Frederick J. Kaskel

Frederick J. Kaskel, M.D., Ph.D.

Area of research

  • glomerular diseases, hypertension, genetic etiologies for disparities in kidney disease, adherence, congenital genitourinary tract abnormalities, chronic kidney disease, translational life-course research

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Location

  • Albert Einstein College of Medicine Jack and Pearl Resnick Campus 1300 Morris Park Avenue Block 516 Bronx, NY 10461

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Research Profiles

Research Profiles

Research Profiles

Professional Interests

Frederick J. Kaskel, M.D., Ph.D., is an internationally recognized clinical investigator and educator in pediatric nephrology. He is a Chief Emeritus, Nephrology Children's Hospital at Montefioire, Albert Einstein College of Medicine. He is a Past President of the American Society of Pediatric Nephrology and the Congress President of the 15th Scientific Congress of the International Pediatric Nephrology Association.

He received his undergraduate bachelor's degree in Biology from Monmouth College, Monmouth, Ill., and his doctorate in Physiology and Medical Degree from the University of Cincinnati College of Medicine and is a Distinguished Alumnus from both of these institutions. He trained in Pediatrics and Pediatric Nephrology at Montefiore Medical Center and Albert Einstein College of Medicine, respectively and was a recipient of an NIH National Research Service Award. Prior to returning to Montefiore Medical Center and the Albert Einstein College of Medicine in 1998 to become the Director of Pediatric Nephrology, he was a tenured Professor of Pediatrics at the State University of New York at Stony Brook.

Dr. Kaskel's research interests range from basic science contributions in developmental renal physiology and mechanisms of renal toxicity and hypertension, to clinical and translational research in the etiologies and treatment of progressive kidney diseases secondary to nephrotic sydnrome and focal segmental glomerulosclerosis and hypertension. His current research is aimed at preventing the epidemic of obesity and cardiovascular risk factors and hypertension. He has received continuous research support from the National Institutes of Health and directs the Training Program in Pediatric Nephrology which prepares new physician investigators for careers in Pediatric Nephrology.

He published over 100 peer-reviewed articles, book chapters, and co-edited a major textbook on Fluids and Electrolytes in Pediatrics. He has numerous collaborations nationally and internationally and is expanding the communications between pediatric nephrology basic and clinical investigators worldwide. He currently plays a major role representing the Department of Pediatrics in the Einstein's prestigious Clinical Translational Science Award.

