2020 Feb 13;5(3): e129694. doi: 10.1172/jci.insight.129694. PMID: 32051343; PMCID: PMC7098801. 

 

19.       Deutsch A, Feng D, Pessin JE, Shinoda K. The Impact of Single-Cell Genomics on Adipose Tissue Research. Int J Mol Sci. 2020 Jul 5;21(13):4773. doi: 10.3390/ijms21134773. PMID: 32635651; PMCID: PMC7369959 

 

20.       Chen F, Amgalan D, Kitsis RN, Pessin JE, Feng D. ATG16L1 autophagy pathway regulates BAX protein levels and programmed cell death. J Biol Chem. 2020 Oct 30;295(44):15045-15053. doi: 10.1074/jbc.RA120.013999. Epub 2020 Aug 26. PMID: 32848017; PMCID: PMC7606669.