Selected Publications

  1. Chandra M, Stokes MB, Kaskel FJ. Multinucleated podocytes: a diagnostic clue to cystinosis. Kidney Int. 2010 Nov;78(10):1052. PMID 21030980
  2. Greenbaum LA, Munoz A, Schneider MF, kaskel FJ, Askenazi DJ, Jenkins R, Hotchkiss H, Moxey-Mims M, Furth SL, Warady BA. The association between abnormal birth history and growth in children with CKD. Clin J Am Soc Nephrol 011 Jan;6(1):14-21. PMC3022235
  3. Gipson DS, Trachtman H, Kaskel FJ, Radeva MK, Gassman J, Greene TH, Moxey-Mims MM, Hogg RJ, Watkins SL, Fine RN, Middelton JP, Vehaskari VM, Hogan SL, Vento S, Flynn PA, Powell LM, McMahan JL, Siegel N, Friedman AL. Clinical trials treating focal segmental glomerulosclerosis should measure patient quality of life. Kidney Int. 2011 Mar;79(6):678-85. PMC3306823
  4. Goilav B, Kaskel FJ. Chronic kidney disease stages are appropriate at all ages.  Blood Purif. 2011;31(1-3):125-   129. PMID 21228580
  5. Thomas R, Sanna-Cherchi S, Warady BA, Furth SL, Kaskel FJ, Gharavi AG. HNF1B and PAX2 mutations are a common cause of renal hypodysplasia in the CKiD cohort. Pediatr Nephrol. 2011 Jun;26(6):897-903. PMC3257470
  1. Gipson DS, Trachtman H, Kaskel FJ, Greene TH, Radeva MK, Gassman JJ, Moxey-Mims MM, Hogg RJ,                            Watkins SL, Fine RN, Hogan SL, Middleton JP, Vehaskari VM, Flynn PA, Powell LM, Vento SM, McMagan JL, Siegel N, D’Agati VD, Friedman AL.  Clinical trial of focal segmental glomerulosclerosis in children and young adults. Kidney Int. 2011 Oct;80(8):868-78. PMC3306824
  2. Furth SL, Abraham AG, Jerry-Fluker J, Schwartz GJ, Benfield M, Kaskel F, Wong C, Mak RH, Moxey-Mims M, Warady BA. Clin J Am Soc Nephrol. 2011 Sep;6(9):2132-40. PMC3358991
  3. Gipson DS, Trachtman H, KaskelFJ, RadevaM, GassmanJ, GreeneT, Moxey-Mims M, HoggR, WatkinsS, FineR, MiddletonJ, VehaskariVM, HoganHL, VentoS, FlynnP, PowellL, McMahanJ, SiegelN, FriedmanA. Clinical trials treating focal segmental glomerulosclerosis should measure patient quality of life. Kidney Int. 2011 Mar; 79(6):678-85. PMC33068223
  4. Skversky AL, Kumar J, Abramowitz MK, Kaskel FJ, Melamed ML. Association of glucocorticoid use and low 25-hydroxyvitamin D levels: results from the National Health and Nutrition Examination Surevey (NHANES):2001-2006. J Clin Endocrinol Metab. 2011 Sep28. PMC3232615
  5. D’Agati V.D., Kaskel, FJ, and Falk RJ. Medical Progress: Focal Segmental Glomerulosclerosis. New England Journal of Medicine 2011 Dec: 365(25):2398-411. PMID 22187987
  6. Wei C, Trachtman H, Li J, Dong, C, Friedman AL, Gassman JJ, McMahan JL, Radeva M, Heil KM,                        Trautmann A, Anaret A, Emre S, Ghiggeri GM, Ozaltin F, Haffner D, Gipson DS, Kaskel, F, Fischer DC,                Schaefer F, Reiser, J. Circulating suPAR in two cohorts of primary FSGS. Clin J Am Soc Nephrol. 23:, 2012.
  7. D’Agati VD, Alser JC, Jennette C, Thomas D, Pullman J, Savino D, Cohen A, Gipson D, Gassman J, Radeva M, Moxey-Mims M, Friedman A, Kaskel F, Trachtman H, Alpers C, Fogo A, Nast C. Histologic Variants in FSGS Clinical Trial biopsies correlate with outcome independent of remission status. Clin J Am Soc Nephrol. 2013; Mar;8(3):399-406. PMID: 23220425
  8. Hogg R, Friedman A, Greene T, Radeva M, Budisavljevic M, Gassman J, Gipson D, Jefferson A, John E,                Kaskel F, Moudgil A, Moxe-Mims M, Ortiz L, Schelling J, Schnaper H, Srivastava T, Trachtman H,                        Vehaskari V, Wong C, Worinicki R, Van Wy S, Zolotnitskaya A. Renal function and proteinuria after                      successful immunosuppressive therapies in patients with focal segmental glomerulosclerosis (FSGS).  Clin J Am Soc Nephrol. 2013 Feb;8(2):211-8. PMID: 23143503
  9. Ferris M, Norwood V, Radeva M, Gassman J, Amira A, Askenazi D, Mato T, Pinsk M, Sharma A, Smoyer W, Stults J, Vyas S, Weiss R, Gipson D, Kaskel F, Friedman A, Moxey-Mins M, Trachtman H. Patient                          recruitment in a multicenter randomized clinical trial for kidney disease: report of the Focal Segmental                     Glomerulosclerosis Clinical Trial. Clin Trans Sci 2013 Feb;6(1):13-20. PMID: 23399084
  10. Gadegbeku C, Gipson D, Holzman L, Ojo A, Song P, Barisoni L, Sampson M, Kopp J, Lemley K, Nelson P,  Lienczewski C, Adler S, Appel G, Cattran D, Choi M, Contreras G, Dell K, Fervenza F,  Gibson K, Greenbaum L, Hernandez J, Hewitt S, Hingorani S, Hladunewich M, Hogan M, Hogan S, Kaskel J,  Lieske J, Meyers K, Nachman P, Nast C, Neu A, Reich H, Sedor J, Sethna C, Trachtman H, Tuttle K, Zilleruelo G, and Kretzler M. Design of the Nephrotic Syndrome Study Network (NEPTUNE) to evaluate primary glomerular nephropathy by a multidisciplinary approach. Kidney International advance online publication, 16 January 2013 doi:10.1038/ki.2012.428.
  11. Akchurin O, Kaskel FJ. Late steroid resistance in childhood nephrotic syndrome: do we now know more that 40 years ago? Pediatr Nephrol. 2013 Aug;28(8):1157-60. PMID: 23708761
  12.    17. Frederick Kaskel, Daniel Batlle, Srinivasan Beddhu, John Daugirdas, Harold Feldman, Maria Ferris,   Lawrence Fine, Barry Freedman, Paul L Kimmel, Michael F Flessner, Robert A. Star, on behalf of the             Kidney Research National Dialogue (KRND). Improving CKD Therapies and Care: A National Dialogue.        CJASN (In Press).
  13. 18. Nephropathic Cystinosis: An International Consensus Document. NDT (in Press).